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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/screening-anxiety-children-adolescents
March 29, 2022 - use (e.g., duloxetine, fluoxetine, escitalopram, sertraline, fluvoxamine, clomipramine)
Combination therapies … KQs 4, 5 (anxiety):
Cognitive behavioral therapy (including exposure therapy) *
Eligible psychotherapy … use (e.g., clonidine, duloxetine, fluoxetine, escitalopram, sertraline, fluvoxamine)
Combination therapies … modalities (e.g., exercise, light therapy, transcranial magnetic nerve stimulation, electroshock treatment … We qualified CQ 5 as being limited to evidence-based treatments and clarified that engagement with care
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/screening-depression-suicide-risk-children-adolescents
August 13, 2020 - use (e.g., duloxetine, fluoxetine, escitalopram, sertraline, fluvoxamine, clomipramine)
Combination therapies … KQs 4, 5 (anxiety):
Cognitive behavioral therapy (including exposure therapy) *
Eligible psychotherapy … use (e.g., clonidine, duloxetine, fluoxetine, escitalopram, sertraline, fluvoxamine)
Combination therapies … modalities (e.g., exercise, light therapy, transcranial magnetic nerve stimulation, electroshock treatment … We qualified CQ 5 as being limited to evidence-based treatments and clarified that engagement with care
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/asymptomatic-bacteriuria-in-adults-screening
September 24, 2019 - identified 5.0% of women who were screened with dip slide as positive for asymptomatic bacteriuria. 33 Treatments … women reported that there were no adverse drug reactions among the 49 women treated with nitrofurantoin therapy … treated with trimethoprim. 28 Another reported that 2 of 32 women (6%) assigned to daily ofloxacin therapy … Therapy vs no therapy for bacteriuria in elderly ambulatory nonhospitalized women. … Urinary tract infections in pregnancy: old and new unresolved diagnostic and therapeutic problems.
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www.uspreventiveservicestaskforce.org/uspstf/document/RecommendationStatementFinal/asymptomatic-bacteriuria-in-adults-screening
September 24, 2019 - adverse effects of antibiotic treatment. … or Interventions
Pregnant persons with asymptomatic bacteriuria usually receive antibiotic therapy … Long-term continuous vs pulse treatment with ofloxacin. … Therapy vs no therapy for bacteriuria in elderly ambulatory nonhospitalized women. … Antimicrobial treatment in diabetic women with asymptomatic bacteriuria.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/3R9N4ojm9Sk7qk8ybD3LU6
October 11, 2019 - or Interventions
Pregnant persons with asymptomatic bacteriuria usually receive an-
tibiotic therapy … There is inadequate direct evidence to determine the
harms of screening and treatment. … Bacteriuria of pregnancy: results of treatment. … Therapy vs no therapy for
bacteriuria in elderly ambulatory nonhospitalized
women. … Antimicrobial treatment in diabetic women
with asymptomatic bacteriuria.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/tobacco-cessation-adults-interventions
July 17, 2025 - feasible to refer to from primary care, including FDA-approved pharmacotherapy (i.e., nicotine replacement therapy … Non-FDA approved therapies and devices (e.g., electronic cigarettes, nicotine pouches)
Broad public … KQ 3 (harms): Serious treatment-related harms at any time point after the intervention began … Therefore, studies evaluating the use of non-FDA-approved therapies for tobacco or smoking cessation … of this review update, we will amend this protocol to reflect the inclusion of these treatments.
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/B73a4kJhxeaYyXK6gozbbY
May 24, 2022 - outcomes
Reporting bias not detected
Moderate for
benefit
VEGF inhibitors are considered first-line therapy … detected
Moderate for
no harm
VEGF inhibitors vs sham:
VEGF inhibitors are considered first-line therapy … Morphology and visual acuity in aflibercept and
ranibizumab therapy for neovascular age-related
macular … Oral zinc-therapy in age-related macular
degeneration: a double blind study. … Introducing
anti-vascular endothelial growth factor therapies
for AMD did not raise risk of myocardial
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/asymptomatic-bacteriuria-in-adults-screening
September 24, 2019 - adverse effects of antibiotic treatment. … or Interventions
Pregnant persons with asymptomatic bacteriuria usually receive antibiotic therapy … Long-term continuous vs pulse treatment with ofloxacin. … Therapy vs no therapy for bacteriuria in elderly ambulatory nonhospitalized women. … Antimicrobial treatment in diabetic women with asymptomatic bacteriuria.
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan44/depression-in-adults-screening
July 03, 2014 - How is treatment managed in patients who screen positive for depression (e.g., how likely is it that … is the patient to receive a full therapeutic dose of treatment)? … What is the acceptability of depression treatment to patients and providers? … Is treatment (psychotherapy or pharmacologic) effective for relatively mild depression? … processes, such as treatment initiation, referral for treatment, referral acceptance, and compliance
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/cognitive-impairment-older-adults
March 06, 2025 - Food and Drug Administration (alone or in combination) for the treatment of mild and/or moderate dementia … , included but not limited to:
Amyloid-targeted therapies (lecanemab, donanemab)
Acetylcholinesterase … Interventions aimed at behavioral and psychological symptom management of dementia (such as behavioral treatments … Vitamins, minerals, and antioxidants
Herbal supplements
Medical foods or fluids or nutrition therapy … (e.g., meal replacement therapy)
Interventions aimed at primary prevention of cognitive impairment
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/hepatitis-c-screening
March 02, 2020 - USPSTF review on HCV screening in adults 5 , 6 and a comparative effectiveness review on antiviral treatments … What is the effectiveness of currently recommended antiviral treatments in improving health outcomes … What is the effectiveness of currently recommended antiviral treatments in achieving an SVR in patients … What are the harms of currently recommended antiviral treatments? … Three studies focused on DAAs, 66 , 68 , 77 1 study evaluated interferon-based treatments and DAAs,
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www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/lipid-disorders-in-children-screening
August 19, 2021 - What are the harms of treatment of FH or multifactorial dyslipidemia in children and adolescents? … What is the optimal timing of statin treatment initiation for FH? … initiation
KQs 4, 5 (Treatment benefits and harms): Treatment studies can have populations identified … benefits and harms): No treatment or usual care
Outcomes
KQs 1, 4 (Screening and treatment … harms): RCTs, CCTs, cohort studies, observational studies
KQ 4 (Treatment benefits): RCTs
KQ
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/AkQC-rTVEsusNWG_TmWWtd
February 01, 2011 - Treatment
Primary treatment for amblyopia
includes the use of corrective lenses,
patching, or atropine … treatment of
the nonaffected eye. … referrals because of false-
positive screening results, and unnec-
essary use of corrective lenses or
treatments … Task Force
Five fair-quality trials with children
�3 years of age demonstrated that
some amblyopia treatments … patching or atropine treat-
ment regimens.1
Evidence on adverse psychosocial ef-
fects of amblyopia treatments
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www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/behavioral-counseling-interventions-promote-healthy-diet-physical-activity-weight-loss-prevent-cardiovascular-disease-adults
May 18, 2023 - Healthy lifestyle counseling with no weight-related messages
Primary prevention of weight gain
Treatment … of cardiovascular disease
Management of diabetes *
Treatment of cancer
Population
Adults … combination:
Behavioral-based interventions (e.g., behavior modification, cognitive behavioral therapy … for weight management (e.g., lorcaserin hydrochloride or phentermine)
Complementary and alternative treatments … Fair or good, according to study design and risk of bias criteria
Poor
* Screening and treatment
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www.uspreventiveservicestaskforce.org/home/getfilebytoken/8YfPLRoMwTeaDgxJdYnYbb
September 24, 2019 - identified 5.0% of women who were
screened with dip slide as positive for asymptomatic bacteriuria.33
Treatments … women reported that there were no adverse
drug reactions among the 49 women treated with nitrofurantoin
therapy … women treated
with trimethoprim.28 Another reported that 2 of 32 women (6%)
assigned to daily ofloxacin therapy … Therapy vs no therapy for
bacteriuria in elderly ambulatory nonhospitalized
women. … Urinary tract infections in pregnancy:
old and new unresolved diagnostic and therapeutic
problems.
-
www.uspreventiveservicestaskforce.org/home/getfilebytoken/eko8Cp28pZ3SHHfyvTXJW5
May 13, 2025 - evidence has demonstrated that screening in preg-
nancy is effective at detecting syphilis and that treatment … The evidence review on harms of treatment was
restricted to studies of syphilis treatment during pregnancy … Eligible treatment harms included allergic re-
action, premature labor, Jarisch-Herxheimer reaction, … of other treatments
in pregnant persons are lacking
None 2 Studies (single-group
cohorts); 39 participants … 2.5%)
IHR among low-risk
persons undergoing
penicillin provocation:
1/40 (2.5%)
Incomplete penicillin
therapy
-
www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/syphilis-infection-in-pregnancy-screening
May 13, 2025 - The evidence review on harms of treatment was restricted to studies of syphilis treatment during pregnancy … Eligible treatment harms included allergic reaction, premature labor, Jarisch-Herxheimer reaction, fetal … Although based on small studies,we found estimates of penicillin treatment harms that could be used for … Studies of other treatments in pregnant persons are lacking
None
2 Studies (single-group cohorts … IHR among low-risk persons undergoing penicillin provocation: 1/40 (2.5%)
Incomplete penicillin therapy
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www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary27/screening-depression-suicide-risk-children-adolescents
October 11, 2022 - Third, treatment-as-usual comparators for suicide risk interventions included active treatments, which … Effectiveness of systemic family therapy versus treatment as usual for young people after self-harm: … A pragmatic randomised controlled trial and economic evaluation of family therapy versus treatment as … Longer-term effectiveness of systemic family therapy compared with treatment as usual for young people … Trial of therapeutic assessment in London: randomised controlled trial of therapeutic assessment versus
-
www.uspreventiveservicestaskforce.org/uspstf/draft-recommendation/syphilis-infection-pregnant-persons
November 19, 2024 - longer duration of treatment. … Harms of Screening and Treatment
Potential harms of screening for and treatment of syphilis infection … For treatment harms, one small study (n=39) reported that 5.1% of patients receiving penicillin therapy … Sexually transmitted infections treatment guidelines, 2021. … reaction from treatment with antibiotic medications.
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www.uspreventiveservicestaskforce.org/uspstf/recommendation/impaired-visual-acuity-screening-older-adults
May 24, 2022 - Photodynamic therapy, a treatment combining verteporfin (a photoreactive agent) and low-level laser light … spots in the treatment area and is no longer in common use. 14 Treatments to reduce progression of dry … that refractive correction (through corrective lens or surgery) and cataract surgery are effective treatments … with intermediate AMD or advanced AMD in 1 eye (OR, 0.73 [99% CI, 0.54-0.99]). 13 Other potential therapies … Photodynamic therapy for neovascular age-related macular degeneration.