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281. Heart-Failure-Natriuretic-Peptide Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/heart-failure-natriuretic-peptide_executive.pdf
     November 01, 2013 - Test Performance and Optimal Decision Cutpoints. … Determinants Affecting Test Performance. … Test Performance and Optimal Cutpoints. … Determinants Affecting Test Performance. … This should provide users of the test with robust information on the applicability of the test to patients

282. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/chronic-kidney-disease-anemia-2011_research-protocol.pdf
     January 01, 2011 - Different forms of iron-deficiency anemia could affect the diagnostic test performance of iron-status … What reference standards are used for the diagnosis of iron status in studies evaluating test accuracy … Question 4 What factors affect the test performance and clinical utility of newer markers of iron … affecting the diagnostic test performance and the effectiveness of test-oriented treatments (KQ 4) … We will test the forms on several studies and revise as necessary before full data extraction.

283. Diagnosis and Treatment of Clinical Alzheimer's-Type Dementia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/alzheimers-type-dementia/research
     October 01, 2022 - Purpose of Review To summarize evidence on cognitive test accuracy for clinical Alzheimer’s-type dementia … Cognitive test accuracy studies must have used explicit CATD diagnostic criteria and a non-CATD control

284. Effectiveness of Screening and Treatment of C. difficile Infections | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/c-diff-infections/research-protocol
     December 01, 2019 - for toxins if the first step test is positive. … Physicians may not always be sufficiently educated as to which diagnostic test is best to use and how … best to resolve a suspected false negative result (e.g., evidence suggests retesting with the same test … Outcomes for each question: Diagnostic Test Outcomes Sensitivity Specificity Predictive values … Timing: Diagnostic testing: time to test Antibiotic and non-standard treatments: variable, generally

285. Topic 0586 LUTS Secondary to BPH NSD FINAL (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0713-140625.pdf
     January 07, 2014 - interested in the adverse effects of pharmacotherapy treatment options, and patient characteristics or test … effects of pharmacotherapy treatment options; a better understanding of the patient characteristics or test … What are the patient characteristics or test results that can be used to determine the optimal pharmacotherapy

286. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-biopsy-executive.pdf
     December 01, 2009 - Studies of diagnostic test performance compare the results of the experimental test to a reference test … The reference test is intended to measure the “true” disease status of each patient. … Studies of diagnostic test performance were examined to see if they met the inclusion criteria. … In general, the smaller the negative likelihood ratio, the more accurate 4 the diagnostic test is … However, each individual woman’s post-test risk varies by her individual pre-test risk of malignancy.

287. Hepatic-Fibrosis White-Paper (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/hepatic-fibrosis_white-paper.pdf
     April 01, 2014 - No test for which we obtained additional data was originally rated low strength of evidence. … No test for which we obtained additional data was originally rated low strength of evidence, where … Comparison of test performance profile for blood tests of liver fibrosis in chronic hepatitis C. … How to use an article about a diagnostic test. B. … Genet Test Mol Biomarkers. 2012 Jun;16(6):531-5. PMID: 22352690. 63.

288. Disposition of Comments Report for Serum Free Light Chain Analysis for the Diagnosis, Management, and Prognosis of Plasma-Cell Dyscrasias (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_disposition-comments.pdf
     August 23, 2012 - This conundrum exemplifies the challenges surrounding evaluation of a test in monoclonal disorders. … This was done to allow for a comparison of test accuracy among patients that were not preselected as … “Hospital stays” may be an unrealistic outcome to measure for a laboratory test (would performing a … Site as a future light chain test for evaluation. … Finally, it is the most useful test in patients with amyloidosis.

289. Does the use of Cytochrome P450 2C19 (CYP2C19) testing to predict response to clopidogrel in people: (1) with acute coronary syndrome, (2) who have suffered other cardiovascular disease-related events (e.g., ischemic stroke, symptomatic… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/does-the-use-of-cytochrome-p450-2c19-cyp2c19-testing-to-predict-response-to-clopidogrel-in-people-1-with-acute-coronary-syndrome-2-who-have-suffered-other-cardiovascular-disease-related-events-eg-ischemic-stroke-symptomatic-
     November 01, 2017 - Briefly describe a specific question, or set of related questions, about a health care test … coronary intervention, lead to improvements in health outcomes compared to a no-testing strategy, or are test

290. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0332_07-29-2010.pdf
     January 01, 2010 - active treatment) lead to improvements in health outcomes compared to a no-testing strategy, or are test … Errors in test assay leading to inaccurate results. b. … This test is already being marketed and there is a critical need for an understanding of how this marker

291. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0411_02-10-2011.pdf
     January 01, 2011 - time/partial thromboplastin time, basic or complete metabolic panel, urinalysis, and urine pregnancy test … (e.g., potassium in patients on diuretics, pregnancy test in women of child-bearing age) 4.

292. Comparative Effectiveness Research Review Disposition of Comments Report (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_disposition-comments.pdf
     February 13, 2012 - We did calculate the positive likelihood ratios and used those to illustrate post-test probability of … disease across a range of pre-test probabilities. … Non- invasive test such as MRI have unknown long term risk of Gd exposure and PET, BSGI and MIBI have … Analytical framework schema (page 27) indicates the non-invasive diagnostic test would occur after … If an available non-invasive diagnostic test could assist clinicians in evaluating women....

293. Disposition of Comments for Imaging Tests for the Staging of Colorectal Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_disposition-comments.pdf
     November 20, 2014 - Estimates of test performance should incorporate information from all sources. … and the other imaging test in the same patients. … So the test of choice is heavily dependent on the clinical situation. … accuracy Our own report was restricted to test accuracy studies that examined comparative test performance … All of these studies used PET/CT, compared test accuracy of PET/CT vs.

294. Layout 1 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/c-diff-infections_executive.pdf
     December 01, 2011 - Direct comparisons of diagnostic tests without a reference test were not included. … We included initial cure, recurrence (variably defined by symptoms with or without a positive test for … Otherwise, there was only low-strength evidence for or against differences in test specificities. … There was moderate evidence that the test specificities in one comparison did not differ. … Bayes’ formula, then the differences in post-test probabilities might not lead to different clinical

295. Biopsy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/biopsy
     December 06, 2016 - In most cases, a biopsy is the only test that can tell for sure if a suspicious area is cancer.

296. Hypertension-Pulmonary-Arterial Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/hypertension-pulmonary-arterial_executive.pdf
     April 01, 2013 - structure and function of the right heart in patients with pulmonary hypertension.7 However, this test … Therefore, although transthoracic echocardiography is the standard screening test for PAH, it is less … NT-proBNP) are two biological substances found in the blood that have been studied as a screening test … Thirty-four studies used RHC as a reference test, 15 studies used 6MWD as a reference test, and 10 … studies used FC as a reference test.

297. Advancing Measurement of Patient-Centered Communication in Cancer Care | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cancer-communication/research
     November 01, 2017 - Objectives The goal of Phase 2 was to refine the Phase 1 framework; identify, develop, and test PCC … Develop and Test Measures : We developed an inventory of PCC survey items by examining published literature … needed to finalize the items including additional cognitive testing, conducting a large-scale field test

298. Renal-Cancer Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/renal-cancer_research-protocol.pdf
     April 20, 2015 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … Methods to detect publication bias for medical test studies are not robust. … Chapter 8: meta-analysis of test performance when there is a "gold standard". … Methods Guide for Medical Test Reviews.

299. Schwitzer_ECCS2012 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/schwitzer_eccs2012.pdf
     July 23, 2012 - This excerpt comes from  an article, “Cancer Society Casts Doubt on Value of Prostate  Cancer Test … initially chose active surveillance after positive results from  a prostate-­‐specific  antigen  test … School of Medicine, tells his physician not to order a PSA   [prostate-­‐specific  antigen]  blood test … or an annual electrocardiogram  since neither test has  been  shown  to  save  lives …  posted  on its  blog: “…[O]ur greatest fear was that forces with an economic interest in the test

300. - (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cystic-fibrosis-hgh_appendixes.pdf
     January 01, 2009 - Sweat Test: A standard diagnostic test for cystic fibrosis that measures the concentration of chloride … Until death or Dec 1984 Student’s t test or Chi-square test and Cox proportional hazards model … Until death or Dec 1984 Student’s t test or Chi-square test and Cox proportional hazards model … Until death or transplant by July 1993 Student’s t test 6 minute walk test MD -101.7 m NS … NR Student’s t test 6 minute walk test MD -43 m (95%CI -53.23, 139.23) NR F-18