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81. Acute Treatments for Episodic Migraine | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/migraine-treatments/research
    December 29, 2020 - No studies evaluate instruments for predicting risk of opioid misuse, opioid use disorder or overdose … No studies evaluated instruments for predicting risk of opioid misuse, opioid use disorder, or overdose

82. | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/o
    Obsessive-Compulsive Disorder Occupational Health Occupational Health for Health Care Providers Opioid

83. App-E-Surv-Report-3-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-3-acute-pain.xlsx
    September 21, 2022 - B Opioid medication use: OR 0.48 (99% CI 0.18 to 1.33) day 1; OR 1.50 (99% CI 0.31 to 7.25) day 7; OR … Rhinoplasty Opioid vs. … use education vs. usual care A: Preoperative opioid education B: No preoperative opioid education NA … A: Preoperative opioid education B: No preoperative opioid education A: 3.09 mg B: 6.18 mg 129 A: NR … Third molar extraction Opioid vs.

84. App-E-Surv-Report-2-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-report-2-acute-pain.xlsx
    September 20, 2022 - B Opioid medication use: OR 0.48 (99% CI 0.18 to 1.33) day 1; OR 1.50 (99% CI 0.31 to 7.25) day 7; OR … Rhinoplasty Opioid vs. … use education vs. usual care A: Preoperative opioid education B: No preoperative opioid education NA … A: Preoperative opioid education B: No preoperative opioid education A: 3.09 mg B: 6.18 mg 129 A: NR … Third molar extraction Opioid vs.

85. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/14_substanceabuse_potential_high_impact_june_2012.pdf
    January 01, 2012 - *Buprenorphine implant (Probuphine) for treatment of opioid dependence Moderately high 3. …  Key Facts: Opioid abuse is one of the most common forms of prescription drug abuse. … antagonist that was recently approved by FDA for treating opioid dependence. … dependence Buprenorphine is a partial opioid agonist that is known to reduce opioid cravings and is … receptors, each of which is thought to play a role in opioid dependence. 22 Blockade of the mu-opioid

86. Disposition of Comments: CER 228, Nonopioid Pharmacologic Treatments for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-228-nonopioid-pharm-chronic-pain-comments.pdf
    April 16, 2020 - therapy when first prescribing opioid therapy1. … ASRA recognizes that all drugs – opioid and nonopioid – carry risks. … We note that the type, dosage, and duration of any pain treatment, including opioid therapy, is best … Oh, that's right...they can't shed light on our issue because it doesn't fit the anti opioid agenda. … One area that is lacking is a discussion of the evidence behind the non opioid nutraceuticals such as

87. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - of prescription opioid use for treating chronic pain has contributed to the rise in opioid dependence … recognizing and responding to an opioid overdose, and different options for opioid abuse treatment. … interventions may include opioid detoxification, opioid replacement therapies (i.e., methadone or … Prescription opioid abuse in chronic pain: a review of opioid abuse predictors and strategies to … curb opioid abuse.

88. AHRQ Evidence-based Practice Center Program Research Gaps Summary: Primary Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/research-gap-primary-care-summary-table.pdf
    March 01, 2022 - and opioid use disorder using standardized methods … associations (e.g., relative risk [RR] >2.0) with long- term opioid use … or higher opioid dose) found mostly strong associations with long-term opioid use … misuse and opioid misuse disorder in older adults … opioid overdose, all-cause death, opioid-related death, and nonopioid-related death).

89. CER 220: Disposition of Comments Report for Comparative Effectiveness of Analgesics To Reduce Acute Pain in the Prehospital Setting (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-220-disposition-comments-analgesics-prehospital-setting.pdf
    September 03, 2019 - This was not specific to opioid vs. … Opioid vs. each non- opioid analgesic (APAP, NSAIDs, ketamine, nitrous oxide) were the focus of this … v. non-opioid. … to non- opioid and opioid to opioid comparisons to determine best practice. … If it as stated, opioid to non-opioid as the focus, the sections discussing the latter are distracting

90. Topic-Brief1-Care-Coordination (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/topic-brief1-care-coordination.pdf
    April 01, 2021 - utilization, opioid-related adverse events) … Among opioid-naïve patients admitted to the hospital, 15 to 25 percent fill an opioid prescription in … utilization, opioid-related adverse events). … opioid and/or benzodiazepine prescriptions, new long acting opioid prescriptions, or new dose escalations … nation’s substance use crisis has rapidly evolved beyond an opioid-centric approach.

91. Topic-Brief1-Care-Coordination (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/topic-brief1-care-coordination.pdf
    April 01, 2021 - utilization, opioid-related adverse events) … Among opioid-naïve patients admitted to the hospital, 15 to 25 percent fill an opioid prescription in … utilization, opioid-related adverse events). … opioid and/or benzodiazepine prescriptions, new long acting opioid prescriptions, or new dose escalations … nation’s substance use crisis has rapidly evolved beyond an opioid-centric approach.

92. White Paper_Living Systematic Reviews: Examining Excluded Full-Text Articles To Better Understand the Evidence Base on Plant-Based Treatments for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/living-systematic-reviews-full-text-articles-white-paper.pdf
    January 01, 2024 - Does integrative medicine reduce prescribed opioid use for chronic pain? … The impact of cannabis access laws on opioid prescribing. … Medical cannabis use reduces opioid prescriptions in patients with Osteoarthritis. … Does integrative medicine reduce prescribed opioid use for chronic pain? … The impact of cannabis access laws on opioid prescribing.

93. App-E-Surveillance-Report-1-Treatments-For-Acute-Pain (xls file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surveillance-report-1-treatments-for-acute-pain.xlsx
    December 22, 2021 - B Opioid medication use: OR 0.48 (99% CI 0.18 to 1.33) day 1; OR 1.50 (99% CI 0.31 to 7.25) day 7; OR … Key Question 1: Acute back pain long-term opioid use observational studies Author, Year (Appendix C … Hip arthroscopy Opioid vs. acetaminophen A: Oxycodone 5 mg/acetaminophen 325 mg oral 1-2 tablets every … B Opioid use (mean [SD] tablets): 6.33 (7.1) vs. 5.69 (5.8), p=0.24 Consumed opioids postoperatively: … Rhinoplasty Opioid vs.

94. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/14_substance_abuse_potential_high_impact_2012-12-11.pdf
    January 01, 2012 - ES-2 Nicotine and Opioid Dependence Interventions ................................................. … Overall high-impact potential: long-acting pharmacotherapy for opioid dependence .................. … For this report, topics that emerged as higher impact focused on treatments for opioid and nicotine …  Key Facts: Opioid abuse is one of the most common forms of prescription drug abuse. … Buprenorphine is a partial opioid agonist that is known to reduce opioid cravings and is U.S.

95. Living Systematic Review on Plant-Based Treatment for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/plant-based-treatments-revised-protocol.pdf
    March 29, 2023 - In the United States, prescription of opioid medications for chronic pain more than tripled from 1999 … to 2015.7 This increase was accompanied by marked increases in rates of opioid use disorder and drug … HHS Acting Secretary Declares Public Health Emergency to Address National Opioid Crisis. … Opioid Treatments for Chronic Pain. Comparative Effectiveness Review No. 229. … J Opioid Manag. 2009 Nov- Dec;5(6):341-57. PMID: 20073408. 17.

96. Evidence Summary Comparative Effectiveness Review No. 250: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/cer-250-cannabis-other-plant-based-treatments-evidence-summary.pdf
    October 01, 2021 - event outcomes (psychosis, cannabis use disorder, cognitive deficits) and outcomes on the impact on opioid … serious harms including dependence, addiction, and physiological withdrawal potential.14 The ongoing opioid … and non-opioid medications, is essential to determining the benefit to harm ratio. … Opioid Treatments for Chronic Pain. Comparative Effectiveness Review No. 229. … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. PMID: 20073408. 11.

97. Evidence Summary Comparative Effectiveness Review No. 250: Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-250-cannabis-other-plant-based-treatments-evidence-summary_0.pdf
    October 01, 2021 - event outcomes (psychosis, cannabis use disorder, cognitive deficits) and outcomes on the impact on opioid … serious harms including dependence, addiction, and physiological withdrawal potential.14 The ongoing opioid … and non-opioid medications, is essential to determining the benefit to harm ratio. … Opioid Treatments for Chronic Pain. Comparative Effectiveness Review No. 229. … J Opioid Manag. 2009 Nov-Dec;5(6):341-57. PMID: 20073408. 11.

98. AHRQ Views Blog Postings Highlighted EPC Program in 2018 | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/news/ahrq-views-blog-highlights-epc-programs
    Managing pain with opioids and non-opioids: AHRQ Intensifies the Battle Against Opioid Misuse in 2017 … evidence review on the use of naloxone by emergency medical services personnel to manage suspected opioid … Shifting Focus: Non-Opioid Strategies For Chronic Pain .

99. #14 SUBSTANCE ABUSE (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - Overall high-impact potential: Evzio for emergency treatment of opioid overdose by nonclinicians .. … Evzio for Emergency Treatment of Opioid Overdose by Nonclinicians  Key Facts: Fatal opioid overdoses … Responding to opioid overdose. [internet]. Harm Reduction Coalition [accessed 2014 May 02]. … Community-based opioid overdose prevention programs providing naloxone - United States, 2010. … FDA approves new hand-held auto-injector to reverse opioid overdose. [internet].

100. Cannabis-Annual-Update2-Table-E5 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cannabis-annual-update2-table-e5.xlsx
     March 13, 2023 - Outcomes Functional Outcomes Quality of Life Outcomes Anxiety and Depression Outcomes Sleep Outcomes Opioid … C (reference) Opioid initiation (adjusted OR): 2.29 (95% CI 0.86 to 6.16) Opioid discontinuation (adjusted … C (reference) Opioid initiation (adjusted OR): 1.11 (95% CI 0.36 to 3.49) Opioid discontinuation (adjusted … B Between-cohort differences in discontinuation of strong opioid analgesics: 71.6% vs. 33.8%, p<0.001 … use at 6 months: Mild opioid analgesics: 0.00 (SD 0.06) vs. 0.04 (SD 0.20) Strong opioid analgesics: