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141. Gout Executive-2016 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gout_executive-2016.pdf
     January 01, 2016 - The safety of tests used to diagnose gout also needs to be considered. … affect the sensitivity or specificity of tests (joints involved, duration of symptoms). … ; instead, we used the term “gout” combined with the terms for the diagnostic tests. … The strength of evidence for these tests is insufficient. … Other tests 0 studies Insufficient None 1b.

142. Test-Performance-Metrics Appendixes (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
     January 01, 2005 - Screening tests typically operate in the less shaded areas, whereas confirmatory tests used to rule … 10 or more and a negative likelihood ratio of 0.1 or less are considered to represent informative tests … diagnostic odds ratios to weigh sensitivity and specificity separately, and to distinguish between tests … with high sensitivity and low specificity and tests with low sensitivity and high specificity.

143. Gout Dx protocol_140715-draft (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
     January 01, 2014 - A question of interest is whether any combination of clinical signs and symptoms and laboratory tests … accessible in the primary or acute care setting will have good predictive value compared with tests … What is the accuracy of clinical signs and symptoms and other diagnostic tests (such as serum uric … Studies that measure sensitivity and specificity for a test or combination of tests to diagnose gout … but instead will use the terms “gout” combined with the terms for the diagnostic tests.

144. Disposition of Comments Report for Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
     January 01, 2011 - Page 3, lines 25-27: I disagree that inflammation doesn't affect the "newer tests." … Nor is there adequate research on whether iron tests perform differently with short vs. long acting … One question that should be considered for future research is whether any of the tests substantially … Do iron tests perform differently with short vs. long acting ESAs 4. … Is it clinically reasonable to use iron tests to only detect excess iron and just give IV iron if tests

145. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - Various tests, including spirometry pre and post bronchodilator, and bronchoprovocation may be used … More recently, fractional exhaled nitric oxide (FeNO) has been added to the list of tests clinicians … There are some data9-11 to suggest that FeNO compares favorably to other predictive tests to address … In addition to have some possible advantages over other tests to select treatment and measure response … Improved tests for a random effects meta-regression with a single covariate.

146. Disposition of Comments for Screening for Glaucoma: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
     April 01, 2012 - We included studies of the following ocular examinations (screening tests) conducted alone or in any … We included studies of the following ocular examinations (screening tests) conducted alone or in any … Methods Was a comparison of the accuracy of different tests for glaucoma a key question? … Key Question 3 explored the accuracy of candidate tests. … tests to be used to screen for glaucoma.

147. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - CRC-screening tests use different approaches, including stool-based tests and direct-visualization … These tests include: computerized tomographic colonography, double-contrast barium enema, and fecal … In combination with other screening tests? Question 2: Clinical Validity a. … Fecal DNA tests may be performed alone or in combination with other CRC-screening tests. … Performance improvements of stool-based screening tests. [Review].

148. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-diff-infections_research-protocol.pdf
     May 24, 2010 - • Interventions: Diagnostic tests: tests for toxin producing C. difficile, such as enzyme immunoassays … Tests for technical feasibility and cost characteristics will be excluded. … Tests must be approved by the U.S. Food and Drug Administration and in current use. … Studies which used in-house laboratory cell cytotoxicity tests will be excluded. … The draft of the AHRQ guidance for evaluation of diagnostic tests will also be used.

149. Topic 0505 Genetic Testing for Developmental Diseases NSD FINAL_SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0594-131115.pdf
     March 13, 2013 - disorder (ASD) in children and is interested to know the clinical utility of these sophisticated genetic tests … Which genetic tests should be conducted? … even more sophisticated genetic testing for DD/ID and ASD A technical brief that examines available tests

150. Research Protocol: Clostridium difficile Infection Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
     December 23, 2014 - Tests to validate a technique in “known” or proven samples. … Tests in which the reference standard is not applied to all samples. … Tests examining cost characteristics. Tests not commercially available in the U.S. … Tests only typing C. difficile strains. … In-house laboratory tests not commercially available.

151. Prioritization and Selection of Harms for Inclusion in Systematic Reviews (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-selection-harms-systematic-reviews.pdf
     February 01, 2018 - Identify the types and number of harms to include for treatments and diagnostic tests. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for imprecision or insensitivity 8. … Check diagnostic tests for Imprecision or insensitivity • Diagnostic tests (e.g. genetic or hematologic … tests, be it genetic or hematologic testing, various scanning technologies, or functional tests; they

152. Topic 0586 LUTS Secondary to BPH NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0713-140625.pdf
     January 07, 2014 - complaint of nocturia, including frequency-volume charts and/or voiding bladder diaries, as well as tests … What are the necessary tests to determine if a patient with a predominant complaint of nocturia has … Should these tests be required or recommended to determine if BPH is the cause of LUTS before treatment … predominant complaint of nocturia include frequency-volume charts and/or voiding bladder diaries, as well as tests

153. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia_research.pdf
     January 01, 2013 - What are the adverse effects or harms associated with the treatments guided by tests of iron status? … To compare the test performance among medical tests, a common reference standard is needed. … These concerns limit the use of bone marrow iron tests in clinical practice. … These concerns limit the use of bone marrow iron tests in clinical practice. … 3 What is the impact of use of these tests on clinical practice?

154. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0359_10-15-2010.pdf
     January 01, 2010 - multiple sclerosis was found to be addressed by a 2011 systematic review on the accuracy of diagnostic tests … Accuracy of diagnostic tests in multiple sclerosis—a systematic review. … largely covered by a 2011 systematic review by Shaffler and colleagues titled Accuracy of Diagnostic Tests

155. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
     March 01, 2017 - Short-term benefits on cognitive tests or biomarkers are uncertain predictors of long-term effects … Intermediate cognitive outcomes were assessed using neuropsychological tests or biomarkers. … To address the multiplicity of cognitive performance tests used, we arbitrarily clustered tests into … Instead we opted to simply show the proportion of tests. … To date, cognitive outcomes have been measured using a wide array of neuropsychological tests.

156. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
     March 01, 2017 - Short-term benefits on cognitive tests or biomarkers are uncertain predictors of long-term effects … Intermediate cognitive outcomes were assessed using neuropsychological tests or biomarkers. … To address the multiplicity of cognitive performance tests used, we arbitrarily clustered tests into … Instead we opted to simply show the proportion of tests. … To date, cognitive outcomes have been measured using a wide array of neuropsychological tests.

157. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - and not “alternative” diagnostic tests? … If not, what are alternative diagnostic tests used to diagnose appendicitis? … Imaging tests have adequate test performance, while clinical signs and symptoms and laboratory tests … imaging tests with clinical and laboratory tests. … I need some guidance on what tests to use on what patients. I think preferably by an algorithm.

158. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
     March 01, 2012 - the gene-detection tests are generally more sensitive. … However, the use of toxin gene- detection tests has increased in recent years. … between tests. … results from expert in- house use of non-commercial tests. … We didn’t want to exclude studies that used other reasonable reference tests.

159. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - LTA and the VerifyNow tests are based on light transmittance, but the VASP assay is not. … These differences result in a lack of standardization among platelet function tests. … We agree that MACE are relevant to the assessment of tests for platelet reactivity. … or combinations of genetic tests were rarely assessed.” … We agree that none of the tests considered in this review are “perfect” predictors.

160. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-screening_research-protocol.pdf
     November 16, 2010 - hand, such strategies have been hampered by the lack of an adequately sensitive and specific test or tests … This review will also include a summary of the diagnostic accuracy of screening examinations/tests … Key Question 3 What is the predictive value of screening tests for open-angle glaucoma? … Key Question 3 explores comparisons of screening/diagnostic tests to the gold/reference standards of … We acknowledge that there is no consensus on the gold standard test (or combination of tests) for the