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81. genetic-testing-developmental-disabilities-protocol-140930 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/genetic-testing-developmental-disabilities_research-protocol.pdf
    September 30, 2014 - Interventions: Genetic tests for diagnosing DDs This Technical Brief only includes tests that are available … We anticipate identifying a large number of tests of interest from GTR. … syndrome,” 155 tests linked to “fragile X syndrome,” and 142 tests linked to “Prader-Willi syndrome … Most of these tests are LDTs. We will also search two other U.S. … for DDs, and new technologies or tests under development.

82. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
    August 01, 2012 - PCDs are a heterogeneous group of disorders that require a panel of tests for accurate diagnosis. … (i.e., SFLC assay in addition to traditional testing) and the comparator (traditional tests alone) … (serum or urine tests [SPEP, UPEP, SIFE, or UIFE], bone marrow evaluation, or skeletal survey). … No direct comparisons between the SFLC assay and traditional tests were performed. … , compared with traditional tests alone, in undiagnosed patients with suspected PCD?

83. Noninvasive Testing for Coronary Artery Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/coronary-artery-disease-testing_research-protocol.pdf
    January 15, 2015 - Noninvasive diagnostic tests can be broadly divided into two categories: functional tests and anatomic … tests. … What is the comparative effectiveness of anatomic tests versus functional tests in those who are at … What is the comparative effectiveness of anatomic tests versus functional tests in those who are at … o Anatomic tests: coronary calcium scoring via EBCT or MDCT, and CCTA o Functional tests (including

84. Methods Guide for Medical Test Reviews Chapter 9 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
    July 01, 2012 - Assess the concordance of difference tests instead of test accuracy. … Tests With Correlated Results Within the Strata of the Disease When the two tests are correlated conditional … A probabilistic model for the comparison of diagnostic tests. … Meta- analysis of diagnostic tests with imperfect reference standards. … Evaluation of diagnostic tests without gold standards.

85. Disposition of Comments for Technical Brief 23 Genetic Testing (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/genetic-testing-developmental-disabilities_disposition-comments.pdf
    June 30, 2015 - polymorphism (SNP)-array tests. … tests.” … So, these 56 tests are not one same test. … 113 different tests. … represent newer versions of tests.

86. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
    September 01, 2012 - , compared with traditional tests, in individual PCDs with regard to: a. … Can it diagnose or detect disease progression earlier than traditional tests? c. … and how do they compare with the SFLC test with and without traditional tests? … Can it diagnose or detect disease progression earlier than traditional tests? c. … and how do they compare with the SFLC test with and without traditional tests?

87. 13-MDM347013 30..38 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-testing-evaluation_research.pdf
    January 01, 2009 - based on an understanding of how tests can benefit or harm patients. … , such as the decision to order more tests or to start, stop, or modify treatment. … to undergoing other tests or no testing at all. … This requires an understanding of how tests can affect patient outcome. … Various randomized designs can be used to evaluate medical tests.

88. 13-MDM347013 30..38 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/whitepaper4-bossuyt02262010-2.pdf
    January 01, 2009 - based on an understanding of how tests can benefit or harm patients. … , such as the decision to order more tests or to start, stop, or modify treatment. … to undergoing other tests or no testing at all. … This requires an understanding of how tests can affect patient outcome. … Various randomized designs can be used to evaluate medical tests.

89. Methods Guide for Medical Test Reviews - Editorial (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - Reviews - Editorial E-1 Editorial Methods Guide for Authors of Systematic Reviews of Medical Tests … Clinicians obtain medical tests for a number of non-overlapping reasons. … An additional two workgroups addressed issues unique to genetic and prognostic tests. … Medical tests. White paper series; Nov. 16, 2009. … Methods guide for authors of systematic reviews of medical tests: a collaboration between the Agency

90. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Index and reference tests are correlated within strata of disease. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards.

91. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Index and reference tests are correlated within strata of disease. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards.

92. Methods Guide for Medical Test Reviews Chapter 7 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
    July 01, 2012 - Our focus will be on diagnostic tests, meaning tests that are used in the diagnostic and management … This is particularly challenging when tests are used as a part of an algorithm. … Tests that are more invasive will naturally have greater harms. … Key Points • One can use GRADE for diagnostic tests. … Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes.

93. Hepatic-Fibrosis White-Paper (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
    April 01, 2014 - However, our review of diagnostic blood tests 5 had limitations. … Optimization and robustness of blood tests for liver fibrosis and cirrhosis. … Routine blood tests to predict liver fibrosis in chronic hepatitis C. … Optimization and robustness of blood tests for liver fibrosis and cirrhosis. … Routine blood tests to predict liver fibrosis in chronic hepatitis C.

94. Hi Les, (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - Hi Les, Medical Tests—White Paper Series Using the Principles of Randomized Controlled … Pap tests takes next priority. … Randomised comparisons of medical tests: sometimes invalid, not always efficient. … Various randomized designs can be used to evaluate medical tests. … Comparative accuracy: assessing new tests against existing diagnostic pathways.

95. Cancer-Pancreas Executive (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
    September 01, 2014 - For any KQs comparing two or more tests, the study must have compared both tests to a reference standard … We also used a minimum of 10 for KQ3b on patient perspectives of imaging tests. … , the harms of concern are different for different tests. … after different tests. … Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma.

96. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0068_01-30-2009.pdf
    January 01, 2009 -  Although immunologic laboratory tests can have great utility in the diagnosis and management of … The nominator has expressed interest in the diagnostic accuracy of the ANA and RF tests in children …  In addition, because these tests are known to have a low predictive value in this population, … Because these tests are used as prognostic indicators, information on the prognostic significance of … the tests may also be helpful to include in a report

97. Methods Guide for Medical Test Reviews Chapter 2 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-topics_methods.pdf
    July 01, 2012 - Chapter 2 2-1 Chapter 2 Developing the Topic and Structuring Systematic Reviews of Medical Tests … Due to the indirect impact of medical tests on clinical outcomes, reviewers need to identify which … This paper highlights challenges unique to systematic reviews of medical tests. … such tests in clinical decisionmaking, such as guiding the decision to perform a biopsy. … Are tests’ cases subsequently confirmed by same reference standard? 6.

98. Methods Guide for Medical Test Reviews Chapter 6 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-applicability_methods.pdf
    July 01, 2012 - Evidence, Agency for Healthcare Research and Quality, Rockville, Maryland Abstract Use of medical tests … should be guided by research evidence about the accuracy and utility of those tests in clinical care … To make informed decisions about medical tests, whether diagnostic, prognostic, or those used to monitor … Rapidly Evolving Tests A third challenge, especially relevant to medical tests, is that, even more than … How and by whom tests are conducted in practice and in studies.

99. Methods Guide for Medical Test Reviews Chapter 10 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
    July 01, 2012 - Reviews Chapter 10 10-1 Chapter 10 Deciding Whether To Complement a Systematic Review of Medical Tests … Therefore, test performance is typically not sufficient for assessing the usefulness of medical tests … Medical tests exert most of their effects in an indirect way. … detected by the more sensitive tests may not have the same treatment response. … Evaluating new screening tests for breast cancer. BMJ 2006; 332(7543):678-679. 20.

100. Addressing Challenges in Genetic Test Evaluation: Evaluation Frameworks and Assessment of Analytic Validity | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/genetic-tests-validity-rating-evaluation/research