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121. Liver Function Tests | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/liver-function-tests

122. Appendicitis Research-Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
     December 09, 2013 - We will use existing systematic reviews to identify single index test studies with test performance … • Have examined test performance outcomes. … Test characteristics include aspects specific to each diagnostic test of interest (e.g., the use and … Of note, studies evaluating the test performance of (the same) single index test will be synthesized … Methods Guide for Medical Test Reviews.

123. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/copd-is-common-and-respiratory-failure-due-to-copd-is-an-increasingly-common-disorder-use-of-non-invasive-positive-pressure-ventilation-nppv-for-patients-with-respiratory-failure-due-to-exacerbatons-of-copd-several-trials-and
     March 11, 2008 - Your Nomination - Please briefly describe in your own words the question about a health care test or … treatment, or intervention works   There is significant potential for side effects/harms using this test … , treatment, or intervention   Funding of this test, treatment, or intervention is uncertain or variable … a new technology/development   There is new evidence of clinical and/or cost effectiveness for this test … What is the specific purpose of the health care test or treatment you have a question about?

124. Topic Suggestion Description | Effective Health Care Program
     effectivehealthcare.ahrq.gov/get-involved/nominated-topics/thrombosis-plays-a-a-key-role-in-the-pathophysiology-of-myocardial-infarction-a-leading-cause-of-morbidity-and-mortality-there-have-been-a-number-of-devices-proposed-for-mechanical-thrombectomy-in-patients-with-in-the-setting
     June 19, 2008 - Your Nomination - Please briefly describe in your own words the question about a health care test or … or problem have considerable health or financial hardships   There is uncertainty about how well the test … treatment, or intervention works   There is significant potential for side effects/harms using this test … , treatment, or intervention   Funding of this test, treatment, or intervention is uncertain or variable … What is the specific purpose of the health care test or treatment you have a question about?

125. CER 174 Executive Summary: Imaging for the Pretreatment of Small Cell Lung Cancer (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
     April 01, 2016 - Test Criteria a. Type of test. … or test strategy compared with another test or test strategy … or test strategy compared with another test or test strategy … or test strategy compared with another test or test strategy … /test strategy compared with another test or test strategy

126. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - Test performance. … Studies must compare the test or test combination being evaluated to a reference standard (see below … Studies must directly compare the test or test combination to another test or test combination of interest … Studies must directly compare the test or test combination to another test or test combination of interest … Test Criteria Type of test.

127. Imaging Tests for the Staging of Colorectal Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colorectal-cancer-staging/research-protocol
     May 21, 2013 - Outcomes Test performance outcomes Test performance (e.g., sensitivity, specificity, understaging, … Test performance . … Studies must directly compare the test or test combination to another test or test combination of interest … Studies must directly compare the test or test combination to another test or test combination of interest … Test Criteria Type of test .

128. Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/appendicitis/research-protocol
     December 10, 2013 - We will use existing systematic reviews to identify single index test studies with test performance outcomes … Have examined test performance outcomes. … Test characteristics include aspects specific to each diagnostic test of interest (e.g., the use and … Of note, studies evaluating the test performance of (the same) single index test will be synthesized … Methods Guide for Medical Test Reviews.

129. Colorectal-Cancer-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
     February 01, 2012 - Especially given the constant changes in test development, test developers and researchers need to … Food and Drug Administration FIT Fecal immunochemical test FOBT Fecal occult blood test (usually used … and reliability of test results. … Initial test validation—study designed to determine ability and diagnostic accuracy of a test in persons … Relative test performance—Diagnostic accuracy (sensitivity, specificity) when compared to another test

130. An Empirical Assessment of Bivariate Methods for Meta-Analysis of Test Accuracy (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/bivariate-methods-utility_research.pdf
     November 01, 2012 - We reanalyzed 308 meta-analyses of test performance. … used to classify patients into two mutually exclusive and exhaustive groups (“test positive” and “test … a Here we use the term “test accuracy” to denote “test performance.” … The diagnostic odds ratio: a single indicator of test performance. … When is the post-coital test normal? A critical appraisal.

131. Liver-Cancer Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
     October 01, 2014 - What is the comparative test performance of imaging- based strategies for detecting HCC? … Data for outcomes other than measures of test performance were sparse. … Ten studies reported test performance of PET for detection of metastatic disease. … Summary of evidence for Key Question 3.a (staging): test performance Table L. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

132. Diagnosis of Celiac Disease | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/celiac-disease/research-protocol
     June 11, 2014 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … (Yes/No/Unclear) Could the conduct or interpretation of the index test have introduced bias? … Methods to detect publication bias for medical test studies are not robust. … Methods Guide for Medical Test Reviews. AHRQ. 2012. McNeish AS, Harms HK, Rey J, et al.

133. Depression-Postpartum-Screening Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
     May 01, 2013 - Test performance was summarized using sensitivity and specificity. … Screening Test Outcome Number of Studies (Subjects) Domains Pertaining to SOE SOE and Test Performance … characteristics of the screening test. … The choice of optimal test and test thresholds, testing algorithms, and test frequency need to be made … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

134. FRN 27 - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
     May 01, 2013 - versus adjunct test for diagnosis. … specialists or as a front-line test. … versus adjunct test for diagnosis. … specialists or as a front-line test. … Test Protocols for the diagnosis of gastroparesis and slow-transit constipation Test Duration of Test

135. Imaging Tests To Check for Kidney Stones in the Emergency Department (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/kidney-stone-imaging_consumer.pdf
     July 01, 2016 - You have come to the emergency department and the emergency doctor has recommended an imaging test to … How you feel about possibly needing a second imaging test. … If the first imaging test is not clear, you may need a second test. … In the past, a CT scan was often used as the first imaging test to check for kidney stones. … - If you have an ultrasound first, you may need a second imaging test, which may be a CT scan.

136. Gene Expression Profiling for Predicting Outcomes in Patients With Stage II Colon Cancer | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/colon-cancer-gene-profiling/research-protocol
     March 13, 2012 - Data from a GEP test can provide information about a cell’s type, its current state of activity, and … investigators may attempt to include the MSI findings as part of their GEP test. … What is the test turn-around time? … with different test results are sufficiently great as to influence treatment decisions. … the genes that are part of the assay, and are the test results reproducible?

137. Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions — An Update to the 2009 Report | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/breast-biopsy-update/research-protocol
     September 20, 2013 - allowing the exploration of the heterogeneity for test performance or harm outcomes. … Further, small studies do not produce precise estimates of test performance. … , reference standard test, and patient flow and timing. … Chapter 8: meta-analysis of test performance when there is a "gold standard". … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

138. breast-biopsy-update-130920 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
     September 20, 2013 - However, the impact aspects of biopsy technique have on test performance and safety are not clear. … The reference standard is used in their definition and is not a “comparator test.” … Further, small studies do not produce precise estimates of test performance. 6. … , reference standard test, and patient flow and timing. … Methods  Guide  for  Medical  Test  Reviews.  

139. celiac-disease-protocol-140612 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
     June 12, 2014 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … (Yes/No/Unclear) Could the conduct or interpretation of the index test have introduced bias? … Methods to detect publication bias for medical test studies are not robust. … Methods Guide for Medical Test Reviews. AHRQ. 2012. 12. McNeish AS, Harms HK, Rey J, et al.

140. Disposition of Comments Report for Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_disposition-comments.pdf
     March 07, 2012 - The potential effect of age on test accuracy is addressed in KQ4. … of a “normal” adult population should have a positive test. … At a 1:160 dilution, 5% of this population should have a positive test. … They are an inherent part of the ANA test procedure. … By index test results we mean results of ANA, RF, and CCP tests.