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421. The Role of Immunotherapy and the Management of Asthma: Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-immunotherapy_research-protocol.pdf
     September 14, 2016 - nonspecific bronchial hyperreactivity as measured by response to methacholine or acetylcholine challenge tests … testing based on allergen specific IgE sensitization diagnosis: Serologic multiallergen screen IgE tests … (skin prick tests, serum tests, or both) o Patients with all severity grades and control status of … proteins that act as intercellular mediators) will not be included as outcomes. 3.- Objective Tests

422. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
     December 01, 2015 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … to identification of new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Five percent of point-of-care Xpert MTB/RIF tests failed compared with 6% of laboratory-run Xpert MTB … /RIF tests (p=0.22). … Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis

423. Quantitative Synthesis: Chapter 5. Network Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
     February 01, 2018 - ://dx.doi.org/10.1016/j.jclinepi.2008.04.012 Single measures for consistency • Global Wald test: Tests … identify specific loops with large inconsistency. ► Limitations include the need for multiple correlated tests … • Statistical tests for inconsistency are commonly under-powered due to limited number of studies

424. Pharmacologic and Non-pharmacologic Therapies in Adult Patients with Acute Exacerbation of COPD: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/copd-research-protocol.pdf
     April 11, 2018 - Mortality; o Quality of life; o Hospital admission; o ICU admission; o Physical capacity (timed walking tests … , endurance tests) o Number of intubations KQ 1, 2,3 & 4: Adverse effects of interventions (harms … • Quality of life; • Hospital admission; • ICU admission; • Physical capacity (timed walking tests … , endurance tests) • Number of intubations None Timing All None Settings Outpatient, hospital … will evaluate potential publication bias by evaluating funnel plots symmetry and using statistical tests

425. Evidence-Summary-Cer-197-Fractional-Exhaled-Nitric-Oxide (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-197-fractional-exhaled-nitric-oxide.pdf
     December 01, 2017 - key questions (KQ 1.b-e), studies were quite heterogeneous in terms of design, population, control tests

426. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
     September 08, 2011 - The qualitative tests use test strips, are rapid (results available in <30 minutes), and are designed … The quantitative tests use luminescence immunoassay, are slower (results available in a few hours … test short enough to be reasonably sure that the target condition did not change between the two tests

427. Procalcitonin for Diagnosis and Management of Sepsis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/procalcitonin/research-protocol
     April 26, 2011 - The qualitative tests use test strips, are rapid (results available in <30 minutes), and are designed … The quantitative tests use luminescence immunoassay, are slower (results available in a few hours), and … index test short enough to be reasonably sure that the target condition did not change between the two tests

428. Immunity After COVID-19 | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/immunity-after-covid/protocol
     September 10, 2020 - Although testing for antibodies to SARS-CoV-2 is becoming more common, how these tests should be utilized … If tests are removed, we will include this information in the report status update and discuss it as

429. Use of Natriuretic Peptide Measurement in the Management of Heart Failure | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
     December 20, 2011 - effect of comorbidities in patients being evaluated will help to further refine the value of these tests … The review is intended to inform physicians, clinical chemists, and policy makers in the use of these tests … case-control studies and cohort studies, 30 the Jadad scale 31 for RCT studies, QUADAS32 for diagnostic tests … For KQ1 and KQ2, we will assess SOE using the method for medical tests 29 and for KQ6 we will use the … evidence being assessed “reflects a single, direct link between the interventions of interest [medical tests

430. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
     December 22, 2014 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … to identification of new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Five percent of point-of-care Xpert MTB/RIF tests failed compared with 6% of laboratory-run Xpert MTB … /RIF tests (p=0.22). … Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis

431. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-2-risk-of-reinfection-from-SARSCoV2_0.pdf
     December 31, 2022 - We considered which tests were used (serologic, virologic, and clinical assessment), when they were … Misclassification can occur if, for example, the tests used to diagnose infection had poor sensitivity … Different cutoffs for the waiting period between first and second positive tests influence the apparent … large proportion of patients in the dataset were excluded from the analysis due to lack of serial tests … Comprehensive characterization of COVID-19 patients with repeatedly positive SARS-CoV-2 tests using

432. Braddock (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/braddock.pdf
     January 01, 2011 - decision-­‐making o Fewer people remaining  undecided o Fewer patients choosing  major surgery, PSA tests

433. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive-2007.pdf
     January 01, 2007 - whether other clinical features (such as demographics or indicators of RAS severity) or diagnostic tests

434. FRN 40 - Screening for Methicillin-Resistant Staphylococcus aureus (MRSA): Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening_research.pdf
     June 01, 2013 - What are the most effective tests for MRSA screening? 5. … • What are the most effective tests for MRSA screening? … What are the most effective tests for MRSA screening? 5. … What are the most effective tests for MRSA screening? 4. … 9 35 4 What are the most effective tests for MRSA screening?

435. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - effect of comorbidities in patients being evaluated will help to further refine the value of these tests … review is intended to inform physicians, clinical chemists, and policy makers in the use of these tests … studies and cohort studies, 30 the Jadad scale 31 for RCT studies, QUADAS 32 for diagnostic tests … For KQ1 and KQ2, we will assess SOE using the method for medical tests 29 and for KQ6 we will use … evidence being assessed “reflects a single, direct link between the interventions of interest [medical tests

436. Opioid Treatments for Chronic Pain | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/opioids-chronic-pain/protocol
     February 27, 2019 - patients with chronic pain being considered for opioid therapy, what is the accuracy of instruments and tests … In patients with chronic pain, what is the effectiveness of use of risk prediction instruments and tests … harms 4a Adults (age ≥18 years) with various types of chronic pain Instruments, genetic/metabolic tests … 18 years) with various types of chronic pain Use of risk prediction instruments, genetic/metabolic tests … ab,kf. 8 and (or/9-11) 12 or 13 14 or 15 Decision Support Techniques/ "Predictive Value of Tests

437. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - options, and affect clinical outcomes, and (4) the safety concerns and risks to women undergoing these tests … CAD in the included population, our analyses again demonstrated differences between performance of tests … Decisions around performing tests (either noninvasive or invasive) in patients with symptoms suspicious … intermediate probability between 10 and 90 percent for which the clinicians must choose noninvasive tests … Women are more likely than men to have false- positive stress tests; i.e., abnormal stress imaging with

438. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/version-2-risk-of-reinfection-from-SARSCoV2.pdf
     July 01, 2022 - We considered which tests were used (serologic, virologic, and clinical assessment), when they were … Misclassification can occur if, for example, the tests used to diagnose infection had poor sensitivity … Different cutoffs for the waiting period between first and second positive tests influence the apparent … large proportion of patients in the dataset were excluded from the analysis due to lack of serial tests … Comprehensive characterization of COVID-19 patients with repeatedly positive SARS-CoV-2 tests using

439. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/version-2-risk-of-reinfection-from-SARSCoV2.pdf
     July 01, 2022 - We considered which tests were used (serologic, virologic, and clinical assessment), when they were … Misclassification can occur if, for example, the tests used to diagnose infection had poor sensitivity … Different cutoffs for the waiting period between first and second positive tests influence the apparent … large proportion of patients in the dataset were excluded from the analysis due to lack of serial tests … Comprehensive characterization of COVID-19 patients with repeatedly positive SARS-CoV-2 tests using

440. Outcome Measures Framework: Literature Review Findings and Implications (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/registry-of-patient-registries_research_1.pdf
     April 15, 2019 - The initial pilot tests revealed a lack of sensitivity. … +for+Multiple+Myeloma&CALId=131&CalName=Prothrombin+Time+(PT)+and+Partial+Thromboplastin+Time+(PTT)+tests … +for+Multiple+Myeloma&CALId=131&CalName=Prothrombin+Time+(PT)+and+Partial+Thromboplastin+Time+(PTT)+tests … +for+Multiple+Myeloma&CALId=131&CalName=Prothrombin+Time+(PT)+and+Partial+Thromboplastin+Time+(PTT)+tests … +for+Multiple+Myeloma&CALId=131&CalName=Prothrombin+Time+(PT)+and+Partial+Thromboplastin+Time+(PTT)+tests