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  1. effectivehealthcare.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
    January 01, 2012 - However, a negative result could help some women avoid more invasive testing. … (San Diego, CA; manufacturer of the testing platform), and stated intentions of filing a premarket … , citing the potential for miscarriages associated with current invasive testing and the desire of … However, a health systems expert noted the opaque nature of the genetic testing method, which could … Invasive prenatal testing for aneuploidy.
  2. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-search-strategies.ppt
    June 01, 2012 - Another task in the first step is to choose the important outcomes that result from the testing encounter … evolving and a new testing strategy may not yet be a named test. … Using a search string to capture the diagnostic testing concept was not necessary. … Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure. … Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/catd-protocol-draft_0.pdf
    November 02, 2018 - Neuropsychological testing may quantify the severity of cognitive impairment and the pattern of cognitive … However, access to comprehensive neuropsychological testing is limited in many clinical settings. … Currently there are no evidence-based guidelines about the merits of either brief cognitive testing … or comprehensive neuropsychological testing in this patient population. … Additional diagnostic testing outcomes will be considered for SOE grading when available data allow.
  4. effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-complaints-tests-children_research-protocol.pdf
    September 29, 2010 - Protocol Project Title: Antinuclear Antibody, Rheumatoid Factor, and Cyclic- Citrullinated Peptide Testing … No systematic reviews examining ANA for pediatric SLE or RF and CCP testing for JIA were identified … of symptoms KQ.3: What are the diagnostic performance characteristics of the ANA, RF, and CCP testing … Antinuclear antibody (ANA) testing. Pediatr Rev 2003;24:320-1. 4. Syed RH, Gilliam BE, Moore TL. … Anti-CCP antibody testing as a diagnostic and prognostic tool in rheumatoid arthritis.
  5. Layout 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer_executive.pdf
    February 01, 2008 - Largely because of widespread PSA testing, the lifetime risk of being detected with prostate cancer in … PSA testing detects more tumors, at an earlier stage, with smaller volume within each stage, and at an … Few enrolled men had prostate cancers waiting detected by PSA testing. … Prostate cancers not detected by PSA testing. … Only 5% of enrollees had prostate cancer detected by PSA testing.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
    January 01, 2010 - One key issue relates to the microbiological testing method applied. … The systematic review, however, will distinguish among screening that uses a testing modality with … (results available on the same day as the testing is performed); or (2). … after testing is performed); or (3). … available >2 days after testing is performed); b.
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-function_executive.pdf
    August 01, 2014 - Clinically, the most important use of troponin testing is to identify patients suspected of having … If the patient presents late in the course of ACS, testing could take place during the “plateau phase … Previous reviews and meta-analyses have investigated the prognostic performance of troponin testing … 1.5 Among studies that directly compared troponin testing in patients with CKD versus patients with … Should cardiac troponin testing include other diagnostic tests, such as stress testing or echocardiography
  8. effectivehealthcare.ahrq.gov/sites/default/files/ch_5-user-guide-to-ocer_130129.pdf
    January 01, 2012 - Therefore, in many clinical circumstances, “no treatment” or “no testing” may not meet usual standards … Comparison with alternative treatment or testing within the same or similar indication is usually a … However, when different treatments or testing modalities are recommended for patients with varying … The standard care could be no treatment or no testing, a single treatment or testing, or a set of existing … treatment or testing modalities.
  9. effectivehealthcare.ahrq.gov/health-topics/thyroid-tests
  10. effectivehealthcare.ahrq.gov/health-topics/laboratory-tests
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-topics_methods.pdf
    July 01, 2012 - medical test review are: to identify and synthesize evidence to evaluate the impacts of alternative testing … The analytic framework was of limited value, as several possible relevant testing strategies were not … The testing strategy in the lower portion of the decision tree entails performing biopsy in all patients … Noninvasive carotid artery testing. A meta- analytic review. … HER2 Testing to Manage Patients With Breast Cancer or Other Solid Tumors.
  12. effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
    January 01, 2013 - achieve Possible Difficult to characterize sampling properties (e.g., confidence intervals) Power of testing … relating to subgroup effects, and a detailed description of the statistical analytical plan on how testing … Evaluate chance findings by testing for interaction. Avoid bias by adhering to sound study design. … To do this, chance findings should be evaluated by testing for interaction; biases should be avoided … significance If confirmatory analyses, do power calculations Describe methods to adjust for multiple testing
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_executive.pdf
    December 01, 2015 - Rationale for Evidence Review Accurate testing of patients presenting with symptoms consistent with … For the populations listed under Key Question 1a, what is the effect of alternative testing strategies … What factors modify the comparative effectiveness of testing for patients with RLQ pain and suspected … It is likely that the lack of separation between the training and testing datasets led to optimistic … Adverse Events of Testing Information on harms was often incomplete and poorly reported.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_disposition-comments.pdf
    March 07, 2012 - We have indicated that IIF is the gold standard for ANA testing and have referenced the ACR consensus … I am not sure that the authors have a clear understanding of ANA testing. … the utility of ANA testing in children with MSK pain. … We have reworded the introduction to address changes in ANA testing (p 2-3). … The authors do not address the issue of changes in ANA testing at all.
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
    March 15, 2010 - Preoperative testing People with sleep apnea are at increased risk of surgical and anesthesia-related … KQ3: How does phased testing (screening tests or battery followed by full test) compare to full testing … Key question 3 evaluates phased testing. We will not otherwise review the order of testing. … to receive general anesthesia KQ 5-7 • Diagnosed with obstructive sleep apnea (OSA) o Formal testing … For program testing and training purposes, we will manually screen 1000 abstracts, each twice.
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/echocardiography_research.pdf
    May 01, 2014 - 12 The criteria vary by previous service and clinical indication, but in gen- eral echocardiography testing … unclear - in the case of stress echo- cardiography, the relationship between the office location of testing … material and increased cost of care after testing is modest.13 However, evidence indicates that physicians … : an empiric analysis of cardiac stress testing with imaging. … Repeat testing among Medicare beneficiaries. Arch Intern Med 2012;172(22):1745-51. 19.
  17. effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-function_research-protocol.pdf
    June 13, 2013 - Previous reviews and meta-analyses have investigated the prognostic performance of troponin testing … Note that for the population with suspected ACS (KQ 1-3), biomarker testing is done so routinely as … part of standard care that “no testing” is not a realistic comparator. … hs troponin I Troponin testing in CKD vs non-CKD Troponin testing vs. … • For the population with suspected ACS (KQ 1-3), biomarker testing is done so routinely as part
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0651-131114.pdf
    June 20, 2013 - Strategies include testing (e.g., imaging tests), decision tools, identifying risk factors for chronicity … Patients with low back pain Intervention(s): Procedures to diagnose and treat low back pain, including: testing
  19. effectivehealthcare.ahrq.gov/products/prostate-cancer-antigen-3-gene/research
  20. Project Name: (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/sleep-apnea_disposition-comments.pdf
    October 25, 2011 - Phase testing is basically a non-productive use of time and money. … Of the 53 patients randomized to testing by PM, 4 patients were without OSA. … Of the 53 patients randomized to testing by PSG, 6 were without OSA. … be missed because of night-to-night variation inherent in the PSG testing process. … results of initial tests) with full testing (overnight PSG) alone.

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