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  1. effectivehealthcare.ahrq.gov/sites/default/files/related_files/type-2-diabetes-medications-update_overview.pdf
    January 17, 2014 - In adults age 18 or older with type 2 diabetes mellitus, what is the comparative effectiveness of treatment … In adults age 18 or older with type 2 diabetes mellitus, what is the comparative effectiveness of treatment … Do safety and effectiveness of these treatment options (Table 2) differ across subgroups of adults with … Several recent studies have evaluated the use of combination therapies in adults with Type 2 Diabetes … Mellitus. . § In addition to updating information on the potential benefits of available treatments
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prioritization-selection-of-harms.pdf
    February 01, 2018 - similar across interventions used to treat a given condition (e.g., medications, non-pharmacological therapies … Title EPC, Year Condition/ Population Harms Related Key Question(s) Interventions Harms Outcomes Therapies … Dual agent therapy (statin + lipid modifying medication) and intensification of statin therapy … Graded Exercise Treatment; pharmaceutical; counseling/behavioral therapy; complimentary alternative … Therapeutic: suppression of adrenal glucocorticoid responsiveness; increased appetite; weight gain
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0278_03-10-2008.pdf
    January 01, 2008 - includes hand washing, in-hospital infection control, appropriate antibiotic prescribing, and effective treatment … Date: 6-2-09 2  The literature on this topic indicates that large studies with more standardized treatment … regimens are needed to evaluate the effectiveness of treatments for CDAD.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0355_09-22-2010.pdf
    January 01, 2010 - benzodiazepine receptor agonists, or antidepressants), complementary and alternative care, relaxation therapy … , cognitive behavioral therapy, hormones Comparator(s): Placebo or comparison to another insomnia … Treatment of chronic insomnia is a dilemma commonly encountered in primary care. … medications are most effective and when medications should be used as opposed to nonpharmacologic treatments
  5. Hunt_Panel_1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/hunt_panel_1.pdf
    January 01, 2010 - Slide  3: Knowledge-­‐Practice Gap • Evidence-­‐based treatments can  double or even  triple … (Twitter) • Reach different people o Support networks o Diabetes patients who do not adhere to treatment
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoporosis-bone-fracture_research-protocol.pdf
    May 14, 2010 - Evidence-based Practice Center Systematic Review Protocol Project Title: Comparative Effectiveness of Treatments … pamidronate, and zoledronic acid • Calcium • Denosumab (awaiting FDA approval) • Menopausal hormone therapy … of pharmacotherapy, and what are the comparative anti-fracture efficacies of continued long-term therapy … follow-up period) (c) KQ4: What are the short- and long-term harms (adverse effects) of the above therapies … monitored (via measurement of bone mineral density) during therapy?
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
    December 01, 2012 - group (i.e., comparison of different treatments, hormonal vs. surgical therapy, or treatment vs. no … Effectiveness of Hormone Therapy Fourteen studies in 19 publications assessed hormonal therapy in treatment … Effectiveness of Surgical Treatments Twenty-six studies addressed surgical treatment. … This report reviews the literature on treatment planning and therapeutic interventions to achieve these … Strength of evidence of surgical treatments for cryptorchidism Outcome Treatment Number of Studies;
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
    March 15, 2010 - Treatment Continuous positive airway pressure (CPAP) is the standard 1st-line therapy for most patients … Treatment KQ5: What is the comparative effect of different treatments for obstructive sleep apnea (OSA … KQ6: In OSA patients prescribed non-surgical treatments, what are the associations of pre- treatmentTreatment, therapy, or intervention (No KQ) (KQ 5) (KQ 5) (KQ 5) Health … Source: www.effectivehealthcare.ahrq.gov Published Online: March 15, 2010 17 40 exp Therapeutics
  9. effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1306.pdf
    June 01, 2013 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address …  Key Facts: Before the approval of ivacaftor, therapies for CF had improved median survival times … Better treatments to prevent COPD exacerbations are needed. … Although the cost of azithromycin therapy would be additive to current treatment costs, its low cost
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/choice-of-mean_white-paper.pdf
    April 01, 2015 - Assistant Professor, Department of Physical Therapy Florida International University Miami, FL Steven … comparison of combined mean differences using change score and endpoints (comparison between different treatments … , diabetes, and alcohol abuse, and the interventions included pharmacologic, behavioral, and other therapies … Diagnosis and Treatment of Obstructive Sleep Apnea in Adults. … Nonpharmacologic Interventions for Treatment-Resistant Depression in Adults.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_clinician.pdf
    January 01, 2017 - Treatments for gout attacks include nonsteroidal anti- inflammatory drugs (NSAIDs), colchicine, and … Management of Gout: �� Effective treatments for gout attacks include NSAIDs, colchicine, and corticosteroids … Table 2: Effectiveness of Treatments for Acute Gout Attack: Key Findings Strategy N Studies N Subjects … Diet, lifestyle, and complementary and alternative medicine therapies for managing gout ��There has … Effectiveness of therapy for gout in subpopulations ��The efficacy of pharmacological therapies for gout
  12. Obesity (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/obesity_hi_impact.pdf
    April 17, 2012 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … All experts generally indicated that these antiobesity therapies have high potential to meet a significant … the company in March 2011. 57 As of July 25, 2011, the system had been approved by the Australian Therapeutic … Goods Administration for inclusion in its therapeutic goods registry for treatment of T2DM and obesity … Orexigen Therapeutics provides a regulatory update on Contrave NDA. [internet].
  13. effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1506.pdf
    June 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Effective treatments are needed. … Patients with AS who did not respond to prior treatment with TNF therapies showed significant improvement … Secukinumab (Cosentyx) for Treatment of Psoriatic Arthritis  Key Facts: Current treatments for PsA … Clinical Pathway at Point of This Intervention AS treatment focuses on physical therapy and exercise
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
    January 01, 2008 - Document Completion Date: 6-25-09 1 Results of Topic Selection Process & Next Steps  Treatment … Nomination Summary: The anonymous nominator is interested in the comparative risks and benefits of treatments … Does treatment response vary for African-Americans as compared to those who are not African-Americans … Treatment of Open-Angle Glaucoma Nomination Summary Document http://effectivehealthcare.ahrq.gov/index.cfm … There are no recent guidelines on the treatment of glaucoma in the US.
  15. Untitled (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/autism-medical-update_research-protocol.pdf
    February 16, 2016 - b)   Is the effectiveness of the therapies reviewed affected by co-interventions or prior treatment … targeting sensory challenges as driving outcomes, either within a single treatment or across treatments … [sh]  OR  therapeutics[mh]  OR  teaching[mh]  OR  psychotherapy[mh]  OR   treatment  outcome[mh]   7275093 …   5   (treatment[tiab]  OR  therapy[tiab]  OR  intervention[tiab]  OR  “control  group”[tiab]     OR … "[Mesh])  OR  (  "drug  therapy"  [Subheading]  OR  "Medication   Therapy  Management"[Mesh]  )   2368930
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0119_06-17-2009.pdf
    January 01, 2009 - Completion Date: 1-12-10 1 Results of Topic Selection Process & Next Steps  Pharmacologic therapy … versus medical foods and nondietary approaches for the treatment of phenylketonuria (PKU) will go forward … They are also interested in the comparative cost effectiveness of these treatments. … Pharmacologic Therapy versus Medical Foods for the Treatment of Phenylketonuria (PKU) Nomination …  Historically, the treatment of PKU has relied on nonpharmacologic therapies, with affected individuals
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
    April 01, 2012 - Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy … 20 Inhaled Nitric Oxide Therapy for Premature Infants. … treatment to an existing treatment after treatment failure Initial treatment with psychosocial … and/or pharmacologic treatments or Continuation of existing treatment without addition of psychosocial … and/or pharmacologic treatment or switch to different treatment Outcomes for children and parents
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0161_09-01-2009.pdf
    January 01, 2009 - All individuals with asthma over the age of 5 Intervention(s): Buteyko breathing Comparator(s): Treatment … how-are-research-topics-chosen/ Topic Number(s): 0205 Document Completion Date: 2-5-10 2  Medical treatment … There is no known cure for asthma; therefore, all treatments are directed toward symptom reduction. … of interest to clinicians, patients, and parents of children with asthma as an adjunct to standard therapies … Although uncommon in the US, it is sometimes used as a treatment strategy outside of the US.
  19. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hemorrhage-postpartum_executive.pdf
    April 01, 2015 - PPH management may also involve adjunctive therapies, such as blood and fluid replacement and/or an … of care, the availability of medications or other therapeutic options, the availability of personnel … Treatment availability and the feasibility of providing certain treatments differ across developed and … This lack of direct comparison of treatment options hinders our ability to understand what treatments … The most effective treatments and the order in which to use treatments remain unclear.
  20. effectivehealthcare.ahrq.gov/sites/default/files/arthritis-horizon-scan-high-impact-1512.pdf
    December 29, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Treatments such as nonsteroidal anti-inflammatory drugs (NSAIDs) are used for first-line therapy to … Patients with AS who did not respond to prior treatment with TNF therapies showed significant improvement … with existing therapies. … Clinical Pathway at Point of This Intervention AS treatment focuses on physical therapy and exercise

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