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21. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_executive.pdf
    October 01, 2010 - Layout 1 Background Cystic fibrosis (CF) is the second most common life-shortening, childhood-onset genetic disease in the United States, affecting approximately 30,000 people in the Nation. The gene responsible for CF encodes the cystic fibrosis transmembrane regulator (CFTR) protein, which regulates sodium and chl…

22. Restless-Legs Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
    November 01, 2012 - 1 Comparative Effectiveness Review Number 86 Treatment for Restless Legs Syndrome Executive Summary Introduction Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and a distressing, irresistible urge to move them. RLS can result in reduced quality o…

23. Colorectal-Cancer-Screening Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
    February 01, 2012 - 1 Comparative Effectiveness Review Number 52 Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults Executive Summary Background Colorectal cancer (CRC) is the third most common cancer in both men and women and is the third leading cause of cancer deaths in the United States.1 Incidence…

24. Colorectal-Surgery-Preparation Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-surgery-preparation_executive.pdf
    April 01, 2014 - 1 Comparative Effectiveness Review Number 128 Oral Mechanical Bowel Preparation for Colorectal Surgery Executive Summary Background In the United States, oral mechanical bowel preparation (OMBP), defined as the use of an oral preparation given prior to surgery to clear fecal material from the bowel lumen,…

25. Antiplatelet-Treatment Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
    September 01, 2013 - 1 Comparative Effectiveness Review Number 125 Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment Executive Summary Background Burden of Disease and Clinical Setting Approximately 82 million Americans currently suffer from some form of cardiovascular disease.1 In the United …

26. Trauma-Child-Interventions Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/trauma-child-interventions_executive.pdf
    February 01, 2013 - 1 Comparative Effectiveness Review Number 107 Child and Adolescent Exposure to Trauma: Comparative Effectiveness of Interventions Addressing Trauma Other Than Maltreatment or Family Violence Executive Summary Background Approximately two-thirds of children and adolescents will experience at least one traum…

27. Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin - Executive Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-199-skin-cancer.pdf
    December 01, 2017 - Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin - Executive Summary Comparative Effectiveness Review Number 199 Treatments for Basal Cell and Squamous Cell Carcinoma of the Skin Evidence Summary Introduction Skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC),…

28. Partial Breast Irradiation for Breast Cancer: Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/pbi-protocol.pdf
    August 09, 2021 - Partial Breast Irradiation for Breast Cancer: Systematic Review Protocol Evidence-based Practice Center Systematic Review Protocol Project Title: Partial Breast Irradiation for Breast Cancer I. Background and Objectives for the Systematic Review With an estimated 2.3 million new cases in 2020, breast canc…

29. Glaucoma-Treatment Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_executive.pdf
    April 01, 2012 - 1 Comparative Effectiveness Review Number 60 Treatment for Glaucoma: Comparative Effectiveness Executive Summary Background Glaucoma is a leading cause of visual impairment and blindness both in the United States and worldwide. It is estimated to affect 60.5 million people worldwide.1 Glaucoma is defined as…

30. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
    January 01, 2006 - Layout 1 Background Osteoarthritis is a chronic condition involving degeneration of cartilage within the joints. It is the most common form of arthritis and is associated with pain, substantial disability, and reduced quality of life. About 6 percent of U.S. adults aged 30 years or older have symptomatic osteoarthr…

31. Asthma-Immunotherapy-2010 Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/asthma-immunotherapy-2010_executive.pdf
    January 01, 2010 - 1 Comparative Effectiveness Review Number 111 Allergen-Specific Immunotherapy for the Treatment of Allergic Rhinoconjunctivitis and/or Asthma: Comparative Effectiveness Review Executive Summary Background Allergic rhinitis is a widespread clinical problem, estimated to affect 20 to 40 percent of the popu…

32. Vte-Prophyalaxis Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/vte-prophyalaxis_executive.pdf
    May 01, 2013 - 1 Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations Executive Summary Introduction Background Pulmonary embolism (PE) and deep vein thrombosis (DVT) are collectively known as venous thromboembolism (VTE). VTE affects an estimated 900,000 Americans every year, resul…

33. Head-Neck-Cancer-Update Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/head-neck-cancer-update_executive.pdf
    December 01, 2014 - 1 Radiotherapy Treatments for Head and Neck Cancer Update Executive Summary Introduction Objectives In May 2010, the Agency for Healthcare Research and Quality (AHRQ) published the results of Comparative Effectiveness Review (CER) No. 20, “Comparative Effectiveness and Safety of Radiotherapy Treatments for H…

34. Renal-Function Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
    August 01, 2014 - 1 Comparative Effectiveness Review Number 135 Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients With Kidney Disease Executive Summary Background Cardiac Troponin Assays Troponin Detection in Normal and Disease States Troponin is a protein complex of three subunits (T, I, and C) that is …

35. 04-E029-1 Summary (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/stroke-transitions-of-care_executive.pdf
    January 01, 2015 - 04-E029-1 Summary Advancing Excellence in Health Care • www.ahrq.gov Agency for Healthcare Research and Quality Evidence-Based Practice Background The Centers for Medicare & Medicaid Services (www.cms.gov), the National Quality Forum (www.qualityforum.org), and the Institute of Medicine (www.iom.edu) have identifi…

36. Letter of Appreciation 2014 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/letter-of-appreciation-2014.pdf
    January 01, 2014 - Letter of Appreciation 2014 DEPARTMENT OF HEALTH & HUMAN SERVICES Agency for Healthcare Research and Quality 540 Gaither Road Rockville MD 20850 www.ahrq.gov Letter of Appreciation We sincerely thank the 280 Peer Reviewers who completed reviews for the Agency for Healthcare Research and Quality (AH…

37. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-2007_executive.pdf
    January 01, 2007 - Layout 1 Background Depressive disorders such as major depressive disorder (MDD), dysthymia, and subsyndromal depression (including minor depression) may be serious disabling illnesses. MDD is the most prevalent, affecting more than 16 percent (lifetime) of U.S. adults. In 2000, the U.S. economic burden of depressiv…

38. Layout 1 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypothyroidism-hyperthyroidism-screening-treatment_executive.pdf
    October 01, 2011 - Layout 1 Background Mildly elevated or decreased serum thyroid stimulating hormone (TSH, also called thyrotropin) levels are the most common abnormalities related to thyroid function. Subclinical thyroid dysfunction, defined as an abnormal TSH with normal levels of serum thyroid hormones (T3 and T4), affects 5 perc…

39. Executive Summary CER 171: Noninvasive Testing for Coronary Artery Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_executive.pdf
    March 01, 2011 - Executive Summary CER 171: Noninvasive Testing for Coronary Artery Disease 1 Comparative Effectiveness Review Number 171 Noninvasive Testing for Coronary Artery Disease Executive Summary Background Nature and Burden of Coronary Artery Disease The public health and economic burdens of coronary artery dise…

40. Colorectal-Cancer-Liver-Metastases-Therapies Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-liver-metastases-therapies_executive.pdf
    December 01, 2012 - 1 Comparative Effectiveness Review Number 93 Local Hepatic Therapies for Metastases to the Liver From Unresectable Colorectal Cancer Executive Summary Background This report aims to compare the effectiveness and harms of several local hepatic therapies for unresectable colorectal cancer (CRC) metastases to …