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effectivehealthcare.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
January 01, 2005 - Sensitivity and Specificity
Sensitivity, also known as the true positive rate, is the probability of testing … Specificity,
or true negative rate, is the probability of testing negative for non-diseased patients
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
April 01, 2013 - 1
Comparative Effectiveness Review
Number 98
PCA3 Testing for the Diagnosis
and Management of Prostate … subjects/populations (at-risk men
or men with a positive biopsy); (3) study interventions
(biomarker testing … KQ 3: Testing PCA3 and Comparators To Identify
Men With Insignificant Cancer Who May Benefit
From Active … Screening for prostate cancer
with prostate-specific antigen testing: American Society of Clinical … PCA3 Testing for the
Diagnosis and Management of Prostate Cancer.
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effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
June 12, 2014 - The validity and acceptability of the various diagnostic testing regimens and criteria have
remained … Finally, in response to a
comment about how previously negative testing affects test accuracy, we added … c- length of time ingesting gluten before diagnostic testing? … , including race, genetics, geography, SES
e- Patients with IgA deficiency
f- Patients previously testing … Positive and negative likelihood ratios
• For KQ 1b, for Clinical decision-making
o Additional testing
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-269-respectful-maternity-care-summary.pdf
January 01, 2024 - • RMC tools have not been subject to widespread testing and no single validated
tool stands out … • Alongside the urgent need to implement RMC, goals for RMC must include
further testing of reliable … concept of respectful maternity care is still being defined, a critical step
towards wider outcomes testing … Before widespread implementation of tools to measure
RMC, further testing of current measures and a
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19-appendix-table-B-1.xlsx
January 24, 2022 - , N (%) Comorbidities, N (%) Assay Type Assay Brand Definition of a positive test Frequency of Ab testing … over the course of the study 05/2020 - 01/2021 Unvacinated, recovered individuals who had a history of testing … stratified, N (%) Male Sex/Gender, N (%) Comorbidities, N (%) Assay Type Assay Brand Frequency of Ab testing … Qatar with RT-PCR test results
Centralized and standardized national anti-SARS-CoV-2 serological testing … every 2 weeks;
Antibody testing every 4 weeks;
Questionnaires re symptoms and exposures every 2 weeks
-
effectivehealthcare.ahrq.gov/sites/default/files/delilberative-methods-design-goold-2.pdf
May 29, 2025 - questioning by participants
• Problem – may assume adversarial positions
Pretesting, cognitive testing
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_disposition-comments.pdf
November 27, 2012 - testing of persons aged 45-65). … Peer Reviewer # 6 Results It is not clear why this testing algorithm was chosen. … They
cannot make this decision if they are not offered testing. … Guidelines for Laboratory Testing and Result Reporting of Antibody to Hepatitis C
Virus. … Inadequate testing represents a barrier to treatment.
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-frameworks.ppt
June 01, 2012 - Potential adverse consequences of testing. … What are possible adverse consequences of testing? … HER2 testing to manage patients with breast cancer or other solid tumors. … Show one set of possible outcomes that result from testing. … Noninvasive carotid artery testing. A meta-analytic review.
-
effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-frameworks.ppt
June 01, 2012 - Potential adverse consequences of testing. … What are possible adverse consequences of testing? … HER2 testing to manage patients with breast cancer or other solid tumors. … Show one set of possible outcomes that result from testing. … Noninvasive carotid artery testing. A meta-analytic review.
-
effectivehealthcare.ahrq.gov/sites/default/files/s89.pdf
October 01, 2007 - Sequential testing procedures are needed to
detect vaccine or drug safety problems as soon as possible … The analysis used maximized sequential prob-
ability ratio testing (maxSPRT), a new signal detection … However, repeated statistical testing of accu-
mulating data requires special methods. … For the purposes of evaluating our surveil-
lance system and testing outcome definitions for future vac … Results of Historical Expected Count Analysis Using Maximized Sequential Probability Ratio Testing to
-
effectivehealthcare.ahrq.gov/sites/default/files/cf_deliberativemethodswebinar_educatingsessionparticipants.pdf
May 29, 2025 - questioning by participants
– Problem – may assume adversarial positions
• Pretesting, cognitive testing
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
August 05, 2010 - What are the postulated advantages and disadvantages of positional MRI testing
compared to contemporary … Guiding question 2:
What is the current availability and cost of positional MRI testing and what are … Approximately how many facilities and of what kind are currently providing
positional MRI testing in … etiology (i.e. undiagnosed by
conventional diagnostic imaging)
Interventions
• Positional MRI testing … Moreover, we will record the outcomes being
assessed in each study, including testing related harms,
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effectivehealthcare.ahrq.gov/sites/default/files/related_files/mhs4-active-infection-rapid-response.pdf
May 01, 2024 - Additionally, owing to the
overlapping findings of the C. difficile testing chapter in MHS III, our … rapid response
also subsumes the C. difficile surveillance and testing topics as they relate to ASC … difficile testing in 2017 has led to an acceleration in publications evaluating C. difficile
testing … Holding firm: Use of
clinical correlation to improve Clostridioides difficile testing. … , time to testing, and mandatory reporting.
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
April 01, 2013 - • There were no studies of the safety of biomarker and
echocardiography testing, nor were there any … We found no studies describing the safety (or harms) of
echocardiography or biomarker testing. … study design did not allow for
NT-proBNP testing to improve
sensitivity beyond that of echo
sPAP … Data on
biomarker testing were essentially limited to a single
test—NT-proBNP—which showed moderate … • Cardiopulmonary exercise testing and exercise
echocardiography have yielded relatively few data,
-
effectivehealthcare.ahrq.gov/sites/default/files/related_files/kidney-stones-protocol.pdf
September 24, 2024 - refers to non-
individualized treatment that is not based on stone composition or metabolic laboratory testing … studies, also known as targeted therapy.1 However,
targeted therapy that relies on urine metabolic testing … American College of Physicians (ACP) Guidelines found insufficient evidence to
recommend metabolic testing … Do harms vary by blood or urine chemistry or genetic testing performed as followup after
treatment is … Test(s)
Method/Processing
o Followup testing
Test(s)
Method/Processing
• Recruitment
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effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research-protocol
-
effectivehealthcare.ahrq.gov/products/antiplatelet-treatment/research
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-search_methods.pdf
July 01, 2012 - search for the concept of
diagnosis, screening or prognosis may not be necessary.2, 3 But because testing … In the AHRQ report,
Testing for BNP and NT-proBNP in the Diagnosis and Prognosis of Heart Failure,25 … on the
names of these tests and did not need to include a search string to capture the diagnostic testing … For this reason, the search
strategy included a search string meant to capture the diagnostic testing … Balion, C., et al., Testing for BNP and NT-
proBNP in the Diagnosis and Prognosis of
Heart Failure.
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effectivehealthcare.ahrq.gov/sites/default/files/comparator-selection-in-observational-chapter-5.pptx
January 01, 2013 - result in confounding by severity if not adequately controlled through design/analysis
No treatment/testing … However, when different treatments or testing modalities are recommended for patients with varying levels … time)
Spectrum of Possible Comparisons (2 of 3)
Usual or Standard Care
When a new treatment or testing … Standard care could be no treatment or no testing, a single treatment or testing, or a set of existing … treatment or testing modalities.
-
effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
December 09, 2013 - on
clinical grounds surgical consultation should be sought without delay for additional
diagnostic testing … Furthermore, diagnostic testing can impact
resource utilization for the management of patients with … Direct harms of testing (e.g., harms from exposure to ionizing radiation,
allergic reactions/kidney … Studies meeting these criteria will be included regardless of the specific role of
testing evaluated … (2) Randomized controlled trials of alternative testing strategies including at least 10
patients