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501. Disposition of Comments for Pulmonary Arterial Hypertension: Screening, Management, and Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_disposition-comments.pdf
     April 25, 2013 - with symptoms suggestive of PAH who have elevated systolic PAP by echocardiography with a biomarker test … ) not rule in A specific test allows me to rule in disease (few false positive tests) not rule out. … We agree that there may be many reasons for an association between test results and clinical outcomes … This stepwise addition of therapy does not test the efficacy of combination versus monotherapy. … screening test.

502. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/fibromyalgia-very-few-doctors-know-how-to-treat-this-pain-some-states-there-are-really-none-more-more-are-being-diagnosed-but-no-treatment-especially-with-severe-pain-fibro-brings-on-ibs-migrainesno-sleep-ect-a-lot-of-meds-ha
     November 01, 2011 - 48.6 KB] Briefly describe a specific question, or set of related questions, about a health care test

503. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/topic-nomination-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hyperplasia-1questions-to-consider-1-what-is-the-comparative-efficacy-and-effectiveness-of-currently-available-and-emerging-treatments-for-lower-urin
     October 31, 2013 - 1.2 MB] Briefly describe a specific question, or set of related questions, about a health care test … What are the patient characteristics or test results that can be used to determine the optimal pharmacotherapy … to diagnose LUTS due to BPH and to predict progression; to develop new drug therapies; identify and test

504. Comparative Effectiveness of Physical Therapy for Knee Pain Secondary to Osteoarthritis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/arthritis-knee-physical-therapy/research-protocol
     March 02, 2011 - (intermediate outcomes of physical therapy): Muscle performance or strength tests: Manual muscle test … Knee goniometry Lower extremity activity profile Measure of balance including single-leg stance test … Speed (potential surrogate for clinical outcomes) – Functional Status Index – Timed Get Up and Go Test … Studies that did not test the associative hypotheses and did not provide adequate information on tested … Methods guide for medical test reviews. Draft Posted November 2010.

505. Interventions To Improve Cardiovascular Risk Factors in People With Serious Mental Illness | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/mental-illness-heart/research
     April 22, 2013 - Comparative effectiveness studies are needed to test multimodal strategies, agents known to be effective

506. CER 5 Renal Artery Stenosis NSD SJ Clean (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/renal-artery-stenosis_overview.pdf
     June 24, 2014 - available.at http://www.nejm.org/doi/full/10.1056/NEJMoa1310753 § The CORAL trial was designed to test

507. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0351_05-10-2010.pdf
     January 01, 2010 - treatment, medical therapies, different surgical techniques Outcome(s): diagnostic ability of test

508. Febrile-Infants-Diagnosis-Management Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/febrile-infants-diagnosis-management_executive.pdf
     March 01, 2012 - The test results (i.e., sensitivity and specificity), positive and negative predictive values (PPV, … Comparison of the diagnostic test characteristics across age groups (neonates: age ≤ 28 days vs. older … It was difficult to compare the test characteristics between detecting bacteremia and meningitis due … Test characteristics of the urine Gram stain in infants test in young febrile infants for the identification of low-risk patients.

509. Comparative Effectiveness of Treatments for Cryptorchidism | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/undescended-testicle/research-protocol
     September 02, 2011 - , selection criteria, reference standard, disease progression bias, verification bias, review bias, test

510. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/undescended-testicle_research-protocol.pdf
     September 02, 2011 - selection criteria, reference standard, disease progression bias, verification bias, review bias, test

511. Interventions to Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer's-Type Dementia | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/cognitive-decline/research-2017
     March 24, 2017 - More work is needed to understand the relationship between intermediate outcomes such as cognitive test

512. Hepatitis-C-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hepatitis-c-screening_executive.pdf
     November 01, 2012 - antibody in the United States is estimated at 1.6 percent.1 Approximately 78 percent of those who test … curve (AUROC).54,55 The AUROC, which is based on sensitivities and specificities across a range of test … was applied to all patients; whether the reference standard was interpreted independently from the test … under evaluation; and whether test cutoff thresholds were predefined.57,58 Following assessment of … Although direct harms of screening appear minimal (since it is a simple blood test), other harms such

513. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/question-what-is-the-etiology-of-cryptorchidism-what-are-the-environmental-factors-maternal-smoking-maternal-diabetes-mellitus-etc-that-may-contribute-to-the-development-of-this-condition-question-what-is-the-ideal-diagnostic
     May 10, 2010 - 590.6 KB] Briefly describe a specific question, or set of related questions, about a health care test

514. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0311_06-17-2008.pdf
     January 01, 2008 - based primarily on medical history and physical examination (may also include evaluation of other test

515. Urinary-Incontinence-Treatment Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/urinary-incontinence-treatment_research-protocol.pdf
     September 30, 2010 - Use of GS Symbol No. 95 44 083; LGA, Equipment Safety Testing Institute, Nurnberg, Germany, 1995; Test … Frequency volume chart Pad tests Paper towel test Ultrasound For KQ2 and KQ3 about treatments … testing: The amount of urine lost during incontinence episodes (comparison of a short provocative test … to a 24-hour pad test). 9. … Studies that did not test the associative hypotheses and did not provide adequate information on tested

516. Future Research Needs for Diagnosis of Obstructive Sleep Apnea (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea-diagnosis-future_research.pdf
     February 01, 2012 - Population 1P: No subgroup analyses available for any test - none of the studies explicitly evaluated … Key Question 2.How does phased testing (screening tests or battery followed by full test) compare to … Population 1P: No subgroup analyses available for any test—none of the studies explicitly evaluated … How does phased testing (screening tests or battery followed by full test) compare to full testing … When a simple RCT (or diagnostic test study) was deemed to be an appropriate study design to address

517. Chronic-Cough Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-cough_executive.pdf
     March 01, 2014 - Effectiveness Reviews (hereafter referred to as the Methods Guide)13 and Methods Guide for Medical Test … Reviews (hereafter referred to as the Medical Test Guide).14 Input From Stakeholders During the topic … We assessed reliability by test-retest reliability, as well as internal consistency. … We tested for heterogeneity using graphical displays and test statistics (Q and I2 statistics). … Methods Guide for Medical Test Reviews.

518. Global Health Evidence Evaluation Framework | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/global-health-evidence-evaluation-framework/white-paper
     June 24, 2013 - from the frameworks for implementation criteria helped to address some of these gaps, yet our pilot test

519. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-for-the-treatment-of-major-depressive-disorder-mdd-key-questions-1-for-the-treatment-of-mdd-what-is-the-comparative-effectiveness-of-ssris-placebo-psychotherapy-exercise-and-alternative-therapies-2-f
     March 11, 2013 - 1.2 MB] Briefly describe a specific question, or set of related questions, about a health care test

520. Machine Learning Methods in Systematic Reviews: Identifying Quality Improvement Intervention Evaluations | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/machine-learning-quality/research
     September 21, 2012 - Machine Learning Methods in Systematic Reviews: Identifying Quality Improvement Intervention Evaluations Research Report September 21, 2012 Web Version [NLM Site] Download Main Document PDF 498.3 KB People using assistive technology may not be able to fully access information in these files. For additio…