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161. Cad-Women-Diagnosis Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_executive.pdf
     June 01, 2012 - More than one NIT test is often required when the initial test results are equivocal. … Systematic reviews of diagnostic test accuracy. Ann Intern Med 2008;149(12):889-97. … Regression methods for meta-analysis of diagnostic test data. … Methods Guide for Medical Test Reviews [posted November 2010]. Rockville, MD. … The Accuracy of the Electrocardiogram during Exercise Stress Test Based on Heart Size.

162. Disposition of Comments for Efficacy and Safety of Screening for Postpartum Depression (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_disposition-comments.pdf
     May 01, 2013 - Performance” or “Diagnostic Test Characterisitic”. … test performance and the resources required to perform the test. … Conceptually, a more resource-intensive test might be preferable to a self-administered test if the … test performance and the resources required to perform the test. … Conceptually, a more resource- intensive test might be preferable to a self- administered test if the

163. Ch 3-User-Guide-To-Ocer 130129 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/ch_3-user-guide-to-ocer_130129.pdf
     September 21, 2012 - A test for interaction is conducted to evaluate if a subgroup variable has a statistically significant … Even though the interaction test has low power to detect a true difference in subgroup effects, there … The interaction test will be statistically significant (at a significance level of 0.05), on average … It should also be noted that a statistical test of interaction does not correspond to an assessment … If the interaction test is not significant: - Report ATE.

164. Heart-Failure-Natriuretic-Peptide Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_executive.pdf
     November 01, 2013 - Test Performance and Optimal Decision Cutpoints. … Determinants Affecting Test Performance. … Test Performance and Optimal Cutpoints. … Determinants Affecting Test Performance. … This should provide users of the test with robust information on the applicability of the test to patients

165. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
     January 01, 2011 - Different forms of iron-deficiency anemia could affect the diagnostic test performance of iron-status … Question 4 What factors affect the test performance and clinical utility of newer markers of iron … We will use separate forms for questions related to diagnostic test performance (KQ 2) and factors … affecting the diagnostic test performance and the effectiveness of test-oriented treatments (KQ 4) … We will test the forms on several studies and revise as necessary before full data extraction.

166. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
     December 01, 2009 - Studies of diagnostic test performance compare the results of the experimental test to a reference test … The reference test is intended to measure the “true” disease status of each patient. … Studies of diagnostic test performance were examined to see if they met the inclusion criteria. … In general, the smaller the negative likelihood ratio, the more accurate 4 the diagnostic test is … However, each individual woman’s post-test risk varies by her individual pre-test risk of malignancy.

167. Hepatic-Fibrosis White-Paper (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
     April 01, 2014 - No test for which we obtained additional data was originally rated low strength of evidence. … No test for which we obtained additional data was originally rated low strength of evidence, where … Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C. … How to use an article about a diagnostic test. B. … Genet Test Mol Biomarkers. 2012 Jun;16(6):531-5. PMID: 22352690. 63.

168. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
     August 23, 2012 - This conundrum exemplifies the challenges surrounding evaluation of a test in monoclonal disorders. … This was done to allow for a comparison of test accuracy among patients that were not preselected as … “Hospital stays” may be an unrealistic outcome to measure for a laboratory test (would performing a … Site as a future light chain test for evaluation. … Finally, it is the most useful test in patients with amyloidosis.

169. Disposition of Comments for Imaging Tests for the Staging of Colorectal Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
     November 20, 2014 - Estimates of test performance should incorporate information from all sources. … and the other imaging test in the same patients. … So the test of choice is heavily dependent on the clinical situation. … accuracy Our own report was restricted to test accuracy studies that examined comparative test performance … All of these studies used PET/CT, compared test accuracy of PET/CT vs.

170. Topic 0586 LUTS Secondary to BPH NSD FINAL (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0713-140625.pdf
     January 07, 2014 - interested in the adverse effects of pharmacotherapy treatment options, and patient characteristics or test … effects of pharmacotherapy treatment options; a better understanding of the patient characteristics or test … What are the patient characteristics or test results that can be used to determine the optimal pharmacotherapy

171. Comparative Effectiveness Research Review Disposition of Comments Report (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_disposition-comments.pdf
     February 13, 2012 - We did calculate the positive likelihood ratios and used those to illustrate post-test probability of … disease across a range of pre-test probabilities. … Non- invasive test such as MRI have unknown long term risk of Gd exposure and PET, BSGI and MIBI have … Analytical framework schema (page 27) indicates the non-invasive diagnostic test would occur after … If an available non-invasive diagnostic test could assist clinicians in evaluating women....

172. Layout 1 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
     December 01, 2011 - Direct comparisons of diagnostic tests without a reference test were not included. … We included initial cure, recurrence (variably defined by symptoms with or without a positive test for … Otherwise, there was only low-strength evidence for or against differences in test specificities. … There was moderate evidence that the test specificities in one comparison did not differ. … Bayes’ formula, then the differences in post-test probabilities might not lead to different clinical

173. Chapter 5: Assessing Risk of Bias as a Domain of Quality in Medical Test Studies | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-bias/methods

174. Chapter 9: Options for Summarizing Medical Test Performance in the Absence of a “Gold Standard” | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-performance/methods

175. Hypertension-Pulmonary-Arterial Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
     April 01, 2013 - structure and function of the right heart in patients with pulmonary hypertension.7 However, this test … Therefore, although transthoracic echocardiography is the standard screening test for PAH, it is less … NT-proBNP) are two biological substances found in the blood that have been studied as a screening test … Thirty-four studies used RHC as a reference test, 15 studies used 6MWD as a reference test, and 10 … studies used FC as a reference test.

176. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … Methods to detect publication bias for medical test studies are not robust. … Chapter 8: meta-analysis of test performance when there is a "gold standard". … Methods Guide for Medical Test Reviews.

177. Effective Health Care (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
     January 01, 2010 - active treatment) lead to improvements in health outcomes compared to a no-testing strategy, or are test … Errors in test assay leading to inaccurate results. b. … This test is already being marketed and there is a critical need for an understanding of how this marker

178. - (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
     January 01, 2009 - Sweat Test: A standard diagnostic test for cystic fibrosis that measures the concentration of chloride … Until death or Dec 1984 Student’s t test or Chi-square test and Cox proportional hazards model … Until death or Dec 1984 Student’s t test or Chi-square test and Cox proportional hazards model … Until death or transplant by July 1993 Student’s t test 6 minute walk test MD -101.7 m NS … NR Student’s t test 6 minute walk test MD -43 m (95%CI -53.23, 139.23) NR F-18

179. Disposition of Comments Report for Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cancer-pancreas_disposition-comments.pdf
     September 23, 2014 - The report acknowledges that CT is usually the first test. … We did not want to assume that the typical test is also the best test. … the literature to support test strategies. … We note that the accuracy of any given imaging test could not be determined, since studies did not … provide results separately for each screening test.

180. Prostate-Cancer-Therapies-Update Consumer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-therapies-update_consumer.pdf
     January 01, 2016 - � PSA blood test: This blood test tells how much PSA (a protein made by the prostate gland) is in … If the test results are not normal, your doctor may recommend more tests, such as a biopsy. … � T1: The cancer is too small to be felt during a digital rectal exam or seen in an imaging test … � T2: The cancer can be felt during a digital rectal exam and may be seen in an imaging test. … During checkups, your doctor may do a digital rectal exam, a PSA blood test, a biopsy, or other tests