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141. Quantitative Synthesis: Chapter 4. Quantifying, Testing, and Exploring Statistical Heterogeneity (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
     July 01, 2019 - owe to multiple contributing factors.8 ► Formal tests for funnel plot asymmetry exist, e.g., Egger’s test … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629- 34. … Misunderstandings about Q and 'Cochran's Q test' in meta-analysis. Stat Med. 2016;35(4):485-95. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629- 34. … Misunderstandings about Q and 'Cochran's Q test' in meta-analysis.

142. Emerging MRI Technologies for Imaging Musculoskeletal Disorders under Loading Stress (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
     November 01, 2011 - Additionally, other uses of the test could have been evaluated (for example predictive accuracy for … If one adopts the approach proposed by the reviewer, then every medical test is an add-on test (since … no patient receives only one test). … Is stress-loading MRI being proposed as a replacement, triage, or add-on test?” … These are important regardless of the role of the test. b) although the goal of this report is not

143. Evidence-Summary-Cer-197-Fractional-Exhaled-Nitric-Oxide (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-197-fractional-exhaled-nitric-oxide.pdf
     December 01, 2017 - The diagnosis of asthma is a clinical diagnosis and is challenging without a criterion standard test … Fractional exhaled nitric oxide (FeNO) testing has been suggested as a diagnostic test for asthma. … having asthma in people ages 5 years and older increases by 2.8 to 7.0 times given a positive FeNO test … • Depending on the FeNO cutoff, the posttest odds of having asthma given a positive FeNO test result … Test performance is modestly better in steroid-naïve asthmatics, children, and nonsmokers than the

144. Evidence Report on the (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/glaucoma-screening_research-protocol.pdf
     November 16, 2010 - Second, there is no single, simple test to identify people with glaucoma. … other hand, such strategies have been hampered by the lack of an adequately sensitive and specific test … glaucoma screening were conducted in the mid 2000s, there have been advances in the devices used to test … perimetry, and direct ophthalmoscopy are performed alone or as a part of a multicomponent screening test … Testability— the ability to perform the test, including measures among those administering the test

145. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - However, the diagnosis remains clinical; there is no single gold standard diagnostic test. … suggested, particularly with eosinophilic inflammation.7, 8 FeNO provides an additional diagnostic test … A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. … Meta-Analysis of Test Performance When There Is a "Gold Standard". … Methods Guide for Medical Test Reviews. Rockville (MD); 2012. 24.

146. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis_research-protocol.pdf
     June 06, 2011 - evidence showing that women at risk for CAD are less often referred for the appropriate diagnostic test … factors) have been reported to induce ECG changes during exercise that diminish the accuracy of the test … Additional factors may improve the accuracy of the exercise test, such as chronotropic and hemodynamic … as the initial test for symptomatic women at intermediate risk for CAD who have normal resting ECG … We will test for heterogeneity while recognizing that the ability of statistical methods to detect

147. Chapter 8: Meta-Analysis of Test Performance When There Is a “Gold Standard” | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-metaanalysis/methods

148. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
     March 14, 2012 - However, the test has been validated and in use since the late 1960s.8 Colonic Scintigraphy … Some experts thought that it would likely be a complementary test rather than an independent test for … • Interventions ○ The test of interest is the wireless motility capsule testing, alone (KQs … Test failure (unable to read test results) 2. … Methods Guide for Medical Test Reviews.

149. Research Protocol: Clostridium difficile Infection Update (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
     December 23, 2014 - for toxins if the first step test is positive. … However, given the rapid evolution of testing strategies, studies of diagnostic test performance often … , reference test, and flow and timing). … Chapter 5: assessing risk of bias as a domain of quality in medical test studies. … Chapter 8: meta-analysis of test performance when there is a "gold standard".

150. Cer-238-Cervical-Ripening-Appendix-E-1 (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-e-1.xlsx
     January 01, 2009 - All patients: After Foley placement, a non-stress test was performed. … /nonstress test prior to study entry. … If variable decelerations were noted on the nonstress test, an amniotic fluid index was determined. … If this test was reactive, then dinoprostone was inserted. … If this test was reactive, then dinoprostone was inserted.

151. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
     December 01, 2013 - The test is intended to simultaneously detect the presence of M. … The test is available in the U.S. as a research-use-only reagent; U.S. marketing approval of a test … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest x-ray results. 138,139 … the sample simultaneously with a nucleic acid amplification test, an acid-fast bacteria smear test … $50 per test).

152. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
     January 28, 2016 - The reader may be under the impression that this test is on par with TTG testing. … 24 months versus older children does not include the recognized phenomenon of young children who test … TTG IgA is widely accepted by the medical community as an appropriate diagnostic test. … geographic locations or populations where serologic tests are the most common initial detection test … We have removed the data on accuracy of EmA test from the Introduction sections.

153. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/09_infectiousdisease_potential_high_impact_june_2012.pdf
     January 01, 2012 - The test is available in the U.S. as a research-use-only reagent; U.S. marketing approval of a test … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest x-ray results. 173,174 … the sample simultaneously with a nucleic acid amplification test, an acid-fast bacteria smear test … $50 per test). … The only on-demand, rapid Mycobacterium tuberculosis test.

154. Introduction to the Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-introduction/slides

155. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
     December 01, 2012 - • What is the test turn-around time, that is, how long does it take to obtain test results? … Turnaround Time, That is, how Long Does it Take To Obtain Test Results? … The potential adverse effects from use of the test are also considered. … Test accuracy (clinical validity, analytic validity) 2. Impact of test on management? 3. … Adverse events of test - directed treatment? 5.

156. Disposition of Comments Report for Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
     January 01, 2011 - Key Question 4 addresses the factors that may affect test performance and clinical utility of newer … How we graded the strength of evidence for the test performance of reticulocyte hemoglobin content ( … Also, just because a test reduces the likelihood of iron administration and can save cost (naturally … RPA recommends the report be very clear about whether any diagnostic test is to be used to predict … It is believed that % HYPO may not an adequate test if samples cannot be delivered to a central lab

157. Assessing Applicability of Medical Test Studies in Systematic Reviews | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-applicability/slides

158. Celiac-Disease Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/celiac-disease_executive.pdf
     January 01, 2016 - This test is less useful in IgA-deficient individuals. DGP antibodies. … • All participants underwent both the “index test” and the reference standard (biopsy). … for EmA IgA • Test for tTG IgA • Test for DGP IgA antibodies • EmA IgG, tTG IgG, and DGP IgG tests … with an EmA or DGP test. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EC017.

159. Disposition of Comments Report for Noninvasive Technologies for the Diagnosis of Coronary Artery Disease in Women (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cad-women-diagnosis_disposition-comments.pdf
     June 12, 2012 - CONCLUSIONS: A multicomponent CMR stress test can accurately diagnose CAD in women. … It is unclear what anatomic differences affect stress test results; and g. … which may influence these test parameters. … I assume this differs by test method. … However, it was unclear from the tables how the test performed in the reference subgroup.

160. Chapter 3: Choosing the Important Outcomes for a Systematic Review of a Medical Test | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-outcomes/methods