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181. Bladder-Cancer-Non-Muscle-Invasive Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bladder-cancer-non-muscle-invasive_research-protocol.pdf
     July 21, 2014 - survival rates from 63 to 15 percent).7 Diagnosis and surveillance of bladder cancer A number of tests … Many of the tests are investigational. … There are five diagnostic biomarker tests approved by the FDA for diagnosis or surveillance of bladder … The CxBladder™ test, which tests for five specific mRNA biomarkers, is a “Laboratory Developed Test” … and tests with high false negative rates could lead to missed diagnoses.

182. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0174_10-20-2009.pdf
     January 01, 2009 - What tests and measures have been used to determine outcomes (e.g., for strength – manual muscle test … What are the psychometric properties of these tests and measures (reliability, validity, minimal clinically

183. Genetic Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/genetic-testing

184. Disposition of Comments for CER 158 Diagnosis of Gout (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout-diagnosis-disposition-160727.pdf
     February 24, 2016 - The confusion on our part between tests for classification and tests for clinical diagnosis in the … Peer Reviewer 2 Methods (page 8) AUC for imaging tests is not very meaningful since imaging tests … Tests used for publication bias are not appropriate for DTA data. … …” Which tests? … We changed "these tests" to "5 clinical algorithms."

185. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - The standard tests have limited efficacy for the diagnosis of PCDs that are characterized predominantly … Table 26 provides an overview of the laboratory tests used to diagnose PCDs. … Question 2 When compared with traditional tests, how well does the SFLC assay independently predict … For questions regarding comparisons of diagnostic tests (KQ 1), we will consider doing Bland-Altman … If the studies do not directly compare the tests of interest, we will use network analysis to estimate

186. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - specifically diagnostic medical tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests.

187. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-risk-bias.ppt
     June 01, 2012 - specifically diagnostic medical tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests. … Empirical evidence of design-related bias in studies of diagnostic tests.

188. Disposition of Comments_Comparative Effectiveness Review No. 276: Diagnosis and Managment of Obsessive Compulsive Disorders in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/obsessive-compulsive-disorder-disposition-comments.pdf
     December 06, 2024 - Prior publications by EPC members inform our opinion that formal statistical tests for publication … visually interpreted or statistically tested, does not accurately identify bias, and use of funnel plot tests … j.sleep.2018.12.024 The inclusion criteria for KQ 1 (Diagnosis of OCD) does not include screening tests

189. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
     January 01, 2011 - Since test results have little direct impact on patient-relevant outcomes, the utility of medical tests … Although overarching studies that assess the overall impact of tests on the clinical management process … What are the adverse effects or harms associated with the treatments guided by tests of iron status … (if all the other kidney tests are normal, there is no CKD) o CKD stage 2: a GFR between 60 and … 90 ml/min with some sign of kidney damage (if all the kidney tests are normal, there is no CKD) o

190. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis_research-protocol.pdf
     June 06, 2011 - However, neither one of these tests is applicable to the symptomatic population under consideration … However, to perform this correction, the proportion of positive tests in the population of interest … To explore additional sources of potential bias, we will also record whether the diagnostic tests were … interpreted in a blinded fashion; that is, without knowledge of results of other diagnostic tests or … Radiation risk from coronary artery disease imaging: how do different diagnostic tests compare?

191. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
     August 23, 2012 - The existence of different disease groups implies that different tests will perform differently by … The FLC ratio has been suggested as part of a panel of tests for the diagnostic evaluation for a variety … of this comparative effectiveness review was to perform a comparative effectiveness analysis among tests … However, no direct comparisons of the predictive ability of these tests were carried out, limiting any … I am not sure I found it in the discussion but a lot of tests are adopted in medicine and only when

192. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatitis-c-screening_research-protocol.pdf
     October 20, 2011 - Clarity: o KQ 1a: “asymptomatic” to “asymptomatic adults without known abnormal liver function tests … Does screening for HCV infection in nonpregnant adults without known abnormal liver function tests … What is the comparative effectiveness of various tests and strategies for the workup to guide treatment … of the KQs, we decided to exclude the following from our review:  Fibroscan ® and breath tests … Blood tests b. Imaging techniques 3.

193. C-Diff-Infections-Surveillance-140925 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections-surveillance-140925.pdf
     January 01, 2014 - , and used a reference test (or combination of tests) to verify the results. … Comparative data were not found for many currently used tests. … currently available gene detection tests. … specificity of the diagnostic tests marked differences in their sensitivity. … Comparative data were not found for many currently used tests.

194. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
     April 01, 2013 - What is the comparative effectiveness of PCA3 compared with the 2 commonly used add-on tests of fPSA … Two proposed intended uses of PCA3 and comparator tests were to inform decisionmaking about biopsy or … Research Need 1 addresses the diagnostic accuracy of PCA3 in comparison to other tests for prostate … All men would undergo biopsy to allow for a head to head comparison of PCA3 to currently used tests. … What is the comparative effectiveness of PCA3 compared to the two commonly used add-on tests of fPSA

195. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Genetic Tests for CYP2C19 Variants Genetic testing for one or more genetic variants can be performed … We refer to all these assays as “phenotypic tests” because they attempt to measure an intermediate … as biomarker tests (and of relevant test-and-treat strategies) for guiding antiplatelet therapy in … Our search included terms for the populations, tests, and drugs of interest. … combinations of tests.

196. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - In addition, I wonder if the language should be stronger that the summary is that use of these tests … Bottom line very clear – no evidence exists to support the clinical utility of the GEP tests to alter … or improve health outcomes and the risks/benefits of using the tests are not clearly defined. … Much more evidence, both in quantity and quality, is needed (especially for predictive tests) before … deploying these tests into practice; a good description of ongoing clinical trials is included in

197. Prostate-Cancer-Test Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
     April 01, 2013 - on messenger RNA from urine were developed.13,14 Two proposed intended uses of PCA3 and comparator tests … is the comparative effectiveness of PCA3 testing as a replacement for, or supplement to, standard tests … is the comparative effectiveness of PCA3 testing as a replacement for, or supplement to, standard tests … the standard prognostic workup (e.g., tumor volume, Gleason score, clinical staging) or monitoring tests … • How does PCA3 compare with the two more frequently used add-on tests (free PSA, PSA velocity) that

198. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
     January 01, 2012 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … pertains to identifying new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Like the MaterniT21 and verifi tests, Ariosa Diagnostics’ Harmony test is based on identification and … Expert Comments: Overall, experts commenting on maternal blood-based fetal DNA testing viewed such tests … , comments provided for the MaterniT21 test would be expected to pertain to those tests as well.

199. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - The diagnosis phase involves the use of additional tests (radiological and/or histopathological) to … In addition to imaging tests, biomarkers for HCC have also been used in surveillance and diagnosis. … "Predictive Value of Tests"/ 14. ROC Curve/ 15. "Reproducibility of Results"/ 16. … We will prioritize studies that directly compare outcomes for two or more imaging tests. … Tests of heterogeneity will be conducted using the standard χ2 tests and I2 statistic, when appropriate

200. Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients Wtih Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_disposition-comments.pdf
     August 11, 2014 - Disposition of Comments Report for Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients … Disposition of Comments Report Research Review Title: Cardiac Troponins Used as Diagnostic and Prognostic Tests … Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients With Kidney Disease. … Summary Change title to: “Critical Review of Cardiac Troponins Used as Diagnostic and Prognostic Tests … with Kidney Disease” We changed the title to “Cardiac Troponins Used as Diagnostic and Prognostic Tests