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201. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - Various tests, including spirometry pre and post bronchodilator, and bronchoprovocation may be used … More recently, fractional exhaled nitric oxide (FeNO) has been added to the list of tests clinicians … There are some data9-11 to suggest that FeNO compares favorably to other predictive tests to address … In addition to have some possible advantages over other tests to select treatment and measure response … Improved tests for a random effects meta-regression with a single covariate.

202. Disposition of Comments Report for Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
     January 01, 2011 - Page 3, lines 25-27: I disagree that inflammation doesn't affect the "newer tests." … Nor is there adequate research on whether iron tests perform differently with short vs. long acting … One question that should be considered for future research is whether any of the tests substantially … Do iron tests perform differently with short vs. long acting ESAs 4. … Is it clinically reasonable to use iron tests to only detect excess iron and just give IV iron if tests

203. Research Protocol: Clostridium difficile Infection Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
     December 23, 2014 - Tests to validate a technique in “known” or proven samples. … Tests in which the reference standard is not applied to all samples. … Tests examining cost characteristics. Tests not commercially available in the U.S. … Tests only typing C. difficile strains. … In-house laboratory tests not commercially available.

204. Disposition of Comments for Screening for Glaucoma: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
     April 01, 2012 - We included studies of the following ocular examinations (screening tests) conducted alone or in any … We included studies of the following ocular examinations (screening tests) conducted alone or in any … Methods Was a comparison of the accuracy of different tests for glaucoma a key question? … Key Question 3 explored the accuracy of candidate tests. … tests to be used to screen for glaucoma.

205. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
     May 18, 2011 - over the past 2 decades. 1 This decrease has been partially attributed to the use of CRC-screening tests … CRC-screening tests use different approaches, including stool-based tests and direct-visualization methods … In combination with other screening tests? … Fecal DNA tests may be performed alone or in combination with other CRC-screening tests. … Performance improvements of stool-based screening tests. [Review].

206. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
     May 24, 2010 - • Interventions: Diagnostic tests: tests for toxin producing C. difficile, such as enzyme immunoassays … Tests for technical feasibility and cost characteristics will be excluded. … Tests must be approved by the U.S. Food and Drug Administration and in current use. … Studies which used in-house laboratory cell cytotoxicity tests will be excluded. … The draft of the AHRQ guidance for evaluation of diagnostic tests will also be used.

207. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - CRC-screening tests use different approaches, including stool-based tests and direct-visualization … These tests include: computerized tomographic colonography, double-contrast barium enema, and fecal … In combination with other screening tests? Question 2: Clinical Validity a. … Fecal DNA tests may be performed alone or in combination with other CRC-screening tests. … Performance improvements of stool-based screening tests. [Review].

208. Topic 0586 LUTS Secondary to BPH NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0713-140625.pdf
     January 07, 2014 - complaint of nocturia, including frequency-volume charts and/or voiding bladder diaries, as well as tests … What are the necessary tests to determine if a patient with a predominant complaint of nocturia has … Should these tests be required or recommended to determine if BPH is the cause of LUTS before treatment … predominant complaint of nocturia include frequency-volume charts and/or voiding bladder diaries, as well as tests

209. Localized Prostate Cancer | Effective Health Care
     effectivehealthcare.ahrq.gov/decision-aids/prostate-cancer/05.html
     June 08, 2018 - diagnosed with prostate cancer have few or no symptoms, some doctors may choose to recommend screening tests … For those men that choose screening, two tests that may be used to detect prostate cancer are: PSA

210. Clostridium difficile Infection Update | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/c-difficile-update/research-protocol
     December 23, 2014 - There are increasing numbers of diagnostic tests designed to detect either the presence of the organism … tests for the presence of the organism followed by a second test for toxins if the first step test is … Tests to validate a technique in “known” or proven samples Tests in which the reference standard is … not applied to all samples Tests examining cost characteristics Tests not commercially available … Tests only typing C. difficile strains.

211. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/bivariate-methods-utility/research
     November 19, 2012 - projects designed to document the current standards and methods used in the meta-analysis of diagnostic tests … validate newly proposed methods, develop new statistical methods to perform meta-analyses of diagnostic tests … into computer software that will be available to all EPCs and others conducting reviews of diagnostic tests

212. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0359_10-15-2010.pdf
     January 01, 2010 - multiple sclerosis was found to be addressed by a 2011 systematic review on the accuracy of diagnostic tests … Accuracy of diagnostic tests in multiple sclerosis—a systematic review. … largely covered by a 2011 systematic review by Shaffler and colleagues titled Accuracy of Diagnostic Tests

213. Prioritization and Selection of Harms for Inclusion in Systematic Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
     February 01, 2018 - Identify the types and number of harms to include for treatments and diagnostic tests. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for Imprecision or insensitivity • Diagnostic tests (e.g. genetic or hematologic … tests, be it genetic or hematologic testing, various scanning technologies, or functional tests; they

214. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/prior-authorizations
     July 17, 2020 - of insurance prior authorizations (and associated delays) on outcomes, for treatments and diagnostic tests … of insurance prior authorizations (and associated delays) on outcomes, for treatments and diagnostic tests

215. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia_research.pdf
     January 01, 2013 - What are the adverse effects or harms associated with the treatments guided by tests of iron status? … To compare the test performance among medical tests, a common reference standard is needed. … These concerns limit the use of bone marrow iron tests in clinical practice. … These concerns limit the use of bone marrow iron tests in clinical practice. … 3 What is the impact of use of these tests on clinical practice?

216. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
     March 01, 2017 - Short-term benefits on cognitive tests or biomarkers are uncertain predictors of long-term effects … Intermediate cognitive outcomes were assessed using neuropsychological tests or biomarkers. … To address the multiplicity of cognitive performance tests used, we arbitrarily clustered tests into … Instead we opted to simply show the proportion of tests. … To date, cognitive outcomes have been measured using a wide array of neuropsychological tests.

217. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
     March 01, 2017 - Short-term benefits on cognitive tests or biomarkers are uncertain predictors of long-term effects … Intermediate cognitive outcomes were assessed using neuropsychological tests or biomarkers. … To address the multiplicity of cognitive performance tests used, we arbitrarily clustered tests into … Instead we opted to simply show the proportion of tests. … To date, cognitive outcomes have been measured using a wide array of neuropsychological tests.

218. Comparative Effectiveness of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/sleep-apnea/research-protocol
     March 15, 2010 - The value of the different tests and of the questionnaires and other screening tools remains unclear. … There is also lack of clarity as to whether the tests can be accurately used to predict the clinical … The Key Questions Diagnosis KQ1: How do different available tests compare to diagnose sleep apnea … Pulse oximetry will be evaluated among the diagnostic tests. … Key question 3 will evaluate different screening tests and protocols.

219. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - and not “alternative” diagnostic tests? … If not, what are alternative diagnostic tests used to diagnose appendicitis? … Imaging tests have adequate test performance, while clinical signs and symptoms and laboratory tests … imaging tests with clinical and laboratory tests. … I need some guidance on what tests to use on what patients. I think preferably by an algorithm.

220. Imaging Tests for the Staging of Colorectal Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research
     September 10, 2014 - Research Protocol Sep. 10, 2014 Systematic Review Jan. 12, 2015 Disposition of Comments Report Imaging Tests … Our objective was to synthesize the available evidence on the comparative effectiveness of imaging tests