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  1. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1506.pdf
    November 01, 2016 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … or payers may require a step-therapy approach starting with existing endometriosis treatments before … or payers may require step therapy in which patients try existing endometriosis treatments before … Experts noted its anticipated higher cost than alternative therapies available as generics may increase
  2. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
    July 01, 2012 - using different tests will have the same response to downstream treatments. … Although the downstream treatments may be the same in all test-and-treat strategies of interest, one … The evidence report also modeled hypothetical treatments with various effectiveness and safety profiles … Evidence exists to estimate the benefits and harms of pharmacologic therapy in those with and without … Specifically, the treatments for MCI in AD are at best only marginally effective,33 and it is unknown
  3. effectivehealthcare.ahrq.gov/sites/default/files/c-diff-infections-nomination-140925.pdf
    February 19, 2014 - strategies Key Question 3: What are the comparative effectiveness and harms of different antibiotic treatments … (c) How do prevention and treatment of CDI affect resistance of other pathogens? … For a first recurrence, the effectiveness of antibiotic therapy is around 60% and further declines with … What are the comparative effectiveness and harms of different antibiotic treatments? … that reflect the new evidence surrounding disinfection as well as potential risk factors; and on new treatments
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0272_03-06-2008.pdf
    January 01, 2008 - The treatments for sleep apnea covered in these nominations include continuous positive airway pressure … )  CPAP is considered first-line therapy for the treatment of sleep apnea in adults. … The nominating agencies for this topic have expressed interest in many second-line therapies for sleep … While there is consistent evidence on the efficacy of CPAP and its use as a first-line therapy, no comparative … effectiveness reviews comparing all of the second-line therapies (specified by the nominators) compared
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/allergy-seasonal_executive.pdf
    July 01, 2013 - Drugs used for the treatment of SAR have wide therapeutic windows—that is, across the range of doses … Study designs that can more efficiently assess the effects of additive therapies are lacking. … Antihistamine therapy in allergic rhinitis. … Alterations in drug disposition during pregnancy: implications for drug therapy. … Montelukast as an adjuvant to mainstay therapies in patients with seasonal allergic rhinitis.
  6. Dia 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/ijzerman_ahrq-webinar-mcda.pdf
    January 01, 2011 - additive value function to determine the relative preference for the alternatives: I want the best treatment … The pattern of choices reveals the implicit decision weights patients attach to therapeutic benefits … , harms, processes and costs that describe the treatment profiles (ISPOR taskforce, 2012) 5 MCDA … impact Co-payment Clinical benefit 1 3 5 7 Adverse event 1/3 1 1/3 1/5 Treatment impact 5 3 1 … impact Co-payment Clinical benefit 0.15 0.42 0.75 0.63 Adverse event 0.05 0.14 0.05 0.02 Treatment
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antidepressants-update_research-protocol.pdf
    July 13, 2011 - These second-generation treatments include selective serotonin reuptake inhibitors (SSRIs) and serotonin … of different antidepressants in all study arms and (2) continued treatment versus switched treatment … effects (KQ4, KQ5) Adherence (KQ4, KQ5) Timing: Acute, continuation and maintenance phase treatments … Also, adverse events may occur at any point after the treatment is received. … Published Online: July 13, 2011 factors influencing the use of the study pharmacological treatments
  8. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - therapeutic effects and better glycemic control. … therapeutic effects and better glycemic control. … Both anti-angiogenic and corticosteroid treatments require ongoing treatment involving multiple intravitreal … and safer intravitreal therapies for DME. … Investigational therapeutic options in the management of DME: investigational pharmacologic treatments
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_appendixes.pdf
    April 01, 2005 - Therapeutic safety of perindopril in the treatment of mild hypertension with concomitant nephropathy … Renovascular hypertension: anatomic and renal function changes during drug therapy. … Enalapril versus triple-drug therapy in the treatment of renovascular hypertension. … Renovascular hypertension: results of medical and surgical therapy. … • Treatments were not specified in 8 natural history studies.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pulmonary-horizon-scan-high-impact-1412.pdf
    October 01, 2015 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Therapies targeting CFTR mutations have been proposed to treat CF; however, therapies targeting molecular … Additionally, 4.2% of patients who received combination therapy discontinued treatment because of adverse … However this expert also noted as more targeted therapies with high treatment costs emerge, payers
  11. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1406.pdf
    September 26, 2014 - therapeutic effects and better glycemic control. … The mode of delivery, an implanted pump, is an established therapy for other drugs or other treatments … Unlike other treatments for T2DM, management of therapy with the ITCA 650 is controlled by the device … , corticosteroids, or anti-VEGF therapies, making this new intervention just another treatment option … Investigational therapeutic options in the management of DME: investigational pharmacologic treatments
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0012_03-21-2008.pdf
    January 01, 2008 - If a patient is asymptomatic, is there benefit from the patient perspective for treatment? 3. … What are the potential harms from treatment and non-treatment? … Does treatment make a difference in morbidity or mortality when sub-clinical hypothyroidism or hyperthyroidism … What are the harms of treatment of sub-clinical hypothyroidism and sub-clinical hyperthyroidism? … further large randomized controlled studies are necessary in order to evaluate the effectiveness of treatment
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-urinary-retention_research.pdf
    September 01, 2014 - modify the harms of treatment? … CUR Treatments Table A1. … Concurrent treatment: NR Previous treatments: NR Intervention: Frequency of CISC/day: 2.22 … Three patients in the laser therapy group required TURP for continuing symptoms. … category after treatment.
  14. Organisation (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-radiation_appendixes.pdf
    June 16, 2008 - Gesellschaft fur Radiooncologie http://www.degro.org/jsp_public/cms/index.jsp European Society for Therapeutic … Radiology and Oncology http://www.estroweb.org/estro/index.cfm American Society for Therapeutic … Relative survival rates after alternative therapies for uveal melanoma. … Clinical application of proton beams in the treatment of uveal melanoma: the first therapies carried … Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/multiple-sclerosis_research-protocol.pdf
    December 17, 2013 - MS cannot be cured with current therapies.6 Attention, therefore, turns to treatment options to slow … What are patient and provider preferences for discontinuation of disease– modifying therapies? … risk and seriousness of health states □ Factors and processes patients with MS use to evaluate the therapy … -------------------------------------- 1 Multiple Sclerosis, Relapsing-Remitting/dt, im, th [Drug Therapy … , Immunology, Therapy] 2 exp Interferon-beta/ 3 interferon beta.mp. 4 glatiramer acetate.mp.
  16. effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_executive.pdf
    June 01, 2013 - treatment? … treatments? … Masking of treatment status was not feasible for RCTs that examined nondrug therapies as comparators … treatment? … Impact of migraine and migraine therapy on productivity and quality of life.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-2.pdf
    February 01, 2018 - Example binary data for effect size computation Treatment Events in Treatment Group Treatment n … Efficacy in the Presence of Treatment-Induced Adverse Events. … Where: mT = mean of treatment group mC = mean of control group Spooled = pooled standard error 5. … ► Assumes that the relative effect of treatment will be the same, regardless of the scale used to … Efficacy in the Presence of Treatment-Induced Adverse Events.
  18. - (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/crohns-disease-future_research.pdf
    July 01, 2016 - KQ 3 What is the comparative safety of therapies alone or in combination used in adults and children … , other treatments and response to prior treatments) • Outcomes other than CDAI not routinely … Pharmacologic Therapies for the Management of Crohn’s Disease. … An evidence-based systematic review on medical therapies for inflammatory bowel disease. … treatments and response to prior treatments) • Outcomes other than CDAI not routinely assessed including
  19. effectivehealthcare.ahrq.gov/sites/default/files/pdf/insomnia_research-protocol.pdf
    April 03, 2014 - Treatment options are not limited to psychological and behavioral therapies and pharmacologic interventions … Aroma therapy Bright-light therapy Brief behavioral therapy Biofeedback Cognitive behavioral therapy … cognitive behavioral therapy and drug therapy) for the treatment of insomnia disorder in adults? … What are the harms of combined treatments (e.g. cognitive behavioral therapy and drug therapy) for insomnia … Cognitive Behavioral Therapy for Insomnia in Older Adults: Background, Evidence, and Overview of Treatment
  20. effectivehealthcare.ahrq.gov/sites/default/files/related_files/insomnia_protocol-140716.pdf
    April 03, 2014 - Treatment options are not limited to psychological and behavioral therapies and pharmacologic interventions … Aroma therapy Bright-light therapy Brief behavioral therapy Biofeedback Cognitive behavioral therapy … cognitive behavioral therapy and drug therapy) for the treatment of insomnia disorder in adults? … What are the harms of combined treatments (e.g. cognitive behavioral therapy and drug therapy) for insomnia … Cognitive Behavioral Therapy for Insomnia in Older Adults: Background, Evidence, and Overview of Treatment

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