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  1. 13-MDM347013 30..38 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/whitepaper4-bossuyt02262010-2.pdf
    January 01, 2009 - based on an understanding of how tests can benefit or harm patients. … , such as the decision to order more tests or to start, stop, or modify treatment. … to undergoing other tests or no testing at all. … This requires an understanding of how tests can affect patient outcome. … Various randomized designs can be used to evaluate medical tests.
  2. 13-MDM347013 30..38 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/outcomes-testing-evaluation_research.pdf
    January 01, 2009 - based on an understanding of how tests can benefit or harm patients. … , such as the decision to order more tests or to start, stop, or modify treatment. … to undergoing other tests or no testing at all. … This requires an understanding of how tests can affect patient outcome. … Various randomized designs can be used to evaluate medical tests.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - Reviews - Editorial E-1 Editorial Methods Guide for Authors of Systematic Reviews of Medical Tests … Clinicians obtain medical tests for a number of non-overlapping reasons. … An additional two workgroups addressed issues unique to genetic and prognostic tests. … Medical tests. White paper series; Nov. 16, 2009. … Methods guide for authors of systematic reviews of medical tests: a collaboration between the Agency
  4. effectivehealthcare.ahrq.gov/products/renal-function
    June 13, 2013 - Cardiac Troponins Used as Diagnostic and Prognostic Tests in Patients With Kidney Disease … Systematic Review Archived Cardiac Troponins Used as Diagnostic and Prognostic Tests
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Index and reference tests are correlated within strata of disease. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards.
  6. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Index and reference tests are correlated within strata of disease. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards. … A probabilistic model for the comparison of diagnostic tests. … Meta-analysis of diagnostic tests with imperfect reference standards.
  7. effectivehealthcare.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay/research
    August 23, 2012 - regarding the role of the serum free light chain (SFLC) assay in diagnosis as an adjunct to traditional tests … standardized protocol was used to extract details on designs, diagnoses, interventions (diagnostic tests … The comparison and outcomes of interest were the role of the SFLC assay as an adjunct to traditional tests … for diagnosis of PCDs, and the effectiveness of the SFLC assay versus traditional tests for studying … therapeutic decisionmaking compared with traditional testing alone and as a substitute for other diagnostic tests
  8. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0068_01-30-2009.pdf
    January 01, 2009 -  Although immunologic laboratory tests can have great utility in the diagnosis and management of … The nominator has expressed interest in the diagnostic accuracy of the ANA and RF tests in children …  In addition, because these tests are known to have a low predictive value in this population, … Because these tests are used as prognostic indicators, information on the prognostic significance of … the tests may also be helpful to include in a report
  9. effectivehealthcare.ahrq.gov/products/methods-guide-editorial
    June 01, 2012 - Methods Guide for Authors of Systematic Reviews of Medical Tests: A Collaboration Between the Agency … Methods Guide for Authors of Systematic Reviews of Medical Tests: A Collaboration Between the Agency
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
    April 01, 2014 - However, our review of diagnostic blood tests 5 had limitations. … Optimization and robustness of blood tests for liver fibrosis and cirrhosis. … Routine blood tests to predict liver fibrosis in chronic hepatitis C. … Optimization and robustness of blood tests for liver fibrosis and cirrhosis. … Routine blood tests to predict liver fibrosis in chronic hepatitis C.
  11. Hi Les, (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - Hi Les, Medical Tests—White Paper Series Using the Principles of Randomized Controlled … Pap tests takes next priority. … Randomised comparisons of medical tests: sometimes invalid, not always efficient. … Various randomized designs can be used to evaluate medical tests. … Comparative accuracy: assessing new tests against existing diagnostic pathways.
  12. effectivehealthcare.ahrq.gov/health-topics/womens-health
    February 13, 2012 - Noninvasive Diagnostic Tests for Breast Abnormalities: Update of a 2006 Review Systematic Review
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
    September 01, 2014 - For any KQs comparing two or more tests, the study must have compared both tests to a reference standard … We also used a minimum of 10 for KQ3b on patient perspectives of imaging tests. … , the harms of concern are different for different tests. … after different tests. … Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma.
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
    December 09, 2013 - The test performance of clinical signs and symptoms, laboratory tests, or imaging tests may be modified … or decision rules, imaging tests, nuclear imaging studies, diagnostic laparoscopy. … Comparators Alternative tests or test combinations (as listed above), clinical observation. … Although these tests are often referred to as tests for publication bias; reasons other than publication … nonspecific and the tests noninformative.64, 65 Therefore, instead of relying on statistical tests,
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0411_02-10-2011.pdf
    January 01, 2011 - In addition, they question whether the benefits and harms of these tests vary by the risk of the surgical … complications, morbidity, mortality, patient delays, harms from unnecessary follow-up of abnormal tests … Do the benefits or harms of routine preoperative tests vary by the risk of the surgical procedure (low … Do the benefits or harms of routine preoperative tests vary by the clinical conditions, comorbidities … Do routine preoperative tests change patient management decisions?
  16. effectivehealthcare.ahrq.gov/products/appendicitis/research-protocol
    December 10, 2013 - The test performance of clinical signs and symptoms, laboratory tests, or imaging tests may be modified … treatment for tests used to diagnose RLQ pain and suspected acute appendicitis? … or decision rules, imaging tests, nuclear imaging studies, diagnostic laparoscopy. … Although these tests are often referred to as tests for publication bias; reasons other than publication … nonspecific and the tests noninformative. 64,65 Therefore, instead of relying on statistical tests,
  17. effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research-protocol
    May 21, 2013 - can be crudely divided into noninvasive and invasive tests. … , staging tests using noninvasive means are also important. … This review will focus on noninvasive imaging tests for staging. … Imaging tests can be broadly divided into two categories—some tests primarily provide anatomical information … and experimental imaging tests from inclusion in the report.
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0488_12-27-2011.pdf
    January 01, 2011 - Nomination Summary: The nominator is interested in the comparative effectiveness of various tests … requiring testing, or with a strong family history of pancreatic cancer) Intervention(s): Imaging tests … resonance imaging (MRI), fludeoxyglucose positron emission tomography (FDG-PET), variants of these tests … , and combinations of tests Comparator(s): The same list of imaging tests, used as comparators
  19. effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
    November 22, 2011 - variants and phenotypic tests for platelet reactivity. … standardized than tests of reactivity. … The figure illustrates that results of genetic tests for CYP2C19 or of phenotypic tests of platelet reactivity … Various randomized designs can be used to evaluate medical tests. … of platelet reactivity as “phenotypic tests” (see above).
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-533_05-24-2013.pdf
    January 01, 2013 - Patients with positive serology tests are then referred for biopsy to confirm CD. … The current strategy uses serial serologic and histopathologic tests to establish the diagnosis. … Objective 1 - Sensitivity and specificity of tests for CD (Celiac 1) a. … What is the sensitivity and specificity of the following tests for CD: i. AGA; ii. … the other aspects that were addressed in the original report and to ensure a link between diagnostic tests

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