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281. Serum-Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research-protocol
     May 02, 2011 - The standard tests have limited efficacy for the diagnosis of PCDs that are characterized predominantly … the SFLC assay as a screening and initial diagnostic tool for PCD could eliminate the need for urine tests … when combined with serum electrophoresis and serum immunofixation and compared with the traditional tests … Question 2 When compared with traditional tests, how well does the SFLC assay independently predict … If the studies do not directly compare the tests of interest, we will use network analysis to estimate

282. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - In addition, I wonder if the language should be stronger that the summary is that use of these tests … Bottom line very clear – no evidence exists to support the clinical utility of the GEP tests to alter … or improve health outcomes and the risks/benefits of using the tests are not clearly defined. … Much more evidence, both in quantity and quality, is needed (especially for predictive tests) before … deploying these tests into practice; a good description of ongoing clinical trials is included in

283. Comparative Effectiveness of Physical Therapy for Knee Pain Secondary to Osteoarthritis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/arthritis-knee-physical-therapy/research-protocol
     March 02, 2011 - Population Same as KQ1 Interventions Tests and measurements (intermediate outcomes of physical … For KQ 2, we will include the studies of tests and measures in adults with knee OA. … Studies that validated tests and measures in populations with other diseases. … Studies that reported absolute values of the diagnostic tests in adults with knee OA. … Available at: https://effectivehealthcare.ahrq.gov/products/methods-guidance-tests/overview-2012/ .

284. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/population-children-18-years-of-age-1-what-are-the-incidences-and-prevalences-of-non-inflammatory-pain-syndromes-eg-benign-hypermobility-syndrome-patellofemoral-stress-syndrome-fibromyalgia-and-growing-pain-in-children-and-ad
     January 30, 2009 - Diagnosing these disease presents challenges, tests such as ANA are frequently used but are not always … Health Care Program Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests

285. Topic 0552 Low Back Pain NSD FINAL SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0651-131114.pdf
     June 20, 2013 - Strategies include testing (e.g., imaging tests), decision tools, identifying risk factors for chronicity … Intervention(s): Procedures to diagnose and treat low back pain, including: testing (e.g., imaging tests

286. Hepatitis Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/hepatitis-testing

287. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
     January 01, 2012 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … pertains to identifying new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Like the MaterniT21 and verifi tests, Ariosa Diagnostics’ Harmony test is based on identification and … Expert Comments: Overall, experts commenting on maternal blood-based fetal DNA testing viewed such tests … , comments provided for the MaterniT21 test would be expected to pertain to those tests as well.

288. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - The diagnosis phase involves the use of additional tests (radiological and/or histopathological) to … In addition to imaging tests, biomarkers for HCC have also been used in surveillance and diagnosis. … "Predictive Value of Tests"/ 14. ROC Curve/ 15. "Reproducibility of Results"/ 16. … We will prioritize studies that directly compare outcomes for two or more imaging tests. … Tests of heterogeneity will be conducted using the standard χ2 tests and I2 statistic, when appropriate

289. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - Assessment of the accuracy of diagnostic tests: the cross-sectional study. … These tools are continuing inter-rater reliability tests. … Genetic and prognostic marker tests, has some unique attributes. … prognostic tests are not addressed in this document. … Empirical evidence of design-related bias in studies of diagnostic tests.

290. Genetic Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/genetic-testing/

291. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
     March 01, 2024 - • Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance … for parental ratings, teacher ratings, teen/child self-reports, clinician tools, neuropsychological tests … Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance Test

292. Pulmonary Arterial Hypertension: Screening, Management, and Treatment | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/hypertension-pulmonary-arterial/research
     April 25, 2013 - Results Sixty studies involving 7,096 patients evaluated biomarker tests, echocardiography, or both … Ninety-nine studies involving 8,655 patients evaluated biomarker tests, echocardiography, or both to

293. Kidney-Disease-Medicine Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
     January 01, 2012 - adverse health consequences, its long asymptomatic phase, the availability of potential screening tests … Harms •Screening or monitoring: false-positive diagnosis or progression, anxiety, unnecessary tests, … - Yield of one-time screening tests based on actual association with persistent CKD. … positive tests; psychological effects of labeling asymptomatic individuals as diseased; medication … positive tests (for progression); medication adverse effects; increased medical visits; increased

294. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bivariate-methods-utility_research.pdf
     November 01, 2012 - Reitsma10, 2005 1 (3 index tests) SROC vs. … Meta-analysis of diagnostic tests for acute sinusitis. … Predictive and diagnostic tests of renal failure: a review. … Systematic review of diagnostic tests for vaginal trichomoniasis. … Intrapartum fetal stimulation tests: a meta- analysis.

295. Depression-Postpartum-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
     May 01, 2013 - This allows an approach that compares total tests or false-positive results as a measure of “cost” or … Strength-of-evidence domains for test characteristics of screening tests for postpartum depression … Strength-of-evidence domains for test characteristics of screening tests for postpartum depression … Strength-of-evidence domains for test characteristics of screening tests for postpartum depression … -based study of two self-administered tests (BDI, EPDS) and two clinician- administered tests (HSRD-

296. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research
     September 25, 2013 - evaluated the analytic validity, prognostic value, and comparative effectiveness of two types of medical tests … analytic validity, prognostic ability for intermediate (platelet reactivity) or clinical outcomes, use of tests

297. Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer's-Type Dementia | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/cognitive-decline/research-2017
     March 24, 2017 - thiazide versus placebo and angiotensin receptor blockers versus placebo on brief cognitive screening tests … inhibitors; diabetes management) showed low-strength evidence for no benefit for some cognitive performance tests

298. Localized Prostate Cancer | Effective Health Care
     effectivehealthcare.ahrq.gov/decision-aids/prostate-cancer/08.html
     June 08, 2018 - Your risk group will also help your doctor decide whether more tests are needed before discussing options

299. Antibiotics-Respiratory-Infection Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
     January 01, 2016 - and patients, clinical strategies such as delayed prescribing or use of point- of-care diagnostic tests … Any point-of-care tests that are available and used in primary care settings for diagnostic purposes … Point-of-Care Tests. … Rapid viral tests included one that was multiviral, and the rest were specific for influenza. … When reported, diagnostic accuracy was consistent for rapid viral and strep tests.

300. Hepatitis-C-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
     November 01, 2012 - What is the comparative effectiveness and comparative diagnostic accuracy of various tests and strategies … We also included studies that reported the diagnostic accuracy of noninvasive tests for evaluating … A number of indices based on panels of blood tests were associated with an AUROC of 0.75 to 0.86 for … Evidence clearly supports that HCV antibody tests are accurate for identifying HCV infection, but that … Diagnostic tests 3: receiver operating characteristic plots. BMJ. 1994;309(6948):188.