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  1. effectivehealthcare.ahrq.gov/sites/default/files/tech-brief-37-opiod-use-adults-comments.pdf
    November 03, 2020 - We do not aim to answer the guiding questions, but instead to describe the literature base that addresses … Where they address the issues raised, they have been summarized. … It is not possible to address all questions in one report. … HHS has released guidance on tapering that addresses these issues and therefore this report did not … attempt to re- address them.
  2. effectivehealthcare.ahrq.gov/sites/default/files/dementia-horizon-scan-high-impact-1406.pdf
    February 01, 2015 - The system is intended to identify interventions that purport to address an unmet need and are up to … hypothesized to underlie AD-related cognitive decline, neuroprotective pharmaceuticals purported to address … Intranasal insulin, if proven effective, may address this need, and potentially represent a disease-modifying … interventions for treating cognitive symptoms of AD, and that intranasal insulin could potentially address … AD, experts agreed, but were widely divided on the potential for intranasal insulin treatments to address
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/long-covid-protocol.pdf
    February 18, 2023 - experience managing ME/CFS may inform management of long COVID, and some proposed models of care address … requires expertise and coordination among multiple specialties, applying a whole-patient perspective that addresses … dual independent review by trained members of the research team for eligibility based on whether they address … Data elements to be abstracted into tables are shown in Table 3, which will be used to address the Guiding
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-treatment-future_research.pdf
    April 01, 2013 - a We identified 46 ongoing studies that may potentially address a future research need. … Nonetheless, we suggested specific research questions that could address each of these needs. … As a result of that search, we identified 46 studies that may potentially address a future research … RCTs as well as cohort studies that address any of the Key Questions evaluated in the CER would help … RCTs and cohort studies that address Key Questions 1a and 1b in the CER would help address this future
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/observational-research-scores_research.pdf
    May 01, 2012 - Study Design Taxonomy Pharmaco-epidemiology and epidemiology more generally address confounding either … The use of a propensity score analysis does not address unmeasured confounding, unless the proposed … Weighting Weighting by the propensity score addresses confounding by reweighting the treated group, … Supplementary data collection with case- cohort analysis to address potential confounding in a cohort … Supplementary data collection with case-cohort analysis to address potential confounding in a cohort
  6. effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-update_disposition-comments.pdf
    September 10, 2014 - EPC reports aim to identify, refine, and (if the literature permits) address Key Questions that are … made to the strength of evidence assessment (e.g., the inclusion of non-comparative outcomes) should address … To address the reviewer’s comments, we have added the following analyses to the report: (1) a descriptive … The Dicussion section addresses some issues related to the reporting of pathology results. … We believe that the changes we have made to the report address the reviewer’s concerns.
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-stenting-future_research.pdf
    January 01, 2014 - controlled trials and properly adjusted observational studies could be used to fill the gaps and help address … An RCT to address the first topic—the adjunctive use of intravascular diagnostic techniques like FFR—for … Therefore, to address this topic, an observational design is a feasible alternative. … Identification of Evidence Gaps The current FRN project was undertaken in order to address the evidence … When randomized trials were deemed to be the most appropriate study design to address an FRN topic,
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
    January 01, 2011 - Key Question 4 addresses the factors that may affect test performance and clinical utility of newer … However, these data do not address Key Question 4. … #2 Results The results section is clear and, to the extent supported by the evidence, appropriately addresses … Response Peer Reviewer #1 Discussion/ Conclusion As stated above refs 70, 191 and 192 certainly address … No study was identified to address this question. No response needed.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_surveillance.pdf
    January 08, 2013 - CCP Test for pSLE in Children With MSK Pain No studies provided information to address this question … date Key Question 5: Clinical Impacts of ANA, RF, and CCP Tests No studies provided information to address … CCP Test for pSLE in Children With MSK Pain No studies provided information to address this question … Know Key Question 5: Clinical Impacts of ANA, RF, and CCP Tests No studies provided information to address
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/models-care-adult-survivors-childhood-cancer-evidence-summary.pdf
    February 01, 2022 - Future research is needed to address two essential research questions related to this review: (1) who
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/primary-research-design_research.pdf
    January 01, 2012 - relevant populations, interventions, comparators, outcomes and settings; and help to assure that research addresses … The eight documents address different aspects of identification of research gaps. … Are research studies currently underway which will address these gaps? … What question (PICO) did the systematic review address? … Does it address gaps?
  12. effectivehealthcare.ahrq.gov/sites/default/files/ch_8-user-guide-to-ocer_130129.pdf
    October 01, 2013 - Primary Data Primary data are collected by the investigator directly from study participants to address … While primary data collection has the advantage of being able to address a specific study question, … Is the age range of the data source appropriate to address the study question? … These data have been linked to many other datasets to address comparative effectiveness questions. … Two methods that can be used to address this challenge are data pooling and networking.
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/disposition-of-comments-cer-192-anxiety-in-children.pdf
    August 31, 2017 - Authors also did not sufficiently address the methodological differences between studies that included … In particular, please address how you adjusted the evidence due to notably different methodological … This section addresses KQ2 that focuses on harms and safety concerns related to treatments. … Results do not address al the aspects of the key questions: Age differences, family burden and contextual … Hopefully this would address your concerns.
  14. effectivehealthcare.ahrq.gov/sites/default/files/developmental-delays-horizon-scan-high-impact-1312.pdf
    December 01, 2013 - The system is intended to identify interventions that purport to address an unmet need and are up to … Medications that address to the underlying cause(s) of social deficits of ASD during early childhood … However, at this time, no medications are available that address and improve ASD core symptoms, including … Experts noted this intervention has the potential to address this unmet need; however, they indicated … No treatments are available to address social dysfunction, experts noted, adding that this intervention
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ace-inhibitor-arb-future_research.pdf
    March 01, 2012 - updated in December 2010) and a horizon scan for recently published and ongoing studies that may address … search used in the original CER, and a search of PubMed® for relevant systematic reviews that may address … While the proposed methods to address each area are not intended to be restrictive of potential study … less common comorbidities, long- term safety/ effectiveness Maybe: Most direct way to address … Modeling Finally, if none of the above options is feasible, simulation modeling may be able to address
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - term=14757617 Use validated criteria to address relevant sources of bias. … Principle 1: Use validated criteria to address relevant sources of bias. … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (2 of 4) Santaguida PL, Riley … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (3 of 4) The authors of the Quality … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (4 of 4) The Agency for Healthcare
  17. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
    June 01, 2012 - term=14757617 Use validated criteria to address relevant sources of bias. … Principle 1: Use validated criteria to address relevant sources of bias. … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (2 of 4) Santaguida PL, Riley … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (3 of 4) The authors of the Quality … Principle 1: Use Validated Criteria To Address Relevant Sources of Bias (4 of 4) The Agency for Healthcare
  18. effectivehealthcare.ahrq.gov/sites/default/files/dementia-agitation-aggression_disposition-comments.pdf
    March 21, 2016 - agitation/aggression address the family caregiver approach to caregiving." … We address this in the discussion section: “Understanding that we may not find studies that reported … The end result of the topic refinement was the key questions used to address this review. … The scope of our review was nonpharmacologic interventions to address agitation/aggression. … Her studies typically address depression, not agitation/aggression.
  19. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/telehealth-during-COVID-19-amendments.pdf
    April 28, 2022 - and will perform meta-analysis where there are sufficient data to pool for analysis20, 21 We plan to address … The framework would address the perceived benefits and harms of telehealth from the perspective of patients … Key Question 3 We will address the question of what is considered a “successful” telehealth intervention … conversations with the Partner, and AHRQ there was agreement that this KQ was better phrased to address … Focusing on study types that will best provide information to address the key question 28 April 2022
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/childhood-cancer-disposition-comments.pdf
    February 16, 2022 - your comment. 18 Peer Reviewer #2 Discussion and Conclusions I think that authors very clearly address … To address this comment, we have added several sentences under “Purpose and Scope” regarding how a … discussed (namely the lack of studies evaluating a formal model of care), these are quite significant to address … o Finally, multiple delivery mechanisms and formats are needed to address geographic disparities, survivor … The report should address this issue both broadly and study by study.

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