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1. Clinical Trials | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/health-topics/clinical-trials

2. Spontaneous Awakening Trials and Spontaneous Breathing Trials Literature Review | Agency for Healthcare Research and Quality
   www.ahrq.gov/hai/tools/mvp/modules/technical/sat-sbt-lit-review.html
   January 01, 2017 - Spontaneous Awakening Trials and Spontaneous Breathing Trials Literature Review AHRQ … Safety Program for Mechanically Ventilated Patients Summary Spontaneous awakening trials (SAT) and … spontaneous breathing trials (SBT) reduce the length of mechanical ventilation, thereby reducing the … 2015) 9 PRO: Controlled trial to assess whether daily coordinated SATs and spontaneous breathing trials … in the ICU by 10 percent (2%–19%, p=0.02; eight trials).

3. A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials | Effective Health Care Program
   effectivehealthcare.ahrq.gov/products/cluster-randomized-trials
   December 02, 2009 - A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials Timeline … Report A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials

4. Design and Implementation of N-of-1 Trials: A User's Guide | Effective Health Care Program
   effectivehealthcare.ahrq.gov/products/n-1-trials
   February 12, 2014 - Design and Implementation of N-of-1 Trials: A User's Guide Timeline May 20, 2013 … February 12, 2014 Research Report Introduction to N-of-1 Trials … Research Report User Engagement, Training, and Support for Conducting N-of-1 Trials … Research Report Statistical Design and Analytic Considerations for N-of-1 Trials … 12, 2014 Research Report Information Technology Infrastructure for N-of-1 Trials

5. Spontaneous Awakening Trials and Spontaneous Breathing Trials Literature Review | Agency for Healthcare Research and Quality
   ce.effectivehealthcare.ahrq.gov/hai/tools/mvp/modules/technical/sat-sbt-lit-review.html
   January 01, 2017 - and Spontaneous Breathing Trials Literature Review … Telemedicine Universal ICU Decolonization Protocol Spontaneous Awakening Trials … Ventilated Patients Summary Spontaneous awakening trials (SAT) and spontaneous breathing trials … in the ICU by 10 percent (2%–19%, p=0.02; eight trials). … and Spontaneous Breathing Trials Literature Review.

6. User Engagement, Training, and Support for Conducting N-of-1 Trials (Chapter 6) | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/n-1-trials/research/

7. Information Technology Infrastructure for N-of-1 Trials (Chapter 5) | Effective Health Care (EHC) Program
   effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014/

8. A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials | Effective Health Care Program
   effectivehealthcare.ahrq.gov/products/cluster-randomized-trials/research
   December 02, 2009 - A Qualitative Study to Understand Barriers to Conducting Cluster Randomized Trials Research Report … Cluster randomized trials: opportunities and barriers identified by leaders of eight health plans. … Abstract Background Cluster randomized trials (CRTs) offer unique advantages over standard randomized … controlled clinical trials (RCTs) and observational methodologies, and may provide a cost-efficient … Cluster randomized trials to study the comparative effectiveness of therapeutics: stakeholders' concerns

9. Collaborative National Networks Examining Comparative Effectiveness Trials (CoNNECT) (pdf file)
   www.ahrq.gov/sites/default/files/wysiwyg/professionals/prevention-chronic-care/decision/mcc/miller_r24grant.pdf
   September 01, 2013 - Collaborative National Networks Examining Comparative Effectiveness Trials (CoNNECT) Expansion … Complex Patients – R24 Grants Collaborative National Networks Examining Comparative Effectiveness Trials … Infrastructure Description The Collaborative National Networks Examining Comparative Effectiveness Trials … CoNNECT: Collaborative National Networks Examining Comparative Effectiveness Trials. … Collaborative National Network Examining Comparative Effectiveness Trials. 60 Second Presentation at

10. Quantitative Synthesis: Chapter 1. Decision To Combine Trials (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-1.pdf
    July 01, 2019 - Decision To Combine Trials Quantitative Synthesis Chapter 1. … Decision to combine trials Decision to combine trials • The first fundamental question in quantitative … Clin Trials. 2013;10(1):20-31. http://dx.doi.org/10.1177/174077451246549 5 8. 3. … Clin Trials. 2013;10(1):20-31. http://dx.doi.org/10.1177/174077451246549 5 8. 3. … Decision to combine trials Decision to combine trials Decision to combine trials Pooling decision

11. Statistical Design and Analytic Considerations for N-of-1 Trials (Chapter 4) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-1/

12. Design and Implementation of N-of-1 Trials: A User’s Guide | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-5/

13. An Ethical Framework for N-of-1 Trials: Clinical Care, Quality Improvement, or Human Subjects Research? (Chapter 2) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-3/

14. Financing and Economics of Conducting N-of-1 Trials (Chapter 3) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-2/

15. A piece of my mind. Trials and tribulations. | PSNet
    psnet.ahrq.gov/issue/piece-my-mind-trials-and-tribulations
    March 30, 2016 - Trials and tribulations. Citation Text: Brown JL. Trials and Tribulations. … Trials and Tribulations. JAMA. 2017;318(7). doi:10.1001/jama.2017.7106.

16. Research Methods | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/research-methods
    February 12, 2014 - User Engagement, Training, and Support for Conducting N-of-1 Trials (Chapter 6) Research Report … Research Report May 15, 2012 Statistical Design and Analytic Considerations for N-of-1 Trials … Health Systems Panel Series Overview January 8, 2019 Introduction to N-of-1 Trials … Research Report February 12, 2014 Information Technology Infrastructure for N-of-1 Trials … Interviews White Paper September 14, 2017 Design and Implementation of N-of-1 Trials

17. Introduction to N-of-1 Trials: Indications and Barriers (Chapter 1) | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/n-1-trials/research-2014-4/

18. Optimizing patient safety in clinical trials by improving transitions of care. | PSNet
    psnet.ahrq.gov/issue/optimizing-patient-safety-clinical-trials-improving-transitions-care
    August 29, 2007 - Study Optimizing patient safety in clinical trials by improving transitions of care … Optimizing patient safety in clinical trials by improving transitions of care. … This article briefly summarizes a multicenter retrospective cross-sectional analysis of 44 clinical trials … conducted from 2009-2019 in the United Arab Emirates to assess the degree to which the trials optimized … Optimizing patient safety in clinical trials by improving transitions of care.

19. Vol 4: Effects of Eicosapentanoic Acid & Docosahexanoic Acid on Mortality Across Diverse Settings: Systematic Review & Meta-Analysis of Randomized Trials & Prospective Cohorts | Agency for Healthcare Research and Quality
    www.ahrq.gov/research/findings/evidence-based-reports/nutritn4tp.html
    April 01, 2018 - Docosahexanoic Acid on Mortality Across Diverse Settings: Systematic Review & Meta-Analysis of Randomized Trials … systematic review and meta-analysis of evidence from prospective cohorts and randomized controlled trials … apparent congruence of these two types of study designs and to describe how randomized intervention trials … Results: In RCTs, the summary relative risks for all-cause mortality (17 trials, 51,264 patients) and … cardiovascular mortality (14 trials, 48,500 patients) were 0.95 (95% confidence interval, CI: 0.89,

20. Creating Efficiencies in the Extraction of Data From Randomized Trials: A Prospective Evaluation of a Machine Learning and Text Mining Tool | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/creating-efficiencies-extraction-data/methods-report
    August 10, 2021 - Creating Efficiencies in the Extraction of Data From Randomized Trials: A Prospective Evaluation of a … Purpose of Study For a sample of 75 randomized trials, we prospectively evaluated an online machine … learning and text mining tool’s ability to (a) automatically extract data elements from randomized trials … For 75 randomized trials published in 2017, we manually extracted and verified data for 21 unique data … Creating Efficiencies in the Extraction of Data From Randomized Trials: A Prospective Evaluation of a