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  1. effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/hypertensive-disorders-pregnancy-protocol-amendment.pdf
    April 20, 2022 - KQ 2: What are the effectiveness, comparative effectiveness, and harms of pharmacological treatments … for HTN or HDP administered postpartum o Antihypertensive medications (single or combination therapies … to prevent preeclampsia (e.g., low-dose aspirin) o Treatments not used to treat HDP (e.g., NSAIDs) … For KQ 3, RCTs that compare MgSO4 with placebo, no treatment, or non-MgSO4 treatments (which are not … Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
    April 01, 2013 - clinically localized disease is distinguishing between men who have aggressive disease and need immediate therapy … Effectiveness Reviews, the program supports systematic appraisals of existing scientific evidence regarding treatments … potential harms related to treatment? … Another47 reported 2-year followup of progression from active surveillance to treatment in men with … Screening, risk assessment, and the approach to therapy in patients with prostate cancer.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
    October 20, 2011 - response in relation to outcomes, such as adherence to treatment. … During discussions with Key Informants, our interest in expanding the scope of HCV treatments arose … , and adherence to HCV antiviral therapy. … What proportion of patients with screen-detected HCV infection receives treatment? … d Refers to eligibility for antiviral treatment based on viral and host factors.
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs-IV-sepsis.pdf
    July 01, 2023 - from 60% for septic shock diagnoses to 27% for unspecified sepsis diagnoses.3 Early detection and treatment … *_ga_1NPT56LE7J*MTY5MjgyNTY5NC41Mi4wLjE2OTI4MjU2OTQuNjAuMC4w 3 of sepsis diagnostic criteria, treatment … and better measures.10 Overview of the PSP PSPs focused on sepsis prediction, recognition, and treatment … Time to Treatment and Mortality during Mandated Emergency Care for Sepsis. … Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-pci-bypass_surveillance.pdf
    May 01, 2013 - trial or systematic review (or guidelines) including at least one new trial that characterized the treatment … A3 A superior new treatment: A pivotal trial or systematic review (or guidelines) whose results identified … another treatment as significantly superior to the one evaluated in the original review, based on efficacy … to the conclusions involve refinement of original estimates or do the potential changes mean some therapies … Comparison of coronary bypass surgery with drug-eluting stenting for the treatment of left main and/
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
    August 05, 2010 - conventional diagnostic imaging) Interventions • Positional MRI testing and positional MRI test-directed treatments … (i.e., effect on additional diagnostic testing, effect on limiting the differential diagnosis) o Therapeutic … impacts (i.e., effect on treatments received, changes in planned treatment regimen) • Clinical outcomes … selection of treatment. … Monitoring: assessing response to treatment or relapse after therapy.
  7. effectivehealthcare.ahrq.gov/sites/default/files/suppl-1-user-guide-to-ocer_130129.pdf
    January 01, 2011 - in order to estimate the comparative effects of alternative treatments. … This issue is especially relevant when assessing the effectiveness of treatments 165 Supplement … Survival benefit associated with adjuvant androgen deprivation therapy combined with radiotherapy … Survival following primary androgen deprivation therapy among men with localized prostate cancer. … The marginal benefits of invasive treatments for acute myocardial infarction: does insurance coverage
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/off-label-use-research-priorities_research.pdf
    May 01, 2009 - This may result from the lack of entirely acceptable and effective treatments, as well as their overlapping … is only limited support for the use of these drugs in this condition, particularly as maintenance therapy … Even as an adjunct to Effective Health Care Research Report Number 12 8 other therapies in … Depression treatment during outpatient visits by U.S. children and adolescents. … Effectiveness of adjunctive antidepressant treatment for bipolar depression.
  9. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-222-evidence-summary-health-equity.pdf
    January 01, 2020 - Abbreviations: BMI = body mass index; EHR = electronic health record; NRT = nicotine replacement therapy … trials indicated improved quit rates with patient navigation, counseling, and nicotine replacement therapy … Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care.
  10. effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
    October 23, 2014 - MITA has extensive knowledge of the substantial benefits afforded by medical imaging and radiation therapy … Americans due to our role as the leading trade association representing medical imaging, radiation therapy … For each stage of care, appropriate testing and treatment are outlined. … That is, changes in therapeutic management or stage reclassification are appropriate terminal points … This is distinct from the outcomes, or endpoints, classically applied in assessing whether therapeutic
  11. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-197-fractional-exhaled-nitric-oxide-disposition-comments.pdf
    December 20, 2017 - Anecdotally in our clinical practice, FeNO has dropped with anti-IL5 therapy. … initially elevated, data supports that it can be helpful to follow it in regards to response to therapy … Quality of the Report: Good This report assesses FENO use in diagnosis, monitoring activity, treatment … Role of FeNO to Identify Asthmatics Who Are Possible Candidates for Treatment with a Biologic. … KQ 1.d: What is the clinical utility of FeNO measurements to monitor response to treatment in individuals
  12. effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-map-hcbs-protocol.pdf
    July 27, 2023 - What do patients want to accomplish with HCBS (i.e., goal of treatment)? … following person-centered approach, used alone or in combination: • Occupational, speech, and physical therapy
  13. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mental-health-app-protocol-updated.pdf
    January 01, 2018 - Adjunctive treatment with apps is affordable, offers a way to reach rural populations and traditionally … to current evidence-base • Usability, including interoperability across platforms, stability • Therapeutic … used for screening, monitoring and management of mental health symptoms or disorders, response to treatment … , supplement to in- person therapy, and post-treatment condition management. … Smartphone apps for the treatment of mental health conditions: status and considerations.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/ptsd-adults-trauma-interventions_disposition-comments.pdf
    April 02, 2013 - particular intervention, as noted by reviewer, or increased risk of seizure, as might be seen with hyper- therapeutic … Offering treatment to all those who are exposed is clearly wasteful. … about harm findings from Table F, and that positive findings for prolonged exposure (PE) and cognitive therapy … It compares the efficacy of a modified prolonged exposure therapy for preventing PTSD and reducing … in individuals with acute stress disorder found no statistically significant difference between treatments
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/antipsychotics-children-future_research.pdf
    February 01, 2012 - adolescents (10–17 years) Bipolar disorder (depression) Adults Bipolar disorder (maintenance) Adjunctive therapy … with other therapies, there is a paucity of data regarding the efficacy and effectiveness of 1st or … Large prospective cohort designs that follow youth with a range of mental health disorders and treatments … adolescents (10–17 years) Bipolar disorder (depression) Adults Bipolar disorder (maintenance) Adjunctive therapy … An RCT has to be large, because the question compares active treatments, and the effect size may be
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/advanced-care-decision-aids_research-protocol.pdf
    December 09, 2013 - templates, intervention-focused health care directives templates, physician orders for life sustaining treatments … The choices being considered may be specific therapy choices, including taking no action, or the clarification … Decision aids for people facing health treatment or screening decisions (Cochrane Review) Issue 1. … Decision aids framework Structured Decision Options Evidence for Options Treatment choices when … not curable Life-prolonging treatment or comfort care ACP Settings Healthy Potentially
  17. effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
    August 01, 2014 - It may not be ethical to randomize or withhold therapy based on troponin values alone, as ACS treatmentTherapeutic options and likelihood of impact on outcomes may vary across stages of CKD. … Many patients may already have indications for these therapies; what additional treatment should clinicians … next steps regarding how best to manage these patients with elevated troponin levels (how and if treatments … would vary from those treatments indicated by clinical factors alone), the applicability of this screening
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/weight-gain-prevention_research-protocol.pdf
    January 01, 2020 - Treatment Guidelines and Meta-analyses on Maintenance of Weight No treatment guidelines for maintenance … Effect of obesity on prostate-specific antigen recurrence after radiation therapy for localized prostate … cancer as measured by the 2006 Radiation Therapy Oncology Group-American Society for TherapeuticTreatment of co-morbid mental illness in primary care: how to minimize weight gain, diabetes, and metabolic
  19. effectivehealthcare.ahrq.gov/products/management-infantile-epilepsy/research
  20. #14 SUBSTANCE ABUSE (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/substance-abuse-horizon-scan-high-impact-1406.pdf
    January 01, 2020 - new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests and procedures, therapeutic … purposes of horizon scanning, AHRQ’s interests are broad and encompass drugs, devices, procedures, treatments … , screening and diagnostics, therapeutics, surgery, programs, and care delivery innovations that address … for pain management or help with treating opioid dependence, interventions include detoxification treatments … , opioid replacement therapy (i.e., methadone or buprenorphine maintenance therapy), or other inpatient

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