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srdrplus.ahrq.gov/published_projects?page=26
June 27, 2021 - effect on neuropsychological development; a small deficit in linear growth (height difference at 7 years … Data in patients 4 to 11 years old suggest lower risk of exacerbations with ICS and LABA controller and … In patients 12 years and older with uncontrolled, persistent asthma, LAMA versus placebo as add-on to … Intermittent ICS added to SABA during an RTI provides benefit to patients less than 5 years of age with … LAMA is effective in the management of uncontrolled, persistent asthma in patients 12 years of age and
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srdrplus.ahrq.gov/published_projects?page=28
June 27, 2021 - Mean participant age was 72 years; all but 2 studies had a mean age <80 years. … In postmenopausal women with osteoporosis, compared with placebo, 4 years of alendronate or raloxifene … reduced risk of incident vertebral fractures (high SOE), 4 years of alendronate reduced risk of incident … fractures in one large trial (10 vs. 5 years, moderate SOE), but not in another smaller trial (7 vs. … 5 years, low SOE).
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srdrplus.ahrq.gov/published_projects?page=9
January 17, 2023 - Analysis including post-trial observation periods up to 20 years and including trials with high-dose … At 18 years of followup, including post-trial observational periods, three primary CVD prevention trials … Aspirin’s CVD benefits appear to begin within the first 1-2 years of administration and the bleeding … However, risk (per 10,000 women over 5.4 to 7.1 years) was statistically significantly increased for … for estrogen-only therapy and over 3.2 to 5.6 years for estrogen plus progestin therapy).
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srdrplus.ahrq.gov/published_projects?page=20
June 27, 2021 - Controlled studies of CLPC (T1-T3a) treatments with duration ≥5 years for mortality and metastases and … AD versus EBR plus initiating concurrent AD may result in little to no difference in mortality at 12 years … and genitourinary toxicity at 3 years. … and urinary and bowel toxicity at 2 years. … Effectiveness may be limited to younger men, those with intermediate risk disease and requires many years
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srdrplus.ahrq.gov/published_projects?page=31
October 31, 2022 - clinical utility and diagnostic accuracy of fractional exhaled nitric oxide (FeNO) in people age 5 years … and older with asthma; and the ability of FeNO measured at age 4 years or younger to predict a future
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srdrplus.ahrq.gov/published_projects?page=5
October 12, 2023 - We included English-language publications of studies conducted among children and adolescents 20 years … 1,230) of statins comprised the largest body of evidence addressing FH treatment with followup up to 2 years … 82 mg/dL greater mean difference in total cholesterol (TC) and LDL-C compared to placebo at up to 2 years … of statins and new onset diabetes (n=9,393), showing no difference in new diabetes diagnoses over 9 years … Only one statin trial had a followup as long as 2 years.
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srdrplus.ahrq.gov/published_projects
February 28, 2024 - Published on January 25, 2024 Screening for Speech and Language Delay and Disorders in Children Age 5 Years … studies of screening test accuracy for speech and language delay or disorders among children age 5 years … trials (RCTs) of interventions for speech and language delay or disorders enrolling children age 6 years … studies of screening test accuracy for speech and language delay or disorders among children age 5 years … trials (RCTs) of interventions for speech and language delay or disorders enrolling children age 6 years
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srdrplus.ahrq.gov/published_projects?page=24
October 31, 2022 - June 27, 2021 Objectives: Objective:
In view of the development of hypoglycemic agents in recent years … The searching process is now updated to March 2019, and will be updated every 1-2 years. … risk ratio [RR] 0.69; 95% confidence interval [CI], 0.59 to 0.84; 7 fewer cases per 1000 women over 5 years … Effects did not differ by age of initiation or duration of use (3 to 5 years), although these effects … Risk reduction persisted at least 8 years after discontinuation in tamoxifen trials with long-term followup
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srdrplus.ahrq.gov/published_projects?page=8
May 30, 2023 - good-quality randomized, controlled trial (RCT) found a relative risk (RR) for progression to active TB at 5 years … that established the effectiveness of isoniazid for preventing active TB was published more than 40 years … benefits and harms of routine skin cancer screening in asymptomatic screening populations aged ≥15 years … fair-quality) evaluated the association between melanoma mortality and skin cancer screening over 4 to 10 years … At 10-years of followup of the Skin Cancer Research to Provide Evidence for Effectiveness of Screening
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srdrplus.ahrq.gov/published_projects?page=27
June 27, 2021 - adverse events of antidepressants in the treatment of major depressive disorder (MDD) in adults 65 years … evaluated treatment of the acute phase (<12 weeks) of MDD which was of moderate severity in patients 65 years … In patients 65 years of age or older with MDD, treatment of the acute phase of MDD with SNRIs (duloxetine
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srdrplus.ahrq.gov/published_projects?page=7
June 13, 2023 - good-quality randomized, controlled trial (RCT) found a relative risk (RR) for progression to active TB at 5 years … that established the effectiveness of isoniazid for preventing active TB was published more than 40 years … good-quality randomized, controlled trial (RCT) found a relative risk (RR) for progression to active TB at 5 years … that established the effectiveness of isoniazid for preventing active TB was published more than 40 years
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srdrplus.ahrq.gov/blog
August 26, 2021 - Over
the last couple of years, we’ve made several improvements...
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srdrplus.ahrq.gov/published_projects?page=11
October 25, 2022 - age-related macular degeneration (AMD) and antioxidant vitamins and minerals for dry AMD in adults age 65 years … associated with better vision-related function and quality of life measures versus sham injection at 1 and 2 years … age-related macular degeneration (AMD) and antioxidant vitamins and minerals for dry AMD in adults age 65 years … Data Synthesis (Results): 22 trials (N=90,624) with followup from 6 months to 6 years compared statin … Data for older persons remains sparse and imprecise, particularly for persons >75 years of age.
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srdrplus.ahrq.gov/
December 02, 2021 - “In my regard, SRDR is among the most relevant developments in
recent years
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srdrplus.ahrq.gov/published_projects?page=43
June 27, 2021 - To assess the efficacy, comparative effectiveness, and adverse effects of drugs newly used (last 10 years … Low-strength evidence also suggests prevention programs can be sustained over several years. … Research on diagnostic testing for and interventions to treat CDI expanded considerably in 4 years.
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srdrplus.ahrq.gov/published_projects?page=36
June 27, 2021 - June 27, 2021 Objectives: Background: Primary congenital glaucoma (PCG) manifests within the first few years
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srdrplus.ahrq.gov/searches/new
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srdrplus.ahrq.gov/published_projects?page=23
June 27, 2021 - We included randomized and nonrandomized controlled trials of children and adolescents up to 18 years … of age for cessation and 25 years of age for prevention.
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srdrplus.ahrq.gov/published_projects?page=17
November 22, 2023 - We identified relevant literature among older adults (age ≥60 years) for an evidence map by systematically … Vertebroplasty (13 trials) is probably more effective at reducing pain and improving function in older (>65 years
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srdrplus.ahrq.gov/published_projects?page=25
June 27, 2021 - screening at different intervals; the effects of earlier versus later initiation of ART; and long-term (≥2 years … 0.33 to 0.66; I2=67%; absolute risk reduction,
-2.0% [95% CI, -2.8% to -1.2%] after 4 months to 4 years