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141. Core Needle and Open Surgical Biopsy for Diagnosis of Breast Lesions — An Update to the 2009 Report | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/breast-biopsy-update/research-protocol
     December 01, 2019 - The reference standard is used in their definition and is not a “comparator test.” … Further, small studies do not produce precise estimates of test performance. … , reference standard test, and patient flow and timing. … Chapter 8: meta-analysis of test performance when there is a "gold standard". … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017.

142. Blood-based Tests for Multiple Cancer Screening: A Systematic Review (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cell-free-dna-protocol.pdf
     June 05, 2024 - KQ 3: Studies that provide data related to test accuracy; both prediagnostic test performance and diagnostic … test performance designs are eligible. … Methods guide for medical test reviews. … Radio Multicancer detection test accuracy Single-cancer detection test accuracy Other Study … cancer and negative test) N False Positives (participants without cancer and positive test)

143. Women's Health Checkup | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/womens-health-checkup
     A Pap test - a test to check for cancer of the cervix , the opening to a woman's uterus. … Your health care provider may also recommend other tests, including a mammogram or a test for HPV

144. Cancer-Pancreas Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/cancer-pancreas_executive.pdf
     September 01, 2014 - Test Criteria a. Type of test. … one of the following three types of conclusions: (1) test A is more accurate than test B, (2) test B … ) may permit more estimates of single test staging accuracy. … Specific test protocols, however, may differ between the studies we included and the typical test parameters … 17 (e.g., for staging small tumors, one test is best, but for large tumors, another test is best

145. Liver-Cancer Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/liver-cancer_research-protocol.pdf
     July 24, 2013 - What is the comparative test performance of imaging techniques for diagnosing HCC? i. … What is the comparative test performance of imaging techniques on diagnostic thinking? c. … and the reference standard, and use preset criteria to define a positive test. … Methods Guide for Medical Test Reviews. AHRQ Publication No. 12-EHC017-EF. … Methods Guide for Medical Test Reviews. AHRQ Publication No.12- EHC017-EF.

146. Protocol: Imaging for Pretreatment Staging of Small Cell Lung Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/lung-cancer-staging_research-protocol.pdf
     December 08, 2014 - Test criteria a. Type of test. … or test strategy compared to another test or test strategy … or test strategy compared to another test or test strategy … or test strategy compared to another test or test strategy … /test strategy compared to another test or test strategy

147. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pregnancy_hi_impact.pdf
     January 01, 2012 - Endoglin urine test for preeclampsia screening 5. … application for a test kit. … test (LDT) to be performed on samples sent to its Sequenom Center for Molecular Medicine. … blood test). 47 This test appears to be closest to product launch and was expected to launch in fall … Many experts suggested that the MaterniT21 test has the potential for controversy.

148. Newborn Screening | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/health-topics/newborn-screening
     September 19, 2012 - All states test for at least 30 of these conditions. … A hearing test that measures the baby's response to sound A skin test that measures the level of oxygen

149. Gene Expression Profiling for Predicting Outcomes in Patients With Stage II Colon Cancer | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colon-cancer-gene-profiling/research-protocol
     December 01, 2019 - Data from a GEP test can provide information about a cell’s type, its current state of activity, and … investigators may attempt to include the MSI findings as part of their GEP test. … What is the test turn-around time? … with different test results are sufficiently great as to influence treatment decisions. … the genes that are part of the assay, and are the test results reproducible?

150. Effective Health Care (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/TND_0488_12-27-2011.pdf
     January 01, 2011 - outcomes (related to accurate diagnosis leading to immediate appropriate management or false negative test … mortality (related to accurate diagnosis leading to immediate appropriate management or false negative test … results resulting in delayed appropriate management)  Harms and costs related to false positive test … Which imaging test or test that can “see” some functions of a cancer (e.g., blood flow, consumption … of sugar, etc.) is the best test to diagnose pancreatic cancer and tell how advanced it is or how widely

151. PREGNANCY, INCLUDING PRETERM BIRTH #12 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/12_pregnancy_potential_high_impact_june_2012.pdf
     January 01, 2012 - (San Diego, CA), which markets a laboratory-developed test and is in the process of developing a test … (Redwood City, CA) developed a test (the verifi™ Non- Invasive Prenatal Test) that is also based on … The test that is furthest along in development is Sequenom, Inc.’s (San Diego, CA) MaterniT21™ test … Sequenom developed the MaterniT21 test, a DNA-based, first-trimester screening assay (blood test) using … http://www.verinata.com/news/non-invasive-prenatal-test/ http://www.verinata.com/news/non-invasive-prenatal-test

152. Efficacy and Safety of Screening for Postpartum Depression | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/depression-postpartum-screening/research-protocol
     December 01, 2019 - ) and specificity (the likelihood that people without the condition will have a negative test). … The sensitivity and specificity of a test are characteristics that are independent of the population … Because of this dependence on prevalence, the PPV and NPV of a specific test can vary across studies, … We will test for heterogeneity using graphical displays and test statistics (Q and I 2 statistics), … Methods Guide for Medical Test Reviews.

153. Appendicitis Research-Protocol (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/appendicitis_research-protocol.pdf
     December 09, 2013 - We will use existing systematic reviews to identify single index test studies with test performance … • Have examined test performance outcomes. … Test characteristics include aspects specific to each diagnostic test of interest (e.g., the use and … Of note, studies evaluating the test performance of (the same) single index test will be synthesized … Methods Guide for Medical Test Reviews.

154. CER 174 Executive Summary: Imaging for the Pretreatment of Small Cell Lung Cancer (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/lung-cancer-staging_executive.pdf
     April 01, 2016 - Test Criteria a. Type of test. … or test strategy compared with another test or test strategy … or test strategy compared with another test or test strategy … or test strategy compared with another test or test strategy … /test strategy compared with another test or test strategy

155. Diagnosis of Celiac Disease: Current State of the Evidence | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/celiac-disease/clinician
     December 01, 2019 - Table 1 : Tests Currently Used To Diagnose Celiac Disease Test Description Notes … This test is included in the algorithms of all recent guidelines. … This test is used in individuals (primarily adults) who want to avoid biopsy. … Adding an EmA test to a tTG test resulted in increased specificity, with either no change or a slight … Adding a DGP test to a tTG test resulted in increased sensitivity but decreased specificity.

156. Colorectal-Cancer-Protocol_130520 (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/pdf/colorectal-cancer-staging_research-protocol.pdf
     May 20, 2013 - Test performance. … Studies must compare the test or test combination being evaluated to a reference standard (see below … Studies must directly compare the test or test combination to another test or test combination of interest … Studies must directly compare the test or test combination to another test or test combination of interest … Test Criteria Type of test.

157. Colorectal-Cancer-Screening Executive (pdf file)
     effectivehealthcare-admin.ahrq.gov/sites/default/files/related_files/colorectal-cancer-screening_executive.pdf
     February 01, 2012 - Especially given the constant changes in test development, test developers and researchers need to … Food and Drug Administration FIT Fecal immunochemical test FOBT Fecal occult blood test (usually used … and reliability of test results. … Initial test validation—study designed to determine ability and diagnostic accuracy of a test in persons … Relative test performance—Diagnostic accuracy (sensitivity, specificity) when compared to another test

158. Use of Natriuretic Peptide Measurement in the Management of Heart Failure | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/heart-failure-natriuretic-peptide/research-protocol
     December 01, 2019 - The review will consider BNP and NT-proBNP test performance, cut points, and factors that affect test … The low specificity of the test, however, limits its use as a rule-in tool. … determinants (e.g., age, gender, co-morbidities) on the test performance characteristics. … determinants (e.g., age, gender, co-morbidities) on the test performance characteristics. … Methods Guide for Medical Test Reviews.

159. Comparative Effectiveness of Fecal DNA Testing in Screening for Colorectal Cancer in Average-Risk Adults | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/colorectal-cancer-screening/research-protocol
     December 01, 2019 - Available fecal DNA tests are instead offered as a direct-to-consumer laboratory-developed test; such … Currently, there is at least one fecal DNA test commercially available in the United States (ColoSure … KQ 2: For absolute test performance: colonoscopy alone or supplemented by another test. … For relative test performance: any established CRC-screening modality. … and comparator test (reference standard) characteristics; and outcomes, including harms.

160. Diagnosis of Gout | Effective Health Care (EHC) Program
     effectivehealthcare-admin.ahrq.gov/products/gout/research-protocol-2014
     March 01, 2020 - KQ2 What are the adverse effects associated with each diagnostic test (including pain, infection at … Assessing Risk of Bias as a Domain of Quality in Medical Test Studies. … Methods Guide for Medical Test Reviews. Rockville (MD); 2012. … Operating characteristics of a rank correlation test for publication bias. … Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629-34.