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  1. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
    July 01, 2012 - The links between testing, test results, and patient outcomes are typically complex: even when testing … In most cases of evaluating medical testing, some type of formal modeling will be useful. … Table 10–2 classifies the results of PET testing. Table 10–2. … Patients without suggestive clinical examination are not candidates for PET testing. … Additional patient outcomes and pathways in evaluations of testing.
  2. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0095_04-10-2009.pdf
    January 01, 2009 - Noninvasive technologies for the diagnosis of CAD including echocardiography, MIBI-SPECT, pharmacologic testing … , stress testing, etc. … Noninvasive technologies for the diagnosis of CAD including echocardiography, MIBI SPECT, pharmacologic testing … , stress testing, etc. … Additionally, reduction in cost and unnecessary repeat testing.
  3. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
    March 13, 2012 - (This report will tabulate a listing of publications that used GEP testing and included patients with … What are the potential benefits and harms of this testing compared to current practice? e. … Is GEP testing a replacement or add-on technology? f. … Question 4 What important issues are raised by using GEP testing for stage II colon cancer? … Genomic Testing: ACCE Model Process for Evaluating Genetic Tests.
  4. effectivehealthcare-admin.ahrq.gov/products/genetic-tests-validity-rating-evaluation/research
    November 01, 2017 - Structured Abstract Objectives This project pursued four objectives related to genetic testing: ( … 1) assess the feasibility of clarifying a set of evaluation frameworks for common testing scenarios; … Consequently, a set of analytic frameworks for common genetic testing scenarios (diagnosis, screening … , prognosis assessment, treatment monitoring, pharmacogenetics, risk/susceptibility assessment, and testing … Significant gaps were identified in evidence on genetic testing variability.
  5. effectivehealthcare-admin.ahrq.gov/products/rtc-design-principles/research
    January 01, 2019 - Critical steps in the pathway between testing and patient outcomes, such as differences in test accuracy … These RCTs should have long-term followup to capture all immediate and downstream consequences of testing … Such uncertainty may arise if further testing occurs before treatment or if other clinical factors or … Other pathways It is possible that the availability of D-dimer lowers the threshold for testing in … Additional patient outcomes and pathways in evaluations of testing.
  6. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
    August 01, 2012 - or IFE), compared with traditional testing alone, improve the diagnostic accuracy for PCDs (MGUS, … to traditional testing on diagnostic performance as insufficient. … SFLC Assay and Diagnostic Testing (KQ1) The addition of SFLC testing to traditional tests of electrophoresis … However, it was not possible to determine whether SFLC testing is superior to traditional 10 testing … Few studies were available for specific comparisons between SFLC testing and traditional testing; the
  7. effectivehealthcare-admin.ahrq.gov/health-topics/laboratory-tests
    November 27, 2018 - Alzheimer's-type Dementia (CATD) Systematic Review Archived September 25, 2013 Testing … Thromboembolism Among Special Populations Research Protocol Archived November 22, 2011 Testing … Report November 9, 2009 Additional Patient Outcomes and Alternative Pathways in Evaluations of Testing
  8. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/reliability-testing-grading-evidence_research.pdf
    May 01, 2012 - non-randomized studies of interventions or exposures Methods Research Report Reliability Testing … v Reliability Testing of the AHRQ EPC Approach to Grading the Strength of Evidence in Comparative … We conducted inter-rater reliability testing using data obtained from two published CERs. … Methods We conducted the inter-rater reliability testing using data obtained from two published CERs … Table A summarizes inter-rater testing results. ES-3 Table A.
  9. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
    January 01, 2010 - Outcome(s): Intermediate outcomes – diagnostic accuracy for detection of tumor; adverse events of testing … active surveillance vs. active treatment) lead to improvements in health outcomes compared to a no-testing … What are the potential harms of testing or subsequent management options associated with use of the … Having a tool with enhanced diagnostic specificity that improves diagnostic testing may partially reduce … While there are currently several guidelines addressing total PSA testing and prostate cancer screening
  10. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_disposition-comments.pdf
    May 20, 2013 - Our decision to exclude breath testing was confirmed with the Key Informants. … WMC testing resulted in changes in management in 84% of patients. … as surrogates for motility testing or to exclude alarm conditions. … The Use of Colonic Testing to Guide Treatment in the Introduction chapter now states, “If testing confirms … “established” standards of upper and lower gut motility testing.
  11. effectivehealthcare-admin.ahrq.gov/products/antibiotics-respiratory-infection/research
    December 01, 2019 - improved or reduced prescribing, but evidence on adverse consequences was lacking (streptococcal antigen testing … , rapid multiviral testing in adults), insufficient (clinician and patient education plus audit and feedback … plus academic detailing), or mixed (delayed prescribing, C-reactive protein [CRP] testing, clinician … communication training, communication training plus CRP testing). … clinic-based education for parents of children 24 months or younger with acute otitis media, point-of-care testing
  12. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis-future_research_1.pdf
    February 01, 2013 - or layered-testing strategies)? … layered-testing strategies? … or layered-testing strategies)? … or layered-testing strategies? … multiple testing or layered-testing strategies?
  13. effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-applicability/methods
    December 01, 2019 - In trials is comparator no testing vs. usual care with ad hoc testing. … Change in sequence of other testing. Change in sequence/intensity of care. … Order of testing varies across subjects and was not randomly assigned. … As lipid testing moved into preventive care, the proportion of individuals with cardiovascular disease … The literature included many studies that did not use gold standards or testing of normals, and many
  14. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/making-healthcare-safer-IV.pdf
    August 04, 2023 - Additionally, owing to the overlapping findings of the C.difficile testing chapter in MHS III, our … rapid response will also subsume the C.difficile surveillance and testing topics as it relates to active … surveillance, along with screening and testing in asymptomatic patients. … in 2017, there has been an acceleration in publications evaluating C.difficile testing and diagnostic … of surveillance cannot be evaluated • Testing stewardship interventions • No microbial organism
  15. effectivehealthcare-admin.ahrq.gov/products/celiac-disease/clinician
    December 01, 2019 - For children younger than 2 years, the ACG guidelines recommend initial testing with tTG IgA, DGP IgA … Testing for the presence of HLA-DQ2 or HLA-DQ8 has excellent sensitivity and negative predictive … a Sensitivity and specificity values are for point-of-care testing. … Testing algorithms All algorithms studied used tTG tests. … Based on 1 previous systematic review, EmA IgA testing has a sensitivity of 90 percent (95% confidence
  16. Decision Modeling (ppt file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/medical-test-reviews-decision-modeling.ppt
    June 01, 2012 - Links between testing, test results, and patient outcomes are complex. … Example: HIV testing Direct effects: Emotional distress from the testing process, cognitive/emotional … For example, testing for HIV has both direct and indirect effects. … summary testing performance (e.g., sensitivity, specificity). … The table shown classifies the results of PET testing.
  17. Decision Modeling (ppt file)

    effectivehealthcare-admin.ahrq.gov/sites/default/files/medical-test-reviews-decision-modeling.ppt
    June 01, 2012 - Links between testing, test results, and patient outcomes are complex. … Example: HIV testing Direct effects: Emotional distress from the testing process, cognitive/emotional … For example, testing for HIV has both direct and indirect effects. … summary testing performance (e.g., sensitivity, specificity). … The table shown classifies the results of PET testing.
  18. effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
    May 01, 2013 - We found two studies evaluating WMC as an add-on to other testing. … Consensus guidelines suggest that WMC testing is a replacement for current testing methods, however … The next series of questions asked about the incremental value of WMC testing in addition to other testingtesting. … We found two studies evaluating WMC as an add-on to other testing.
  19. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antibiotics-respiratory-infection_executive.pdf
    January 01, 2016 - Rapid Streptococcus Antigen Testing. … C-Reactive Protein Testing. … The combination of communication training and CRP testing was not different from CRP testing alone … + Procalcitonin testing + Rapid strep testing + Combination of patient and provider education plus audit … training, communication training plus CRP testing).
  20. effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
    September 01, 2013 - Genetic testing for CYP2C19 ii. … Genetic testing for CYP2C19 followed by phenotypic testing for platelet reactivity iii. … Phenotypic testing for platelet reactivity iv. No testing b. … Use of phenotypic testing (but not genetic testing) as a monitoring test can be considered a variation … Combined Testing for CYP2C19 Variants and Phenotypic Testing To Guide Antiplatelet Treatment Of the

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