-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1506.pdf
November 01, 2016 - new (and new uses of existing) pharmaceuticals, medical
devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … or payers may require a step-therapy
approach starting with existing endometriosis treatments before … or payers may require step therapy in which patients try existing endometriosis
treatments before … Experts noted
its anticipated higher cost than alternative therapies available as generics may increase
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
July 01, 2012 - using
different tests will have the same response to downstream treatments. … Although the downstream
treatments may be the same in all test-and-treat strategies of interest, one … The evidence report also modeled hypothetical treatments with various effectiveness and safety profiles … Evidence exists to estimate the benefits and harms of pharmacologic therapy in those
with and without … Specifically, the treatments for MCI in AD are at best only marginally
effective,33 and it is unknown
-
effectivehealthcare.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
February 19, 2014 - strategies
Key Question 3: What are the comparative effectiveness and harms of different
antibiotic treatments … (c) How do prevention and treatment of CDI affect
resistance of other pathogens? … For a first recurrence, the
effectiveness of antibiotic therapy is around 60% and further declines with … What are the comparative effectiveness and harms of different antibiotic treatments? … that reflect the new evidence surrounding disinfection as
well as potential risk factors; and on new treatments
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0272_03-06-2008.pdf
January 01, 2008 - The
treatments for sleep apnea covered in these nominations include continuous positive
airway pressure … )
CPAP is considered first-line therapy for the treatment of sleep apnea in adults. … The nominating
agencies for this topic have expressed interest in many second-line therapies for sleep … While there is consistent evidence on the efficacy
of CPAP and its use as a first-line therapy, no comparative … effectiveness reviews comparing all of the
second-line therapies (specified by the nominators) compared
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
July 01, 2013 - Drugs used for the treatment of SAR have wide therapeutic
windows—that is, across the range of doses … Study designs that can more efficiently
assess the effects of additive therapies are lacking. … Antihistamine therapy in allergic rhinitis. … Alterations in drug disposition during
pregnancy: implications for drug therapy. … Montelukast as an adjuvant to mainstay
therapies in patients with seasonal allergic rhinitis.
-
effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
January 01, 2011 - additive value function to determine
the relative preference for the alternatives:
I want the best treatment … The pattern of choices
reveals the implicit decision weights patients attach to therapeutic
benefits … , harms, processes and costs that describe the treatment
profiles (ISPOR taskforce, 2012)
5
MCDA … impact Co-payment
Clinical benefit 1 3 5 7
Adverse event 1/3 1 1/3 1/5
Treatment impact 5 3 1 … impact Co-payment
Clinical benefit 0.15 0.42 0.75 0.63
Adverse event 0.05 0.14 0.05 0.02
Treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
July 13, 2011 - These second-generation treatments include selective serotonin
reuptake inhibitors (SSRIs) and serotonin … of different antidepressants in all
study arms and (2) continued treatment versus switched treatment … effects (KQ4, KQ5)
Adherence (KQ4, KQ5)
Timing: Acute, continuation and maintenance phase treatments … Also,
adverse events may occur at any point after the treatment is received. … Published Online: July 13, 2011
factors influencing the use of the study pharmacological treatments
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
December 01, 2015 - therapeutic effects and better glycemic control. … therapeutic effects and better glycemic control. … Both anti-angiogenic and corticosteroid treatments require ongoing treatment involving multiple
intravitreal … and safer intravitreal therapies for DME. … Investigational
therapeutic options in the management of DME:
investigational pharmacologic treatments
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes.pdf
April 01, 2005 - Therapeutic safety of perindopril in the
treatment of mild hypertension with
concomitant nephropathy … Renovascular hypertension: anatomic and
renal function changes during drug therapy. … Enalapril versus
triple-drug therapy in the treatment of
renovascular hypertension. … Renovascular hypertension: results of
medical and surgical therapy. … • Treatments were not specified in 8
natural history studies.
-
effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
October 01, 2015 - new (and new uses of existing) pharmaceuticals, medical
devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … Therapies targeting CFTR mutations have been proposed to
treat CF; however, therapies targeting molecular … Additionally, 4.2% of patients
who received combination therapy discontinued treatment because of adverse … However this expert also noted as more targeted therapies with
high treatment costs emerge, payers
-
effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
September 26, 2014 - therapeutic effects and better glycemic control. … The mode of
delivery, an implanted pump, is an established therapy for other drugs or other treatments … Unlike other treatments for T2DM, management of therapy with the ITCA 650 is
controlled by the device … , corticosteroids, or anti-VEGF therapies, making this new
intervention just another treatment option … Investigational
therapeutic options in the management of DME:
investigational pharmacologic treatments
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0012_03-21-2008.pdf
January 01, 2008 - If a patient is asymptomatic, is there benefit from the patient perspective for
treatment?
3. … What are the potential harms from treatment and non-treatment? … Does treatment make a difference in morbidity or mortality when sub-clinical hypothyroidism or
hyperthyroidism … What are the harms of treatment of sub-clinical hypothyroidism and sub-clinical hyperthyroidism? … further large randomized
controlled studies are necessary in order to evaluate the effectiveness of treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research.pdf
September 01, 2014 - modify the harms of treatment? … CUR Treatments
Table A1. … Concurrent treatment:
NR
Previous treatments:
NR
Intervention: Frequency
of CISC/day: 2.22 … Three patients in the laser therapy group
required TURP for continuing symptoms. … category after treatment.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_appendixes.pdf
June 16, 2008 - Gesellschaft fur
Radiooncologie
http://www.degro.org/jsp_public/cms/index.jsp
European Society for Therapeutic … Radiology and Oncology
http://www.estroweb.org/estro/index.cfm
American Society for Therapeutic … Relative survival rates after alternative therapies
for uveal melanoma. … Clinical application of proton beams in the treatment
of uveal melanoma: the first therapies carried … Peripheral dose in ocular
treatments with CyberKnife and Gamma Knife radiosurgery compared
to proton
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
December 17, 2013 - MS cannot be cured with current therapies.6 Attention, therefore, turns to treatment
options to slow … What are patient and provider preferences for discontinuation of disease–
modifying therapies? … risk and seriousness of health states
□ Factors and processes patients with MS use to evaluate the therapy … --------------------------------------
1 Multiple Sclerosis, Relapsing-Remitting/dt, im, th [Drug Therapy … , Immunology,
Therapy]
2 exp Interferon-beta/
3 interferon beta.mp.
4 glatiramer acetate.mp.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_executive.pdf
June 01, 2013 - treatment? … treatments? … Masking of
treatment status was not feasible for RCTs that examined
nondrug therapies as comparators … treatment? … Impact of migraine and migraine
therapy on productivity and quality of life.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
February 01, 2018 - Example binary data for effect size computation
Treatment
Events in
Treatment
Group
Treatment
n … Efficacy in the
Presence of Treatment-Induced Adverse Events. … Where:
mT = mean of treatment group
mC = mean of control group
Spooled = pooled standard error
5. … ► Assumes that the relative effect of treatment will be the same, regardless of
the scale used to … Efficacy in the
Presence of Treatment-Induced Adverse Events.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
July 01, 2016 - KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … , other
treatments and
response to prior
treatments)
• Outcomes other than
CDAI not routinely … Pharmacologic Therapies for the Management of
Crohn’s Disease. … An
evidence-based systematic review on medical
therapies for inflammatory bowel disease. … treatments and
response to prior
treatments)
• Outcomes other than
CDAI not routinely
assessed including
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_research-protocol.pdf
April 03, 2014 - Treatment options are not limited to psychological and behavioral therapies and
pharmacologic interventions … Aroma therapy
Bright-light therapy
Brief behavioral therapy
Biofeedback
Cognitive behavioral therapy … cognitive behavioral therapy and drug therapy) for the treatment of insomnia
disorder in adults? … What are the harms of combined treatments (e.g. cognitive behavioral therapy
and drug therapy) for insomnia … Cognitive Behavioral Therapy for
Insomnia in Older Adults: Background,
Evidence, and Overview of Treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_protocol-140716.pdf
April 03, 2014 - Treatment options are not limited to psychological and behavioral therapies and
pharmacologic interventions … Aroma therapy
Bright-light therapy
Brief behavioral therapy
Biofeedback
Cognitive behavioral therapy … cognitive behavioral therapy and drug therapy) for the treatment of insomnia
disorder in adults? … What are the harms of combined treatments (e.g. cognitive behavioral therapy
and drug therapy) for insomnia … Cognitive Behavioral Therapy for
Insomnia in Older Adults: Background,
Evidence, and Overview of Treatment