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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/major-depressive-disorder_clinician.pdf
    September 01, 2016 - Many patients with MDD are treated in primary care settings, where SGAs are the most prescribed treatment … Approximately 40 percent of patients treated with SGAs do not respond to first-step treatment and approximately
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/migraine-prevention_disposition-comments.pdf
    April 18, 2013 - reduction of monthly migraine attacks by 50 percent in 249 (95 percent CI, 178 to 320) per 1,000 treated … Reviewer 3 Children Report, Results: We estimated that 713 children per 1,000 treated would have no … The number of attributable events per 1000 treated is 1000* absolute risk difference or 713. … The study also provides an excellent jumping off point for patients who are being newly treated for … Migraine is commonly treated by combination therapy and this needs to be further explored.
  3. effectivehealthcare.ahrq.gov/sites/default/files/related_files/abnormal-uterine-bleeding_executive.pdf
    March 01, 2013 - These improvements were significantly greater than changes in comparison groups treated with NSAIDs … COCs Five RCTs included groups treated with COCs.31,41,43,52,53 Measured reduction in bleeding was … A pooled analysis of trials found mild neurologic and GI adverse events were more common in those treated … as from 10 placebo and comparison groups.47,48 Side effect profiles were similar across those treated … The risk of valvular regurgitation in patients with Parkinson's disease treated with dopamine receptor
  4. 04-E029-1 Summary (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-surveillance_executive.pdf
    December 01, 2011 - Because prediction tools are imperfect, these men are monitored closely and treated with curative intent … these studies, due to the differences in patient characteristics and risk profile between patients treated … Observational Management Strategies Versus Radiation Therapy Studies generally reported that men treated … Retrospective studies also reported that men treated with RT had lower mortality than men on WW. … They also reported higher rates of urinary strictures in men treated with RT compared with men on WW.
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adult-treatment_executive.pdf
    April 01, 2013 - It compared EMDR, fluoxetine, and placebo.26 The trial found that EMDR- and fluoxetine-treated subjects … -29.8; p = 0.01) and greater likelihood of remission for those treated with both prolonged exposure … and paroxetine than for those treated with prolonged exposure plus placebo.27 Evidence was limited … Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials … Symptom reduction and suicide risk among patients treated with placebo in antipsychotic clinical trials
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/predictors-trauma-care_research-protocol.pdf
    May 31, 2017 - mortality,6 and survival among patients with serious injuries is 25 percent higher when patients are treated … Patients without serious injuries can be treated effectively outside of major trauma centers and at … Key Question 1: For patients with known or suspected trauma who are treated out-of- hospital by EMS … Key Question 2: For patients with known or suspected trauma who are treated out-of- hospital by EMS personnel … Key Question 3: For patients with known or suspected trauma who are treated out-of- hospital by EMS personnel
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/undescended-testicle_executive.pdf
    December 01, 2012 - on success of testicular descent were pooled and the weighted proportions (sum of all successfully treated … One good- quality study compared endocrine function in children with surgically treated or untreated … treatments for cryptorchidism Treatment Comparison Number of Studies; Total Subjects; Testes Treated … colleagues that describe long-term outcomes, including the ability to father children, among men treated … These studies suggest that while men who were treated for unilateral cryptorchidism as children do
  8. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/antidepressants-update_executive.pdf
    December 01, 2011 - Two RCTs reported similar rates of maintenance of response and relapse for patients treated with fluoxetine … a pooled analysis of two identical RCTs did not find any differences in response rates in patients treated … Based on one double-blinded RCT, no differences in adherence between patients treated with paroxetine … study not meeting inclusion criteria suggested that hyponatremia was more common in elderly patients treated … with various antidepressants than in placebo-treated patients.
  9. PEPTIC ULCER #11 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1406.pdf
    June 01, 2014 - Of the 566 subjects, 173 subjects were treated in Phase 3 SBS studies (134/173 [77%] at the dose of … The most commonly reported (≥10%) adverse reactions in patients treated…across all clinical studies … After 24 weeks of treatment, 54% of patients treated with teduglutide reduced the number of infusion … days per week by 1 or more days, compared with 23% of patients treated with placebo experiencing such … Anemia may be treated with vitamin B12, folic acid, and increased dietary iron.
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/horizon-scan_research-2015.pdf
    January 01, 2015 - sales and a cost of $69,000 per patient treated, we estimated that about 1,600 patients per year are … currently treated with radium-223. … If 3,053 inoperable patients previously treated with medical therapy undergo transfemoral TAVI in 2015 … Thus we estimated that an additional 8% (256,000) patients could be treated in the next year. … In 2013, ivacaftor sales were $371.3 million; which suggests that about 1,140 patients were treated
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-balancing-harms-benefits_research.pdf
    February 01, 2014 - major GI bleed (which corresponds to 5.6 MI prevented and 57.4 GI bleeds induced if 1,000 people are treated … assumed cardiovascular events and major bleeds were of equal weight, stating that for 1,000 people treated … incidence rates to express the number of events per person-time or per a certain number of persons treated … or in excess by treatment across outcomes (equation 4 in Table 8) per a certain number of persons treated … transformed the typical NNT to the metric used by Gail/NCI (difference in number of events between treated
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0265_02-29-2008.pdf
    January 01, 2008 - Can we identify patients who should be more aggressively treated for pain to prevent chronic conditions
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/lysosomal-storage-diseases-therapies_disposition-comments.pdf
    January 01, 2014 - It is treated with a FDA approved drug, Cystagon. This is nowhere in your document. 2. … We have no verification for adults treated at home with Lumizyme. 2. … It includes: - 123 non treated subjects from the Survey Study - 7 subjects treated with Naglazyme in … subjects treated with Naglazyme in the Phase III pivotal trial … There are long-term concerns about the storage in neurons that are not being treated by ERT.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_executive.pdf
    January 01, 2016 - Many lesions can be treated with pharmacologic agents; however, refractory lesions that possess immediate … IH is diagnosed and treated by clinicians including pediatricians, dermatologists, otolaryngologists … Thus, the potential for greater clearance was much higher in patients treated with oral propranolol, … Evidence was deemed insufficient to comment on pigmentation changes and bleeding for children treated … Another study found the likelihood of subsequent laser treatment was lower in participants treated
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/acute-pain-protocol-amended.pdf
    June 10, 2018 - Medicine (IOM) report described the “need for a cultural transformation in the way pain is viewed and treated … dwarfed, however, by the burdens of chronic pain, which can result when acute pain is not effectively treated … Which acute pain conditions are most commonly treated in select settings (emergency rooms; inpatient … • Which acute pain conditions are most often treated in each setting: o Emergency Departments o Inpatient
  16. S143 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
    October 01, 2007 - characteristics that lead to selection of statin therapy, then it may be possible to find both a statin-treated … that it becomes impossible to find a control individual with exactly the same characteristics as each treated … will involve 102,400 potential matching groups, so that finding an untreated indi- vidual for each treated … overwhelm beneficial pharmacologic effects, leading to apparently higher risks of AMI among statin- treated
  17. Decision Modeling (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-decision-modeling.ppt
    June 01, 2012 - In this particular case, patients with AD were treated with acetylcholinesterase inhibitors, which caused … Step 2 (continued) All patients with positive results from positron emission tomography testing are treated … from the previous slide, the patients that test positive with positron emission tomography (PET) are treated
  18. Decision Modeling (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-decision-modeling.ppt
    June 01, 2012 - In this particular case, patients with AD were treated with acetylcholinesterase inhibitors, which caused … Step 2 (continued) All patients with positive results from positron emission tomography testing are treated … from the previous slide, the patients that test positive with positron emission tomography (PET) are treated
  19. Diabetes Mellitus (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/diabetes-horizon-scan-high-impact-1512.pdf
    December 01, 2015 - additional intervention compared with 31% of sham- treated eyes (p<0.001). … Almost 90% of patients were being treated with up to 3 oral antidiabetic medications. … “Patients treated with ITCA 650 60 mcg experienced superior reductions in HbA1c versus those treated … of sham-treated eyes showed disease progression (p<0.001). … Alimera Sciences announces first patient treated with commercially available Iluvien.
  20. effectivehealthcare.ahrq.gov/products/binge-eating/consumer

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