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  1. effectivehealthcare.ahrq.gov/sites/default/files/pdf/test-performance-metrics_appendixes.pdf
    January 01, 2005 - A-1 Appendix: Test Performance Metrics The basic definitions of test performance are based upon … It expresses the ability of a medical test to maximize true positives. … It expresses the ability of a test to minimize false positives. … If the threshold (cutpoint) for test positive is set higher—say when the test provides a continuously … How to use an article about a diagnostic test. B.
  2. effectivehealthcare.ahrq.gov/sites/default/files/related_files/prostate-cancer-test_executive.pdf
    April 01, 2013 - 11 Also, issues such as who to test, when to test and retest, and the most effective clinical tPSA … The intended use of the test is to inform decisionmaking about repeat biopsy. … An AUC of 1.0 indicates a perfect test, and an AUC of 0.5 indicates a worthless test. 4 matching … was preserved by computing differences between PCA3 test results and comparator test results within … The effect of even a great test is limited if uptake is low.
  3. effectivehealthcare.ahrq.gov/products/test-performance-metrics
    June 01, 2012 - Appendix: Methods Guide for Medical Test Reviews: Test Performance Metrics Timeline … Initiated June 01, 2012 Methods Guide – Chapter Appendix: Test
  4. effectivehealthcare.ahrq.gov/products/test-performance-metrics/appendixes/
  5. effectivehealthcare.ahrq.gov/sites/default/files/pdf/prostate-cancer-test_research-protocol.pdf
    October 14, 2011 - Was the reference standard independent of the index test (i.e., the index test did not form part of … Was the execution of the index test described in sufficient detail to permit replication of the test … when the test is used in practice? … For the pooled results, was a test done to assess homogeneity (i.e., Chi-squared test, I2)? … but decrease test specificity.
  6. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-bias_methods.pdf
    July 01, 2012 - in Medical Test Studies P. … Variation in test technology When the characteristics of a medical test change over time as a result … of an index test. … the sensitivity and specificity of the test may lead to over-optimistic measures of test performance … Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index
  7. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-metaanalysis_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews 8-1 Chapter 8 Meta-Analysis of Test Performance When … Introduction The Methods Guide to Medical Test Reviews (also referred to as the Medical Test Methods … This chapter of the Medical Test Methods Guide focuses on choosing strategies for meta- analysis of test … questions driving the evidence synthesis (e.g., “Is this test alone or in combination with a test-and-treat … medical test evidence focuses on summarizing test performance data; thus their meta-analysis was chosen
  8. effectivehealthcare.ahrq.gov/products/prostate-cancer-test
    October 14, 2011 - PCA3 Testing for the Diagnosis and Management of Prostate Cancer Timeline May 04, 2011 Topic Initiated October 14, 2011 Research Protocol Archived PCA3 Testing for the Diagnosis and Management of Prostate Cancer April 01, 2013 Systematic Rev…
  9. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guide-editorial_methods.pdf
    July 01, 2012 - Methods Guide for Medical Test Reviews - Editorial E-1 Editorial Methods Guide for Authors of … The most common outcome in an evaluation of this test is the accuracy of the test in identifying clinically … Clinicians, while interested in this proxy outcome, would find more value in the ability of the test … Cochrane Diagnostic Test Accuracy Working Group. Handbook for DTA reviews. … Editorial printed in Methods Guide for Medical Test Reviews (AHRQ Publication No. 12-EHC017).
  10. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-outcomes_methods.pdf
    July 01, 2012 - Test Diagnostic Test Prognostic Test Clinical management + +++ +++ Direct health effects + ++ ++ … , a diagnostic test, and a prognostic test. … Costs of the test. … Direct test effects. The test under consideration is a radiographic test. … Costs of the test.
  11. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-introduction_methods.pdf
    July 01, 2012 - Guide for Medical Test Reviews David B. … This Methods Guide for Medical Test Reviews (referred to hereafter as the Medical Test Methods Guide … Development of the Medical Test Methods Guide In developing this Medical Test Methods Guide, we sought … Indeed, test performance characteristics have been treated as sufficient criteria of test value (i.e … category Diagnostic accuracy efficacy Clinical validity Test accuracy Test performance Performance
  12. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-prognostic_methods.pdf
    July 01, 2012 - A diagnostic test is used to help determine whether a patient has a disease at the time the test is … Therefore, the “reference test” for a prognostic test is the observed proportion of the population who … Much as for a diagnostic test, a systematic review of a prognostic test could then assess the accuracy … Was the test used and interpreted the same way by all sites/studies including any interdeterminate test … Grouped Mortality Probabilities Estimated by the First Prognostic Test + a New Prognostic Test
  13. Prognostic Tests (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/medical-test-reviews-prognostic.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Methods guide for medical test reviews. … by the test. … Like a diagnostic test, a systematic review could then assess the accuracy of the prognostic test by … Was the test used and interpreted the same way by all sites/studies, including any indeterminate test
  14. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-performance_methods.pdf
    July 01, 2012 - performance compares the results of an index test with a reference test. … Perhaps the simplest case of test performance evaluation includes an “index test” and a reference test … Reference Test (-) Index Test (+) Index Test (-) We now have five unknowns: the sensitivity … One explores how well one test agrees with the other test(s), and perhaps asks if one test can be used … Comparison of a screening test and a reference test in epidemiologic studies. II.
  15. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-topics_methods.pdf
    July 01, 2012 - pathways, technical details of the test, characteristics of clinicians or operators using the test, … and logically flow from a test strategy. … as the old test and the new test has advantages over the old test such as causing fewer adverse effects … those identified by the older test? … the old test and the new test has advantages over the old test such as having fewer adverse effects
  16. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-decision-models_methods.pdf
    July 01, 2012 - Instead, one should compare complete test-and-treat strategies (for which test performance is but a … Define how the test will be used. … (test-and-treat strategy) based on considerations of test characteristics alone. … However, in other cases, harms can be induced both by the treatment and the test (e.g., if the test is … clinical utility of a test.
  17. Prognostic Tests (ppt file)

    effectivehealthcare.ahrq.gov/sites/default/files/related_files/medical-test-reviews-prognostic.ppt
    June 01, 2012 - Methods guide for medical test reviews. … Methods guide for medical test reviews. … by the test. … Like a diagnostic test, a systematic review could then assess the accuracy of the prognostic test by … Was the test used and interpreted the same way by all sites/studies, including any indeterminate test
  18. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-applicability_methods.pdf
    July 01, 2012 - Test Studies in Systematic Reviews Katherine E. … test (i.e., as a replacement), but in reality the test is proposed to be used as a triage test to guide … Exclude a priori if test results cannot be mapped to disease status (i.e., 2x2 or other test performance … Placement of test in the sequence of care (e.g. relationship of test to treatment or follow-on management … Routine Preventive Care Over Time Routine use of a medical test as a screening test might be considered
  19. effectivehealthcare.ahrq.gov/products/prostate-cancer-test/research-protocol
    October 14, 2011 - Was the reference standard independent of the index test (i.e., the index test did not form part of the … Was the execution of the index test described in sufficient detail to permit replication of the test? … the test is used in practice? … For the pooled results, was a test done to assess homogeneity (i.e., Chi-squared test, I 2 )? … but decrease test specificity.
  20. effectivehealthcare.ahrq.gov/sites/default/files/pdf/methods-guidance-tests-grading_methods.pdf
    July 01, 2012 - (e.g., test versus no test) with clinical outcomes as the study endpoint, the reader is referred to … Common Challenges Diagnostic test studies commonly focus on the accuracy of the test in making a disease … Of note, directness does apply to how a test is used in comparison to another test. … evaluated is not the exact test used in practice, or if the test accuracy is being calculated in a … Assessing risk of bias as a domain of quality in medical test studies.

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