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361. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
     April 01, 2013 - What is the comparative effectiveness of PCA3 compared with the 2 commonly used add-on tests of fPSA … Two proposed intended uses of PCA3 and comparator tests were to inform decisionmaking about biopsy or … Research Need 1 addresses the diagnostic accuracy of PCA3 in comparison to other tests for prostate … All men would undergo biopsy to allow for a head to head comparison of PCA3 to currently used tests. … What is the comparative effectiveness of PCA3 compared to the two commonly used add-on tests of fPSA

362. Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-cancer-imaging/research-protocol
     December 01, 2019 - $115 for ultrasound to $1114 for PET-CT, 9,10 increasing the need to determine whether more expensive tests … and bone, in addition to obtaining medical histories, physical examinations, and relevant laboratory tests … For example, are patients aware that the accuracy of these imaging tests varies? … Do any themes, such as cost, accuracy of tests, or discomfort, inconvenience, often arise when metastatic … Do patients generally know how much they will have to pay out of pocket for imaging tests?

363. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Genetic Tests for CYP2C19 Variants Genetic testing for one or more genetic variants can be performed … We refer to all these assays as “phenotypic tests” because they attempt to measure an intermediate … as biomarker tests (and of relevant test-and-treat strategies) for guiding antiplatelet therapy in … Our search included terms for the populations, tests, and drugs of interest. … combinations of tests.

364. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - In addition, I wonder if the language should be stronger that the summary is that use of these tests … Bottom line very clear – no evidence exists to support the clinical utility of the GEP tests to alter … or improve health outcomes and the risks/benefits of using the tests are not clearly defined. … Much more evidence, both in quantity and quality, is needed (especially for predictive tests) before … deploying these tests into practice; a good description of ongoing clinical trials is included in

365. Hemophilia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/hemophilia
     July 11, 2024 - Blood tests can tell if you have it.

366. Management of Renal Masses and Localized Renal Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/renal-cancer/research-protocol
     December 01, 2019 - biopsy) Composite models (combination of demographics, clinical characteristics, blood/urine tests … . 38-39 The results of the diagnostic tests will be tabulated and sensitivity, specificity, positive … For a comparison of two diagnostic tests, directness implies head-to-head comparisons against a common … Grading a Body of Evidence on Diagnostic Tests. In: Chang SM, Matchar DB, Smetana GW, et al, eds. … leukocytestiab OR RBCtiab OR erythrocytetiab OR thrombocytetiab OR platelettiab OR Blood Coagulation Tests

367. Topic 0552 Low Back Pain NSD FINAL SJ (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0651-131114.pdf
     June 20, 2013 - Strategies include testing (e.g., imaging tests), decision tools, identifying risk factors for chronicity … Intervention(s): Procedures to diagnose and treat low back pain, including: testing (e.g., imaging tests

368. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
     January 01, 2012 - AHRQ is interested in innovations in drugs and biologics, medical devices, screening and diagnostic tests … pertains to identifying new (and new uses of existing) pharmaceuticals, medical devices, diagnostic tests … Like the MaterniT21 and verifi tests, Ariosa Diagnostics’ Harmony test is based on identification and … Expert Comments: Overall, experts commenting on maternal blood-based fetal DNA testing viewed such tests … , comments provided for the MaterniT21 test would be expected to pertain to those tests as well.

369. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/chronic-kidney-disease-anemia-2011/research
     December 01, 2019 - synthesis of data for Key Question 2 was complicated by the lack of generally accepted reference standard tests … We concluded that there is a low level of evidence for a reduction in the number of iron status tests … In addition, results from two RCTs showed a reduction in the number of iron status tests and resulting

370. Principles in Developing and Applying Guidance for Comparing Medical Interventions | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-principles/methods
     December 01, 2019 - Present benefits and harms for different treatments and tests in a consistent way so that decisionmakers … Presenting benefits and harms for different treatments and tests in a consistent way so that decisionmakers … Balance of Benefits and Harms CERs aim to present benefits and harms for different treatments and tests … address issues such as when and how to use modeling, how to assess the quality of studies of medical tests … outcomes on decisions to use a medical test, and the assessment of studies of genetic and prognostic tests

371. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - The diagnosis phase involves the use of additional tests (radiological and/or histopathological) to … In addition to imaging tests, biomarkers for HCC have also been used in surveillance and diagnosis. … "Predictive Value of Tests"/ 14. ROC Curve/ 15. "Reproducibility of Results"/ 16. … We will prioritize studies that directly compare outcomes for two or more imaging tests. … Tests of heterogeneity will be conducted using the standard χ2 tests and I2 statistic, when appropriate

372. Spina Bifida | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/spina-bifida
     October 25, 2024 - Screening tests during pregnancy can check for spina bifida.

373. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - Assessment of the accuracy of diagnostic tests: the cross-sectional study. … These tools are continuing inter-rater reliability tests. … Genetic and prognostic marker tests, has some unique attributes. … prognostic tests are not addressed in this document. … Empirical evidence of design-related bias in studies of diagnostic tests.

374. Malnutrition | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/malnutrition
     May 22, 2023 - To diagnose the cause of the problem, your doctor may do blood tests and a nutritional assessment.

375. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
     March 01, 2024 - • Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance … for parental ratings, teacher ratings, teen/child self-reports, clinician tools, neuropsychological tests … Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance Test

376. Kidney-Disease-Medicine Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/kidney-disease-medicine_executive.pdf
     January 01, 2012 - adverse health consequences, its long asymptomatic phase, the availability of potential screening tests … Harms •Screening or monitoring: false-positive diagnosis or progression, anxiety, unnecessary tests, … - Yield of one-time screening tests based on actual association with persistent CKD. … positive tests; psychological effects of labeling asymptomatic individuals as diseased; medication … positive tests (for progression); medication adverse effects; increased medical visits; increased

377. Tonsillitis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/tonsillitis
     Your child will probably also have one or more tests to check for strep throat, since it can cause tonsillitis … For both tests, the provider uses a cotton swab to collect a sample of fluids from your child's tonsils

378. Polycystic Ovary Syndrome | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/polycystic-ovary-syndrome
     May 14, 2019 - To diagnose PCOS, your health care provider may do a physical exam, pelvic exam, blood tests, and an

379. Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/arthritis-knee-physical-therapy/research
     December 01, 2019 - Observational studies provided evidence of the association between changes in knee joint functional tests … interventions were not consistently evaluated according to the clinical importance of improvement in scales and tests

380. Pediatric Quality Measures Program 3.0: An Evidence Map of Measures for Vision, Hearing, and Developmental Screening and Followup | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/pqmp/protocol
     August 01, 2024 - What are the most commonly used types of screening tests or interventions for which we should look for … OR assessments[tiab] OR evaluation[tiab] OR evaluations[tiab])) OR photoscreening[tiab] OR “vision tests … ”[mh] OR “vision test”[tiab] OR “vision tests”[tiab] 139,320 4 "Hearing Tests"[mh] OR “hearing screening … tiab] OR audiological[tiab]) AND (screen[tiab] OR screening[tiab] OR screens[tiab] OR test[tiab] OR tests … Protocols for Intrahospital Transitions Research Protocol Jul 22, 2024 Blood-based Tests