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221. Supplemental Project To Assess the Transparency of Reporting Requirements: Tympanostomy Tubes in Children With Otitis Media (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/transparency-tympanostomy_research.pdf
     June 01, 2017 - Outcomes Study Outcomes NCT00365092 Auditory continuous performance test Child Behavior Checklist … Children’s version of the Hearing in Noise Test Comprehensive Test of Phonological Processing Disruptive … Child Behavior Checklist Children's Version of the Hearing in Noise Test Comprehensive Test of … Test–Revised Percentage of Consonants Correct–Revised Screening Test for Auditory Processing Disorders … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.

222. AHRQ Slide Template 2009 (ppt file)
     effectivehealthcare.ahrq.gov/sites/default/files/data-extraction.ppt
     January 01, 2009 - Pilot-test the forms on several published papers. … Use an iterative process and have several individuals test the form on multiple studies. … Characteristics of the Index Test and Reference Standard Characteristics of the Index Test and Reference … Here we get information on the characteristics of the index test and the reference standard, as well … as the criteria that test readers used.

223. Hypertension-Pulmonary-Arterial Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hypertension-pulmonary-arterial_research-protocol.pdf
     January 30, 2013 - An echocardiogram is a noninvasive test that provides an estimate of pulmonary artery pressures at rest … The test also helps to exclude valvular, primary myocardial, and congenital causes of Source: … (NT-proBNP) are two biological substances found in the blood that have been studied as a screening test … of PAH, biomarker testing may potentially identify patients with false- negative echocardiographic test … We will test for statistical heterogeneity using graphical displays and test statistics (Q and I2 statistics

224. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy_disposition-comments.pdf
     March 11, 2010 - Executive Summary Under study selection you say the reference test is intended to measure the “true” … is the most accurate test available? … It has been given in the footnote under the table, pre-test risk of 30%. … definition of sensitivity is always “in comparison to a reference test”. … You cannot calculate sensitivity without comparing the investigational test to a reference test.

225. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/diagnostic-tests-accuracy/research

226. Data Points 15: Breast Cancer Diagnostic Workup: Prognostic factor testing among older women with ductal carcinoma in situ and early invasive breast cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/dcis-prognostic-tests_research.pdf
     August 22, 2012 - analysis showed that our claims-based measure was, although slightly lower, close to SEER rates of test … Women with invasive disease have higher rates of lymph node test- ing overall than women with DCIS, and

227. Chapter 12: Systematic Review of Prognostic Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-prognostic/methods

228. Topic 0505 Genetic Testing for Developmental Diseases NSD FINAL_SJ (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0594-131115.pdf
     March 13, 2013 - Topic 0505 Genetic Testing for Developmental Diseases NSD FINAL_SJ § Genetic Testing for Developmental Diseases Nomination Summary Document …

229. PEPTIC ULCER #11 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/peptic-ulcer-horizon-scan-high-impact-1512.pdf
     December 01, 2015 - Clinical experts suggested the simple office-based test might encourage more primary care physicians … This test will ultimately save more lives than cervical Pap smears. It is much less invasive. … The patient gets the test done in a familiar location at low cost. … Sponge test a low-cost, easier way to spot signs of cancer. [internet]. … 'Sponge' test for gullet cancer looks promising. [internet].

230. Work Plan for Methods Research on (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/study-design-classification_research.pdf
     December 01, 2010 - Test 1 Tester characteristics. … Test 2 Tester characteristics. … Results of taxonomy testing Test 1—30 studies; 6 testers Test 2— 15 studies; 6 testers Overall … Test 1 Tester characteristics. … Accuracy of testing compared to reference standard Test 1 30 studies Test 2 15 studies Number

231. Disposition of Comments for CER 153 Non-Muscle-Invasive Bladder Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_disposition-comments.pdf
     October 27, 2015 - --how often and how long should the interval use of cystoscopy be performed based on either pre-test … I believe that the most timely and useful information concerns the analysis of the test performance … probability…” Should this AHRQ report be able to spell out the pre-test probabilities? … related to the pre-test probability of a urothelial malignancy as AHRQ has done for the progression … Follow-up of the negative evaluation of microscopic hematuria related to pre-test probabilities 2.

232. FRN 35 - Preventive Pharmacological Treatments for Migraine in Adults: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/migraine-future_research.pdf
     April 01, 2013 - The most important multimodal treatments to test are those commonly used in practice and are likely … The most important drug combinations to test are those commonly used in practice or those suggested … Studies should be adequately powered to test hypothesized relationships, including among subgroups. … Resource use, size and duration High; large sample sizes to test differences among subgroups would … The most important multimodal treatments to test are those commonly used in practice and are likely

233. Quantitative Synthesis: Chapter 5. Network Meta-Analysis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-5.pdf
     February 01, 2018 - can be assessed using standard methods for evaluating homogeneity: ► I2 ► 𝝉𝝉𝟐𝟐 ► Cochran Q test … http://dx.doi.org/10.1016/j.jclinepi.2008.04.012 Single measures for consistency • Global Wald test … being easily interpreted. • Various approaches exist for comparing direct and indirect estimates: ► Z-test … ► Side-splitting Loop-based approaches • Z-test: Used to compare difference of pooled effect sizes … • Investigators should test relevant assumptions where possible, regardless of method chosen.

234. Disposition of Comments Report for Imaging Techniques for the Diagnosis and Staging of Hepatocellular Carcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_disposition-comments.pdf
     October 23, 2014 - The finding may be a reflection of the low pre test probability of HCC in the surveillance population … How does a negative ultrasound affect post-test probability? … Could use incidence rates of HCC in say HCV cirrhotics as pre-test probability. … pre- test probabilities of HCC. … The table is on test performance; the Zhang study does not report test performance (sensitivity/specificity

235. Gestational-Diabetes-Screening-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/gestational-diabetes-screening-diagnosis_executive.pdf
     October 01, 2012 - receive a subsequent diagnostic test.14 Typically, a 50 g oral glucose challenge test (OGCT) is initially … The domain of the index test was generally rated as low risk of bias (53 percent). … Limited data support the use of HbA1c as a screening test. … HbA1c does not perform as well as the 50 g OGCT as a screening test for GDM. … in favor of proceeding directly to a diagnostic test for GDM.

236. ASSESSING THE QUALITY OF INCLUDED STUDIES (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/assessing-the-risk-of-bias_draft-report.pdf
     June 02, 2011 - Pilot test and train Determine composition of the review team. … a health condition and typically compare results with those from another medical test. … We refer the reader to the AHRQ Medical Test Guidance). … for genetic test studies. … Systematic reviews of diagnostic test accuracy. Ann Intern Med. 2008 Dec 16;149(12):889-97. 21.

237. Disposition of Comments for Screening for Glaucoma: Comparative Effectiveness (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_disposition-comments.pdf
     April 01, 2012 - • Pachymetry (corneal thickness measurement) when used in conjunction with another test to diagnose … • Pachymetry (corneal thickness measurement) when used in conjunction with another test to diagnose … • Pachymetry (corneal thickness measurement) when used in conjunction with another test to diagnose … • Pachymetry (corneal thickness measurement) when used in conjunction with another test to diagnose … However, modeling allows you to test these factors and to come up with an optimal screening strategy

238. Mrsa-Screening-2010 Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/mrsa-screening-2010_research-protocol.pdf
     January 01, 2010 - that uses a testing modality with a rapid turnaround time (results available on the same day the test … Studies will be stratified by the turnaround time of the test used, rather than by the testing modality … Once the screening test results are received, patients who screen positive may be isolated; patients … Abbreviations: KQ = key question; MRSA = methicillin-resistant Staphylococcus aureus; Test + = positive … MRSA-screening test result; Test – = negative MRSA-screening test result.

239. Bladder-Cancer-Non-Muscle-Invasive Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/bladder-cancer-non-muscle-invasive_executive.pdf
     October 01, 2015 - , proportion who did not undergo reference standard test, results, and sources of funding. … a Positive Test Negative Likelihood Ratio (95% CI) Post-Test Probability of HCC Following a … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017. … Chapter 8: meta- analysis of test performance when there is a “gold standard”. … Meta-analysis of diagnostic and screening test accuracy evaluations: methodologic primer.

240. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/plasma-cell-dyscrasias-sflc-assay_research-protocol.pdf
     May 02, 2011 - Food and Drug Administration and classified as an immunoglobulin (light chain-specific) immunological test … this review; however, a systematic review of the evidence of the comparative effectiveness of this test … We will use separate forms for questions related to diagnostic test performance (KQ1), MGUS (KQ 2), … We will test the forms on several studies and revise the forms as necessary before full data extraction … Serum test for assessment of patients with Bence Jones myeloma. Lancet 2003;361:489-91. 6.