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21. Methods Guide for Medical Test Reviews Chapter 11 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-genetic_methods.pdf
    July 01, 2012 - is the intended use of the test result that determines whether it is a diagnostic or predictive test … of a genetic test result. … , including a predictive genetic test. … Is the test qualitative or quantitative? 9. … How reproducible is the test over time?

22. Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Available medical test data are usually focused on test performance or accuracy; therefore, meta-analyses … = proportion of test negatives among diseased/proportion of test negatives among healthy Diagnostic … Measures Used To Assess Test Performance (2 of 2) Here are a few more ways to assess test performance … effect, or when the time between symptom onset and the diagnostic test affects test performance.

23. Meta-analysis of Test Performance Evidence When There is a “Gold Standard” Reference Standard (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-meta-analysis.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Available medical test data are usually focused on test performance or accuracy; therefore, meta-analyses … = proportion of test negatives among diseased/proportion of test negatives among healthy Diagnostic … Measures Used To Assess Test Performance (2 of 2) Here are a few more ways to assess test performance … effect, or when the time between symptom onset and the diagnostic test affects test performance.

24. Methods Guide for Medical Test Reviews Chapter 4 (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-search_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews Chapter 4 4-1 Chapter 4 Effective Search Strategies for … Although I have written this chapter of the Methods Guide for Medical Test Reviews (also referred to … as the Medical Test Methods Guide) as guidance for Evidence-based Practice Centers (EPCs), I hope it … of the relevant test strategies under consideration. … Chapter 4 of Methods Guide for Medical Test Reviews (AHRQ Publication No. 12-EHC017).

25. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/products/appendicitis/research
    December 14, 2015 - The test performance and impact on outcomes of alternative diagnostic strategies are unclear. … We performed Bayesian meta-analyses to estimate summary test performance using random-effects models; … too heterogeneous to support definitive conclusions; therefore, most of our results pertain to the test … Information on diagnostic test performance among the elderly was limited. … strategies on the same population are few and have evaluated different test comparisons.

26. Evidence-based Practice | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/health-topics/evidence-based-practice
    September 01, 2019 - June 2, 2014 Linking Evidence Reviews to Organizational Guideline Planning: A Pilot Test … Archived July 31, 2012 Chapter 5: Assessing Risk of Bias as a Domain of Quality in Medical Test

27. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-frameworks.ppt
    June 01, 2012 - regarding the test. … test, a triage test, or an add-on to existing test strategies? … as the old test; plus, the new test has advantages. … The example cases involve a replacement test, an add-on test, and a triage test. … For example, when a new test is as sensitive and as specific as the old test and the new test has advantages

28. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-applicability.ppt
    June 01, 2012 - after another test. … for the new test. … of the test users. … to evaluate the test. … Availability of the test Technology of the test Contemporary clinical use of the test Current treatment

29. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-intro.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Guide for Medical Test Reviews. … Medical Test Reviews (3 of 4) Here we define a medical test as any test used in a health care context … Development of the Methods Guide for Medical Test Reviews (1 of 3) The Methods Guide for Medical Test … Instead, test development and test performance characteristics are the focus of those reports.

30. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-genetic.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Methods guide for medical test reviews. … Methods guide for medical test reviews. … Methods guide for medical test reviews. … of a genetic test result.

31. What is the most effective therapy for a depressed patient who has not responded to an SSRI? | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/what-is-the-most-effective-therapy-for-a-depressed-patient-who-has-not-responded-to-an-ssri
    March 17, 2008 - Your Nomination - Please briefly describe in your own words the question about a health care test or … or problem have considerable health or financial hardships   There is uncertainty about how well the test … treatment, or intervention works   There is significant potential for side effects/harms using this test … , treatment, or intervention   Funding of this test, treatment, or intervention is uncertain or variable … What is the specific purpose of the health care test or treatment you have a question about?

32. Should subclinical hypothroidism be treated? | Effective Health Care (EHC) Program
    effectivehealthcare.ahrq.gov/get-involved/nominated-topics/should-subclinical-hypothroidism-be-treated
    March 21, 2008 - Your Nomination - Please briefly describe in your own words the question about a health care test or … or problem have considerable health or financial hardships   There is uncertainty about how well the test … treatment, or intervention works   There is significant potential for side effects/harms using this test … , treatment, or intervention   Funding of this test, treatment, or intervention is uncertain or variable … What is the specific purpose of the health care test or treatment you have a question about?

33. Hi Les, (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/rtc-design-principles_research.pdf
    January 01, 2009 - replacement for the existing test, an add-on test after the existing test, or as a triage test before … test. … Add-on test Test result Test neg Pathway B* Management Test pos Pathway A* FP TP … Management Test result Test pos Pathway A Test neg Pathway B Existing test Test … Triage test Test result Test pos Add existing test Test pos Pathway A Test neg Pathway

34. Evaluating Practices and Developing Tools for Comparative Effectiveness Reviews of Diagnostic Test Accuracy: Methods for the Joint Meta-Analysis of Multiple Tests (pdf file)
    effectivehealthcare.ahrq.gov/sites/default/files/pdf/diagnostic-tests-accuracy_research.pdf
    January 01, 2013 - only the second test. … and multinomial distributions for more than one test).45,46 The Case of a Single Test Consider … By definition, the TPR of the test is equal to π Dk , 1 , and the FPR of the test is equal to π Dk , … 1 and Test 2 are positive, the probability that Test 1 and Test 3 are positive, the probability that … Test 2 and Test 3 are positive, and the probability that all three tests are positive.

35. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-intro.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Guide for Medical Test Reviews. … Medical Test Reviews (3 of 4) Here we define a medical test as any test used in a health care context … Development of the Methods Guide for Medical Test Reviews (1 of 3) The Methods Guide for Medical Test … Instead, test development and test performance characteristics are the focus of those reports.

36. Considering the Range of Decision-Relevant Effects (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-choosing-outcomes.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Outcomes Screening Test Diagnostic Test Prognostic Test Clinical management + +++ +++ Direct health … by test type. … , a diagnostic test, a prognostic test, and a genetic test — each with important outcomes. … The test under consideration is a radiographic test.

37. Considering the Range of Decision-Relevant Effects (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-choosing-outcomes.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Outcomes Screening Test Diagnostic Test Prognostic Test Clinical management + +++ +++ Direct health … by test type. … , a diagnostic test, a prognostic test, and a genetic test — each with important outcomes. … The test under consideration is a radiographic test.

38. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-applicability.ppt
    June 01, 2012 - after another test. … for the new test. … of the test users. … to evaluate the test. … Availability of the test Technology of the test Contemporary clinical use of the test Current treatment

39. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Methods guide for medical test reviews. … “Truly” Diseased “Truly” Healthy RS (+) RS (-) RS (+) RS (-) Index test (+) 1 2 2 1 Index test … (-) 1 2 2 1 RS (+) RS (-) Index test (+)  = 1 + 2  = 1 + 2 Index test (-)  = 1 + … Comparison of a screening test and a reference test in epidemiologic studies. II. … Comparison of a screening test and a reference test in epidemiologic studies. II.

40. PowerPoint Presentation (ppt file)
    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-options-summarizing.ppt
    June 01, 2012 - Methods guide for medical test reviews. … “Truly” Diseased “Truly” Healthy RS (+) RS (-) RS (+) RS (-) Index test (+) 1 2 2 1 Index test … (-) 1 2 2 1 RS (+) RS (-) Index test (+)  = 1 + 2  = 1 + 2 Index test (-)  = 1 + … Comparison of a screening test and a reference test in epidemiologic studies. II. … Comparison of a screening test and a reference test in epidemiologic studies. II.