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61. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer_disposition-comments.pdf
    May 27, 2010 - We understand that a large amount of work was put into this study and such a comprehensive document … Comments relate to the interpretation by the authors on the clinical relevance of major aspects in this large … technical improvement is not expected to yield measurable differences in tumor control, unless a very large … with anticipated local disease control rates of ~90% in the modern era, it will take an extremely large … General Comment To conclude, . . . and the radiation oncology community at-large are well positioned

62. Use of Antiplatelet Therapy in Patients Receiving Coronary Stents | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/coronary-stents-antiplatelet-therapy/abstract
    January 31, 2011 - Adverse events after stopping clopidogrel in post-acute coronary syndrome patients: insights from a large

63. Osteoporosis-Bone-Fracture Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoporosis-bone-fracture_executive.pdf
    March 01, 2012 - osteoporosis- related fracture at some point in his lifetime.3 The economic burden of osteoporosis is large … Controlled clinical trials and large observational studies (N>1,000) that reported fracture outcomes … Controlled clinical trials and large case control or cohort studies (over 1,000 participants) that … • A large body of literature showed mixed results for an effect of vitamin D in lowering the risk … • Esophageal cancer: Four large observational studies identified for this report examined the risk

64. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-patients-with-crohns-disease-what-treatments-or-therapies-alone-or-in-conjunction-with-one-another-provide-the-highest-rate-of-disease-management-with-the-lowest-risk-of-long-term-complications-particularly-in-young-women
    March 10, 2009 - (For example, you are developing a clinical guideline, working with a policy with large uncertainty about … reform, costs must be addressed and the "best medicines" for my disease are currently unaffordable to a large

65. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-of-conventional-computed-tomography-ct-multidetector-computed-tomography-mdct-ct-colonography-fludeoxyglucose-positron-emission-tomography-fdg-pet-or-fdg-petct-magnetic-resonance-imaging-mri-ultrasou
    December 27, 2011 - (For example, you are developing a clinical guideline, working with a policy with large uncertainty about … The risk of colorectal cancer affects a large percentage of the general US population, men and women.

66. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-and-harms-of-treatments-for-traumatic-brain-injury-preliminary-key-questions-1-what-is-the-comparative-effectiveness-of-the-treatments-for-tbi-for-grades-i-iv-2-for-patients-what-are-the-
    December 07, 2009 - (For example, you are developing a clinical guideline, working with a policy with large uncertainty about … States are faced with developing policies with large uncertainty about the appropriate approach and effectiveness

67. Telehealth: Mapping the Evidence for Patient Outcomes From Systematic Reviews | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/telehealth/technical-brief
    June 30, 2016 - Purpose The purpose of this brief is to provide an overview of the large and disparate body of evidence … A large volume of research reported that telehealth interventions produce positive outcomes when used

68. Cer-242-Radiation-Therapy-Brain-Metastases-Evidence-Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-242-radiation-therapy-brain-metastases-evidence-summary.pdf
    June 01, 2021 - Radiation Therapy for Brain Metastases Evidence Summary Main Points • We identified a large … Eligible studies included RCTs as well as large non-randomized controlled trials and cohort studies … varied, 25 trials were terminated early and the quality of adverse assessment and reporting showed large … Despite the large number of identified research studies, analyses were limited as studies evaluated

69. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/key-questions-1-does-routine-preoperative-testing-compared-to-no-testing-or-alternative-testing-strategies-improve-outcomes-such-as-surgical-complications-other-morbidity-and-mortality-among-patients-undergoing-elective-surge
    February 10, 2011 - efficiency,14,15 decrease postponement of surgery,7,14,15 and improve the patient experience.14,15 A large … efficiency,14,15 decrease postponement of surgery,7,14,15 and improve the patient experience.14,15 A large … (For example, you are developing a clinical guideline, working with a policy with large uncertainty about

70. Assessing Applicability (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/assessing-applicability.ppt
    January 01, 2009 - Studies conducted in large academic medical centers in major cities might not be as applicable to rural … Unfortunately, these clinical trials, by and large, compared bypass surgery versus angioplasty with or … In contemporary practice, however, a large subset of patients undergo angioplasty with a drug-eluting … Finally, the settings for the studies are large tertiary medical centers, which may overestimate the … These trials were conducted in select, large, tertiary care medical centers and may not be applicable

71. Methods Future Research Needs Number 8: Framework for Considering Study Designs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-framework_research.pdf
    March 01, 2012 - In either case, the resource requirements will be large or very large, given that the effect size between … Sample size may be very large given the increasing availability of large administrative claims and … Sample size can be very large given the increasing availability of relatively inexpensive large administrative … Size of the study sample may range from small to very large. … Study size may be small or large, depending on the intervention or the availability of data.

72. Psychological and Pharmacological Treatments for Adults With Posttraumatic Stress Disorder (PTSD) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/ptsd-adult-treatment/research
    April 03, 2013 - Effect sizes for reducing PTSD symptoms were large (e.g., 28.9- to 32.2-point reduction in Clinician-Administered

73. Community Pharmacy/Call Center Assessment of Medication Effectiveness & Safety | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/medicine-safety-call-center/research
    December 02, 2009 - Abstract Adverse drug events impose a large cost on the society in terms of lives and healthcare costs

74. Future Research Needs for Treatment of Obstructive Sleep Apnea (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-treatment-future_research.pdf
    February 01, 2012 - Moderate resources may be necessary to recruit and follow a large cohort over a long timeframe. … In summary, the online Web site discussion of numerous topics by a large stakeholder panel was only … When considering clinical outcomes, there is a potential for a large loss in followup. … However, there is potential for large data loss due to long-term followup. … Represents a significant disease burden; large proportion or priority population 2b.

75. Topic Suggestion Description | Effective Health Care Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-asthmatic-and-asthma-prone-children-what-is-the-comparative-effectiveness-of-treating-with-allergen-specific-immunotherapy-plus-standard-vs-standard-alone
    September 03, 2009 - suggesting immunotherapy may have very significant disease-reduction potential but there has never been a large-scale … (For example, you are developing a clinical guideline, working with a policy with large uncertainty about

76. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
    July 01, 2011 - Large differences compared with in-laboratory PSG cannot be excluded for all portable monitors. … The large majority of relevant trials have compared autotitrating CPAP (autoCPAP) with fixed CPAP and … • By meta-analysis, CPAP results in a statistically significant large reduction in AHI (-20 events … • Conclusion: Despite no evidence or weak evidence on clinical outcomes, given the large magnitude … • Conclusion: Despite no evidence or weak evidence on clinical outcomes, given the large magnitude

77. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-cancer-medications_executive.pdf
    September 01, 2009 - raloxifene, and tibolone for the primary prevention of breast cancer, mortality, and fractures: • Eight large … Strength of Evidence Symbols +++ High: Consistent results from numerous (>5) or large definitive trials … raloxifene, and tibolone when used for primary prevention of breast cancer: • In addition to the 8 large … endometrial cancer in clinical trials but was associated with more cases of endometrial cancer in a large … Strength of Evidence Symbols +++ High: Consistent results from numerous (>5) or large definitive trials

78. Assessing Applicability (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/assessing-applicability.ppt
    January 01, 2009 - Studies conducted in large academic medical centers in major cities might not be as applicable to rural … Unfortunately, these clinical trials, by and large, compared bypass surgery versus angioplasty with or … In contemporary practice, however, a large subset of patients undergo angioplasty with a drug-eluting … Finally, the settings for the studies are large tertiary medical centers, which may overestimate the … These trials were conducted in select, large, tertiary care medical centers and may not be applicable

79. White Paper: Living Systematic Reviews: Practical Considerations for Adapting Scope and Communicating the Evolving Evidence (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/scope-communicating-evolving-evidence-white-paper.pdf
    July 01, 2023 - Considering the large amount of information being presented, the TEP indicated that the use of colors … Studies) [SOE] Comparable THC/CBD Oromucosal Spray No effect (5) [+] No effect (3) [+] Large … effect (6) [+] Moderate effect (6) [+] Large effect (6) [+] High THC – Synthetic, Oral … Potential effecta (4) [+] Insufficient (1) Large effect (2) [++] Potential effecta (2) [+] … (1) Large effect (1) [+] No evidence No evidence Low THC – Topical CBD No evidence No evidence

80. White Paper: Living Systematic Reviews: Practical Considerations for Adapting Scope and Communicating the Evolving Evidence (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/scope-communicating-evolving-evidence-white-paper_0.pdf
    December 01, 2023 - Considering the large amount of information being presented, the TEP indicated that the use of colors … Studies) [SOE] Comparable THC/CBD Oromucosal Spray No effect (5) [+] No effect (3) [+] Large … effect (6) [+] Moderate effect (6) [+] Large effect (6) [+] High THC – Synthetic, Oral … Potential effecta (4) [+] Insufficient (1) Large effect (2) [++] Potential effecta (2) [+] … (1) Large effect (1) [+] No evidence No evidence Low THC – Topical CBD No evidence No evidence