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161. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-applicability.ppt
     June 01, 2012 - Tests are rapidly evolving. … Tests are rapidly evolving and change often. … Example 2: Antenatal tests are applied earlier and earlier in gestation. … Preventive practices change the utility of medical tests. … Tests that are used both for screening and diagnosis also pose challenges.

162. PowerPoint Presentation (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-applicability.ppt
     June 01, 2012 - Tests are rapidly evolving. … Tests are rapidly evolving and change often. … Example 2: Antenatal tests are applied earlier and earlier in gestation. … Preventive practices change the utility of medical tests. … Tests that are used both for screening and diagnosis also pose challenges.

163. Santa_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/santa_eccs2012.pdf
     February 01, 2013 - Slide 7: Comparison of Heart Disease Screening  Tests  (1 of 2) • Began  with the grades used … the ratings in five tiers, using Consumer Reports symbols. • Found  that: o Highly  rated  tests …  underused   o Poorly  rated  tests  overused Slide 8: Comparison of Heart Disease Screening …  Tests  (2 of 2) Image of Consumer Reports Heart/Vascular  Prevention Test Ratings: Asymptomatic … Slide 10: Cardiovascular Screening  Tests  in Healthy People 40 to 60 Years  of Age (2 of 2) •

164. Cancer-Pancreas Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-pancreas_research-protocol.pdf
     August 09, 2013 - tests. … Any Key Questions comparing two or more tests. … The study must have compared both tests to a reference standard. 3. … ’s true condition changed between tests)? … standard was unknowable until after the tests were read)?

165. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
     January 28, 2016 - Some discussion about the costs of the different tests would have been great. … We have removed the statement about ordering IgG tTG tests from the Introduction. … of both IgA tTG and IgA EmA tests reported in recent systematic reviews. … that of the other serological tests.” … and similar specificity of IgA tTG tests”.

166. Wireless-Motility-Capsule Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
     May 01, 2013 - KQ 2 WMC in combination with other tests vs. … Tests Alone We summarized the results from KQ 3 and KQ 4 in Table B. … KQ 2 WMC in combination with other tests vs. … KQ 4 WMC in combination with other diagnostic tests vs. other tests alone Diagnostic accuracy … Chapter 7: Grading a Body of Evidence on Diagnostic Tests.

167. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research
     February 29, 2012 - study and a subset analysis of one of the larger studies were both poor quality and evaluated different tests … No studies have evaluated the relative acceptability of fecal DNA tests to FIT tests. … Conclusions Fecal DNA tests have insufficient evidence about its diagnostic accuracy to screen for

168. Disposition of Comments Report for Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_disposition-comments.pdf
     September 23, 2014 - Disposition of Comments Report for Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma … Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma. … We have added information about insurance coverage of various tests. … , and it is important to know whether the tests are differentially accurate. … In addition, some diagnostics tests are synergistic.

169. Glaucoma-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_executive.pdf
     April 01, 2012 - KQ3 What is the predictive value of screening tests for open- angle glaucoma? … individual or combination tests. … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for … comprise the candidate tests under investigation. … The tests used to diagnose glaucoma are categorized broadly into tests of optic nerve structure or

170. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antiplatelet-treatment_research-protocol.pdf
     November 22, 2011 - variants and phenotypic tests for platelet reactivity. … standardized than tests of reactivity. … The figure illustrates that results of genetic tests for CYP2C19 or of phenotypic tests of platelet … Various randomized designs can be used to evaluate medical tests. … of platelet reactivity as “phenotypic tests” (see above).

171. Gene Expression Profiling for Predicting Outcomes in Patients With Stage II Colon Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colon-cancer-gene-profiling/research-protocol
     March 13, 2012 - Given the additional studies on tests reported in that publication and the emergence of new tests, follow-up … Food and Drug Administration (FDA) status of these tests? … Currently, how widely used are these tests? … Impact of Gene Expresion Profiling Tests on Breast Cancer Outcomes. … Genomic Testing: ACCE Model Process for Evaluating Genetic Tests.

172. Diagnosis of Celiac Disease | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/celiac-disease/research-protocol
     June 11, 2014 - A number of diagnostic methods have been developed; they include various serology tests, HLA typing, … Serology tests include Anti-gliadin antibodies (AGA), IgA & IgG; Anti-tissue Transglutaminase (tTG), … These tests are often used by providers as a panel in order to increase specificity and prevent false … positives that are associated with tests that don’t work well under varying circumstances. … The diagnosis of celiac disease is further complicated by the limitations of the various tests, lack

173. Imaging for Pretreatment Staging of Small Cell Lung Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/lung-cancer-staging/research-protocol
     December 08, 2014 - Imaging Tests This section discusses several types of imaging tests used in the process of staging … MDCT of the chest is often one of the first tests performed to diagnose possible lung cancer. … Grading a body of evidence on diagnostic tests. AHRQ Publication No. 12-EHC079-EF. … ’s true condition changed between tests)? … standard was unknowable until after the tests were read)?

174. celiac-disease-protocol-140612 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
     June 12, 2014 - A number of diagnostic methods have been developed; they include various serology tests, HLA typing, … Serology tests include Anti-gliadin antibodies (AGA), IgA & IgG; Anti-tissue Transglutaminase (tTG), … These tests are often used by providers as a panel in order to increase specificity and prevent false … positives that are associated with tests that don’t work well under varying circumstances. … For example, some guidelines propose a different sequence of tests for diagnosing population groups

175. Colon-Cancer-Gene-Profiling Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
     March 13, 2012 - Given the additional studies on tests reported in that publication and the emergence of new tests, follow-up … As this project proceeds, additional tests will likely be identified. … Food and Drug Administration (FDA) status of these tests? c. … Currently, how widely used are these tests? … Genomic Testing: ACCE Model Process for Evaluating Genetic Tests.

176. Glaucoma-Screening Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_surveillance.pdf
     January 01, 2013 - comments addressed the use of a combination of tests for screening purposes. … (other screening tests are described below) did not know. … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for … studies either comparing tests or assessing combinations of tests. 24 Conclusions From … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for

177. FRN 27 - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
     May 01, 2013 - Great variability existed in administering diagnostic tests and in assessing those tests. … WMC data compared with other tests in nondiseased populations 9 10. Concurrent tests 10 11. … of those tests. … WMC data compared with other tests in non-diseased populations 9 10. Concurrent tests 10 11. … Concurrent tests 1 2 2 4 9 10 11.

178. Having a breast biopsy. A review of the research for women and thier families (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_consumer.pdf
     May 01, 2016 - Followup tests and breast biopsy If a shadow is seen on your mammogram, a lump is felt, or you have … other symptoms, your doctor will likely do more tests. … These tests tell your doctor if you need a biopsy. … Most women who have followup tests find out they do not need a biopsy. … You also may need more imaging tests or surgery.

179. Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/wireless-motility-capsule/research-protocol
     March 14, 2012 - Clinicians proceed to diagnostic tests based on patients' initial symptomatic presentation. … However, these tests are not perfect and have limitations that will be addressed later in this section … For each of the diagnostic tests, we would collect information on the criteria used to make a diagnosis … Clinical utility of diagnostic tests for constipation in adults: a systematic review. … Chapter 7: grading a body of evidence on diagnostic tests. J Gen Intern Med 2012;27: in press.

180. Celiac-Disease Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_executive.pdf
     January 01, 2016 - , which include combination tests and algorithms, remain controversial. … New research has found DGP tests to be more accurate than tTG tests in small children; strength of evidence … of IgA tTG tests and excellent specificity of both IgA tTG and IgA EmA tests reported in prior SRs … tTG tests. … IgA DGP and IgG DGP tests are not as sensitive as IgA tTG tests in non–IgA-deficient adults.