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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
    January 01, 2005 - Sensitivity and Specificity Sensitivity, also known as the true positive rate, is the probability of testing … Specificity, or true negative rate, is the probability of testing negative for non-diseased patients
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
    April 01, 2013 - 1 Comparative Effectiveness Review Number 98 PCA3 Testing for the Diagnosis and Management of Prostate … subjects/populations (at-risk men or men with a positive biopsy); (3) study interventions (biomarker testing … KQ 3: Testing PCA3 and Comparators To Identify Men With Insignificant Cancer Who May Benefit From Active … Screening for prostate cancer with prostate-specific antigen testing: American Society of Clinical … PCA3 Testing for the Diagnosis and Management of Prostate Cancer.
  3. effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
    June 12, 2014 - The validity and acceptability of the various diagnostic testing regimens and criteria have remained … Finally, in response to a comment about how previously negative testing affects test accuracy, we added … c- length of time ingesting gluten before diagnostic testing? … , including race, genetics, geography, SES e- Patients with IgA deficiency f- Patients previously testing … Positive and negative likelihood ratios • For KQ 1b, for Clinical decision-making o Additional testing
  4. effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-269-respectful-maternity-care-summary.pdf
    January 01, 2024 - • RMC tools have not been subject to widespread testing and no single validated tool stands out … • Alongside the urgent need to implement RMC, goals for RMC must include further testing of reliable … concept of respectful maternity care is still being defined, a critical step towards wider outcomes testing … Before widespread implementation of tools to measure RMC, further testing of current measures and a
  5. effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
    January 24, 2022 - , N (%) Comorbidities, N (%) Assay Type Assay Brand Definition of a positive test Frequency of Ab testing … over the course of the study 05/2020 - 01/2021 Unvacinated, recovered individuals who had a history of testing … stratified, N (%) Male Sex/Gender, N (%) Comorbidities, N (%) Assay Type Assay Brand Frequency of Ab testing … Qatar with RT-PCR test results Centralized and standardized national anti-SARS-CoV-2 serological testing … every 2 weeks; Antibody testing every 4 weeks; Questionnaires re symptoms and exposures every 2 weeks
  6. effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-goold-2.pdf
    May 29, 2025 - questioning by participants • Problem – may assume adversarial positions  Pretesting, cognitive testing
  7. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_disposition-comments.pdf
    November 27, 2012 - testing of persons aged 45-65). … Peer Reviewer # 6 Results It is not clear why this testing algorithm was chosen. … They cannot make this decision if they are not offered testing. … Guidelines for Laboratory Testing and Result Reporting of Antibody to Hepatitis C Virus. … Inadequate testing represents a barrier to treatment.
  8. effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-frameworks.ppt
    June 01, 2012 - Potential adverse consequences of testing. … What are possible adverse consequences of testing? … HER2 testing to manage patients with breast cancer or other solid tumors. … Show one set of possible outcomes that result from testing. … Noninvasive carotid artery testing. A meta-analytic review.
  9. effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-frameworks.ppt
    June 01, 2012 - Potential adverse consequences of testing. … What are possible adverse consequences of testing? … HER2 testing to manage patients with breast cancer or other solid tumors. … Show one set of possible outcomes that result from testing. … Noninvasive carotid artery testing. A meta-analytic review.
  10. S89 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
    October 01, 2007 - Sequential testing procedures are needed to detect vaccine or drug safety problems as soon as possible … The analysis used maximized sequential prob- ability ratio testing (maxSPRT), a new signal detection … However, repeated statistical testing of accu- mulating data requires special methods. … For the purposes of evaluating our surveil- lance system and testing outcome definitions for future vac … Results of Historical Expected Count Analysis Using Maximized Sequential Probability Ratio Testing to
  11. Slide 1 (pdf file)

    effectivehealthcare.ahrq.gov/sites/default/files/cf_deliberativemethodswebinar_educatingsessionparticipants.pdf
    May 29, 2025 - questioning by participants – Problem – may assume adversarial positions • Pretesting, cognitive testing
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
    August 05, 2010 - What are the postulated advantages and disadvantages of positional MRI testing compared to contemporary … Guiding question 2: What is the current availability and cost of positional MRI testing and what are … Approximately how many facilities and of what kind are currently providing positional MRI testing in … etiology (i.e. undiagnosed by conventional diagnostic imaging) Interventions • Positional MRI testing … Moreover, we will record the outcomes being assessed in each study, including testing related harms,
  13. effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-active-infection-rapid-response.pdf
    May 01, 2024 - Additionally, owing to the overlapping findings of the C. difficile testing chapter in MHS III, our … rapid response also subsumes the C. difficile surveillance and testing topics as they relate to ASC … difficile testing in 2017 has led to an acceleration in publications evaluating C. difficile testing … Holding firm: Use of clinical correlation to improve Clostridioides difficile testing. … , time to testing, and mandatory reporting.
  14. effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
    April 01, 2013 - • There were no studies of the safety of biomarker and echocardiography testing, nor were there any … We found no studies describing the safety (or harms) of echocardiography or biomarker testing. … study design did not allow for NT-proBNP testing to improve sensitivity beyond that of echo sPAP … Data on biomarker testing were essentially limited to a single test—NT-proBNP—which showed moderate … • Cardiopulmonary exercise testing and exercise echocardiography have yielded relatively few data,
  15. effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
    September 24, 2024 - refers to non- individualized treatment that is not based on stone composition or metabolic laboratory testing … studies, also known as targeted therapy.1 However, targeted therapy that relies on urine metabolic testing … American College of Physicians (ACP) Guidelines found insufficient evidence to recommend metabolic testing … Do harms vary by blood or urine chemistry or genetic testing performed as followup after treatment is …  Test(s)  Method/Processing o Followup testing  Test(s)  Method/Processing • Recruitment
  16. effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
  17. effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-search_methods.pdf
    July 01, 2012 - search for the concept of diagnosis, screening or prognosis may not be necessary.2, 3 But because testing … In the AHRQ report, Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure,25 … on the names of these tests and did not need to include a search string to capture the diagnostic testing … For this reason, the search strategy included a search string meant to capture the diagnostic testing … Balion, C., et al., Testing for BNP and NT- proBNP in the Diagnosis and Prognosis of Heart Failure.
  19. effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
    January 01, 2013 - result in confounding by severity if not adequately controlled through design/analysis No treatment/testing … However, when different treatments or testing modalities are recommended for patients with varying levels … time) Spectrum of Possible Comparisons (2 of 3) Usual or Standard Care When a new treatment or testing … Standard care could be no treatment or no testing, a single treatment or testing, or a set of existing … treatment or testing modalities.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
    December 09, 2013 - on clinical grounds surgical consultation should be sought without delay for additional diagnostic testing … Furthermore, diagnostic testing can impact resource utilization for the management of patients with … Direct harms of testing (e.g., harms from exposure to ionizing radiation, allergic reactions/kidney … Studies meeting these criteria will be included regardless of the specific role of testing evaluated … (2) Randomized controlled trials of alternative testing strategies including at least 10 patients

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