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221. Colorectal-Cancer-Staging Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-staging_executive.pdf
     September 01, 2014 - T2-weighted MRI) Outcomes: • Test performance outcomes – Test performance (sensitivity, specificity … Single test performance. … performance for a particular imaging test. 3. … Comparative test performance. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

222. Methods Research Report: Testing a Machine Learning Tool for Facilitating Living Systematic Reviews of Chronic Pain Treatments (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/methods-report-testing-machine-learning-tool-chronic-pain.pdf
     November 01, 2020 - Publication No. 21-EHC004 November 2020 ii Key Messages Purpose of Project To develop and test … text word-only search strategies without MEDLINE® indexing for three chronic pain living reviews, test … This project had three stages: develop optimized search strategies (Stage 1), test machine learning … machine learning classifier on optimized searches (Stage 2), and test machine learning classifier on … and to test the performance of a machine classifier on the optimized search strategies.

223. Topic 0451 Celiac Disease NSD FINAL (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-533_05-24-2013.pdf
     January 01, 2013 - nominator is a celiac disease (CD) patient interested in finding out about “easier Summary: ways” to test … Staff-Generated PICO Population(s): Patients with suspected CD with a positive serology test Intervention … (s): Alternative confirmatory test strategies including additional serologic testing, HLA typing and … avoidance of the potential harms associated with biopsy Key Questions Is there an “easier way” to test

224. Bone Infections | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/bone-infections
     include Pain in the infected area Chills and fever Swelling, warmth, and redness A blood test … or imaging test such as an x-ray can tell if you have a bone infection.

225. Executive Summary CER 171: Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/coronary-artery-disease-testing_executive.pdf
     March 01, 2011 - test-negative people. … Moreover, the impact of a negative test or the treatment downstream from a positive test may extend … pathways were followed after the initial test, which test(s) may lead to the most appropriate treatment … Studies did not provide information on the impact of test results on post-test risk stratification … Documentation of management of those who test positive compared with those who test negative and followup

226. Osteogenesis Imperfecta | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/osteogenesis-imperfecta
     No single test can identify OI. … Your doctor may also test your collagen (from skin) or genes (from blood).

227. Key Questions 1. Does routine preoperative testing compared to no testing or alternative testing strategies improve outcomes (such as surgical complications, other morbidity, and mortality) among patients undergoing elective surgery? 2.… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/key-questions-1-does-routine-preoperative-testing-compared-to-no-testing-or-alternative-testing-strategies-improve-outcomes-such-as-surgical-complications-other-morbidity-and-mortality-among-patients-undergoing-elective-surg
     November 01, 2017 - Briefly describe a specific question, or set of related questions, about a health care test … potassium in patients on diuretics, pregnancy test in women of child-bearing age) Do routine preoperative … time/partial promboplastin time basic or complete metabolic panel, urinalysis, and urine pregnancy test … variation in preoperative testing, decrease costs, maximize quality, improve physician confidence with test

228. Prostate-Cancer-Risk-Assessment-Genes Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/prostate-cancer-risk-assessment-genes_executive.pdf
     July 01, 2012 - pre-analytic or analytic variables)43 Clinical validity A measurement of the accuracy with which a test … predictive value Clinical utility Degree to which benefits are provided by positive and negative test … The commercial availability of a test panel was defined as a clinical test offered (or soon to be offered … ) by a certified laboratory, or licensed or certified kit reagent test panels sold for use by clinical … What are the sources of variation in accuracy or analytical validity across different test platforms

229. Huntington's Disease | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/huntingtons-disease
     A blood test can tell you if have the HD gene and will develop the disease. … Genetic counseling can help you weigh the risks and benefits of taking the test.

230. Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: A Comparative Effectiveness Review | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/wireless-motility-capsule/research-protocol
     December 01, 2019 - However, the test has been validated and in use since the late 1960s. 8 Colonic Scintigraphy Colon … For this test, the manometry catheter is placed with endoscopic and fluoroscopic guidance after a full … Some experts thought that it would likely be a complementary test rather than an independent test for … Interventions The test of interest is the wireless motility capsule testing, alone (KQs 1 and 3) … Methods Guide for Medical Test Reviews.

231. Breast-Abnormalities-Tests-Update Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-abnormalities-tests-update_research-protocol.pdf
     July 01, 2010 - that affected the accuracy of the noninvasive test being evaluated. … ” because the outcome of test accuracy is indirectly related to health outcomes. … Meta-DiSc: a software for meta- analysis of test accuracy data. … Sensitivity: the proportion of women with breast cancer who test positive for breast cancer. … Specificity: the proportion of women with benign lesions who test negative for breast cancer.

232. Chlamydia Infections | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/chlamydia-infections
     women, providers sometimes use (or ask you to use) a cotton swab to get a sample from your vagina to test … You should go to your health provider for a test if you have symptoms of chlamydia, or if you have a … Pregnant women should get a test when they go to their first prenatal visit .

233. Prediabetes | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/prediabetes
     Your doctor can use an A1C test or another blood test to find out if your blood glucose levels are

234. Cervical Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/cervical-cancer
     Your health care provider can find abnormal cells by doing a Pap test to examine cells from the cervix … You may also have an HPV test.

235. Diabetic Kidney Problems | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/diabetic-kidney-problems
     December 15, 2009 - Tests include a urine test to detect protein in your urine and a blood test to show how well your kidneys

236. Fecal DNA Testing in Screening for Colorectal Cancer in Average Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research
     December 01, 2019 - excluded initial validation studies of fecal DNA testing, we found only three studies that examined the test … analytic sensitivity of assays, it is unclear if these advances are applicable to the currently available test … evaluated acceptability found that fecal DNA testing is generally acceptable, although an important test

237. Evidence-Summary-Cer-197-Fractional-Exhaled-Nitric-Oxide (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/evidence-summary-cer-197-fractional-exhaled-nitric-oxide.pdf
     December 01, 2017 - The diagnosis of asthma is a clinical diagnosis and is challenging without a criterion standard test … Fractional exhaled nitric oxide (FeNO) testing has been suggested as a diagnostic test for asthma. … having asthma in people ages 5 years and older increases by 2.8 to 7.0 times given a positive FeNO test … • Depending on the FeNO cutoff, the posttest odds of having asthma given a positive FeNO test result … Test performance is modestly better in steroid-naïve asthmatics, children, and nonsmokers than the

238. Sickle Cell Anemia | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/sickle-cell-anemia
     A blood test can show if you have the trait or anemia. … Most states test newborn babies as part of their newborn screening programs.

239. Disposition of Comments for CER 171 Noninvasive Testing for Coronary Artery Disease (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/coronary-artery-disease-testing_disposition-comments.pdf
     March 29, 2016 - TEP 2 Introduction p.11 - again, CACS should be removed since it is a screening test quite different … Really well done, especially the differentiation by pre- test risk groups and by site of testing. … A negative stress test would provoke further evaluation for other etiologies of the chest pain. … But only the pre-test risks reported by authors of the studies were used for stratification. … Classification of patient pre-test risk was based on how it was described in the studies.

240. PCA3 Testing in the Diagnosis and Management of Prostate Cancer: Future Research Needs (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/prostate-cancer-antigen-3-gene_research.pdf
     April 01, 2013 - Highest priority went to establishing the diagnostic accuracy of the test. … Hence, the value of such a test would obviously be limited. … accuracy alone would not necessarily equate to test effectiveness. … The value of such a test would obviously be limited. … Lack of information on how demographics impact PCA3 test. 5.