-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/restless-legs_research-protocol.pdf
December 16, 2011 - therapy, can occur during the first 2 years of treatment and sometimes many
years into treatment. … ; 1
= very good, 4 = unchanged or
worsened)
Side-effects (item 4; 1 = none, 4
= outweighs therapeutic … What are the benefits from RLS treatments when compared to placebo or no treatment?
b. … What are the harms from RLS treatments when compared to placebo or no treatment?
b. … Comparators
Placebo (or sham treatments), no treatment, or other active comparator
Outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ear-infection_research-protocol.pdf
August 07, 2012 - Nonpharmacological Interventions
Autoinflation of the Eustachian tube
Complementary and alternative therapies … Treatments and Treatment Strategies That Will Be Addressed in This Review: Rationale for
inclusion … Comparators included no treatment, watchful waiting,
and other established treatments. … KQ 1: What is the comparative effectiveness of the following treatment options (active treatments and … Treatments That Will Not Be Addressed in This Review: Rationale for Exclusion
Treatments and Treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1506.pdf
June 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … for patients whose conditions fail to
respond to available medications and behavioral therapies for … Personalized drug therapy has traditionally lagged behind behavioral
therapy in this regard because … Double-blind,
placebo-controlled trial of ketamine therapy in
treatment-resistant depression (TRD … Therapeutic options in
treatment-resistant depression. Ann Med.
2011 Nov;43(7):512-30.
-
effectivehealthcare.ahrq.gov/sites/default/files/05_depression_potential_high_impact_2012-12-10.pdf
January 01, 2012 - Overall high-impact potential: deep brain stimulation (Reclaim DBS Therapy or
Libra DBS) for treatment-resistant … and psychotherapy as first- and
second-line therapies and electroconvulsive therapy or repetitive … treatments for treatment-resistant
MDD, investigators have sought new approaches because available … DBS therapy is incompatible with some other device-based depression treatments. … Overall high-impact potential: deep brain stimulation (Reclaim DBS Therapy or Libra DBS)
for treatment-resistant
-
effectivehealthcare.ahrq.gov/sites/default/files/suppl-2-user-guide-to-ocer_130129.pdf
January 01, 2011 - primary goal of nonexperimental comparative
effectiveness research is to compare the effect of
study treatments … studies, marginal
exchangeability can rarely be assumed, since
patients and providers typically select treatments … To simplify,
consider a randomized trial of antihypertensive
treatments (CCB or other) and the outcome … alcohol abuser but remained in the study
suggests that she did not experience adverse effects
of therapy … Treatment
(A) is randomized.
-
effectivehealthcare.ahrq.gov/sites/default/files/ch_10-user-guide-to-ocer_130129.pdf
January 01, 2011 - Consider, for example, HIV
patients who may be treated with antiretroviral
therapy. … The use of antiretroviral therapy may
change over time and decisions about therapy may
in part be based … In the HIV example, CD4 count
may be affected by prior therapy decisions, but
CD4 count levels may … themselves go on to alter
subsequent therapy decisions and the final survival
outcome. … A difficulty arises in
that CD4 count is both a confounding variable
(for subsequent therapy and final
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
January 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … recently and will be used in place of existing treatments
in some patients and as an addition to treatment … Although cost information is not yet available, oral
microbiome-based therapeutics (i.e., capsules) … Hypertension Therapeutic device $1,000,000,000 $500,000,000
Lomitapide (Juxtapid) for Treatment … Competition could eventually lower the price of of these
treatments.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stone-prevention_executive.pdf
March 01, 2013 - laboratory results is associated with better
clinical health outcomes than empiric therapy. … In adults with a history of nephrolithiasis,
what is the evidence that pharmacological therapies to … with placebo, usual care/no treatment, or other available
active treatments. … when added to this diet therapy. … Few trials
directly compared active pharmacological treatments.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-treatment-ssri_research-protocol.pdf
June 15, 2010 - • Comparators: CPG may not provide recommendations on comparator treatments. … Depression Treatment after Unsatisfactory Response to SSRIs when used as First-line Therapy
… Medicine (e.g., Biofields therapies (Reiki, Qi Gong) and
bioelectromagnetic based therapies)
e) Biologically … The search strategy was not delimited by treatments or outcomes. … per week, number of total treatments, treatment fidelity for psychotherapy), treatment duration
(total
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0108_05-24-2009.pdf
January 01, 2009 - Completion Date: 1-12-10
1
Results of Topic Selection Process & Next Steps
Acute migraine treatment … IV Benadryl, Toradol, and Reglan in an emergency
department or clinical setting for acute migraine treatment … has been effective in treating migraines in patients and would like to see evidence
supporting this treatment … There appears to be significant clinical uncertainty surrounding acute migraine treatment in … A review specifically focused on the treatment combination posed by the nominator would not be
-
effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1406.pdf
June 01, 2014 - , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … cognitive behavior therapies. … efficacy for suicidal ideation
and as an adjunct treatment to behavior and brain-stimulation therapies … added to existing therapies. … Therapeutic options in
treatment-resistant depression. Ann Med. 2011
Nov;43(7):512-30.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/suicidal-thoughts-young-people-exe-sum.pdf
April 01, 2025 - No eligible study evaluated neurotherapeutics
therapies. … factors common to
all psychotherapeutic approaches and supportive treatments, such as empathy,
therapeutic … Control treatments across most comparison studies mostly involved treatment as
usual, which consisted … These treatments were
often matched to the intervention treatment in format (e.g. group and individual … A comparative study of mode
deactivation therapy (MDT) as an effective
treatment of adolescents with
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
February 01, 2008 - Even if differences in therapeutic
effectiveness exist, differences in adverse effects,
convenience, … It is not known
whether these therapies are better or worse than
other treatments for localized prostate … The absolute risk of
impotence and treatment-related morbidity appeared to
be similar to other treatments … radiation therapy vs. other treatments. 1
systematic review of nonrandomized studies found no direct … • The most commonly reported patient characteristics used as
stratifying factors for therapeutic outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
December 01, 2011 - therapy (ADT), are
offered with curative intent. … with or without androgen deprivation therapy (ADT). … Observational Management Strategies Versus
Combined Active Treatments or Combined
Radiation Treatment … EBRT and BT
(combination therapy) had a higher rate of receiving
treatments for urethral stricture compared … grouping treatments or selectively excluding treatments.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c_research-protocol.pdf
November 30, 2011 - , and adherence to
HCV antiviral therapy. … with the level of detail suggested by the key informants, including the comparative
effectiveness of treatments … Input from Key Informants: Review of Hepatitis C Treatments
During the topic refinement process, … Question 2
What is the comparative effectiveness of antiviral treatments on intermediate outcomes … is not applicable to
those who failed previous therapies or are nonresponders.
-
effectivehealthcare.ahrq.gov/sites/default/files/08_functional_limitations_potential_high_impact_2012-12-10.pdf
January 01, 2012 - uncontrolled by other therapeutic agents. … would be very accepting of this therapy because of the lack of other effective treatments,
marking … patients an effective therapy option within the current treatment model. … Edison (NJ): Oceana
Therapeutics, Inc.; 2010 Dec 2. 65 p.
48. … Oceana Therapeutics announces U.S. launch of
Solesta, the only nonsurgical FDA approved
treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
June 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … with one or more standard therapies, including
corticosteroids, immunomodulators, or tumor necrosis … unmet
need for new therapeutic options for patients with IBS. … , alternative therapies are needed. … FDA approves two therapies to treat IBS-D.
[internet]. Silver Spring (MD): U.S.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0359_10-15-2010.pdf
January 01, 2010 - Patients with multiple sclerosis or clinically isolated syndrome
Intervention(s): Disease-modifying therapies … for delay of relapse and disability,
treatments to address symptoms of multiple sclerosis, including … pharmaceutical and
non-pharmaceutical treatments
Comparator(s): Comparative effectiveness of disease-modifying … therapies, comparative
Diagnosis and Treatment of Multiple Sclerosis
Nomination Summary Document … There is no cure for MS; treatments aim to reduce the frequency and
hasten recovery from relapses and
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-illness-adults-prisons_research-protocol.pdf
September 13, 2012 - , or
dialectical therapy)
X X X X
Psychopharmacologic therapies (includes,
first-generation antipsychotics … (ACT/FACT)
X
Modified therapeutic community X X X
Other treatments (e.g., art therapy,
music … Drug therapy/
Exp antidepressive agents/
Psychotropic drugs/
Therapeutic use.fs. … / OR exp
psychotherapy/ OR cognitive therapy/ OR exp complementary therapies/ OR
counseling/ OR exp … OR cognitive therapy OR (cognitive ADJ
behav* ADJ (therapy OR treatment)) OR CBT OR (community based
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_executive.pdf
July 01, 2011 - all patients, since such
decisions should be individualized.
11
The second alternative to CPAP therapeutic … were potentially
Treatment transient and could be alleviated with either stopping treatment
OSA treatments … Treatment • By meta-analysis, MAD results in a statistically significant
OSA treatments reduction in … to sham surgery, conservative therapy, or no treatment. … Treatments to improve • A single study evaluated the effect of cognitive behavioral
compliance therapy