-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/masks-surveillance-2-report.pdf
October 01, 2020 - Chandler Weeks, M.P.H.
Marian S. McDonagh, Pharm.D. … Suggested citation: Chou R, Dana T, Jungbauer R, Weeks C, McDonagh M.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - direct head-to-
head comparisons: double-blind, placebo-controlled RCTs
Minimum study duration
6 weeks … Good or fair quality, controlled observational studies
Minimum study duration
For RCTs: 6 weeks … case-control studies,
large database reviews)
Uncontrolled trials
Minimum study duration
For RCTs: 6 weeks … Definition of Terms
Acute Phase: first phase of depression management, usually 6 to 12 weeks in length
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
June 01, 2014 - daily.7
Clinical trials: In a clinical trial of 52 patients, investigators reported that after 52 weeks … exposed to at least one dose of GATTEX (190 patient-years of exposure; mean
duration of exposure was 17 weeks … After 24
weeks of treatment, 54% of patients treated with teduglutide reduced the number of infusion … used to increase nutrient absorption; however, somatropin has
not been evaluated for longer than 4 weeks … Safety
and efficacy of teduglutide after 52 weeks of
treatment in patients with short bowel intestinal
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/psoriasis-chronic_disposition-comments.pdf
November 27, 2012 - impossible to compare drugs over the long-term because if a given drug is
not working at 12 or 16 weeks … If therapies are not working
by 12-16 weeks, they will not work later. … Although
therapies may be stopped after 12 to 16
weeks in patients who fail treatment, there
are patients … who are on these therapies
much longer than 16 weeks when therapies
are successful. … We have
provided the PASI for both 12 and 24 weeks.
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1412.pdf
December 01, 2014 - daily.7
Clinical trials: In a clinical trial of 52 patients, investigators reported that after 52 weeks … exposed to at least one dose of GATTEX (249 patient-years of exposure; mean
duration of exposure was 22 weeks … After 24
weeks of treatment, 53.8% of patients treated with teduglutide reduced the number of infusion … used to increase nutrient
absorption; however, somatropin has not been evaluated for longer than 4 weeks … Safety
and efficacy of teduglutide after 52 weeks of
treatment in patients with short bowel intestinal
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1312.pdf
December 01, 2013 - with placebo through week 24 (p<0.001).7 Effects on pulmonary
function were observed as early as 2 weeks … authors, “Patients treated with ivacaftor had sustained improvements in FEV1 and
weight up to 144 weeks … , the
decrease in exacerbation rate compared with the prior placebo rate was maintained up to 144 weeks … of PERSIST and in 34 (23.6%) adults and 10 (20.8%) children during the
subsequent 48 weeks. … of treatment
(96 weeks of persist).
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/restless-legs_executive.pdf
November 01, 2012 - English, evaluated pharmacologic
and/or nonpharmacologic interventions for RLS, lasted
at least 4 weeks … this report is a comparative effectiveness review.17
Only two placebo-controlled trials lasted 24 weeks … or
more,26,34 and none exceeded 28 weeks. … Cabergoline17 improved IRLS scores
more than levodopa in a single trial lasting 30 weeks
(n=361) among … Twelve 30-minute near-infrared light treatment sessions
were applied over 4 weeks.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1512.pdf
December 01, 2015 - (for
a total of 96 weeks of treatment). … In an interim analysis, after 48 total weeks of treatment with
lumacaftor/ivacaftor, patients who had … for 32 weeks. … for 20 weeks in addition to their optimized steroid regimen. … of treatment); and -73.1 mL for patients initiating
treatment with nintedanib (48 weeks of treatment
-
effectivehealthcare.ahrq.gov/get-involved/nominated-topics/antenatal-care
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/menopause-protocol-130612.pdf
June 12, 2013 - Osteoporotic fractures
Agent-specific adverse events
• Timing
Outcome assessment at least 12 weeks … RCTs should have at
least 25 patients
randomized per arm
who are studied for at
least 12 weeks; these … for
RCTs should have at
least 25 patients
randomized per arm
who are studied for at
least 12 weeks … translates
into similar efficacy at
12 weeks.56, 57
Source: www.effectivehealthcare.ahrq.gov … centrally acting
agents (SSRI, SNRI,
gabapentin, and
pregabalin) minimum
trial duration will be 4
weeks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
May 01, 2013 - present during
the same 2-week period, with a secondary
criterion of onset of symptoms within
4 weeks … Other diagnostic standards allow the definition of onset to
extend beyond 4 weeks and up to 12 months … The KQs were then
4
posted for public comment for 4 weeks from November
8 to December 6, 2011, … vs.
8 weeks to 6 months
1 (534) High NA Direct Imprecise Insufficient
Delivery vs. 6 weeks 1 (113 … gestation or 6 weeks postpartum.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-d-opioid-chronic-pain-surveill-report-1.xlsx
September 30, 2015 - Adverse Events and Withdrawals Due to Adverse Events Sponsor Quality
Hruschak, 2021 RCT
Duration: 6 weeks … , adjusted for race and depression)
Pain severity (0 to 10): 7.15 (SD 2.38) vs. 7.36 (SD 1.55) at 9 weeks … difference -0.21 (95% CI -1.71 to 1.29)*
Pain interference (0 to 70): 32.8 (SD 17.94) vs. 42.0 (10.71) at 9 weeks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/episodic-migraine-surveillance-report-3.pdf
August 01, 2022 - therapy for outcomes related to pain,
function, pain relief satisfaction, and quality of life up to 4 weeks … ; 2 weeks to 4 weeks? … ; 2 weeks to 4 weeks? … ; 2 weeks to 4 weeks? … ; 2
weeks to 4 weeks
None
Settings ED, physician’s office, hospital None
Study design Original
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_surveillance.pdf
October 01, 2012 - 227 Adults with CKD (GFR
20-45 ml/min/ 1.73 m2
BSA)
Change from baseline in
estimated GFR
52 weeks … Patients receiving bardoxolone methyl had
significant increases in eGFR compared with
placebo at 24 weeks … urinary albumin-
to-creatinine ratio
(UACR) of 100-3000
mg/g
Change from baseline in
UACR
8 weeks … Harcourt,
20118
Randomized
crossover trial of 2
weeks each on a
low and high
AGE- containing … Renal function,
inflammatory profile
(MCP-1) and macrophage
migration inhibitory factor
(MIF)
4 weeks
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-cough_executive.pdf
March 01, 2014 - Cough that lasts more than
4 weeks in children younger than
14 years of age or more than 8 weeks … The KQs were then posted
for public comment in September 2011 for 4 weeks,
and the comments received … We accepted as
chronic any cough described as such, or that exceeded
8 weeks in adults and adolescents … or 4 weeks in children
≤14 years of age. … Thirty-
three (33) studies (69 percent) had a followup duration of
2 weeks or less.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - two oral DMARDs,
improved ACR 50 response rates, disease
activity scores, but no difference at 56 weeks … patients with early RA, significantly
lower radiographic progression and fewer
eroded joints at 56 weeks … but no
differences by 56 weeks. … two oral DMARDs, improved ACR 50
response rates, disease activity scores, but no difference
at 56 weeks … but no differences by 56 weeks.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/rheumatoid-arthritis-medicine_surveillance.pdf
March 01, 2013 - two oral DMARDs,
improved ACR 50 response rates, disease
activity scores, but no difference at 56 weeks … patients with early RA, significantly
lower radiographic progression and fewer
eroded joints at 56 weeks … but no
differences by 56 weeks. … two oral DMARDs, improved ACR 50
response rates, disease activity scores, but no difference
at 56 weeks … but no differences by 56 weeks.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/ced%20-appendix-2.xlsx
May 29, 2025 - Questions why comment period is only 3 weeks and outside the usual Notice and Comment period. … second comment period and CMS schedule a second MEDCAC meeting focused on the AHRQ CED analysis (3 weeks … Alliance for Regenerative Medicine Questions why comment period is only 3 weeks and outside the usual … second comment period and CMS schedule a second MEDCAC meeting focused on the AHRQ CED analysis (3 weeks
-
effectivehealthcare.ahrq.gov/sites/default/files/leong-presenation.pdf
May 29, 2025 - The trips to the physician were grueling because it was a two hour trip every two weeks for 5 years. … The visits every two weeks
never addressed that.
-
effectivehealthcare.ahrq.gov/sites/default/files/s44.pdf
October 01, 2007 - Six months of de-
layed savings in 10% of nebulized medication users would
equal 2.5 weeks of delayed … After many months of delays, a further delay in savings equal
to 2.5 weeks was tolerable to PharmaCare … Against our preference, PharmaCare sent the
letter announcing the policy 6 weeks ahead to all physicians … Controls were told of their
6-month exemption 2 weeks later in a separate letter. … Just 6 weeks after the end of the 6-month delay,
we presented preliminary findings at a scientific conference