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161. Liver-Cancer Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/liver-cancer_executive.pdf
     October 01, 2014 - What is the comparative test performance of imaging- based strategies for detecting HCC? … Data for outcomes other than measures of test performance were sparse. … Ten studies reported test performance of PET for detection of metastatic disease. … Summary of evidence for Key Question 3.a (staging): test performance Table L. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

162. Options for Summarizing Medical Test Performance in the Absence of a "Gold Standard" | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/methods-guidance-tests-performance
     March 01, 2021 - SHARE: Options for Summarizing Medical Test … created December 2020 Internet Citation: Options for Summarizing Medical Test

163. Diagnosis, Prevention, and Treatment of C. difficile: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/c-difficile-update/clinician
     December 01, 2019 - such as the glutamate dehydrogenase [GDH] assay; if the first test is positive, a second test for toxins … on diarrheal (unformed) stool, unless ileus due to C. difficile is suspected.* Diagnostic Test … The first step is a fast screen for the presence or absence of C. difficile using a test such as the … If the first test gives a positive result, a second test for C. difficile toxins is performed. … Nucleic Acid Amplification Test: loop-mediated isothermal amplification Sensitivity 12 Sensitive

164. Depression-Postpartum-Screening Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/depression-postpartum-screening_executive.pdf
     May 01, 2013 - Test performance was summarized using sensitivity and specificity. … Screening Test Outcome Number of Studies (Subjects) Domains Pertaining to SOE SOE and Test Performance … characteristics of the screening test. … The choice of optimal test and test thresholds, testing algorithms, and test frequency need to be made … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

165. Biomarkers for Assessing and Managing Iron Deficiency Anemia in Late-Stage Chronic Kidney Disease: Future Research Needs | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/chronic-kidney-disease-anemia/research
     December 01, 2019 - meta-analysis of 55 studies (published before 1990) showed that ferritin radioimmunoassay was the most powerful test … determination, TSAT, and red cell volume distribution, for diagnosing adult patients with iron deficiency, but test … The accurate assessment of iron status is dependent on the validity and reliability of laboratory test … results, and differences in test performance pose a dilemma regarding the most appropriate test to guide

166. Screening and Diagnosis of Gestational Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gestational-diabetes-screening-diagnosis/research-protocol
     December 01, 2019 - receive a subsequent diagnostic test. 1,8 Typically, a 50 g oral glucose challenge screening test is … A hierarchical regression approach to meta-analysis of diagnostic test accuracy evaluations. … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a single graphical test. Br Med J 1997;315:629–34. … Glucose Tolerance Test/ 16. Glucose Intolerance/ 17. Blood Glucose/ 18. Risk Factors/ 19.

167. FRN 27 - Wireless Motility Capsule Versus Other Diagnostic Technologies for Evaluating Gastroparesis and Constipation: Future Research Needs (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/wireless-motility-capsule-future_research.pdf
     May 01, 2013 - versus adjunct test for diagnosis. … specialists or as a front-line test. … versus adjunct test for diagnosis. … specialists or as a front-line test. … Test Protocols for the diagnosis of gastroparesis and slow-transit constipation Test Duration of Test

168. Imaging Tests To Check for Kidney Stones in the Emergency Department (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/kidney-stone-imaging_consumer.pdf
     July 01, 2016 - You have come to the emergency department and the emergency doctor has recommended an imaging test to … How you feel about possibly needing a second imaging test. … If the first imaging test is not clear, you may need a second test. … In the past, a CT scan was often used as the first imaging test to check for kidney stones. … - If you have an ultrasound first, you may need a second imaging test, which may be a CT scan.

169. breast-biopsy-update-130920 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/breast-biopsy-update_research-protocol.pdf
     September 20, 2013 - However, the impact aspects of biopsy technique have on test performance and safety are not clear. … The reference standard is used in their definition and is not a “comparator test.” … Further, small studies do not produce precise estimates of test performance. 6. … , reference standard test, and patient flow and timing. … Methods  Guide  for  Medical  Test  Reviews.  

170. celiac-disease-protocol-140612 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/celiac-disease_research-protocol.pdf
     June 12, 2014 - Risk: Low/High/Unclear Domain 2: Index Test(s) (complete for each index test used) Were the index … test results interpreted without knowledge of the reference standard? … (Yes/No/Unclear) Could the conduct or interpretation of the index test have introduced bias? … Methods to detect publication bias for medical test studies are not robust. … Methods Guide for Medical Test Reviews. AHRQ. 2012. 12. McNeish AS, Harms HK, Rey J, et al.

171. Disposition of Comments Report for Antinuclear Antibody, Rheumatoid Factor, and Cyclic-Citrullinated Peptide Tests for Evaluating Musculoskeletal Complaints in Children (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/musculoskeletal-complaints-tests-children_disposition-comments.pdf
     March 07, 2012 - The potential effect of age on test accuracy is addressed in KQ4. … of a “normal” adult population should have a positive test. … At a 1:160 dilution, 5% of this population should have a positive test. … They are an inherent part of the ANA test procedure. … By index test results we mean results of ANA, RF, and CCP tests.

172. Tonsillitis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/tonsillitis
     It could be a rapid strep test, a throat culture, or both. … With the rapid strep test, testing is done in the office, and you get the results within minutes. … The throat culture is a more reliable test. … So sometimes if the rapid strep test is negative (meaning that it does not show any strep bacteria),

173. Screening and Diagnosing Gestational Diabetes Mellitus | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gestational-diabetes-screening-diagnosis/research
     December 01, 2019 - with any other screening or diagnostic test; any screening with no screening; women who met various … The 50 g oral glucose challenge test with a glucose threshold of 130 mg/dL versus 140 mg/dL improves … GDM compared with Carpenter and Coustan GDM, Carpenter and Coustan 1 abnormal oral glucose tolerance test … supports a positive association with increasing plasma glucose on a 75 g or 100 g oral glucose tolerance test … The 50 g oral glucose challenge test has high NPV but variable PPV.

174. Procalcitonin for Diagnosis and Management of Sepsis | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/procalcitonin/research-protocol
     December 01, 2019 - Whether or not the semiquantitative test will yield similar results to the quantitative test is unknown … Was the reference standard independent of the index test (i.e. the index test did not form part of the … Was the execution of the index test described in sufficient detail to permit replication of the test? … test is used in practice? … Were uninterpretable/intermediate test results reported?

175. Colon-Cancer-Gene-Profiling Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colon-cancer-gene-profiling_research-protocol.pdf
     March 13, 2012 - Data from a GEP test can provide information about a cell’s type, its current state of activity, and … What is the test turn-around time? d. … Those identified thus far are as follows: • Oncotype DX® Colon Cancer test (Genomic Health, Inc., … with different test results are sufficiently great as to influence treatment decisions. … the genes that are part of the assay, and are the test results reproducible?

176. Wireless-Motility-Capsule Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/wireless-motility-capsule_executive.pdf
     May 01, 2013 - Second, the physician needs to test for gastric emptying. … Should it be used as a stand-alone test? … Discrepancy exists when one test shows disease and the other test does not show disease. … test, it is difficult to get a clear picture of which test was most helpful in making a diagnosis … as superior to another test.

177. Topic 0438 Risk stratification and CAD NSD FINAL_SJ-2 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND-0520-131115.pdf
     November 15, 2013 - While the test performance characteristics for each of these diagnostic strategies are known, the relative … There is no clear guidance of what the test or combination of tests to use for patients with different … reviews primarily focus on NITs to diagnose symptomatic patients with suspected CAD and solely on the test … two or more NITs, evaluated NITs in the asymptomatic populations, and looked at outcomes other than test

178. Diagnosis of Celiac Disease: Current State of the Evidence (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/celiac-disease_clinician.pdf
     July 01, 2016 - This test is included in the algorithms of all recent guidelines. … This is a newer test that may give a positive result in some individuals with celiac disease who are … This test is used in individuals (primarily adults) who want to avoid biopsy. … Adding an EmA test to a tTG test resulted in increased specificity, with either no change or a slight … Adding a DGP test to a tTG test resulted in increased sensitivity but decreased specificity.

179. Evidence-based Practice Center Systematic Review Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-screening_research-protocol.pdf
     May 18, 2011 - Available fecal DNA tests are instead offered as a direct-to-consumer laboratory-developed test; such … What are the absolute test-performance characteristics (e.g., sensitivity, specificity) of fecal DNA … KQ 2: For absolute test performance: colonoscopy alone or supplemented by another test. … For relative test performance: any established CRC- screening modality. … and comparator test (reference standard) characteristics; and outcomes, including harms.

180. Disposition of Comments for CER 157 Appendicitis (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/appendicitis_disposition-comments.pdf
     December 14, 2015 - We provide complete test-specific information in the main text of the report. … test performance and the impact of tests on clinical outcomes. … Changes in technology over time may be a modifier of test performance. … reference standard test used which I presume it was histology. … What is paired test vs parallel arm design?