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61. PROPOSALS FOR A PHASED EVALUATION OF (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/whitepaper3-lijmer02262010-2.pdf
    January 01, 2009 - Premature dissemination of testing technologies can lead to erroneous diagnoses and preventable delays … The ultimate question in decisions about testing is how much net gain from testing there will be for … The benefits from testing may be limited to a subset of those tested, so sample size requirements can … be substantial.45 Trials of testing need a well-defined protocol that links testing, results, and downstream … All of these practical problems are challenging but not insurmountable, and trials of testing can be

62. Hi Les, (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - Critical steps in the pathway between testing and patient outcomes, such as differences in test accuracy … These RCTs should have long-term followup to capture all immediate and downstream consequences of testing … It may involve no prior testing if the new test is intended for primary screening or for monitoring … Other pathways It is possible that the availability of D-dimer lowers the threshold for testing in … Additional patient outcomes and pathways in evaluations of testing.

63. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
    July 01, 2016 - Testing for the presence of HLA-DQ2 or HLA-DQ8 has excellent sensitivity and negative predictive value … For children younger than 2 years, the ACG guidelines recommend initial testing with tTG IgA, DGP IgA … a Sensitivity and specificity values are for point-of-care testing. b Sensitivity and specificity values … a Sensitivity and specificity values are for point-of-care testing. b Sensitivity and specificity values … Testing algorithms �� All algorithms studied used tTG tests.

64. Evidence-based Practice Center Systematic Review Protocol - Management of Infantile Epilepsies (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-252-infantile-epilepsies-disposition-comments.pdf
    October 25, 2022 - Since the report did not contain a Key Question or Contextual Question about genetic testing, it would … We did look through our database and identified some studies of genetic testing and genome sequencing … We did look through our database and identified some studies of genetic testing and genome sequencing … We did look through our database and identified some studies of genetic testing and genome sequencing … Thank you for this comment, AHRQ may consider genetic testing for future reports.

65. Work Plan for Methods Research on (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
    December 01, 2010 - from the 30 studies used for the first round of testing. … The same analyses were conducted for the second round of testing. … Pilot testing the tool in the context of each review is highly recommended. … The same analyses were conducted for the second round of testing. … We made minor revisions following the final round of testing that merit further testing.

66. Evidence-based Practice Center Systematic Review Protocol (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
    September 08, 2011 - Direct evidence of the impact of testing on health outcomes is shown by link A (morbidity, function … , quality of life and/or mortality) and link G (adverse events of testing). … An early link in an indirect chain of evidence concerns the diagnostic accuracy of testing (B). … HER2 Testing to Manage Patients With Breast Cancer or Other Solid Tumors. … The harms of the testing procedure itself would relate to venipuncture. II.

67. Cancer Quality-ASSIST Supportive Oncology Quality Indicator Set: Feasibility, Reliability, and Validity Testing (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/cancer-quality-indicator-testing_research.pdf
    April 01, 2010 - Cancer Quality-ASSIST Supportive Oncology Quality Indicator Set: Feasibility, Reliability, and Validity Testing … Quality-ASSIST supportive oncology quality indicator set: feasibility, reliability, and validity testing … Cancer Quality-ASSIST supportive oncology quality indicator set: feasibility, reliability, and validity testing … had both reliability and validity issues, leaving a set of 41 indicators most promising for further testing … communication are very different from those assessing discrete, concrete events like fecal occult blood testing

68. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
    December 22, 2014 - Standard basic testing for TB costs about $40, and drug susceptibility testing can add another $102 … As for susceptibility testing, compared with conventional culture-based susceptibility testing, the … Xpert MTB/RIF point-of- care testing had similar sensitivity to laboratory-based Xpert MTB/RIF testing … Xpert MTB/RIF into a TB diagnostic algorithm, TB testing without molecular testing was calculated … When all health-system costs were considered, TB testing without molecular testing was most costly

69. Disposition of Comments for PCA3 Testing for the Diagnosis and Management of Prostate Cancer (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_disposition-comments.pdf
    April 01, 2013 - Disposition of Comments for PCA3 Testing for the Diagnosis and Management of Prostate Cancer Comparative … Effectiveness Research Review Disposition of Comments Report Research Review Title: PCA3 Testing … PCA3 Testing for the Diagnosis and Management of Prostate Cancer. … None of the included studies had men enrolled due to results of PCA3 testing. … TEP # 11 General I read the report "PCA3 testing for ... " with interest.

70. Brooks_ECCS2012 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/brooks_eccs2012.pdf
    January 01, 2012 - Slide 13: Patient Decision Aid Image of Testing for Prostate Cancer: “Should  I be tested? … men. • There are  tests  to  find it early. • We don’t  yet  know  if the benefits of testing …  outweigh the risks. • Men  should learn  about  prostate cancer and testing,  then  decide … if testing  is the right  choice for them.

71. Methods Guide for Medical Test Reviews Chapter 6 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-applicability_methods.pdf
    July 01, 2012 - In trials is comparator no testing vs. usual care with ad hoc testing. … Bone density testing reported in relation to fracture risk reduction without consideration of prior … Order of testing varies across subjects and was not randomly assigned. … The literature included many studies that did not use gold standards or testing of normals and many … For example, we could not estimate clinical usefulness of HPV testing among older women from trends

72. Kidney Tests | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/kidney-tests

73. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
    January 28, 2016 - This is the inverse of the KQ4, the adverse effects of testing. … Would have liked more discussion about testing in the less than 3 yr old. … The reader may be under the impression that this test is on par with TTG testing. … —that do compare the performance of testing and the accuracy in standardized serum samples. … In addition, there are several studies that have examined variation between labs and in testing.

74. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
    September 06, 2016 - the diagnosis of asthma is challenging, given their inability to participate in the usual diagnostic testing … Comparators KQ 1.a: Standard diagnostic testing of asthma made by healthcare providers based on history … the available tests (Blood eosinophils, induced sputum, bronchalveolar lavage, allergy tests (skin testing … • Use of bronchodilators prior to FeNO testing • Whether appropriate testing protocol was followed … We will iteratively continue testing the form until no additional items or unresolved questions exist

75. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0404_01-14-2011.pdf
    January 01, 2011 - Intervention(s): Newer drugs (inhaled treprostinil and ambrisentan); combination therapies; use of testing … antagonists, prostanoids, endothelin antagonists, phosphodiesterase inhibitors); monotherapy; no use of testing … What are the optimal testing strategies and modalities (vasoreactivity, biomarker) for guiding the diagnosis

76. Infectious Disease Including HIV/AIDS #09 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
    December 01, 2015 - Standard basic testing for TB costs about $40, and drug susceptibility testing can add another $102 … As for susceptibility testing, compared with conventional culture-based susceptibility testing, the … Xpert MTB/RIF point-of- care testing had similar sensitivity to laboratory-based Xpert MTB/RIF testing … Xpert MTB/RIF into a TB diagnostic algorithm, TB testing without molecular testing was calculated … When all health-system costs were considered, TB testing without molecular testing was most costly

77. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
    August 23, 2012 - Followup testing was omitted as an intervention in the definition of KQ5, but the use of FLC, SPEP ( … The frequency of follow up testing in the various risk groups is certainly an area for more research … The IMWG criteria for progression and relapse only use SFLC testing in the absence of any other signs … Peer Reviewer #2 General Our clinical practice has incorporated FLC assays into testing for PCD. … compared to standard testing alone.

78. Evidence-Summary-Cer-197-Fractional-Exhaled-Nitric-Oxide (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-197-fractional-exhaled-nitric-oxide.pdf
    December 01, 2017 - Fractional exhaled nitric oxide (FeNO) testing has been suggested as a diagnostic test for asthma. … years) and children (ages of 5-18 years), using asthma management algorithms that incorporate FeNO testing … • FeNO testing can identify patients who are more likely to respond to inhaled corticosteroids (SOE … In children ages 0-4 years with recurrent wheezing, how accurate is FeNO testing in predicting the … Key Points • It is unclear whether FeNO testing in children at ages 0-4 years with symptoms suggestive

79. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research

80. Effective Health Care (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0488_12-27-2011.pdf
    January 01, 2011 - primarily adults) at high risk for pancreatic cancer (with signs or symptoms of the disease requiring testing … index.cfm/join-the-email-list1/ Topic Number: 0407 Document Completion Date: 02-14-12 2 invasive testing … (e.g., biopsies and surgery), unnecessary treatment (e.g., surgery), unnecessary further testing, and