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241. Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma Cell Dyscrasias: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay-future_research.pdf
     September 01, 2012 - Is the test an add-on or does it replace an existing, more complicated or more invasive test? … Does the test result in improved health outcomes? c. … Is the test an add-on or does it replace an existing, more complicated or more invasive test? … Does the test result in improved health outcomes? c. … and others are randomized to forego the test.

242. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0068_01-30-2009.pdf
     January 01, 2009 - escalate the economic and social burden of medical care through their high rate of false positive test

243. EHC Research Protocol: Management of Colonic Diverticulitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/diverticulitis-research-protocol.pdf
     January 01, 2019 - Specifically, (1) the systematic review will summarize existing systematic reviews on the test accuracy … What is the test accuracy of CT imaging for the diagnosis or staging of acute diverticulitis? … † Older studies are of little relevance to contemporary practice given changes in diagnostic test … For Key Question 1a (test accuracy), we will focus on test sensitivity and specificity for diagnosis … We expect that these will include: 17 • Test accuracy for o Diagnosing acute diverticulitis

244. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-quantitative-synthesis_methods.pdf
     October 01, 2010 - Variation among studies is inevitable whether or not the test of heterogeneity detects it. … A test for the presence of statistical heterogeneity, for example, Cochran‘s Q test, as well as a measure … Further, interpretation of Q statistic should consider the limitations of the test that it has low … Use of permutation test for meta- regression can help assess the level of statistical significance of … Our recommendations and those of the Cochrane Handbook 12 follow similar principles to test

245. Conducting Quantitative Synthesis when Comparing Medical Interventions: AHRQ and the Effective Health Care Program (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/methodsguide_conductingquantitativesynthesis.pdf
     October 01, 2010 - Variation among studies is inevitable whether or not the test of heterogeneity detects it. … A test for the presence of statistical heterogeneity, for example, Cochran‘s Q test, as well as a measure … Further, interpretation of Q statistic should consider the limitations of the test that it has low … Use of permutation test for meta- regression can help assess the level of statistical significance of … Our recommendations and those of the Cochrane Handbook 12 follow similar principles to test

246. Core-Needle Biopsy for Breast Abnormalities (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_clinician.pdf
     May 01, 2016 - Sensitivity is an estimate of the proportion of all cases of cancer that are identified by a diagnostic test … Information on study- or population-level characteristics that could be modifiers of test performance … reported on groups of patients at high baseline risk of breast cancer and because comparisons of test

247. Imaging Tests to Check for Kidney Stones in the Emergency Department | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/kidney-stone-imaging/consumer

248. Additional Patient Outcomes and Alternative Pathways in Evaluations of Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/outcomes-testing-evaluation/research

249. Chapter 7: Grading a Body of Evidence on Diagnostic Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-grading/methods

250. Antipsychotics for the Prevention and Treatment of Delirium: A Systematic Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/delirium-research-protocol.pdf
     June 01, 2018 - critically ill patients found that among 12-month survivors, ~25% had cognitive test scores similar … We will create standardized forms for data extraction and pilot test them. … analyses when there is higher heterogeneity.24 Publication bias will be examined by using Begg’s test … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.

251. Antibody Response Following SARS-CoV-2 Infection and Implications for Immunity: Final Update of a Rapid, Living Review (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/version-3-immunity-after-COVID-19.pdf
     December 31, 2022 - unvaccinated individuals, prior infection reduced the risk of hospitalization after a positive NAAT test … In our review, a central question is whether an antibody test obtained in everyday practice provides … A related but separate question is whether the test reliably confirms or excludes previous infection … Based on our updated results, it is highly likely that an antibody test specific for previous infection … if antibodies are present, the individual will have some protection at the time of the serological test

252. Antibiotics-Respiratory-Infection Clinician (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/antibiotics-respiratory-infection_clinician.pdf
     March 01, 2016 - Other point-of-care tests (such as the rapid strep test, multi-viral polymerase chain reaction [PCR … ��The combination of a rapid strep test with a clinical score (FeverPAIN or a scale based on the presence … tests to rapidly determine the likelihood that a patient has a specific infection (e.g., rapid strep test … of a throat swab sample, multi-viral PCR or an influenza-specific test of throat/nasopharyngeal secretions

253. FRN 29: Future Research Needs on Procalcitonin-Guided Antibiotic Therapy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin-future_research.pdf
     August 01, 2014 - Level 2 • Diagnostic accuracy: Measures of the performance of the test to provide diagnoses. … clinically obvious cases to establish test-pathologic correlation before extending the test to more … percentage of patients improved with/without test, morbidity avoided, QALY. … Procalcitonin test in the diagnosis of bacteremia: a meta-analysis. … The older assays have not been successful as a rule-out test.

254. Screening and Diagnosing Gestational Diabetes Mellitus Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_disposition-comments.pdf
     January 01, 2020 - The authors aimed to identify test properties for GDM screening and diagnostic tests, evaluate potential … Therefore it is critical for this report to recommend that ONE TEST be used internationally. … If countries, areas decide different cut points for diagnosis but the same test--data can still be … As best I can tell, there is one study to support the 75 gram 2 hour test as a single test, and really … I strongly urge that this report recommend the adoption of one test (75g) (even if more analysis to

255. Methods Research Report: Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive Web-Based Presentation and Discussion of Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/linking-evidence-reviews-methods_0.pdf
     October 01, 2018 - Methods Research Report: Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … Report Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … Methods Research Report Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … vi Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test of an Interactive, … Goal/Objective The primary goal of the COER cyberseminar project was to develop and test a method to

256. Technical Brief Summary - Impact of Community Health Worker Certification on Workforce and Service Delivery for Asthma and Other Selected Chronic Diseases (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/technical-brief-34-health-worker-certification-summary.pdf
     March 01, 2020 - Opportunities for additional research include: Conducting pragmatic randomized controlled trials to test … May keep out candidate CHWs with extensive experience in the community who are not good test-takers.

257. Interventions to Improve Care of Bereaved Persons (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bereaved-persons-protocol.pdf
     June 01, 2023 - We will assess the potential for publication bias for all key outcomes using the Begg and the Egger test … effectiveness and safety (compared to passive comparators such as no screening strategy, diagnostic test … • Directness: Describes whether the intervention (approach, test, or treatment) and the comparator … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a simple, graphical test.

258. Systematic Review of Prognostic Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-prognostic/slides

259. Technical Brief Disposition of Comments Report for Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colon-cancer-gene-profiling_disposition-comments.pdf
     December 14, 2012 - #10 PR Background The point is well taken about the value of including test results describing MSI … Are there any other genetic test results that might be relevant to the validity or utility of GEP, such … Public Seidenfeld Background P 3 Their use should not be Agree; need to test prediction of clinical … First and foremost, it must be emphasized that the evaluation of a test in a randomized clinical trial … No other test has similar data, and, thus, no other test can make that claim.

260. Brooks_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/brooks_eccs2012.pdf
     January 01, 2012 - Brooks_ECCS2012       Slide 1: Addressing  Tensions  When Conventional Wisdom, Clinical Practice   and  Evidence  Collide: Prostate Cancer Screening  Guidelines Durado  Brooks, M.D., M.P.H. Director, Prostate  and  Colorectal Cancers American Cancer…