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281. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
     March 01, 2017 - Short-term benefits on cognitive tests or biomarkers are uncertain predictors of long-term effects … Intermediate cognitive outcomes were assessed using neuropsychological tests or biomarkers. … To address the multiplicity of cognitive performance tests used, we arbitrarily clustered tests into … Instead we opted to simply show the proportion of tests. … To date, cognitive outcomes have been measured using a wide array of neuropsychological tests.

282. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - and not “alternative” diagnostic tests? … If not, what are alternative diagnostic tests used to diagnose appendicitis? … Imaging tests have adequate test performance, while clinical signs and symptoms and laboratory tests … imaging tests with clinical and laboratory tests. … I need some guidance on what tests to use on what patients. I think preferably by an algorithm.

283. Interventions to Improve Appropriate Antibiotic Use for Acute Respiratory Tract Infections | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antibiotics-respiratory-infection/research-protocol
     December 01, 2020 - Clinical strategies include delayed prescribing of antibiotics or use of point-of-care diagnostic tests … Examples include inflammatory tests (e.g., procalcitonin, c-reactive protein [CRP], white blood cell, … Reporting bias will be assessed following EPC guidance (Appendix A), 13 using tests for funnel plot … in such tests to participate in reviewing the draft report. … Expert review of the point of care tests evidence review will improve the final report.

284. Emergency Medical Services | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/emergency-medical-services?page=1
     November 27, 2012 - Developing the Topic and Structuring Systematic Reviews of Medical Tests: Utility of PICOTS, Analytic … Guidelines Systematic Review Archived February 13, 2012 Noninvasive Diagnostic Tests … Research Protocol Archived June 28, 2010 Comparative Effectiveness of Non-Invasive Diagnostic Tests

285. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
     March 01, 2012 - the gene-detection tests are generally more sensitive. … However, the use of toxin gene- detection tests has increased in recent years. … between tests. … results from expert in- house use of non-commercial tests. … We didn’t want to exclude studies that used other reasonable reference tests.

286. Comparative Effectiveness of Screening for Glaucoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/glaucoma-screening/research-protocol
     December 01, 2019 - hand, such strategies have been hampered by the lack of an adequately sensitive and specific test or tests … This review will also include a summary of the diagnostic accuracy of screening examinations/tests for … Key Question 3 What is the predictive value of screening tests for open-angle glaucoma? … Key Question 3 explores comparisons of screening/diagnostic tests to the gold/reference standards of … We acknowledge that there is no consensus on the gold standard test (or combination of tests) for the

287. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/plasma-cell-dyscrasias-sflc-assay-future/research
     December 01, 2019 - International Myeloma Working Group (IMWG) currently considers the SFLC assay to be an adjunct to traditional tests … serum protein electrophoresis (SPEP) and serum immunofixation electrophoresis (SIFE) to replace urine tests … You Might Also Like Research Protocol Jul 22, 2024 Blood-based Tests

288. Optic Nerve Disorders | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/optic-nerve-disorders
     Tests for optic nerve disorders may include eye exams, ophthalmoscopy (an examination of the back of … your eye), and imaging tests .

289. Lipid Metabolism Disorders | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/lipid-metabolism-disorders
     Newborn babies get screened for some of them, using blood tests. … Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder.

290. Multiple Myeloma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/multiple-myeloma
     September 19, 2012 - fevers Feeling very thirsty Frequent urination Doctors diagnose multiple myeloma using lab tests … , imaging tests, and a bone marrow biopsy.

291. Carbohydrate Metabolism Disorders | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/carbohydrate-metabolism-disorders
     Newborn babies get screened for many of them, using blood tests. … Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder.

292. Crohn's Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/crohns-disease
     April 02, 2014 - rectum Weight loss Fever Your doctor will diagnose Crohn's disease with a physical exam, lab tests … , imaging tests, and a colonoscopy.

293. Kidney Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/kidney-cancer
     July 18, 2017 - abdomen Weight loss for no reason Pain in your side that does not go away Loss of appetite Tests … to diagnose kidney cancer include blood, urine, and imaging tests.

294. PCA3 Testing for the Diagnosis and Management of Prostate Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/prostate-cancer-test/research-protocol
     December 01, 2019 - However, several reference laboratories offer PCA3 testing as laboratory-developed tests (tests developed … the standard prognostic workup (e.g., tumor volume, Gleason score, clinical staging) or monitoring tests … This figure depicts the comparative effectiveness of using PCA3 testing versus other screening tests … Tests will be performed to determine whether a threshold effect is present, and if so, an analysis of … This comparison might be made in several ways, depending on the characteristics of the tests and the

295. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0398_06-17-2008.pdf
     January 01, 2008 - What impact would standardization of these marker tests have on the effectiveness of iron replacement …  The two traditional tests used to assess serum iron status are TSAT and serum ferritin. … Although both tests are easy to perform, there are some limitations to using these traditional laboratory

296. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glaucoma-screening_research-protocol.pdf
     November 16, 2010 - hand, such strategies have been hampered by the lack of an adequately sensitive and specific test or tests … This review will also include a summary of the diagnostic accuracy of screening examinations/tests … Key Question 3 What is the predictive value of screening tests for open-angle glaucoma? … Key Question 3 explores comparisons of screening/diagnostic tests to the gold/reference standards of … We acknowledge that there is no consensus on the gold standard test (or combination of tests) for the

297. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - LTA and the VerifyNow tests are based on light transmittance, but the VASP assay is not. … These differences result in a lack of standardization among platelet function tests. … We agree that MACE are relevant to the assessment of tests for platelet reactivity. … or combinations of genetic tests were rarely assessed.” … We agree that none of the tests considered in this review are “perfect” predictors.

298. Enlarged Prostate (BPH) | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/enlarged-prostate-bph
     December 16, 2014 - Tests for BPH include a digital rectal exam, blood and imaging tests, a urine flow study, and examination

299. Screening and Diagnosis of Gestational Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gestational-diabetes-screening-diagnosis/research-protocol
     December 01, 2019 - The sensitivity and specificity of these tests reflect how correctly they are able to rule in and rule … Tests with poor performance may result in patient stress, anxiety, and unnecessary investigation and … KQ1: What are the sensitivities, specificities, reliabilities, and yields of current screening tests … We will not grade the evidence on the test properties of the screening and diagnostic tests (KQ1). … "Predictive Value of Tests"/ 26.

300. Emerging Approaches to Diagnosis and Treatment of Non-Muscle-Invasive Bladder Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/bladder-cancer-non-muscle-invasive/research-protocol
     December 01, 2020 - Many of the tests are investigational. … There are five diagnostic biomarker tests approved by the FDA for diagnosis or surveillance of bladder … The CxBladder™ test, which tests for five specific mRNA biomarkers, is a “Laboratory Developed Test” … and tests with high false negative rates could lead to missed diagnoses. … Rationale for evidence review The comparative effectiveness of the diagnostic tests and treatments