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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0313_02-09-2009.pdf
January 01, 2009 - association
Nomination
Summary:
The nominator questions the effectiveness of medical and dietary therapy … and prevention of recurrence
Comparator(s): No treatment/other treatments
Outcome(s): Prevention of … How does medical and dietary therapy for stone prevention impact quality of life
overall and in specific … What are the costs and outcomes of medical treatments for stone disease?
5. … What are the complications associated with various types of medical treatments for
stone disease?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/presentations-future_research.pdf
April 01, 2012 - 20
Inhaled Nitric Oxide Therapy for Premature Infants. … Types of identified research needs were both methodological and topical and also
included recommendations … for patients as well as others)
The PICOTS formulation should be used to present each recommended topical … treatment to an
existing treatment
after treatment
failure
Initial treatment with
psychosocial … and/or
pharmacologic
treatments
or
Continuation of
existing treatment
without addition of
psychosocial
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_644-03-07-2013.pdf
January 01, 2013 - ,
music therapy, aroma therapy, reminiscence therapy, and light therapy
Comparator(s): Those listed … Although pharmacological agents are often used in the treatment of depression and anxiety, they … Psychosocial interventions such as sensory-stimulation, music therapy, and
cognitive-behavioral therapy … may be more efficacious than pharmacological treatments. … search of the literature, there is evidence specific to non-pharmacological interventions for
the treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0272_03-06-2008.pdf
January 01, 2008 - The
treatments for sleep apnea covered in these nominations include continuous positive
airway pressure … )
CPAP is considered first-line therapy for the treatment of sleep apnea in adults. … The nominating
agencies for this topic have expressed interest in many second-line therapies for sleep … While there is consistent evidence on the efficacy
of CPAP and its use as a first-line therapy, no comparative … effectiveness reviews comparing all of the
second-line therapies (specified by the nominators) compared
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0262_05-11-2007.pdf
January 01, 2007 - What constitutes an adequate diagnostic evaluation on which to base treatment of
UI?
2. … How effective is pharmacologic treatment of UI?
3. … How effective is non-pharmacologic treatment of UI?
4. … Does site of care (office, hospital, nursing home) influence choice of best treatment?
5. … Does this make a clinical difference in response to treatment?
8.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0440_06-01-2011.pdf
January 01, 2011 - Staff-Generated PICO
Population(s): Cancer patients completing primary treatment, including adults … cancers, with the potential for improved survival; improvement in quality of life and
health due to treatment … of late or continuous treatment side effects or psychosocial
effects of having cancer; greater patient … Harms: Earlier initiation of treatment for cancer progression that does not increase
survival (thereby … shortening the asymptomatic period with no side effects of treatment);
more frequent screening with
-
effectivehealthcare.ahrq.gov/sites/default/files/substanceabuse_hi_impact.pdf
January 01, 2012 - new (and new uses of existing) pharmaceuticals, medical devices,
diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and care delivery
innovations that address … Therefore, an unmet need exists for therapies to address these limitations. … and/or counseling.
13
Opiate substitution
therapy is intended to transition the patient to treatment … About buprenorphine therapy. [internet].
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-215-depression-older-adults-comments.pdf
March 28, 2019 - CER 215 Adverse Effects of Pharmacologic Treatments of Major Depression in Older Adults
Comparative … Adverse Effects of Pharmacologic Treatments of Major
Depression in Older Adults. … In older persons, it is quite typical
that antidepressants cannot be titrated to “therapeutic ranges … Suboptimal use of antidepressants in
the elderly8 Clinical Therapeutics [Clin Ther], ISSN: 0149-
2918 … P. 35, bottom paragraph: It is not
clear here what therapy/therapies were compared to placebo
when
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0210_12-07-2009.pdf
January 01, 2009 - injury
Intervention(s): Physical, behavioral, speech, occupational, and/or cognitive
rehabilitation therapies … What is the comparative effectiveness of treatment for TBI for grades I-IV?
2. … For patients, what are the potential harms of TBI treatment interventions?
3. … Are there particular forms of therapy, including number of treatments, length of
treatments, frequency … of treatments, or total duration of treatments that are most
effective?
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0404_01-14-2011.pdf
January 01, 2011 - Summary:
The nominator is interested in the effectiveness and comparative effectiveness of
medical treatments … Compare two newer drug therapies, both FDA approved, for the treatment of
PAH (inhaled treprostinil … and ambrisentan) to older treatments
b. … Compare combination drug therapies to monotherapy drug treatment
Pulmonary Arterial Hypertension … Based on disease etiology and severity of the disease, the timing and
optimal combinations of drug therapy
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0334_08-04-2010.pdf
January 01, 2010 - Selection Process & Next Steps
Pharmacogenetic testing for CYP2C19 variants for guiding antiplatelet treatment … Intervention(s): Genetic testing for CYP2C19 variants to guide treatment selection. … Because this is a comparison of testing strategies, there exist several treatment options
that may be … Note that a no-testing strategy
implies treatment following the current guidelines (i.e., clopidogrel … antiplatelet therapy for the prevention of major adverse
cardiovascular outcomes, compared to alternative
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
September 01, 2012 - o Does the use of the SFLC assay influence the type of treatment (e.g., radiation
therapy)? … of treatment or use of
adjunctive therapy or stem-cell transplantation) in patients with PCDs? … o Does the use of the SFLC assay influence the type of treatment (e.g., radiation
therapy)? … of treatment or
use of adjunctive therapy or stem-cell transplantation) in patients with PCDs? … Does the use of the SFLC assay influence the type of treatment (e.g.,
radiation therapy)?”
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0064_11-23-2008.pdf
January 01, 2008 - Document Completion Date: 6-25-09
1
Results of Topic Selection Process & Next Steps
Treatment … Nomination
Summary:
The anonymous nominator is interested in the comparative risks and benefits of
treatments … Does treatment response vary for African-Americans as compared to those who are
not African-Americans … Treatment of Open-Angle Glaucoma
Nomination Summary Document
http://effectivehealthcare.ahrq.gov/index.cfm … There
are no recent guidelines on the treatment of glaucoma in the US.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0376-140408.pdf
November 06, 2013 - calls, short-term case management, bridge visits, psychoeducation, referral to
assertive community treatment … observation [including emergency department],
intensive case management [ICM)], intensive outpatient treatment … including
outpatient commitment, Assertive Community Treatment [ACT])
Transition support services … Key Questions
from Nominator:
Patient insight into illness
Treatment … sufficient to address safety and
dangerousness concerns
Satisfaction with care
Relapse
Treatment
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0007_03-17-2008.pdf
January 01, 2008 - professional association
Nomination
Summary:
The nominator is interested in the most effective therapy … Population(s): Adults with a diagnosis of depression
Intervention(s): Treatment of depression after … failure with SSRI
Comparator(s): Other antidepressants, cognitive behavioral therapy, or a combination … Outcome(s): Improved symptoms of depression and quality of life, harms associated
with treatments … areas of this nomination, no
comparative effectiveness reviews were identified that compared all the therapies
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0368_11-08-2010.pdf
January 01, 2010 - , sham, or standard
treatment. … from specific physical
diseases
Interventions: Mindfulness-based stress programs
Comparators: No treatment … , sham, or standard treatment
Outcomes: Patient-reported outcomes, such as stress and well-being, and … clinical
biomarker outcomes, such as cortisol
Timing: Duration of therapy, duration of improvements … Setting: Group and individual treatment settings
Key Questions
from Nominator:
None
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND__0250_05-20-2010.pdf
January 01, 2010 - Prevention in Atrial Fibrillation
Population(s): Adults with AF
Intervention(s): Anticoagulation therapy … What are the accuracy and utility of methods of
risk stratification to guide choice of therapy (e.g. … What are the comparative benefits and harms of newer surgical and less invasive
therapies, such as AVJ … ablation, cardiac resynchronization therapy, left atrial
appendage occlusive devices, and autonomic … In recent years, technological advancements, new marketed drugs, and new therapeutic
considerations
-
effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1506.pdf
June 01, 2015 - , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … with one or more standard therapies, including
corticosteroids, immunomodulators, or tumor necrosis … unmet
need for new therapeutic options for patients with IBS. … , alternative therapies are needed. … FDA approves two therapies to treat IBS-D.
[internet]. Silver Spring (MD): U.S.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0260_07-16-2010.pdf
January 01, 2010 - Document Completion Date: 12-13-10
1
Results of Topic Selection Process & Next Steps
Treatments … Pharmacological, psychological, or complementary and alternative
interventions
Comparator(s): No treatment … , placebo, or comparative effectiveness of treatments
Outcome(s): Reduced severity of tinnitus … however, there is no single review that addresses all of the interventions that have been
studied in the treatment … Treatments for Tinnitus
Nomination Summary Document
http://effectivehealthcare.ahrq.gov/index.cfm/
-
effectivehealthcare.ahrq.gov/sites/default/files/pregnancy-horizon-scan-high-impact-1512.pdf
November 01, 2016 - new (and new uses of existing) pharmaceuticals, medical
devices, diagnostic tests and procedures, therapeutic … , screening and diagnostics, therapeutics, surgery, programs, and
care delivery innovations that address … or payers may require a step-
therapy approach starting with existing endometriosis treatments before … or payers
3
may require step therapy in which patients try existing endometriosis treatments before … They noted its anticipated higher cost than alternative therapies available as
generics may increase