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261. Laboratory Biomarkers for Iron Deficiency Anemia in Late Stage Chronic Kidney Disease | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/chronic-kidney-disease-anemia-2011/research-protocol
     August 29, 2011 - Since test results have little direct impact on patient-relevant outcomes, the utility of medical tests … Although overarching studies that assess the overall impact of tests on the clinical management process … What are the adverse effects or harms associated with the treatments guided by tests of iron status? … A meta-analysis of diagnostic tests, such as summary receiver operating curve, will be undertaken when … (if all the other kidney tests are normal, there is no CKD) CKD stage 2: a GFR between 60 and 90 ml

262. Can screening among the general adult male population for elevated PCA3 (also known as DD3) gene expression, to identify those at risk for prostate cancer who may be candidates for prostate biopsy, reduce morbidity and mortality? | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/can-screening-among-the-general-adult-male-population-for-elevated-pca3-also-known-as-dd3-gene-expression-to-identify-those-at-risk-for-prostate-cancer-who-may-be-candidates-for-prostate-biopsy-reduce-morbidity-and-mortality
     July 29, 2010 - see compared: Use of commercially available PCA3 expression assays for prostate cancer screening tests … Tests are currently available to detect PCA3 mRNA expression.

263. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - The standard tests have limited efficacy for the diagnosis of PCDs that are characterized predominantly … Table 26 provides an overview of the laboratory tests used to diagnose PCDs. … Question 2 When compared with traditional tests, how well does the SFLC assay independently predict … For questions regarding comparisons of diagnostic tests (KQ 1), we will consider doing Bland-Altman … If the studies do not directly compare the tests of interest, we will use network analysis to estimate

264. Disposition of Comments for CER 158 Diagnosis of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-diagnosis-disposition-160727.pdf
     February 24, 2016 - The confusion on our part between tests for classification and tests for clinical diagnosis in the … Peer Reviewer 2 Methods (page 8) AUC for imaging tests is not very meaningful since imaging tests … Tests used for publication bias are not appropriate for DTA data. … …” Which tests? … We changed "these tests" to "5 clinical algorithms."

265. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - specifically diagnostic medical tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests.

266. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - specifically diagnostic medical tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests.

267. Screening for Hepatitis C | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/hepatitis-c-screening/research-protocol
     October 20, 2011 - below: Clarity: KQ 1a: “asymptomatic” to “asymptomatic adults without known abnormal liver function tests … parts: Does screening for HCV infection in nonpregnant adults without known abnormal liver function tests … Question 4 This KQ has two parts: What is the comparative effectiveness of various tests and strategies … individuals without signs or symptoms suggestive of liver disease or known abnormal liver function tests … We will use standard x 2 tests to assess the presence of statistical heterogeneity among studies and

268. Effective Health Care Program
     effectivehealthcare.ahrq.gov/health-topics/c%C3%A1ncer-0
     December 08, 2017 - in Patients With Advanced Cancer Systematic Review November 19, 2020 Imaging Tests

269. Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/arthritis-knee-physical-therapy/research
     November 06, 2012 - Observational studies provided evidence of the association between changes in knee joint functional tests … interventions were not consistently evaluated according to the clinical importance of improvement in scales and tests

270. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
     January 01, 2011 - Since test results have little direct impact on patient-relevant outcomes, the utility of medical tests … Although overarching studies that assess the overall impact of tests on the clinical management process … What are the adverse effects or harms associated with the treatments guided by tests of iron status? … (if all the other kidney tests are normal, there is no CKD) o CKD stage 2: a GFR between 60 and … 90 ml/min with some sign of kidney damage (if all the kidney tests are normal, there is no CKD) o

271. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis_research-protocol.pdf
     June 06, 2011 - However, neither one of these tests is applicable to the symptomatic population under consideration … However, to perform this correction, the proportion of positive tests in the population of interest … To explore additional sources of potential bias, we will also record whether the diagnostic tests were … interpreted in a blinded fashion; that is, without knowledge of results of other diagnostic tests or … Radiation risk from coronary artery disease imaging: how do different diagnostic tests compare?

272. Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/cancer-pancreas/

273. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
     August 23, 2012 - The existence of different disease groups implies that different tests will perform differently by … The FLC ratio has been suggested as part of a panel of tests for the diagnostic evaluation for a variety … of this comparative effectiveness review was to perform a comparative effectiveness analysis among tests … However, no direct comparisons of the predictive ability of these tests were carried out, limiting any … I am not sure I found it in the discussion but a lot of tests are adopted in medicine and only when

274. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
     October 20, 2011 - Clarity: o KQ 1a: “asymptomatic” to “asymptomatic adults without known abnormal liver function tests … Does screening for HCV infection in nonpregnant adults without known abnormal liver function tests reduce … What is the comparative effectiveness of various tests and strategies for the workup to guide treatment … individuals without signs or symptoms suggestive of liver disease or known abnormal liver function tests … Blood tests b. Imaging techniques 3.

275. Prostate-Cancer-Test Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
     April 01, 2013 - on messenger RNA from urine were developed.13,14 Two proposed intended uses of PCA3 and comparator tests … is the comparative effectiveness of PCA3 testing as a replacement for, or supplement to, standard tests … is the comparative effectiveness of PCA3 testing as a replacement for, or supplement to, standard tests … the standard prognostic workup (e.g., tumor volume, Gleason score, clinical staging) or monitoring tests … • How does PCA3 compare with the two more frequently used add-on tests (free PSA, PSA velocity) that

276. Prenatal Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/prenatal-testing

277. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/chronic-kidney-disease-anemia-2011/research
     October 12, 2012 - synthesis of data for Key Question 2 was complicated by the lack of generally accepted reference standard tests … We concluded that there is a low level of evidence for a reduction in the number of iron status tests … In addition, results from two RCTs showed a reduction in the number of iron status tests and resulting

278. C-Diff-Infections-Surveillance-140925 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
     January 01, 2014 - , and used a reference test (or combination of tests) to verify the results. … Comparative data were not found for many currently used tests. … currently available gene detection tests. … specificity of the diagnostic tests marked differences in their sensitivity. … Comparative data were not found for many currently used tests.

279. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
     April 01, 2013 - What is the comparative effectiveness of PCA3 compared with the 2 commonly used add-on tests of fPSA … Two proposed intended uses of PCA3 and comparator tests were to inform decisionmaking about biopsy or … Research Need 1 addresses the diagnostic accuracy of PCA3 in comparison to other tests for prostate … All men would undergo biopsy to allow for a head to head comparison of PCA3 to currently used tests. … What is the comparative effectiveness of PCA3 compared to the two commonly used add-on tests of fPSA

280. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Genetic Tests for CYP2C19 Variants Genetic testing for one or more genetic variants can be performed … We refer to all these assays as “phenotypic tests” because they attempt to measure an intermediate … as biomarker tests (and of relevant test-and-treat strategies) for guiding antiplatelet therapy in … Our search included terms for the populations, tests, and drugs of interest. … combinations of tests.