-
effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
May 18, 2011 - Systematic Review May. 17, 2012 Disposition of Comments Report Comparative Effectiveness of Fecal DNA Testing … (FOBT) or fecal immunohistochemical testing (FIT) annually; and flexible sigmoidoscopy every 5 years … with or without fecal blood testing (FOBT or FIT). 3, 4
Some disagreement occurs between guideline … Question 6: Harms
What are the potential harms of fecal DNA testing? … FOBT = Fecal Occult-Blood Testing
USPSTF = U.S.
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effectivehealthcare.ahrq.gov/get-involved/nominated-topics/key-questions-1-does-routine-preoperative-testing-compared-to-no-testing-or-alternative-testing-strategies-improve-outcomes-such-as-surgical-complications-other-morbidity-and-mortality-among-patients-undergoing-elective-surge
February 10, 2011 - Key Questions
Does routine preoperative testing compared to no testing or alternative testing strategies … What are the harms of routine preoperative testing compared to no testing or to an alternative testing … compared to no testing or alternative testing. … It is unclear why routine preoperative testing is still widespread. … It is unclear why routine preoperative testing is still widespread.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0411_02-10-2011.pdf
January 01, 2011 - 09-12-11
1
Results of Topic Selection Process & Next Steps
Routine preoperative testing … improves
patient outcomes compared to patients receiving no preoperative testing or alternative
testing … Does routine preoperative testing compared to no testing or alternative testing
strategies improve outcomes … What are the harms of routine preoperative testing compared to no testing or to an
alternative testing … No recent comprehensive review related to preoperative testing in ambulatory surgery patients
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0334_08-04-2010.pdf
January 01, 2010 - Date: 3-22-11
1
Results of Topic Selection Process & Next Steps
Pharmacogenetic testing … Intervention(s): Genetic testing for CYP2C19 variants to guide treatment selection. … Comparator(s): A no-testing (for CYP2C19 variants) strategy or a strategy of testing for
Pharmacogenetic … who are candidates for clopidogrel treatment,
compared to alternative testing strategies or a no-testing … strategies or a no-
testing strategy?
-
effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
November 22, 2011 - Randomized trials of testing strategies versus no-testing strategies can address the question of whether … the use of testing (e.g., genetic testing to determine CYP2C19 status or phenotypic testing of platelet … Genetic testing for CYP2C19
Genetic testing for CYP2C19 followed by phenotypic testing for platelet … reactivity
Phenotypic testing for platelet reactivity
No testing
How do modifying factors (e.g … Use of phenotypic testing (but not genetic testing) as a monitoring test can be considered as a variation
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effectivehealthcare.ahrq.gov/health-topics/lupus-0
March 07, 2012 - March 7, 2012
Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Testing
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effectivehealthcare.ahrq.gov/health-topics/prader-willi-syndrome
September 30, 2014 - Genetic Testing for Developmental and Intellectual Disabilities
Research Protocol
Archived
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effectivehealthcare.ahrq.gov/products/prostate-cancer-test
October 14, 2011 - PCA3 Testing for the Diagnosis and Management of Prostate Cancer
Timeline
May 04, 2011 … Initiated
October 14, 2011
Research Protocol
Archived
PCA3 Testing … of Prostate Cancer
April 01, 2013
Systematic Review
Archived
PCA3 Testing
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effectivehealthcare.ahrq.gov/products/antiplatelet-treatment
November 22, 2011 - Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment … Topic Initiated
November 22, 2011
Research Protocol
Archived
Testing … Antiplatelet Treatment
September 25, 2013
Systematic Review
Archived
Testing
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effectivehealthcare.ahrq.gov/health-topics/neurologic-diseases
May 20, 2013 - Treatments for Low Back Pain
Consumer Summary
Archived
November 15, 2016
Noninvasive Testing … Coronary Artery Disease
Systematic Review
Archived
March 29, 2016
Noninvasive Testing … ) Depression: A Systematic Review
Research Protocol
August 31, 2016
Genetic Testing … and Autism Spectrum Disorder
Technical Brief
Archived
June 30, 2015
Genetic Testing
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
July 01, 2012 - Direct health effects of testing
Emotional, cognitive, social, behavioral re-
sponses to testing … Legal, ethical effects of testing
Costs
Outcome Origins
From Testing Process
From Test Results … Legal and ethical effect of testing. … Legal and ethical effects of testing. … Legal and ethical effects of testing.
-
effectivehealthcare.ahrq.gov/products/machine-learning-tool
November 03, 2020 - Testing a Machine Learning Tool for Facilitating Living Systematic Reviews of Chronic Pain Treatments … 2020
Topic Initiated
November 03, 2020
Research Report
Testing
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
April 01, 2013 - Patients with elevated
PCA3 values PCA3 testing
Current standard of
care without PCA3
testing … aggressive therapy
PCA3 testing
Current standard of
care without PCA3
testing
Decision to
biopsy … Patients with
elevated PCA3
values
PCA3
testing
Current
standard of
care without
PCA3
testing … or standard testing alone. … or standard testing alone.
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effectivehealthcare.ahrq.gov/get-involved/nominated-topics/for-women-when-comparing-noninvasive-testingwhich-testing-method-echocardiography-mibi-spect-pharmacological-testing-etc-is-more-accurate-in-diagnosing-coronary-artery-disease-there-has-been-inadequate-studies-done-on-women-f
April 10, 2009 - For women, when comparing noninvasive testing,which testing method (echocardiography, MIBI-SPECT, pharmacological … testing, etc.) is more accurate in diagnosing coronary artery disease. … Nuclear stress testing compared with echocardiographic stress testing has not been adequately compared … and risks associated with more invasive testing. … is needed for the newer stress testing methods and comparison of these methods.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
September 25, 2013 - for
CYP2C19 variants and phenotypic testing for platelet reactivity,
focusing on standardizing testing … This appears to be a very rigorous review of platelet
function testing and CYP2C19 genetic testing for … We reviewed several studies comparing testing versus
no-testing strategies for tests measuring platelet … Use of phenotypic
testing (but not genetic testing) as a monitoring test can be
considered a variation … Pharmacokinetic and
pharmacodynamic testing (such as platelet function testing) in
healthy volunteers
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-533_05-24-2013.pdf
January 01, 2013 - Testing … The current strategy for diagnosing CD involves serial serologic and
histopathologic testing. … After initial evaluation and testing for iron, folate and vitamin B12
deficiencies and ruling out other … Objective 4 - Expected consequences of testing for CD (Celiac 4)
a. … What are the expected consequences of testing for CD in the following populations:
i.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
June 01, 2012 - Setting Who will use the prognostic test; how the test will be used; what the applicable testing scenario … Cost-effectiveness: Do the improvements in patient outcomes justify the additional costs of testing and … Were the subjects somehow referred or selected for testing? What was the testing scenario? … The second question asks about the subject selection and testing scenario. … Subpart A asks about uniformity of testing across all sites or all studies being reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
June 01, 2012 - Setting Who will use the prognostic test; how the test will be used; what the applicable testing scenario … Cost-effectiveness: Do the improvements in patient outcomes justify the additional costs of testing and … Were the subjects somehow referred or selected for testing? What was the testing scenario? … The second question asks about the subject selection and testing scenario. … Subpart A asks about uniformity of testing across all sites or all studies being reported.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/preoperative-testing_disposition-comments.pdf
January 29, 2014 - vs
non-testing. … versus not testing (or other
protocols for testing). … routine or per protocol vs. ad hoc testing. … One of the key issues of preoperative testing is that more testing
may be required in places less able … The study evaluates all
preoperative testing.
-
effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research-protocol
October 14, 2011 - Research Protocol Apr. 1, 2013 Systematic Review Jul. 31, 2013 Disposition of Comments Report PCA3 Testing … These programs are based on the premise that PSA testing can lead to early detection of prostate cancer … However, testing total PSA levels to decide which patients should undergo a biopsy has been found to … by and used at a single laboratory testing site). … The Key Questions (KQs) present three proposed scenarios in which this testing may be used.