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301. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
     December 22, 2014 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … to identification of new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Five percent of point-of-care Xpert MTB/RIF tests failed compared with 6% of laboratory-run Xpert MTB … /RIF tests (p=0.22). … Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis

302. Disposition of Comments_Comparative Effectiveness Review No. 274: Diagnosis and Treatment of Tethered Spinal Cord (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-274-tethered-spinal-cord-disposition-comments.pdf
     October 25, 2024 - some details are provided in the results sections, a summary table listing the different diagnostic tests … We have clarified that the review was not restricted to a set of specific tests or interventions

303. Blumenthal-notes-151008 copy-Teresa (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/blumenthal-presentation.pdf
     May 29, 2025 - this or you  might have these risks or these benefits but it’s contingent   on how these imaging tests … or these lab tests turn out.  

304. Cell-Free-Dna-Appendix-C-Prepub-Final (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c-prepub-final.xlsx
     January 01, 2025 - A positive test included a positive response on both initial and confirmation tests. … Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study. … Case-control design; cancer cases were not consecutively or randomly selected; no reporting of whether tests … No The comparisons reported for radiation exposure was radiation among persons with false-positive tests … cancers and no rationale was offered; presumably these are the cancers that have existing screening tests

305. Cell-Free-Dna-Final-App-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-final-app-c.xlsx
     January 01, 2025 - A positive test included a positive response on both initial and confirmation tests. … Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study. … Case-control design; cancer cases were not consecutively or randomly selected; no reporting of whether tests … No The comparisons reported for radiation exposure was radiation among persons with false-positive tests … cancers and no rationale was offered; presumably these are the cancers that have existing screening tests

306. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - effect of comorbidities in patients being evaluated will help to further refine the value of these tests … review is intended to inform physicians, clinical chemists, and policy makers in the use of these tests … studies and cohort studies, 30 the Jadad scale 31 for RCT studies, QUADAS 32 for diagnostic tests … For KQ1 and KQ2, we will assess SOE using the method for medical tests 29 and for KQ6 we will use … evidence being assessed “reflects a single, direct link between the interventions of interest [medical tests

307. Genetic Testing for Developmental Disabilities, Intellectual Disability, and Autism Spectrum Disorder | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/genetic-testing-developmental-disabilities/technical-brief

308. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - options, and affect clinical outcomes, and (4) the safety concerns and risks to women undergoing these tests … CAD in the included population, our analyses again demonstrated differences between performance of tests … Decisions around performing tests (either noninvasive or invasive) in patients with symptoms suspicious … intermediate probability between 10 and 90 percent for which the clinicians must choose noninvasive tests … Women are more likely than men to have false- positive stress tests; i.e., abnormal stress imaging with

309. Disposition of Comments for Use of Natriuretic Peptide Measurement in the Management of Heart Failure (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_disposition-comments.pdf
     November 20, 2013 - gathered in patients with suspected heart failure, including history, physical examination, and other tests … Heterogeneity tests can be helpful but the interpretation of the data should not be solely based upon … When the authors discuss the results, they state that these tests are good to rule out disease, but … The performance of tests of publication bias and other sample size effects in systematic reviews of … General diagnostic tests, likely ordered a the same time as the BNP (e.g.

310. Diagnosis and Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-fatigue_executive.pdf
     July 01, 2016 - harms from diagnosis were also included, such as psychological harms, labeling, risk from diagnostic tests … Studies of the results of laboratory tests or studies focusing on individual symptoms were not included … results suggest that some scales could be reasonable candidates for further evaluation as diagnostic tests … Two studies found that results of cardiopulmonary exercise tests were different for ME/CFS patients … No studies evaluated how diagnostic tests vary by patient subgroups or how to rule out related conditions

311. S143 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/s143.pdf
     October 01, 2007 - depression) and substantial difference with respect to other variables (such as lipid-related laboratory tests … Noninitiators (N � 3579) P Statin Initiators (N � 2901) Noninitiators (N � 2901) P Mean no. lipid lab tests … disease-related hospitalizations in the past year 0.46 0.31 �0.01 0.40 0.39 0.79 Mean no. laboratory tests

312. #06 Developmental Delays ADHD, and Autism (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/06_devdelays_potential_high_impact_2012-12-10.pdf
     January 01, 2012 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … pertains to identifying new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests

313. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
     May 01, 2013 - One advantage of sensitivity and specificity is that, because they are characteristics of the tests … the consistent uncertainties identified in current recommendations is how well currently available tests … Effective Management of Positive Screening Tests for Postpartum Depression Screening is often focused … these estimates by increasing the overall sample size and may make any differences between specific tests … This allows an approach that compares total tests or false-positive results as a measure of “cost” or

314. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_executive-2007.pdf
     January 01, 2007 - whether other clinical features (such as demographics or indicators of RAS severity) or diagnostic tests

315. Braddock (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/braddock.pdf
     January 01, 2011 - decision-­‐making o Fewer people remaining  undecided o Fewer patients choosing  major surgery, PSA tests

316. For women, when comparing noninvasive testing,which testing method (echocardiography, MIBI-SPECT, pharmacological testing, etc.) is more accurate in diagnosing coronary artery disease. There has been inadequate studies done on women for… | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-women-when-comparing-noninvasive-testingwhich-testing-method-echocardiography-mibi-spect-pharmacological-testing-etc-is-more-accurate-in-diagnosing-coronary-artery-disease-there-has-been-inadequate-studies-done-on-women-

317. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - How do these tests compare in different subgroups of patients, based on: race, sex, body mass index … Key Question 2.How does phased testing (screening tests or battery followed by full test) compare to … Other tests could include four-phase rhinomanometry and brain magnetic resonance imaging. … How do these tests compare in different subgroups of patients, based on: race, sex, body mass index … How does phased testing (screening tests or battery followed by full test) compare to full testing

318. Urinary-Incontinence-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/urinary-incontinence-treatment_executive.pdf
     April 01, 2012 - We focused on the predictive likelihood ratios of UI in women examined with index tests when compared … Ratios of 1 indicated that the tests likely do not provide accurate UI diagnosis. … We examined consistency in results across studies with Chi square tests and I square statistics. … We assumed publication bias, and did conduct formal statistical tests. … The majority of studies demonstrated that the tests had only small diagnostic value in distinguishing

319. Editorial. Methods Guide for Authors of Systematic Reviews of Medical Tests: A Collaboration Between the Agency for Healthcare Research and Quality (AHRQ) and the Journal of General Internal Medicine | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guide-editorial/methods

320. Emerging MRI Technologies for Imaging Musculoskeletal Disorders under Loading Stress (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
     November 01, 2011 - potential benefits" - it seems that it would be logical to at least briefly discuss the validity of the tests … [sic] a) We agree that study reliability is an important aspect of the evaluation of imaging tests … reference standard used •Adequate description of test and reference for replication •Blinded comparison of tests … with the expected condition •Adequate description of methods for replication •Blinded performance of tests … page 44, lines 21-22 not sure what "despite the special features" has to do with assessment of tests