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1. Draft Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/draft-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-testing
   January 18, 2024 - Draft Research Plan BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … §Genetic testing may be done on the index patient, a relative with cancer, or a relative with highest … What are the adverse effects of: 3a) risk assessment, 3b) genetic counseling, 3c) genetic testing, and … This may include testing other family members at higher risk before testing the index patient, including … men, in addition to the potential benefits and harms of testing for family members of the index case

2. Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-testing
   April 11, 2024 - Final Research Plan BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … What are the adverse effects of: 3a) risk assessment, 3b) genetic counseling, 3c) genetic testing, and … This may include testing other family members at higher risk before testing the index patient, including … men, in addition to the potential benefits and harms of testing family members of the index case. … What is the diagnostic accuracy of single vs. multigene panel testing for detecting pathogenic BRCA1

3. Recommendation: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/recommendation/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
   August 20, 2019 - and harms of genetic testing, interpretation of results after testing, and discussion of management … and harms of genetic testing, interpretation of results after testing, and discussion of management … Genetic Testing Testing for BRCA1/2 mutations should be performed only when an individual has personal … evaluated population-based BRCA1/2 mutation testing vs family history–based testing. 75 Results showed … BRCA1 gene testing.

4. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer: Updated Evidence Report and Systematic Review for the USPSTF (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/MzHhsgTBL37rRvvJfkfgMZ
   August 20, 2019 - (Includes testing other high-risk family members, including men, before testing the index patient and … Approaches BRCA1/2 mutation testing 1 RCT (n = 1034) Universal testing of Ashkenazi Jews for founder … family history–based testing. … testing. … gene testing.

5. Evidence Summary: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
   August 20, 2019 - What are adverse effects of genetic testing? … family history–based testing. … testing. … BRCA1 gene testing. … Approaches BRCA1/2 mutation testing 1 RCT (n = 1034) Universal testing of Ashkenazi Jews

6. Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing
   August 24, 2017 - Final Research Plan BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … counseling prior to testing. … Testing may be done on the index patient, a relative with cancer, or a relative with highest risk, as … Women who undergo genetic testing may have benign results or likely benign, or they may have a result … (Approaches include testing other high-risk family members, including men, before testing the index patient

7. Archived: Final Research Plan: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
   www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan11/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
   December 15, 2012 - Final Research Plan BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … Among patients with an increased risk of a BRCA mutation, testing will categorize individuals as BRCA … * Clinically significant deleterious mutations of BRCA1 or BRCA2. ** Testing may be done … , interpretation of results after testing, and discussion of management options. … Comparisons KQs 1 and 3: Risk assessment and genetic testing versus none.

8. Clinical Summary: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/y3mQMyN2Y8mxKvPPXjM6kV
   Clinical Summary: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer … Clinical Summary: Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer … Grade: B Do not perform routine risk assessment, genetic counseling, or genetic testing. … and harms of genetic testing, interpretation of results after testing, and discussion of management … Genetic Testing Tests for BRCA1/2 mutations are highly sensitive and specific for known mutations.

9. Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: Clinical Summary of USPSTF Recommendation (pdf file)
   www.uspreventiveservicestaskforce.org/home/getfilebytoken/RGu5KsFRY2YEAsDC9EQox9
   Risk Assessment, Genetic Counseling, and Genetic Testing for BRCA-Related Cancer in Women: Clinical Summary … of USPSTF Recommendation RISK ASSESSMENT, GENETIC COUNSELING, AND GENETIC TESTING FOR BRCA-RELATED … positive screening results should receive genetic counseling and, if indicated after counseling, BRCA testing … Grade: B Do not routinely recommend genetic counseling or BRCA testing to women whose family history … Screening Tests Genetic risk assessment and BRCA mutation testing are generally multistep processes

10. Archived: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
    December 24, 2013 - Update in Progress for BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … It is essential that before testing, the individual is fully informed about the implications of testing … The consequences of genetic testing for individuals and their relatives require more study. … Genetic testing may identify such mutations. … Although the preferred BRCA testing strategy is initial testing of a family member with breast or ovarian

11. JAMA (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/pACFPdCoN8fVoddBs-_CLE
    November 12, 2019 - and harms of genetic testing, in- terpretation of results after testing, and discussion of manage- ment … Genetic Testing Testing for BRCA1/2 mutations should be performed only when an individual has personal … and harms of genetic testing, interpretation of results after testing, and discussion of management … c If testing for BRCA2. d If testing for BRCA1. … gene testing.

12. Archived: Letter to the Editor and Response from the Evidence-Based Practice Center: Human Papillomavirus Testing to Screen for Cervical Cancer: Cervical Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/letter-to-the-editor-and-response-from-the-evidence-based-practice-center--human-papillomavirus-testing-to-screen-for-cervical-cancer/cervical-cancer-screening-2012
    February 15, 2012 - Letter to the Editor and Response from the Evidence-Based Practice Center: Human Papillomavirus Testing … (Table 3 of the report) indicating that HPV testing is able to detect non-regressive lesions earlier … As the protective effect is similar with all strategies, the least costly (HPV testing with cytology … Human papillomavirus testing in the prevention of cervical cancer. … Cervical cancer screening with both human papillomavirus and Papanicolaou testing vs Papanicolaou testing

13. Evidence Summary: Chlamydia and Gonorrhea: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-evidence-summary/chlamydia-and-gonorrhea-screening
    September 14, 2021 - Sensitivity of gonococcal testing was 89% or greater for all anatomical samples. … False-positive and false-negative testing rates were low across anatomical sites and collection methods … Testing for asymptomatic chlamydial and gonococcal infections was highly accurate at most anatomical … The sensitivity of urine testing was more variable than anatomical site testing in 5 studies (range, … in males, false-positive rates were 0.4% for meatal testing 19 and 0.3% to 0.7% for urine testing,

14. Final Research Plan: Chlamydia and Gonorrhea: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/final-research-plan/chlamydia-and-gonorrhea-screening
    May 02, 2019 - Screening strategies include testing for concurrent sexually transmitted infections, including HIV, or … What is the diagnostic accuracy of anatomic site–specific testing and collection methods for identifying … ) or other reference standard (if study does not use nucleic acid amplification testing), specific to … , and the included risk groups and risk behaviors; clarified the gold standard for testing as nucleic … acid amplification testing (or other standards reported by studies if nucleic acid amplification testing

15. Archived: Evidence Summary: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary17/brca-related-cancer-risk-assessment-genetic-counseling-and-genetic-testing-2013
    December 15, 2013 - by selective testing of high-risk persons. … Data were not available to determine the optimum age for testing and how the age at testing influences … Risk factor analysis and implications for genetic testing. JAMA . 1997;278:1242-50. … BRCA1 gene testing. … Benefit finding in response to BRCA1/2 testing. Ann Behav Med . 2008;35:61-9.

16. Liquid-Based Cytology and Human Papillomavirus Testing to Screen for Cervical Cancer: A Systematic Review for the U.S. Preventive Services Task Force (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/_9KLmyQyMnoE3agQJsgNE-
    November 01, 2011 - primary screening with HPV testing alone, primary HPV testing with cytology triage of positive HPV (reflex … Harms of HPV Testing Human papillomavirus testing could increase harms rel- ative to cytology by increasing … Efficacy of HPV DNA testing with cytology triage and/or repeat HPV DNA testing in primary cervical cancer … Human papillomavirus testing in the prevention of cervical cancer. … Cervical cancer screening with both human papillomavirus and Papanicolaou testing vs Papanicolaou testing

17. Archived: Breast and Ovarian Cancer: BRCA Genetic Testing, September 2005 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/breast-and-ovarian-cancer-brca-testing-screening-2005
    September 15, 2005 - archived Final Recommendation Statement Breast and Ovarian Cancer: BRCA Genetic Testing … Update in Progress for BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing … against routine referral for genetic counseling or routine breast cancer susceptibility gene (BRCA) testing … The impact of BRCA testing on ethical, legal, and social issues needs to be better clarified. … Risk factor analysis and implications for genetic testing. JAMA 1997;278:1242-50.

18. Archived: Cervical Cancer: Screening | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/recommendation/cervical-cancer-screening-2012
    March 15, 2012 - Grade: A Screen with cytology every 3 years or co-testing (cytology/HPV testing) every 5 years. … The benefits of screening with co-testing (cytology/HPV testing) every 5 years outweigh the harms. … Among women age 30 to 65 years, HPV testing combined with cytology (co-testing) every 5 years offers … may increase with HPV testing. … Women age 30 to 65 years should be screened with cytology and HPV testing (co-testing) every 5 years

19. Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Recommendation Statement (pdf file)
    www.uspreventiveservicestaskforce.org/home/getfilebytoken/ER_LzXdmdRcZ463r4UrGtz
    September 01, 2005 - Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Recommendation … Statement Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility … Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility. … The impact of BRCA testing on ethical, legal, and social issues needs to be better clarified. … Risk factor analysis and implications for genetic testing. JAMA. 1997; 278:1242-50.

20. Archived: Evidence Summary: Breast and Ovarian Cancer: BRCA Genetic Testing, September 2005 | United States Preventive Services Taskforce
    www.uspreventiveservicestaskforce.org/uspstf/document/evidence-summary/breast-and-ovarian-cancer-brca-testing-screening-2005
    September 15, 2005 - What are the benefits of genetic counseling before testing? … What Are the Benefits of Genetic Counseling before Testing? … BRCA1 gene testing. … Genetic testing for cancer susceptibility: indications for genetic testing. SEER Data. … What are the benefits of genetic counseling before testing?