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181. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/procalcitonin_research-protocol.pdf
     September 08, 2011 - Whether or not the semi-quantitative test will yield similar results to the quantitative test is unknown … o Was the reference standard independent of the index test (i.e. the index test did not form part of … o Was the execution of the index test described in sufficient detail to permit replication of the test … the test is used in practice? … o Were uninterpretable/intermediate test results reported?

182. Procalcitonin for Diagnosis and Management of Sepsis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/procalcitonin/research-protocol
     April 26, 2011 - Whether or not the semiquantitative test will yield similar results to the quantitative test is unknown … Was the reference standard independent of the index test (i.e. the index test did not form part of the … Was the execution of the index test described in sufficient detail to permit replication of the test? … test is used in practice? … Were uninterpretable/intermediate test results reported?

183. Disposition of Comments for Technical Brief 23 Genetic Testing (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/genetic-testing-developmental-disabilities_disposition-comments.pdf
     June 30, 2015 - However, we would include any study that compare a test of interest with a nongenetic test. … In the tables in Appendix D, we reported information on “Genetic Counseling Required Pre-Test or Post-Test … So, these 56 tests are not one same test. … A clinical test is either an FDA-cleared/approved commercial kit or a laboratory-developed test (LDT … , it is the diagnostic test.

184. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1412.pdf
     December 22, 2014 - ................................................................................ 10 Xpert MTB/RIF Test …  The topic “OraQuick in-home rapid test for detection of HIV infection” was archived after being … test that is run on Cepheid’s GeneXpert® real-time polymerase chain reaction (PCR) system. … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest radiographs.108,109 The … the sample simultaneously with a nucleic acid amplification test, an acid- fast bacteria smear test

185. Challenges in and Principles for Conducting Systematic Reviews of Genetic Tests Used as Predictive Indicators | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-genetic/slides
     September 01, 2013 - investigators with the methodological framework and guidance outlined in the Methods Guide for Medical Test … This module is one of 12 in the collection, Training Modules for the Methods Guide for Medical Test

186. Deciding Whether to Complement a Systematic Review of Medical Tests with Decision Modeling | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-decision-models/slides
     September 01, 2013 - investigators with the methodological framework and guidance outlined in the Methods Guide for Medical Test … This module is one of 12 in the collection, Training Modules for the Methods Guide for Medical Test

187. Santa_ECCS2012 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/santa_eccs2012.pdf
     February 01, 2013 - • The most common screening test was an electrocardiogram, followed by a stress  test and  ultrasound … 2) • 11 percent had  talked  with  their  physician  about followup if the  screenin test … • 9 percent  had discussed the accuracy of the test. … • 4 percent knew about the potential complications from  the test. … • 1 percent had  discussed  with  their  physician  whether  or not the  test saved

188. Developing the Topic and Structuring Systematic Reviews of Medical Tests: Utility of PICOTS, Analytic Frameworks, Decision Trees, and Other Frameworks | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-topics/slides
     September 01, 2013 - investigators with the methodological framework and guidance outlined in the Methods Guide for Medical Test … This module is one of 12 from the collection, Training Modules for the Methods Guide for Medical Test

189. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research
     February 29, 2012 - excluded initial validation studies of fecal DNA testing, we found only three studies that examined the test … analytic sensitivity of assays, it is unclear if these advances are applicable to the currently available test … evaluated acceptability found that fecal DNA testing is generally acceptable, although an important test

190. Gout Dx protocol_140715-draft (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/gout_research-protocol-2014.pdf
     January 01, 2014 - What are the adverse effects associated with each diagnostic test (including pain, infection at the … Assessing Risk of Bias as a Domain of Quality in Medical Test Studies. … Methods Guide for Medical Test Reviews. Rockville (MD); 2012. 14. … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.

191. Glaucoma-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_executive.pdf
     April 01, 2012 - SAP Suprathreshold Test Evidence From Burr et al., 2007. … SAP Threshold Test Evidence From Burr et al., 2007. … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for … standard if the candidate test was one of function or a test of function as the reference if the … candidate test were one of structure.

192. Colorectal-Cancer-Staging Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
     September 01, 2014 - T2-weighted MRI) Outcomes: • Test performance outcomes – Test performance (sensitivity, specificity … Single test performance. … performance for a particular imaging test. 3. … Comparative test performance. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

193. Methods Research Report: Testing a Machine Learning Tool for Facilitating Living Systematic Reviews of Chronic Pain Treatments (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-report-testing-machine-learning-tool-chronic-pain.pdf
     November 01, 2020 - Publication No. 21-EHC004 November 2020 ii Key Messages Purpose of Project To develop and test … text word-only search strategies without MEDLINE® indexing for three chronic pain living reviews, test … This project had three stages: develop optimized search strategies (Stage 1), test machine learning … machine learning classifier on optimized searches (Stage 2), and test machine learning classifier on … and to test the performance of a machine classifier on the optimized search strategies.

194. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-of-conventional-computed-tomography-ct-multidetector-computed-tomography-mdct-ct-colonography-fludeoxyglucose-positron-emission-tomography-fdg-pet-or-fdg-petct-magnetic-resonance-imaging-mri-ultrasou
     December 27, 2011 - , 2011 Briefly describe a specific question, or set of related questions, about a health care test … pre-therapy staging (including the assessment of liver metastasis) of colorectal cancer Which imaging test … or test that can “see” some functions of a cancer (e.g. blood flow, consumption of sugar etc) is the … best test to tell how advanced a colorectal cancer is and if spread has occurred outside it to other

195. Topic 0451 Celiac Disease NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-533_05-24-2013.pdf
     January 01, 2013 - nominator is a celiac disease (CD) patient interested in finding out about “easier Summary: ways” to test … Staff-Generated PICO Population(s): Patients with suspected CD with a positive serology test Intervention … (s): Alternative confirmatory test strategies including additional serologic testing, HLA typing and … avoidance of the potential harms associated with biopsy Key Questions Is there an “easier way” to test

196. Executive Summary CER 171: Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/coronary-artery-disease-testing_executive.pdf
     March 01, 2011 - test-negative people. … Moreover, the impact of a negative test or the treatment downstream from a positive test may extend … pathways were followed after the initial test, which test(s) may lead to the most appropriate treatment … Studies did not provide information on the impact of test results on post-test risk stratification … Documentation of management of those who test positive compared with those who test negative and followup

197. Advancing Measurement of Patient-Centered Communication in Cancer Care | Effective Health Care Program
     effectivehealthcare.ahrq.gov/products/cancer-communication/research
     March 28, 2013 - Objectives The goal of Phase 2 was to refine the Phase 1 framework; identify, develop, and test PCC … Develop and Test Measures : We developed an inventory of PCC survey items by examining published literature … needed to finalize the items including additional cognitive testing, conducting a large-scale field test

198. Troponin cardiac marker interpretation during renal function impairment | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/troponin-cardiac-marker-interpretation-during-renal-function-impairment
     June 17, 2008 - 149 KB] Briefly describe a specific question, or set of related questions, about a health care test

199. Comparative Effectiveness of Non-Invasive Diagnostic Tests for Breast Abnormalities – An Update of a 2006 Report | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/breast-abnormalities-tests-update/research-protocol
     June 28, 2010 - If an available noninvasive diagnostic test could assist clinicians in evaluating women who have been … that affected the accuracy of the noninvasive test being evaluated. … because the outcome of test accuracy is indirectly related to health outcomes. … Sensitivity: the proportion of women with breast cancer who test positive for breast cancer. … Specificity: the proportion of women with benign lesions who test negative for breast cancer.

200. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - pre-analytic or analytic variables)43 Clinical validity A measurement of the accuracy with which a test … predictive value Clinical utility Degree to which benefits are provided by positive and negative test … The commercial availability of a test panel was defined as a clinical test offered (or soon to be offered … ) by a certified laboratory, or licensed or certified kit reagent test panels sold for use by clinical … What are the sources of variation in accuracy or analytical validity across different test platforms