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321. Colonic Diseases | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/colonic-diseases
     April 02, 2014 - Pharmacological Management of Crohn's Disease: Future Research Needs Systematic Review Archived April 2, 2014 Pharmacologic Therapies for the Management of Crohn’s Disease: Comparative Effectiveness Systematic Review Archived February 25, 2014 Imaging Tests for the Diagnosi…

322. Digestive Diseases | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/digestive-diseases
     May 20, 2013 - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs Systematic Review Archived May 20, 2013 Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: A Comparative E…

323. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/wysiwyg/pdf/version-2-risk-of-reinfection-from-SARSCoV2.pdf
     July 01, 2022 - Nine studies used antibody test results to assign patients to the “positive” or “negative” cohorts;23 … , 26, 28, 30, 31, 33, 37-39 three used a combination of antibody test results and PCR;9, 29, 36 and … 13 days after the initial positive PCR test.14 A large proportion of patients in the dataset … This finding applies only to people who have had a negative antibody test (e.g., for surveillance in … Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection.

324. Version 2_Risk of Reinfection From SARS-CoV-2 -- An Update of an Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: A Living Rapid Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/product/pdf/version-2-risk-of-reinfection-from-SARSCoV2.pdf
     July 01, 2022 - Nine studies used antibody test results to assign patients to the “positive” or “negative” cohorts;23 … , 26, 28, 30, 31, 33, 37-39 three used a combination of antibody test results and PCR;9, 29, 36 and … 13 days after the initial positive PCR test.14 A large proportion of patients in the dataset … This finding applies only to people who have had a negative antibody test (e.g., for surveillance in … Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection.

325. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/tethered-spinal-cord-protocol.pdf
     July 19, 2023 - Surgical detethering, other surgeries, physical therapy, bracing Final health outcomes: KQ1: Test … : The index test domain evaluates whether the conduct or interpretation of the test could have introduced … bias, taking into account whether the results of the test were interpreted without knowledge of the … results were interpreted without knowledge of the results or index test … • Directness: Describes whether the intervention (test, treatment, or strategy) and the comparator

326. Disposition of Comments for Comparative Effectiveness Review 130 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/preoperative-testing_disposition-comments.pdf
     January 29, 2014 - value of routine preoperative testing is very clinically meaningful, as well as extremely relevant to test … to the Introduction about how preoperative testing (like all routine testing) will find abnormal test … Peer Reviewer #8 Methods Page 14, lines 35-36: Test of equivalence does look at 95% CI. … Peer Reviewer #8 Results Also the authors noted that “However, in no scenario (specific test(s) used … The rest of their analyses focus on the predictive value of abnormal test results, which we did not

327. Effectiveness of Noninvasive Diagnostic Tests for Breast Abnormalities | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/breast-abnormalities-tests/research
     February 09, 2006 - actually have cancer, suggesting that many of them could avoid biopsy if a non-invasive diagnostic test

328. Antibiotics-Respiratory-Infection Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
     March 01, 2016 - Other point-of-care tests (such as the rapid strep test, multi-viral polymerase chain reaction [PCR … ��The combination of a rapid strep test with a clinical score (FeverPAIN or a scale based on the presence … tests to rapidly determine the likelihood that a patient has a specific infection (e.g., rapid strep test … of a throat swab sample, multi-viral PCR or an influenza-specific test of throat/nasopharyngeal secretions

329. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/sleep-apnea_research-protocol.pdf
     March 15, 2010 - However, it is acknowledged that it is not a definitive test to either diagnose or rule out obstructive … In part, this is due to a lack of robust standardized criteria as to the test parameters measured and … What is the correlation between the choice of initial diagnostic test to determine the diagnosis of … Objective (e.g., Multiple Sleep Latency Test, Maintenance of Wakefulness Test); only validated measures … This approach is recommended for analyses in which neither test can be considered a reference (gold)

330. Disposition of Comments for PCA3 Testing for the Diagnosis and Management of Prostate Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_disposition-comments.pdf
     April 01, 2013 - Even though this test is not invasive, it is a reasonable point that it does require manipulation; … In order to facilitate a comparison of a new test associated with managing patients with a potential … PR # 8 Results Your results do not necessarily support the FDA approved indication for this test. … the massage, this test may have acceptability concerns to patients. … PR # 12 Discussion/ Conclusions This test is clearly not a major improvement over PSA.

331. Comparative Effectiveness of Diagnosis and Treatment of Obstructive Sleep Apnea in Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/sleep-apnea/research-protocol
     March 15, 2010 - However, it is acknowledged that it is not a definitive test to either diagnose or rule out obstructive … In part, this is due to a lack of robust standardized criteria as to the test parameters measured and … KQ3: How does phased testing (screening tests or battery followed by full test) compare to full testing … The report will not assume that measurements from any test are interchangeable with measurements from … This approach is recommended for analyses in which neither test can be considered a reference (gold)

332. Microsoft Word - cognitive-decline-protocol-160322.docx (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_research-protocol.pdf
     March 22, 2016 - Consequently, short-term studies may be inadequate to test effectiveness of interventions to prevent … biomarker protein levels in a patient’s blood or cerebrospinal fluid (CSF), or decline in cognitive test … association between outcome measures examined in KQs 1 or 2 including (but not limited to) cognitive test … centered  outcomes: Incident AD Intermediate outcomes: Biomarker protein  level(s) Cognitive  test … For  KQ2:  To  test  the  efficacy,  comparative  effectiveness,  and  harms  of   interventions to  

333. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/does-the-use-of-cytochrome-p450-2c19-cyp2c19-testing-to-predict-response-to-clopidogrel-in-people-1-with-acute-coronary-syndrome-2-who-have-suffered-other-cardiovascular-disease-related-events-eg-ischemic-stroke-symptomatic-p
     August 04, 2010 - 148.2 KB] Briefly describe a specific question, or set of related questions, about a health care test … coronary intervention, lead to improvements in health outcomes compared to a no-testing strategy, or are test

334. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_disposition-comments.pdf
     March 01, 2012 - However, estimates of the magnitude of differences in test sensitivities were not very precise. … When a new test is evaluated using a more sensitive reference test, the estimate of its sensitivity … This was a standardized test and is relatively accurate. … Of course culture alone is insufficient and needs to be combined with a test for toxins. … a less sensitive references test on the estimated differences in test sensitivities should be minimized

335. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cognitive-decline_executive.pdf
     March 01, 2017 - Intermediate outcomes, such as measures of biomarkers and cognitive test performance, are included. … more spotty and so less persuasive; vitamin B12 and folic acid showed benefit in brief cognitive test … • Low-strength evidence shows no benefit on cognitive test performance of any fixed antihypertensive … • Low-strength evidence shows no benefit on brief cognitive test performance, executive/attention/ … Vitamin B12 and folic acid also showed benefit in brief cognitive test performance and memory, but not

336. Interventions To Prevent Age-Related Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer’s-Type Dementia (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cognitive-decline_executive.pdf
     March 01, 2017 - Intermediate outcomes, such as measures of biomarkers and cognitive test performance, are included. … more spotty and so less persuasive; vitamin B12 and folic acid showed benefit in brief cognitive test … • Low-strength evidence shows no benefit on cognitive test performance of any fixed antihypertensive … • Low-strength evidence shows no benefit on brief cognitive test performance, executive/attention/ … Vitamin B12 and folic acid also showed benefit in brief cognitive test performance and memory, but not

337. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/population-children-18-years-of-age-1-what-are-the-incidences-and-prevalences-of-non-inflammatory-pain-syndromes-eg-benign-hypermobility-syndrome-patellofemoral-stress-syndrome-fibromyalgia-and-growing-pain-in-children-and-ad
     January 30, 2009 - 132.9 KB] Briefly describe a specific question, or set of related questions, about a health care test … patterns escalate the economic and social burden of medical care through their high rate of false positive test

338. Effectiveness of Noninvasive Diagnostic Tests for Breast Abnormalities Appendices (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests_appendixes.pdf
     May 23, 2005 - In the quantitative section, there is another test of robustness. … Evidence Tables Evidence Tables Diagnostic Test Characteristics No diagnostic test is perfect … Studies of diagnostic test performance compare test results on a group of patients, some of whom have … Each patient undergoes the experimental test as well as a second “gold standard” reference test to determine … test characteristics.

339. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0068_01-30-2009.pdf
     January 01, 2009 - escalate the economic and social burden of medical care through their high rate of false positive test

340. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
     September 01, 2012 - Is the test an add-on or does it replace an existing, more complicated or more invasive test? … Does the test result in improved health outcomes? c. … Is the test an add-on or does it replace an existing, more complicated or more invasive test? … Does the test result in improved health outcomes? c. … and others are randomized to forego the test.