-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/osteoarthritis-pain_research-protocol.pdf
August 05, 2010 - Nonpharmacologic
interventions (such as physical therapy, weight reduction, and exercise) also help … Question 2
Do the comparative benefits and harms of oral treatments for osteoarthritis vary for
certain … preparations, or of different topical medications
compared with one another? … Note that selection of candidates for therapy is
outside the scope of this review. … Am J Therapeutics. Previous
Report, 2004;11:17-25.
9.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-treatment_executive.pdf
April 01, 2012 - Medical Treatment of Open-Angle Glaucoma
KQ1a: Comparative Effectiveness of Medical
Treatments for … Reducing Visual Impairment
• No studies of medical therapy were identified
that directly addressed … Circadian Intraocular Pressure
• Our conclusions regarding the effect of topical
therapies in lowering … any significant conclusions about the
comparative effectiveness of most currently used therapies. … The Ocular
Hypertension Treatment Study: a randomized trial determines
that topical ocular hypotensive
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_executive.pdf
January 01, 2006 - Nonpharmacologic
interventions (such as physical therapy,
weight reduction, and exercise) also help
improve … Do the comparative benefits and harms of oral
treatments for osteoarthritis vary for certain
demographic … • Acetaminophen at therapeutic doses does not
appear to be associated with an increased risk
of hepatotoxicity … Comparison of oral medications with topical
preparations
• Topical NSAIDs: efficacy
• Studies of topical … • Most trials showing therapeutic benefits from
glucosamine were conducted using
pharmaceutical-grade
-
effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/epc-pain-management-grand-rounds-slides.pptx
March 01, 2022 - Low-THC THC to CBD ratio equals 1:≥2 ratio Extracted or purified from whole-plant, whole-plant CBD topical … Oral Large effect (1)
[+] Insufficient (1) Large effect (1)
[+] No evidence No evidence
Low-THC – Topical … for acute treatment of migraine.
3 Key Questions (KQs)
KQ 1: Opioid therapy
KQ 2: Nonopioid pharmacologic … therapy
KQ 3: Nonpharmacologic therapy
35
Methods
Followed the established methodologies of systematic … opioid therapy/nonopioid pharmacologic therapy/nonpharmacologic therapy
Outcome: Pain, function, satisfaction
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/diabetic-neuropathy_research-protocol.pdf
May 09, 2016 - Agents lidocaine, capsaicin, other topical treatments (clonidine, doxepin,
pentoxyifylline)
Other … Topical ketamine cream in the treatment of
painful diabetic neuropathy: a randomized, placebo-controlled … Randomized control trial of topical clonidine
for treatment of painful diabetic neuropathy. … therapy”[tiab] OR “cognitive Psychotherapy”[tiab]
OR “behavioral therapy”[tiab] OR “behavioral therapies … Treatment
Xylocaine (Lidocaine) AstraZeneca
Qutenza (Capsaicin) Acorda Therapeutics, Inc
20
!
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/ear-infection_research-protocol.pdf
August 07, 2012 - Nonpharmacological Interventions
Autoinflation of the Eustachian tube
Complementary and alternative therapies … Treatments and Treatment Strategies That Will Be Addressed in This Review: Rationale for
inclusion … Comparators included no treatment, watchful waiting,
and other established treatments. … Pharmacological treatments: oral or topical nasal steroids. … Treatments That Will Not Be Addressed in This Review: Rationale for Exclusion
Treatments and Treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/nonpharm-treatment-chronic-pain-protocol.pdf
December 11, 2018 - Pharmacologic Treatment
Pharmacologic treatments for chronic pain may include nonsteroidal anti-inflammatory … therapies (cognitive-behavioral therapy, biofeedback, relaxation techniques, acceptance
and commitment … What are the benefits and harms of noninvasive nonpharmacologic
therapies compared with sham treatment … /
14 exp Physical Therapy Modalities/
15 exp Braces/
16 exp Mind-Body Therapies/ … /
14 exp Physical Therapy Modalities/
15 exp Braces/
16 exp Mind-Body Therapies/
-
effectivehealthcare.ahrq.gov/sites/default/files/nonopioid-chronic-pain-summary.pdf
April 01, 2020 - Topical diclofenac showed
small improvement in pain in the short term. … , but less applicable to selecting among
nonopioid treatments. … also reviewed evidence that
may help inform decisions regarding prioritization
of nonopioid drug therapies … by clinicians and
patients when selecting therapy. … Opioid Treatments
for Chronic Pain: A Systematic Review.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/app-e-surv-rept-1-acute-pain.xlsx
May 29, 2025 - Total treatment time 8 to 9 minutes, and standard treatment
B: Standard treatment: Advice about activity … department Turkey Musculoskeletal pain (blunt upper extremity trauma with no fracture or dislocation) Topical … NSAID vs. topical capsaicin A: Topical ibuprofen (5%; cream) 3 times per day for 3 days
B: Topical capsaicin … Knee or hip arthroplasty Nonpharmacological therapy vs. no nonpharmacological therapy A: Music therapy … : Music therapy 30 minutes 3 times per day postoperatively in hospital and for 2 days post discharge
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/infantile-hemangioma_clinician.pdf
June 01, 2016 - ) and surgical
interventions (such as laser therapy or excision in appropriate
cases). … PDL therapy
only fades IH lesions and does not stop their proliferation. … alternative or
adjunctive therapies are appropriate after first-line treatment
is unsuccessful, and … Overall, the role of laser therapy in
treating IH lesions is not clearly described in the literature … corticosteroid therapies were unsuccessful.
-
www.ahrq.gov/sites/default/files/wysiwyg/hai/tools/mrsa-2/004-ss-antimicrobial-prophylaxis-part-2.pptx
April 01, 2025 - One day versus seven days of preventive antibiotic therapy in orthopedic surgery. … One day versus seven days of preventive antibiotic therapy in orthopedic surgery. … Is topical vancomycin an option? … are rare and emphasize importance of thorough allergy screening
Anaphylaxis to cefazolin
Alternative treatment … One day versus seven days of preventive antibiotic therapy in orthopedic surgery.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_surveillance.pdf
October 29, 2012 - What are the harms from pharmacological treatments when compared with no active
treatment?
4. … e.g., consideration of magnitude/direction of changes
in estimates, potential changes in practice or therapy … Oestrogen
therapy
for
urinary
incontinence
in
post-‐menopausal
women.
… exp Evidence-Based Medicine/ or evidence.mp. (1044915)
60 58 and 59 (235)
61 limit 58 to "therapy … Incontinence/rehabilitation"[Mesh] OR "Urinary Incontinence/surgery"[Mesh] OR
"Urinary Incontinence/therapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0251_05-20-2010.pdf
January 01, 2010 - Date: 11-15-10
1
Results of Topic Selection Process & Next Steps
Prevention and treatment … (e.g., mechanical debridement, chemical debridement, semipermeable dressings,
topical applications … of pressure ulcers with dressings and is
particularly interested in treatment stratified by the stage … What are the benefits and harms of pressure ulcer treatment regimens including the
evidence for treatment … Standard, adjunctive, and novel therapies for the prevention and treatment of pressure ulcers have
proliferated
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/osteoarthritis-pain-2006_appendixes.pdf
January 01, 2006 - Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and
patient … Alimentary Pharmacology & Therapeutics. 20(1):51-63, 2004 Jul 1.
Appendix F. … assessed pain measurement with
adequate power (70%) to detect minimum clinical difference between treatments … corticosteroid at the site of application;
use of a topical product, treatment, or device at the application … with
drugs having a
therapeutic
effecton the
knee joint)
no yes Dolorgiet
Pharmaceuticals
(Germany
-
www.ahrq.gov/sites/default/files/wysiwyg/hai/abate/introduction/prelaunch-activities.pdf
March 01, 2022 - approval by relevant committees, which
may include infection prevention, nursing governance, pharmacy & therapeutics … Prior to launching targeted decolonization, ensure that all stocked prophylactic topical skin
products … Topical prescription products prescribed for treatment do not
need to be checked as they are required … Medicated or wound care skin products
If your patient is prescribed a treatment regimen for the … Such products can include steroid creams, antifungal creams, and
burn or wound creams for treatment
-
www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/prevention-of-dental-caries-in-children-younger-than-age-5-years-screening-and-interventions1
January 02, 2020 - How effective are preventive interventions (dietary fluoride supplementation, topical fluoride application … KQs 4, 5 (preventive interventions): Preventive interventions: oral fluoride supplementation, topical … interventions): Interventions not available for preschool children or not available in the United States; treatment … for existing caries
Comparisons
No intervention or placebo
Active treatment
Outcomes
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-topic-refinement_methods.pdf
January 01, 2013 - a particular technology; share their opinions about the
advantages or disadvantages about specific treatments … , therapy,
or intervention
(depicted with solid line)
(KQ X)
(KQ X)
(KQ X)
(KQ X) … (or if no current treatments are available, what is your
understanding of the natural progression of … In general, the figure illustrates how [treatment 1] versus [treatment 2] may result
in intermediate … PICO (Outcome):
Outcomes include
looking at potential
harms and
benefits of various
treatments
-
www.ahrq.gov/sites/default/files/wysiwyg/policymakers/chipra/measure_retirement/supplemental-materials/supplementaldoc1.pdf
September 01, 2014 - MeSH Terms by CHIPRA Core Measure Topical Areas of Interest
CHIPRA Measure
Topical Area
Maternal … (asthma)
Therapeutic use
(asthma)
Primary health care
Followup for Children
Prescribed … and control
(ADHD)
Rehabilitation (ADHD)
Therapy (ADHD)
HbA1c Testing for
Children with … sufficient evidence that directly
addresses the review’s focus; however, prior to 2008, the Multimodal Treatment … Study of ADHD provided evidence that high-quality medication treatment (including
monthly followup
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/infantile-hemangioma_disposition-comments.pdf
January 15, 2016 - The
likely outcome of this paper will be that topical timolol will be
used because of safety profile … treatment of choice in children that have contra-
indications to beta-blocker therapy or in the minority … row pertaining to harms of topical, oral and
intralesional propranolol. … focuses on the volume of medication administered),
number and timing of doses, use of concomitant therapies … Certainly, there will be better treatment
outcomes when evaluating effects of timolol therapy in small
-
www.ahrq.gov/hai/universal-icu-decolonization/universal-icu-ape4.html
September 01, 2013 - Safety and Adverse Events
Protocol Training, Part 1: Mupirocin
Background
2% Topical … Topical wound treatment.
Nasal ointment is not systemically absorbed. … Protocol Training, Part 2: Chlorhexidine (CHG)
Background
Topical cleansing agent, over the counter