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181. Antiplatelet-Treatment Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_executive.pdf
     September 01, 2013 - Because these studies include both test-positive and test-negative patients in each treatment arm, they … test results and then randomize them into non–test-based treatment groups. … Key Question 4: Harms of Testing and of Test-Directed Treatment Harms of Test-Directed Treatment All … The test for interaction (a test for heterogeneity of treatment effects across genotype groups) was … alternative test-and-treat strategies provided information on harms of test-directed treatment.

182. Comparative Effectiveness of Non-Invasive Diagnostic Tests for Breast Abnormalities – An Update of a 2006 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-abnormalities-tests-update/research-protocol
     December 01, 2019 - If an available noninvasive diagnostic test could assist clinicians in evaluating women who have been … that affected the accuracy of the noninvasive test being evaluated. … because the outcome of test accuracy is indirectly related to health outcomes. … Sensitivity: the proportion of women with breast cancer who test positive for breast cancer. … Specificity: the proportion of women with benign lesions who test negative for breast cancer.

183. Diabetes and Pregnancy | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/diabetes-and-pregnancy
     June 05, 2014 - Most women get a test to check for diabetes during their second trimester of pregnancy. … Women at higher risk may get a test earlier. … your health care team about A meal plan for your pregnancy A safe exercise plan How often to test

184. Eye Care | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/eye-care
     The exam includes several tests: A visual field test to measure your side (peripheral) vision. … A visual acuity test, where you read an eye chart about 20 feet away, to check on how well you see at … refractive error and are going to need glasses or contacts , then you will also have a refraction test … When you have this test, you look through a device that has lenses of different strengths to help your

185. ADHD Diagnosis and Treatment in Children and Adolescents | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/attention-deficit-hyperactivity-disorder/research
     November 01, 2024 - Diagnostic test performance likely depends on whether youth with attention deficit hyperactivity disorder … Studies evaluating neuropsychological tests of executive functioning (e.g., Continuous Performance Test … Studies have rarely assessed test-retest reliability, no findings have been replicated prospectively … The Advanced Test of Attention repeated after 2 weeks Insufficient Misdiagnosis impact 0 studies No … Studies should also include assessment of test-retest reliability to help discern whether variability

186. Disposition of Comment Report for Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_disposition-comments.pdf
     May 20, 2013 - The guidelines currently say that it is a replacement test. … and WMC test being conducted weeks to months apart. … when the gastric emptying scintigraphy test was ordered. … Some experts thought that it would likely be a complementary test rather than an independent test for … In this way, they are no better or worse than WMC test results.

187. Plasma-Cell-Dyscrasias-Sflc-Assay Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/plasma-cell-dyscrasias-sflc-assay_executive.pdf
     August 01, 2012 - The traditional test comparators reported varied in each study. … All 3 compared test results to the diagnosis of disease verified by medical records. … The traditional test comparators differed in each study. … Methods Guide for Medical Test Reviews. … How to use an article about a diagnostic test. B.

188. C- Evidence-based Practice Center Technical Brief Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/musculoskeletal-disorders-imaging_research-protocol.pdf
     August 05, 2010 - treatments Outcomes • Test performance of positional MRI • Intermediate outcomes of patients: … iv Proposed use of the test: replacement test (e.g. instead of conventional MRI), triage test (e.g. … use of positional MRI todecide whether a myelogram is needed), or add- on/confirmatory test (e.g. use … Screening: use of the test to identify disease in the absence of clinical symptoms. b. … Patient management or treatment planning: use of the test to determine the management plan, including

189. Comparative effectiveness of conventional computed tomography (CT), multidetector computed tomography (MDCT) (CT colonography), fludeoxyglucose positron emission tomography (FDG-PET) or FDG-PET/CT, magnetic resonance imaging (MRI),… | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/get-involved/nominated-topics/comparative-effectiveness-of-conventional-computed-tomography-ct-multidetector-computed-tomography-mdct-ct-colonography-fludeoxyglucose-positron-emission-tomography-fdg-pet-or-fdg-petct-magnetic-resonance-imaging-mri-ultraso
     November 01, 2017 - Briefly describe a specific question, or set of related questions, about a health care test … pre-therapy staging (including the assessment of liver metastasis) of colorectal cancer Which imaging test … or test that can “see” some functions of a cancer (e.g. blood flow, consumption of sugar etc) is the … best test to tell how advanced a colorectal cancer is and if spread has occurred outside it to other

190. Appendixes: Blood-based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-appendices.pdf
     May 22, 2024 - PICOTS Inclusion Criteria Exclusion Criteria Comparator KQs 1, 2, 4 • No screening test. … KQ 3 • Studies that provide data related to test accuracy; both prediagnostic test performance and … diagnostic test performance designs are eligible. … MCST = multicancer screening test; NA = not applicable. … Modeled reductions in late-stage cancer with a multi-cancer early detection test.

191. Breast-Abnormalities-Tests-Update Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/breast-abnormalities-tests-update_executive.pdf
     February 01, 2012 - Sensitivity is a measure of how accurately the test can identify women with cancer; specificity is a … measure of how accurately the test can identify women who do not have cancer. … test with high specificity will rarely misclassify women without cancer as having cancer. … This estimate is known as a “pre-test” or “prior” probability. … if an additional imaging test will be helpful in guiding management decisions.

192. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/heart-failure-natriuretic-peptide_research-protocol.pdf
     December 20, 2011 - The review will consider BNP and NT-proBNP test performance, cut points, and factors that affect test … The low specificity of the test, however, limits its use as a rule-in tool. … Adverse events associated with administration of the test, or being exposed to the results. … Adverse events associated with administration of the test, or being exposed to the results. … Methods Guide for Medical Test Reviews.

193. Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/antiplatelet-treatment/research
     December 01, 2019 - We also searched the Food and Drug Administration Web site and ClinicalTrials.gov, and contacted test … outcomes, use of tests to guide antiplatelet therapy, or adverse events from testing itself or from test-directed … Test-retest reliability and interassay agreement for genotyping assays appeared adequate; however, few … Only 12 studies provided information on analytic test performance, and they reported variable results … Comparative data on alternative test strategies (genetic versus phenotypic) are lacking.

194. Imaging Tests for the Diagnosis and Staging of Pancreatic Adenocarcinoma | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cancer-pancreas/research
     December 01, 2019 - For studies of a single imaging test, the key outcomes were accuracy and procedural harms. … For data on single-test accuracy, procedural harms, patient tolerance, and screening accuracy, we tabulated … developing pancreatic adenocarcinoma, available studies do not correlate the results of a given imaging test … comparative data on patient-oriented outcomes and factors that could influence comparative accuracy, and test-specific

195. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/depression-postpartum-screening_research-protocol.pdf
     May 01, 2013 - ) and specificity (the likelihood that people without the condition will have a negative test). … The sensitivity and specificity of a test are characteristics that are independent of the population … or can be indirectly estimated from given estimates of the test sensitivity and specificity and the … We will test for heterogeneity using graphical displays and test statistics (Q and I2 statistics), while … Methods Guide for Medical Test Reviews.

196. Comparative Effectiveness of Noninvasive Technologies for the Diagnosis of Coronary Artery Disease (CAD) in Women | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/cad-women-diagnosis/research-protocol
     December 01, 2019 - evidence showing that women at risk for CAD are less often referred for the appropriate diagnostic test … being at low, intermediate, or high risk for the disease to guide the decision about which diagnostic test … factors) have been reported to induce ECG changes during exercise that diminish the accuracy of the test … Additional factors may improve the accuracy of the exercise test, such as chronotropic and hemodynamic … propose that evidence of sex-specific limitations is insufficient to remove the stress exercise ECG test

197. Effectiveness of Early Diagnosis, Prevention, and Treatment of Clostridium difficile Infection | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/c-diff-infections/research
     December 01, 2019 - Evidence on diagnostic tests was quantitatively synthesized focusing on differences between test sensitivities … difficile toxins may be more sensitive than immunoassays for toxins A and B while the comparisons of these test … More precise estimates of the magnitude of differences in test sensitivities and specificities are needed … More importantly, studies have not established that any of the possible differences in test accuracy

198. Infectious Disease Including HIV/AIDS #09 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/infectious-disease-horizon-scan-high-impact-1506.pdf
     December 01, 2015 - The Xpert MTB/RIF (M. tuberculosis/rifampicin) test is a nucleic acid–based test that is run on the … TB test manufacturer’s GeneXpert® real-time polymerase chain reaction (PCR) system. … cartridge costs between $49 and $63 per test when purchasing a set of 10 tests. … results (e.g., tuberculin skin test, QuantiFERON-TB Gold test), and/or chest radiographs.122,123 The … the sample simultaneously with a nucleic acid amplification test, an acid- fast bacteria smear test

199. Disposition of Comments Report for Testing of CYP2C19 Variants and Platelet Reactivity for Guiding Antiplatelet Treatment (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/antiplatelet-treatment_disposition-comments.pdf
     September 25, 2013 - ” of a pharmacogenetic test). … We are aware of the somewhat superior properties of the Harbord test (compared to the Egger test). … Teirstein Methods VerifyNow P2Y12 Test The VerifyNow P2Y12 Test requires no sample manipulation prior … In particular, for 3a there were several direct comparisons of phenotype test vs. no-test strategies … Is this different from or the same as random assignment to test/no test strategies?

200. Glaucoma-Screening Surveillance (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/glaucoma-screening_surveillance.pdf
     January 01, 2013 - Four studies examined the accuracy of the FDT N-30 threshold test. … SAP Suprathreshold Test Evidence From Burr et al., 2007. … SAP Threshold Test Evidence From Burr et al., 2007. … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for … Based on analyses of the common criterion for each test, test accuracy, combination tests, tests for