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101. Cell-Free-Dna-Appendix-C-Prepub-Final (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendix-c-prepub-final.xlsx
     January 01, 2025 - indicated a negative test. … cancer and negative test) N False Positives (participants without cancer and positive test) Author … So unclear whether test components/thresholds were entirely prespecified. … The test is proprietary. … As inventor, he has a clear interest in favorable results for the test.

102. Cell-Free-Dna-Final-App-C (xls file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cell-free-dna-final-app-c.xlsx
     January 01, 2025 - indicated a negative test. … cancer and negative test) N False Positives (participants without cancer and positive test) Author … So unclear whether test components/thresholds were entirely prespecified. … The test is proprietary. … As inventor, he has a clear interest in favorable results for the test.

103. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
     July 01, 2016 - This test is included in the algorithms of all recent guidelines. … This is a newer test that may give a positive result in some individuals with celiac disease who are … This test is used in individuals (primarily adults) who want to avoid biopsy. … Adding an EmA test to a tTG test resulted in increased specificity, with either no change or a slight … Adding a DGP test to a tTG test resulted in increased sensitivity but decreased specificity.

104. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - Available fecal DNA tests are instead offered as a direct-to-consumer laboratory-developed test; such … , the comparator must be colonoscopy alone or supplemented by another test (i.e., CT colonography). … KQ 2: For absolute test performance: colonoscopy alone or supplemented by another test. … For relative test performance: any established CRC- screening modality. … and comparator test (reference standard) characteristics; and outcomes, including harms.

105. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - We provide complete test-specific information in the main text of the report. … test performance and the impact of tests on clinical outcomes. … Changes in technology over time may be a modifier of test performance. … reference standard test used which I presume it was histology. … What is paired test vs parallel arm design?

106. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Because these studies include both test-positive and test-negative patients in each treatment arm, they … test results and then randomize them into non–test-based treatment groups. … Key Question 4: Harms of Testing and of Test-Directed Treatment Harms of Test-Directed Treatment All … The test for interaction (a test for heterogeneity of treatment effects across genotype groups) was … alternative test-and-treat strategies provided information on harms of test-directed treatment.

107. Hepatitis Testing | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/health-topics/hepatitis-testing

108. Chapter 1: Introduction to the Methods Guide for Medical Test Reviews | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-introduction/methods

109. Chapter 6: Assessing Applicability of Medical Test Studies in Systematic Reviews | Effective Health Care (EHC) Program
     effectivehealthcare.ahrq.gov/products/methods-guidance-tests-applicability/methods

110. Disposition of Comment Report for Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_disposition-comments.pdf
     May 20, 2013 - The guidelines currently say that it is a replacement test. … and WMC test being conducted weeks to months apart. … when the gastric emptying scintigraphy test was ordered. … Some experts thought that it would likely be a complementary test rather than an independent test for … In this way, they are no better or worse than WMC test results.

111. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
     August 01, 2012 - The traditional test comparators reported varied in each study. … All 3 compared test results to the diagnosis of disease verified by medical records. … The traditional test comparators differed in each study. … Methods Guide for Medical Test Reviews. … How to use an article about a diagnostic test. B.

112. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - The review will consider BNP and NT-proBNP test performance, cut points, and factors that affect test … The low specificity of the test, however, limits its use as a rule-in tool. … Adverse events associated with administration of the test, or being exposed to the results. … Adverse events associated with administration of the test, or being exposed to the results. … Methods Guide for Medical Test Reviews.

113. Diagnosis and Treatment of Clinical Alzheimer’s-Type Dementia: Evidence Summary (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/Evidence%20Summary_1.pdf
     April 01, 2020 - Alzheimer’s-Type Dementia: Evidence Summary Purpose of Review To summarize evidence on cognitive test … Cognitive test studies were heterogeneous in several ways. … They varied in their definitions of normal cognition and in test scoring metrics. … Further, few studies examined the classification accuracy of test combinations. … or combination of tests is most accurate and which cut-point is best for each test and test metric

114. C- Evidence-based Practice Center Technical Brief Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
     August 05, 2010 - treatments Outcomes • Test performance of positional MRI • Intermediate outcomes of patients: … iv Proposed use of the test: replacement test (e.g. instead of conventional MRI), triage test (e.g. … use of positional MRI todecide whether a myelogram is needed), or add- on/confirmatory test (e.g. use … Screening: use of the test to identify disease in the absence of clinical symptoms. b. … Patient management or treatment planning: use of the test to determine the management plan, including

115. Slide 1
     effectivehealthcare.ahrq.gov/sites/default/files/estimation-and-reporting_chapter-3.pptx
     January 01, 2013 - prespecified covariates Describe how overall and subgroup effects will be reported if an interaction test … A test for interaction is conducted to evaluate if a subgroup variable has a statistically significant … Cautions: The interaction test generally has low power to detect differences in subgroup effects. … It should also be noted that a statistical test of interaction does not correspond to an assessment of … It is necessary to appropriately report the results of an interaction test.

116. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
     May 01, 2013 - ) and specificity (the likelihood that people without the condition will have a negative test). … The sensitivity and specificity of a test are characteristics that are independent of the population … or can be indirectly estimated from given estimates of the test sensitivity and specificity and the … We will test for heterogeneity using graphical displays and test statistics (Q and I2 statistics), while … Methods Guide for Medical Test Reviews.

117. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
     December 01, 2015 - The Xpert MTB/RIF (M. tuberculosis/rifampicin) test is a nucleic acid–based test that is run on the … TB test manufacturer’s GeneXpert® real-time polymerase chain reaction (PCR) system. … cartridge costs between $49 and $63 per test when purchasing a set of 10 tests. … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest radiographs.122,123 The … the sample simultaneously with a nucleic acid amplification test, an acid- fast bacteria smear test

118. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - ” of a pharmacogenetic test). … We are aware of the somewhat superior properties of the Harbord test (compared to the Egger test). … Teirstein Methods VerifyNow P2Y12 Test The VerifyNow P2Y12 Test requires no sample manipulation prior … In particular, for 3a there were several direct comparisons of phenotype test vs. no-test strategies … Is this different from or the same as random assignment to test/no test strategies?

119. Executive Summary: ADHD Diagnosis and Treatment in Children and Adolescents (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/cer-267-adhd-executive-summary.pdf
     March 01, 2024 - • Diagnostic test performance likely depends on whether youth with attention deficit hyperactivity … Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance Test … Studies have rarely assessed test-retest reliability, no findings have been replicated prospectively … Diagnostic test performance likely depends on whether youth with ADHD are being differentiated from … Studies have rarely assessed test-retest reliability, no findings have been replicated prospectively

120. Glaucoma-Screening Surveillance (pdf file)
     effectivehealthcare.ahrq.gov/sites/default/files/related_files/glaucoma-screening_surveillance.pdf
     January 01, 2013 - Four studies examined the accuracy of the FDT N-30 threshold test. … SAP Suprathreshold Test Evidence From Burr et al., 2007. … SAP Threshold Test Evidence From Burr et al., 2007. … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for