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241. Evidence Report on the (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/glaucoma-screening_research-protocol.pdf
     November 16, 2010 - Second, there is no single, simple test to identify people with glaucoma. … other hand, such strategies have been hampered by the lack of an adequately sensitive and specific test … glaucoma screening were conducted in the mid 2000s, there have been advances in the devices used to test … perimetry, and direct ophthalmoscopy are performed alone or as a part of a multicomponent screening test … Testability— the ability to perform the test, including measures among those administering the test

242. Emerging MRI Technologies for Imaging Musculoskeletal Disorders under Loading Stress (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/musculoskeletal-disorders-imaging_disposition-comments.pdf
     November 01, 2011 - Additionally, other uses of the test could have been evaluated (for example predictive accuracy for … If one adopts the approach proposed by the reviewer, then every medical test is an add-on test (since … no patient receives only one test). … Is stress-loading MRI being proposed as a replacement, triage, or add-on test?” … These are important regardless of the role of the test. b) although the goal of this report is not

243. Management of Renal Masses and Localized Renal Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/renal-cancer/research-protocol
     December 01, 2019 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … Methods to detect publication bias for medical test studies are not robust. … Chapter 8: meta-analysis of test performance when there is a "gold standard". … Methods Guide for Medical Test Reviews.

244. For women, when comparing noninvasive testing,which testing method (echocardiography, MIBI-SPECT, pharmacological testing, etc.) is more accurate in diagnosing coronary artery disease. There has been inadequate studies done on women for… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/for-women-when-comparing-noninvasive-testingwhich-testing-method-echocardiography-mibi-spect-pharmacological-testing-etc-is-more-accurate-in-diagnosing-coronary-artery-disease-there-has-been-inadequate-studies-done-on-women-
     November 01, 2017 - Briefly describe a specific question, or set of related questions, about a health care test

245. Fractional Exhaled Nitric Oxide Clinical Utility in Asthma Management (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/asthma-nitric-oxide_research-protocol.pdf
     September 06, 2016 - However, the diagnosis remains clinical; there is no single gold standard diagnostic test. … suggested, particularly with eosinophilic inflammation.7, 8 FeNO provides an additional diagnostic test … A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. … Meta-Analysis of Test Performance When There Is a "Gold Standard". … Methods Guide for Medical Test Reviews. Rockville (MD); 2012. 24.

246. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/cad-women-diagnosis_research-protocol.pdf
     June 06, 2011 - evidence showing that women at risk for CAD are less often referred for the appropriate diagnostic test … factors) have been reported to induce ECG changes during exercise that diminish the accuracy of the test … Additional factors may improve the accuracy of the exercise test, such as chronotropic and hemodynamic … as the initial test for symptomatic women at intermediate risk for CAD who have normal resting ECG … We will test for heterogeneity while recognizing that the ability of statistical methods to detect

247. Quantitative Synthesis: Chapter 4. Quantifying, Testing, and Exploring Statistical Heterogeneity (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/ehc-presentation-quantitative-synthesis-chapter-4.pdf
     July 01, 2019 - owe to multiple contributing factors.8 ► Formal tests for funnel plot asymmetry exist, e.g., Egger’s test … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629- 34. … Misunderstandings about Q and 'Cochran's Q test' in meta-analysis. Stat Med. 2016;35(4):485-95. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629- 34. … Misunderstandings about Q and 'Cochran's Q test' in meta-analysis.

248. Laboratory Biomarkers for Iron Deficiency Anemia in Late Stage Chronic Kidney Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/chronic-kidney-disease-anemia-2011/research-protocol
     December 01, 2019 - Different forms of iron-deficiency anemia could affect the diagnostic test performance of iron-status … What reference standards are used for the diagnosis of iron status in studies evaluating test accuracy … Adverse effects or harms associated with testing and associated treatments (e.g., test-related anxiety … the diagnostic test performance and the effectiveness of test-oriented treatments (KQ 4). … We will test the forms on several studies and revise as necessary before full data extraction. D.

249. What is the comparative effectiveness of genetic and other diagnostic tests to identify and treat intellectual and developmental disabilities caused by genetic mutations in post-natal to early childhood populations? | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/what-is-the-comparative-effectiveness-of-genetic-and-other-diagnostic-tests-to-identify-and-treat-intellectual-and-developmental-disabilities-caused-by-genetic-mutations-in-post-natal-to-early-childhood-populations
     November 01, 2017 - Briefly describe a specific question, or set of related questions, about a health care test or treatment

250. Efficacy and Safety of Screening for Postpartum Depression | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-postpartum-screening/research
     December 01, 2019 - associated with an increased risk of postpartum depression, only two studies directly reported an effect on test … insufficient evidence to evaluate whether timing relative to delivery, setting, or provider affected test … The ideal characteristics of a screening test for postpartum depression, including sensitivity, specificity

251. Gastrointestinal Bleeding | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/gastrointestinal-bleeding
     August 05, 2010 - The amount of bleeding can be so small that only a lab test can find it. … The test used most often to look for the cause of GI bleeding is called endoscopy .

252. HIV/AIDS | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/hivaids
     November 21, 2016 - A blood test can tell if you have HIV infection. … Your health care provider can do the test, or you can use a home testing kit.

253. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule_research-protocol.pdf
     March 14, 2012 - However, the test has been validated and in use since the late 1960s.8 Colonic Scintigraphy … Some experts thought that it would likely be a complementary test rather than an independent test for … • Interventions ○ The test of interest is the wireless motility capsule testing, alone (KQs … Test failure (unable to read test results) 2. … Methods Guide for Medical Test Reviews.

254. Research Protocol: Clostridium difficile Infection Update (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/c-difficile-update_research-protocol.pdf
     December 23, 2014 - for toxins if the first step test is positive. … However, given the rapid evolution of testing strategies, studies of diagnostic test performance often … , reference test, and flow and timing). … Chapter 5: assessing risk of bias as a domain of quality in medical test studies. … Chapter 8: meta-analysis of test performance when there is a "gold standard".

255. Disposition of Comments for CER 162 Diagnosis of Celiac Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/celiac-disease_disposition-comments.pdf
     January 28, 2016 - The reader may be under the impression that this test is on par with TTG testing. … 24 months versus older children does not include the recognized phenomenon of young children who test … TTG IgA is widely accepted by the medical community as an appropriate diagnostic test. … geographic locations or populations where serologic tests are the most common initial detection test … We have removed the data on accuracy of EmA test from the Introduction sections.

256. Cer-238-Cervical-Ripening-Appendix-E-1 (xls file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/cer-238-cervical-ripening-appendix-e-1.xlsx
     January 01, 2009 - All patients: After Foley placement, a non-stress test was performed. … /nonstress test prior to study entry. … If variable decelerations were noted on the nonstress test, an amniotic fluid index was determined. … If this test was reactive, then dinoprostone was inserted. … If this test was reactive, then dinoprostone was inserted.

257. Disposition of Comments Report for Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/chronic-kidney-disease-anemia-2011_disposition-comments.pdf
     January 01, 2011 - Key Question 4 addresses the factors that may affect test performance and clinical utility of newer … How we graded the strength of evidence for the test performance of reticulocyte hemoglobin content ( … Also, just because a test reduces the likelihood of iron administration and can save cost (naturally … RPA recommends the report be very clear about whether any diagnostic test is to be used to predict … It is believed that % HYPO may not an adequate test if samples cannot be delivered to a central lab

258. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/infectiousdisease_hi_impact.pdf
     December 01, 2013 - The test is intended to simultaneously detect the presence of M. … The test is available in the U.S. as a research-use-only reagent; U.S. marketing approval of a test … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest x-ray results. 138,139 … the sample simultaneously with a nucleic acid amplification test, an acid-fast bacteria smear test … $50 per test).

259. Technical Brief 13: Gene Expression Profiling for Predicting Outcomes in Stage II Colon Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_technical-brief.pdf
     December 01, 2012 - • What is the test turn-around time, that is, how long does it take to obtain test results? … Turnaround Time, That is, how Long Does it Take To Obtain Test Results? … The potential adverse effects from use of the test are also considered. … Test accuracy (clinical validity, analytic validity) 2. Impact of test on management? 3. … Adverse events of test - directed treatment? 5.

260. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/09_infectiousdisease_potential_high_impact_june_2012.pdf
     January 01, 2012 - The test is available in the U.S. as a research-use-only reagent; U.S. marketing approval of a test … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest x-ray results. 173,174 … the sample simultaneously with a nucleic acid amplification test, an acid-fast bacteria smear test … $50 per test). … The only on-demand, rapid Mycobacterium tuberculosis test.