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141. Colon-Cancer-Gene-Profiling Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
     March 13, 2012 - Data from a GEP test can provide information about a cell’s type, its current state of activity, and … What is the test turn-around time? d. … Those identified thus far are as follows: • Oncotype DX® Colon Cancer test (Genomic Health, Inc., … with different test results are sufficiently great as to influence treatment decisions. … the genes that are part of the assay, and are the test results reproducible?

142. Wireless-Motility-Capsule Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
     May 01, 2013 - Second, the physician needs to test for gastric emptying. … Should it be used as a stand-alone test? … Discrepancy exists when one test shows disease and the other test does not show disease. … test, it is difficult to get a clear picture of which test was most helpful in making a diagnosis … as superior to another test.

143. Topic 0438 Risk stratification and CAD NSD FINAL_SJ-2 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/TND-0520-131115.pdf
     November 15, 2013 - While the test performance characteristics for each of these diagnostic strategies are known, the relative … There is no clear guidance of what the test or combination of tests to use for patients with different … reviews primarily focus on NITs to diagnose symptomatic patients with suspected CAD and solely on the test … two or more NITs, evaluated NITs in the asymptomatic populations, and looked at outcomes other than test

144. Localized Prostate Cancer | Effective Health Care
     effectivehealthcare.ahrq.gov/decision-aids/prostate-cancer/08.html
     June 08, 2018 - Sometimes your doctor will be concerned that your cancer may have spread even though test results appear … Your doctor may suggest certain treatment options based on his or her concerns about what the test results … whether you have clinically localized prostate cancer and what risk group you fit into based on your test

145. Use of Natriuretic Peptide Measurement in the Management of Heart Failure | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
     December 20, 2011 - The review will consider BNP and NT-proBNP test performance, cut points, and factors that affect test … The low specificity of the test, however, limits its use as a rule-in tool. … determinants (e.g., age, gender, co-morbidities) on the test performance characteristics. … determinants (e.g., age, gender, co-morbidities) on the test performance characteristics. … Methods Guide for Medical Test Reviews.

146. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
     July 01, 2016 - This test is included in the algorithms of all recent guidelines. … This is a newer test that may give a positive result in some individuals with celiac disease who are … This test is used in individuals (primarily adults) who want to avoid biopsy. … Adding an EmA test to a tTG test resulted in increased specificity, with either no change or a slight … Adding a DGP test to a tTG test resulted in increased sensitivity but decreased specificity.

147. Diagnosis of Celiac Disease: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/celiac-disease/clinician
     July 26, 2016 - Table 1 : Tests Currently Used To Diagnose Celiac Disease Test Description Notes HLA = human … This test is included in the algorithms of all recent guidelines. … This test is used in individuals (primarily adults) who want to avoid biopsy. … Adding an EmA test to a tTG test resulted in increased specificity, with either no change or a slight … Adding a DGP test to a tTG test resulted in increased sensitivity but decreased specificity.

148. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-screening/research-protocol
     May 18, 2011 - Available fecal DNA tests are instead offered as a direct-to-consumer laboratory-developed test; such … Currently, there is at least one fecal DNA test commercially available in the United States (ColoSure … KQ 2: For absolute test performance: colonoscopy alone or supplemented by another test. … For relative test performance: any established CRC-screening modality. … and comparator test (reference standard) characteristics; and outcomes, including harms.

149. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - Available fecal DNA tests are instead offered as a direct-to-consumer laboratory-developed test; such … What are the absolute test-performance characteristics (e.g., sensitivity, specificity) of fecal DNA … KQ 2: For absolute test performance: colonoscopy alone or supplemented by another test. … For relative test performance: any established CRC- screening modality. … and comparator test (reference standard) characteristics; and outcomes, including harms.

150. Diagnosis of Gout | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/gout/research-protocol-2014
     July 17, 2014 - KQ2 What are the adverse effects associated with each diagnostic test (including pain, infection at … Assessing Risk of Bias as a Domain of Quality in Medical Test Studies. … Methods Guide for Medical Test Reviews. Rockville (MD); 2012. … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.

151. Efficacy and Safety of Screening for Postpartum Depression | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/depression-postpartum-screening/research-protocol
     March 09, 2012 - ) and specificity (the likelihood that people without the condition will have a negative test). … The sensitivity and specificity of a test are characteristics that are independent of the population … Because of this dependence on prevalence, the PPV and NPV of a specific test can vary across studies, … We will test for heterogeneity using graphical displays and test statistics (Q and I 2 statistics), … Methods Guide for Medical Test Reviews.

152. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - We provide complete test-specific information in the main text of the report. … test performance and the impact of tests on clinical outcomes. … Changes in technology over time may be a modifier of test performance. … reference standard test used which I presume it was histology. … What is paired test vs parallel arm design?

153. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Because these studies include both test-positive and test-negative patients in each treatment arm, they … test results and then randomize them into non–test-based treatment groups. … Key Question 4: Harms of Testing and of Test-Directed Treatment Harms of Test-Directed Treatment All … The test for interaction (a test for heterogeneity of treatment effects across genotype groups) was … alternative test-and-treat strategies provided information on harms of test-directed treatment.

154. Health Occupations | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/health-occupations
     January 17, 2012 - Archived June 22, 2017 Using the Principles of Randomized Controlled Trial Design to Guide Test … Needs Systematic Review Archived January 24, 2013 Methods Guide for Medical Test … Comparing Medical Interventions Methods Guide – Chapter December 30, 2010 Appendix: Test

155. Disposition of Comment Report for Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_disposition-comments.pdf
     May 20, 2013 - The guidelines currently say that it is a replacement test. … and WMC test being conducted weeks to months apart. … when the gastric emptying scintigraphy test was ordered. … Some experts thought that it would likely be a complementary test rather than an independent test for … In this way, they are no better or worse than WMC test results.

156. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
     August 01, 2012 - The traditional test comparators reported varied in each study. … All 3 compared test results to the diagnosis of disease verified by medical records. … The traditional test comparators differed in each study. … Methods Guide for Medical Test Reviews. … How to use an article about a diagnostic test. B.

157. C- Evidence-based Practice Center Technical Brief Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
     August 05, 2010 - treatments Outcomes • Test performance of positional MRI • Intermediate outcomes of patients: … iv Proposed use of the test: replacement test (e.g. instead of conventional MRI), triage test (e.g. … use of positional MRI todecide whether a myelogram is needed), or add- on/confirmatory test (e.g. use … Screening: use of the test to identify disease in the absence of clinical symptoms. b. … Patient management or treatment planning: use of the test to determine the management plan, including

158. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
     January 01, 2013 - prespecified covariates Describe how overall and subgroup effects will be reported if an interaction test … A test for interaction is conducted to evaluate if a subgroup variable has a statistically significant … Cautions: The interaction test generally has low power to detect differences in subgroup effects. … It should also be noted that a statistical test of interaction does not correspond to an assessment of … It is necessary to appropriately report the results of an interaction test.

159. Breast-Abnormalities-Tests-Update Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_executive.pdf
     February 01, 2012 - Sensitivity is a measure of how accurately the test can identify women with cancer; specificity is a … measure of how accurately the test can identify women who do not have cancer. … test with high specificity will rarely misclassify women without cancer as having cancer. … This estimate is known as a “pre-test” or “prior” probability. … if an additional imaging test will be helpful in guiding management decisions.

160. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - The review will consider BNP and NT-proBNP test performance, cut points, and factors that affect test … The low specificity of the test, however, limits its use as a rule-in tool. … Adverse events associated with administration of the test, or being exposed to the results. … Adverse events associated with administration of the test, or being exposed to the results. … Methods Guide for Medical Test Reviews.