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  1. Hi Les, (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - Test-treatment pathway Treatment effects. … more sensitive test, just as they are needed to assess the efficacy of new treatments. … Results of conservative surgery and radiation therapy for multiple synchronous cancers of one breast … Standard for breast conservation therapy in the management of invasive breast carcinoma. … The role of before-after studies of therapeutic impact in the evaluation of diagnostic technologies
  2. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_executive.pdf
    September 01, 2011 - as therapies for patients with TRD: electroconvulsive therapy (ECT), repetitive transcranial magnetic … Comparisons of these nonpharmacologic therapies are our main interest. … How do the efficacy, effectiveness, or harms of treatment with nonpharmacologic treatments for TRD differ … Direct comparisons of treatment strategies, holding consistent any coexisting or concomitant therapies … When ongoing treatment is uncontrolled and reflects a variety of treatments—e.g., some patients continue
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/instrumental-variable-methods_research.pdf
    April 01, 2010 - Example 2: The Hospital Formulary Suppose that a new thrombolytic therapy is introduced for the treatment … The new medication is thought to be more effective than existing therapies, but it is expensive and … Thus, providers who preferentially use one treatment must not also preferentially use other treatments … For example, in effectiveness studies, underuse of a therapy results in the IV up-weighting the treatment … Estimating probit models with self-selected treatments. Stat Med 2006;25:389-413. 63.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/treatment-resistant-depression_disposition-comments.pdf
    September 01, 2011 - Therefore it is good that this report includes trials comparing to controls, sham therapies and pharmacological … The study compares baseline and post-treatment outcomes after electroconvulsive therapy. … Their call for action, such as more uniformity in diagnosis and in therapeutic protocols, is well thought … patient receiving long-term dynamic therapy was better off than 96% of patients receiving other treatments … Cognitive therapy versus medication in augmentation and switch strategies as second-step treatments
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0495_05-24-2013.pdf
    January 01, 2013 - Treatment options for metastatic breast cancer include hormone therapy and chemotherapy as well as radiation … therapy and/or surgery for pain relief … bone scintigraphy, CT, MRI, x-ray, ultrasound, PET/CT and FDG- PET can be used to assess response to therapy … , the results of which may affect treatment strategies and outcomes. … A variety of techniques may be used based on treatment strategy and location of metastases.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0351_05-10-2010.pdf
    January 01, 2010 - and associated abnormalities and their impact on treatment and outcomes. … cryptorchidism (undescended testicle) Intervention(s): diagnostic methods (imaging, laparoscopy), hormone therapy … , surgical therapy, specific surgical techniques, early treatment, follow-up care, counseling of patient … of treatment, medical therapies, different surgical techniques Outcome(s): diagnostic ability … uncertainty regarding appropriate diagnostic approaches for cryptorchidism as well as appropriate therapeutic
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypothyroidism-hyperthyroidism-screening-treatment_research-protocol.pdf
    March 11, 2010 - This uncertainty impacts the decision-making for clinicians who are considering treatments for subclinical … or other acceptable options of thyroid replacement therapy, and may include inclusion of activities … Adverse reactions are usually due to therapeutic overdosage and resulting hyperthyroidism. … OR 1-9 11. therapeutic use [sh] 12. treatment [tiab] 13. therapy [tiab] 14. … OR clinical trial[Publication Type] OR random*[Title/Abstract] OR random allocation[MeSH Terms] OR therapeutic
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/fibromyalgia_executive.pdf
    January 01, 2015 - Treatment components may include drugs, exercise programs, cognitive behavioral therapy (CBT), patient … Pharmacologic Therapies The majority of included studies reported the effects of pharmacologic therapies … Psychological Therapies Four studies examined the effects of psychological therapies in subgroups of … Mixed Types of Treatments Four studies assessed combination therapies, and each study had high risk … Multidisciplinary treatment of fibromyalgia: does cognitive behavior therapy increase the response
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0352_09-22-2010.pdf
    January 01, 2010 - Date: 03-19-12 1 Results of Topic Selection Process & Next Steps  Perinatal depression treatment … of depression with antidepressants and other therapies during preconception and pregnancy. … with antidepressants; use of other treatments, including cognitive behavioral therapy, other counseling … Potential harms and benefits of depression treatment must be weighed against the potential harms of …  A review addressing perinatal depression treatment will be a good companion to an in-process
  10. effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1512.pdf
    January 28, 2016 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Sovaldi and Sovaldi combination therapies. … of This Intervention No FDA-approved vaccines or antiviral agents exist for EVD, although several therapeutic … SVR12 was 76% in patients naïve to treatment after 8 weeks of therapy.
  11. #05 DEPRESSION (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/depression-horizon-scan-high-impact-1306.pdf
    October 01, 2014 - Overall high-impact potential: deep brain stimulation (Reclaim DBS Therapy or Libra DBS) for treatment-resistant … and psychotherapy as first- and second-line therapies and electroconvulsive therapy or repetitive … They cited suboptimal current treatments, lack of an FDA-approved treatment for this condition, and … DBS therapy is incompatible with some other device- based depression treatments. … of Psychotic Depression Deep Brain Stimulation (Reclaim DBS Therapy or Libra DBS) for Treatment-Resistant
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/binge-eating_executive.pdf
    December 01, 2015 - includes the influence of other patients suffering from the condition in the therapeutic process. … .70-72 Behavioral Interventions: Inpatient Treatment Versus Inpatient Treatment Plus Active Therapiestreatments for BED patients are pharmacological agents and therapies that combine psychological and … Multivariate therapeutic approach to binge-eating disorder: combined nutritional, psychological and … Binge eating disorder in obesity: comparison of different therapeutic strategies.
  13. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes_hi_impact.pdf
    March 01, 2012 - Many patients with T2DM fail to meet treatment goals and require additional therapy with one of two … One expert with a clinical perspective also noted that initiation of treatment with this therapy might … Both treatments were generally well tolerated. … compliance Experts agreed that while any new therapy for the treatment of diabetes would be welcome … of T2DM Intervention SGLT2 inhibitors for treatment of T2DM While many current treatments help
  14. effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - The high cost of emerging HCV therapies combined with the large population of patients requiring treatment … SVR12 was 76% in patients naïve to treatment after 8 weeks of therapy. … The high cost of emerging HCV therapies combined with the large population of patients requiring treatment … Janssen Therapeutics. … Titusville (NJ): Janssen Therapeutics; 2014 Nov. 44 p.
  15. QR Medica Web Site (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/ebc-challenge-1stplace-qrmedica.pdf
    January 01, 2013 - Patients and guardians can use the patient education tools to understand proper diagnosis and treatment … A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions … A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions … A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions … Key Elements of Treatment Evidence shows that success with treatment of ROM with long-term antibiotics
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/treatment-resistant-depression_research-protocol.pdf
    December 09, 2009 - are looking for other options beyond pharmacologic therapy. … of a biologic intervention), do non-pharmacologic interventions such as electroconvulsive therapy (ECT … How do these non-pharmacologic treatments compare with pharmacological treatments in efficacy or effectiveness … How do the efficacy, effectiveness, or harms of treatment with non-pharmacologic treatments for treatment-resistant … New treatments without a current evidence that require further research, such as Magnetic Seizure Therapy
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-anemia-update_executive.pdf
    April 01, 2013 - Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … Review Number 113 Effective Health Care Program 2 The development of intensified antineoplastic therapies … How do different criteria for discontinuing therapy or for optimal duration of therapy compare regarding … Criteria for Discontinuing Therapy or for Optimal Duration of Therapy No randomized controlled trials … or defining optimal duration of therapy.
  18. Tinnitus Executive (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/tinnitus_executive.pdf
    August 01, 2013 - treatments. … oxygen therapy • Complementary and alternative medicine therapies: Gingko biloba extracts; acupuncture … therapy Combination Therapies • Any combination of tinnitus interventions (e.g., pharmacological treatment … with cognitive behavioral therapy) KQ3: Any treatment/therapy used to reduce/help/cope with tinnitus … Acceptance and commitment therapy versus tinnitus retraining therapy in the treatment of tinnitus:
  19. PEPTIC ULCER #11 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/11_pepticulcer_potential_high_impact_june_2012.pdf
    January 01, 2012 - , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … Patients sometimes also use alternative therapies. … , Germany), is being used by some clinicians and patients as a nonsurgical therapeutic alternative … nonsurgical therapeutic alternative for patients with treatment-refractory disease. … Some noted that this treatment is priced less expensively than some currently approved UC treatments
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0367_11-08-2010.pdf
    January 01, 2010 - Results of Topic Selection Process & Next Steps  Efficacy and safety of screening and treatment … for depression Comparator(s): Different approaches to screening and treatment, including different … primary care), various screening tools, medication, cognitive, individual or group, and hormonal therapies … For women in the postpartum period, what is the effectiveness and safety of screening and treatment … targeted screening, timing of screening interventions, screening instruments, intervention settings, and treatments

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